ALS Muscle Imaging Study

Condition: Amyotrophic lateral sclerosis

Eligibility

Key Inclusion Criteria:

  • Confirmed diagnosis of amyotrophic lateral sclerosis (ALS)
  • Duration of symptoms ≤36 months
  • At least 18 years old
  • Slow vital capacity or forced vital capacity ≥60% of predicted

Key Exclusion Criteria:

  • Using invasive ventilatory assistance
  • Diagnosis of another active or unstable medical illness that may interfere with study participation
  • Any condition of the upper or lower extremities which prevents serial strength testing

Study Name

A Longitudinal and Cross-sectional Muscle Imaging Study in Amyotrophic Lateral Sclerosis (ALS) (IRB no. 000000413)

Summary

The purpose of this study is to determine whether new magnetic resonance imaging (MRI) techniques can detect muscle changes over time in amyotrophic lateral sclerosis (ALS). Researchers will compare the data obtained from muscle MRIs with other measurements like the ALS-Functional Rating Scale-Revised, pulmonary function tests, strength assessments (hand-held dynamometry and ATLIS-Accurate Test of Limb Isometric Strength), respiratory function tests, and vital signs (including height and weight). This is a longitudinal study in which participants are tested at approximately 3-month intervals until the study ends (up to 1 year).

Principal Investigator