Neurology & Neurosurgery Clinical Trials

Providing state-of-the-art care for people with brain and nervous system disorders is our most important commitment. As a neurology or neurosurgery patient at Cedars-Sinai, you have access to clinical trials and research aimed at improving testing methods, treatments, quality of life and recovery. These studies are open to people with a broad range of neurological conditions.

Questions? See the Clinical Trial FAQs.



Amyotrophic Lateral Sclerosis (ALS)

Condition:

Amyotrophic lateral sclerosis

Participants Must:

Be at least 18 years old; with diagnosis of clinically possible, laboratory supported probable, probable or clinically definite ALS.

Summary:

The objective of this study is to assess an investigational strength measurement device called Accurate Test of Limb Isometric Strength (ATLIS) in patients with amyotrophic lateral sclerosis (ALS). ATLIS is designed to evaluate muscle strength and measures the isometric strength of 12 muscle groups in the arms and legs.

Condition:

Amyotrophic lateral sclerosis

Participants Must:

Be at least 18 years old; with diagnosis of familial or sporadic ALS, or those with primary lateral sclerosis or progressive bulbar/muscular atrophy forms of motor neuron disease.

Summary:

This study focuses on individuals who have been diagnosed with amyotrophic lateral sclerosis (ALS) or a related motor neuron disease (MND) such as primary lateral sclerosis, progressive muscular atrophy, or progressive bulbar palsy. The purpose of the study is to collect specimens and data for future analyses.

Condition:

Amyotrophic lateral sclerosis

Participants Must:

Be between 18–60 years old; with ALS diagnosed as possible, laboratory-supported probable, probable or definite.

Summary:

This study focuses on patients who have been diagnosed with amyotrophic lateral sclerosis (ALS) with symptoms less than two years. The study is designed to test the investigational use of NurOwn (MSC-NTF cells), a type of cell derived from an individual’s own bone marrow. Researchers aim to determine whether repeated dosing of NurOwn is safe without causing too many side effects and whether it may decrease the rate of ALS decline.

Condition:

Amyotrophic lateral sclerosis

Participants Must:

  • Have a clinical diagnosis of amyotrophic lateral sclerosis
  • Be at least 18 years old
  • Be able to provide informed consent

Summary:

The purpose of this study is to collect medical information, key event dates and treatment information on patients with amyotrophic lateral sclerosis (ALS) to determine the natural history of the disease and whether utilized interventions affect the disease course.  

Brain Injury

Condition:

Traumatic brain injury

Participants Must:

  • Have non-penetrating traumatic brain injury
  • Be able to place intracranial monitors and assign to treatment group within six hours of arrival at enrolling hospital, but no later than 12 hours from injury
  • Be at least 14 years old

Summary:

This study focuses on patients with severe traumatic brain injury (TBI). The purpose of the study is to compare two ways of treating patients with brain injury. Participants will be randomly assigned to one of two groups. One group will receive medical care based on monitoring of pressure in the brain (intracranial pressure or ICP) alone. The other group will receive medical care based on ICP and the amount of oxygen in the brain.

Brain Tumors

Condition:

Brain tumors

Participants Must:

Be an adult and child identified as having a probable brain tumor which is best treated by surgical resection.

Summary:

The purpose of this study is to collect brain tumor samples taken during a scheduled surgical procedure to determine possible eligibility and interest in participating in current IRB-approved vaccine trials. The tumor tissue will be removed during the surgery regardless of research participation. The processed tumor tissue would then be maintained in a separate registry and analyzed for eligibility in any of the IRB-approved vaccine trials.

Condition:

Brain tumors

Participants Must:

Be an adult and pediatric patient; with a suspected or pathology-proven brain, breast, head, neck, or skin tumor who are undergoing a tumor resection; or undergoing temporal lobectomy as standard of care for epilepsy.

Summary:

The purpose of this study is to evaluate the investigational use of laser-induced fluorescence spectroscopy (LIFS) to detect brain tumors at the time of surgery. LIFS is a technique that utilizes a beam of light (laser) to differentiate tumor tissue from normal brain tissue.

Condition:

Brain tumors

Summary:

This study focuses on patients who have recurrent or progressive brain cancer. The purpose of the study is to evaluate the effects of a gene therapy in combination with an immune therapy. Specifically, researchers will evaluate the safety and effects of combining Ad-RTS-hIL-12 and veledimex with cemiplimab-rwlc in patients with brain tumors that are unresponsive to standard of care.

Carotid Stenosis

Condition:

Carotid stenosis

Participants Must:

Be at least 35 years old; have no medical history of stroke or transient ischemic attack on the same side of the body as the stenosis (narrowing) within 180 days of study group assignment.

Summary:

This study evaluates differences between treatment options for patients with asymptomatic carotid stenosis (narrowing of the carotid arteries without symptoms). Carotid artery disease is caused by a thickened area (plaque) in the artery, which narrows the artery and may limit blood flow to the brain.

Charcot-Marie-Tooth (CMT) and Other Neuromuscular Disorders

Condition:

Charcot-Marie-Tooth disease

Participants Must:

Have documented, disease causing mutation in the MPZ gene (for CMT1B) or in MFN2 (for CMT2A); have two documented, disease causing mutations in the GDAP1 gene (for CMT4A) or two mutations in the SH3TC2 gene (for CMT4C).

Summary:

The purpose of this study is to determine the natural history, or speed of progression, of Charcot Marie Tooth disease (CMT). The study will follow a group of people over time who have, or are at risk of developing, CMT and will also include a group of participants (“controls”) who do not have CMT.

Summary:

The purpose of this study is to establish a repository of DNA and tissue samples to be used for future research studies investigating the clinical and genetic features of various types of neurologic and neuromuscular conditions.

Epilepsy

Condition:

Epilepsy

Participants Must:

Have drug-resistant focal epilepsy and have agreed to undergo monitoring with implanted depth electrodes in the future.

Summary:

This study focuses on individuals who have medically intractable epilepsy (epilepsy that cannot be controlled by treatment) and who are scheduled to undergo insertion of electrodes into their brain to help find the source of seizures. The purpose of the study is to examine whether preoperative functional magnetic resonance imaging (functional MRI) can be used to help localize areas of the brain from which seizures originate. Researchers aim to determine whether functional MRI studies provide additional information beyond that provided by depth electrode monitoring (which participants will undergo as part of standard care). The study will also examine whether high-resolution structural MRIs can help localize the electrodes that patients will be implanted with at a later time.

Multiple Sclerosis

Condition:

Multiple sclerosis, neuroimmune conditions

Participants Must:

Be at least 18 years old and diagnosed with a neurological condition

Summary:

The purpose of this study is to create a data and specimen repository to evaluate new ways of diagnosing multiple sclerosis (MS) and to distinguish these diagnostic techniques from mimics in order to prevent misdiagnosis. A repository is a collection of data and/or specimens that are stored with the intent of supporting future research.

Condition:

Multiple sclerosis

Participants Must:

Must be 18-60 years old; meets criteria for relapsing-remitting multiple sclerosis; must be either JC virus antibody-negative or low positive OR negative for hepatitis B and C and tuberculosis

Summary:

The purpose of this study is to identify the most appropriate treatment strategy for individuals with multiple sclerosis (MS), especially shortly after diagnosis when it may be most possible to increase a patient’s chance for preventing longer-term disability.

Neurologic and Neuromuscular Disorders

Condition:

Neurologic and neuromuscular disorders

Participants Must:

  • Group 1: Adults and children with evidence of a neurologic or neuromuscular disorder
  • Group 2: Adults (at least 18 years old) who are family members of individuals in group 1
  • Group 3: Unrelated healthy adults (at least 18 years old) who are used as a comparison group

Summary:

The purpose of this study is to establish a repository of blood/DNA samples to be used for future research studies examining the clinical and genetic features of various types of neurologic and neuromuscular disorders, including conditions that may not be genetically based.

Parkinson's Disease

Condition:

Parkinson's disease

Participants Must:

Be 40-85 years old. Have the ability to safely undergo fludeoxyglucose (18F) positron emission tomography (FDG-PET)/ magnetic resonance imaging (MRI). Have the ability to comply with study procedures.

Summary:

This study focuses on individuals who have been diagnosed with either Parkinson's disease (PD) or the related condition, multiple system atrophy (MSA). The purpose of the study is to use imaging techniques to track changes in glucose metabolism (the way the brain uses energy), which may improve understanding of PD and related diseases such as MSA, and to develop new treatments for these conditions. Researchers aim to determine the effects of brain glucose metabolism on the body in PD and MSA patients and in those who have insulin resistance or diabetes.

Condition:

Parkinson's disease, insulin resistance

Participants Must:

Have diagnosis of idiopathic Parkinson's disease; concurrent enrollment in the study, Liraglutide in Parkinson's Disease.

Summary:

This study aims to determine the effects of a drug called liraglutide on brain glucose metabolism in Parkinson's disease (PD) patients. The study focuses on patients diagnosed with idiopathic PD who have already agreed to participate in another study, Liraglutide in Parkinson's Disease.

Condition:

Parkinson's disease

Participants Must:

Be at least 18 years old; with clinical diagnosis of Parkinson's disease.

Summary:

The purpose of this study is to examine the history of Parkinson's disease in patients. Researchers aim to learn about medical information, key dates, and treatment related to patients' disease. The study will also evaluate whether biomarkers can be useful in predicting the progression of Parkinson's disease.

Stroke

Condition:

Stroke

Summary:

Participants must be acute ischemic stroke patients; treated with 0.9 mg/kg IV rt-PA within 3 hours of stroke onset or time last known well; at least 18 years old.

Condition:

Stroke

Participants Must:

Be at least 18 years old; have transient ischemic attack with ABCD2≥4 or ischemic stroke within the past 14 days.

Summary:

This study focuses on individuals who have had a recent stroke or transient ischemic attack (TIA, often called a "mini-stroke") and who are still in the hospital (initial hospitalization or rehabilitation stay). The purpose of the study is to determine whether treatment for sleep apnea in patients who have had a stroke or TIA improves recovery from stroke and helps prevent future stroke, heart problems, and death. Sleep apnea is a disorder in which breathing stops or nearly stops repeatedly during sleep. This condition affects most (about 75 out of 100) stroke and TIA patients.

Condition:

Stroke

Participants Must:

Be between 30–80 years old. Patients 30 to 49 years old are required to meet additional criteria; with transient ischemic attack or non-severe stroke within 30 days of enrollment.

Summary:

This study focuses on patients who have been evaluated and/or treated by a neurosurgeon and/or neurologist at Cedars-Sinai for symptomatic intracranial stenosis. The purpose of the study is to evaluate the outcomes of a surgical approach called indirect revascularization (encephaloduroarteriosynangiosis or EDAS) for narrowing of the blood vessels in the brain.

Condition:

Stroke

Participants Must:

  • Have stroke symptom onset within 4.5 to 24 hours
  • Be at least 18 years old
  • Show signs and symptoms consistent with the diagnosis of an acute anterior circulation ischemic stroke

Summary:

The purpose of this study is to compare the effects of a drug called tenecteplase to placebo (inactive substance) in patients with acute ischemic stroke. Participants will receive either tenecteplase or placebo (inactive substance), in addition to the current standard of care for stroke.