The Use of Airway Clearance Devices in ALS

Condition: Amyotrophic lateral sclerosis (ALS)

Eligibility

Key Inclusion Criteria

  • Suspected, possible, probable, probable (lab-supported) or definite ALS
  • At least 18 years old
  • Novel to airway clearance device use

Key Exclusion Criteria

  • Any contraindication for pulmonary ventilation or perfusion scan
  • Any contraindication for use of a pulmonary clearance device
  • Susceptibility to pneumothorax

Full Study Name

Utilization of Pulmonary Clearance Devices in Amyotrophic Lateral Sclerosis (IRB no. 39699)

Summary

This study focuses on patients with amyotrophic lateral sclerosis (ALS) who have some changes in breathing. The purpose of the study is to examine the use of one airway clearance medical device compared to the use of two airway clearance medical devices together. The first device is a passive form of high frequency chest compression (HFCC), designed to help clear the airway of mucus and other secretions through mechanical knocking of the chest area. The second device, called a cough assist, aids patients to clear mucus and secretions that they would otherwise be unable to clear with coughing.

Researchers aim to determine whether the use of HFCC on its own, or the use of both HFCC and cough assist together, is effective for maintaining a healthy airway and clear secretions. The use of two airway clearance medical devices together is investigational.

Phase

Phase IV


Principal Investigator

Ashraf Elsayegh, MD

Contact