Detecting Acute Pulmonary Embolism Without IV Contrast

Condition: Pulmonary embolism

Eligibility

Key Inclusion Criteria

  • At least 18 years old
  • Diagnosed with an acute pulmonary embolism by computed tomography (CT) angiogram within the past 48 hours
  • Non-English speakers will be included with the use of the short form consent.

Key Exclusion Criteria

  • Considered to be an unsuitable candidate for any reason, or is put at risk by the study procedures
  • Receives thrombolytic therapy or mechanical clot removal prior to study CT
  • Unable to receive the study CT within 48 hours of CT angiogram

Full Study Name

Detecting Acute Pulmonary Embolism Without IV Contrast: Applying Novel Imaging Analysis of Non-Contrast CT Scans in Patients With Acute Pulmonary Embolism (IRB no. 42313)

Summary

This study focuses on adults who have been diagnosed with an acute (new, sudden) pulmonary embolism by computed tomography (CT) angiogram within the past 48 hours. The purpose of the study is to determine whether a new software analysis technique applied to non-contrast CT scans can detect pulmonary emboli in patients diagnosed with acute pulmonary emboli by CT angiogram. Pulmonary embolism is most commonly diagnosed by performing a CT scan of the chest while injecting IV contrast to outline the blood vessels in the lungs and any blood clots in those vessels. 

Researchers believe that the study’s software analysis technique will help doctors diagnose pulmonary embolism from CT scans without having to inject IV contrast. This would be helpful to patients with kidney problems, as IV contrast poses risks of kidney damage.

Principal Investigator

Aaron Weinberg, MD

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