CLOVERS

Condition: Sepsis-induced hypotension

Eligibility

Key Inclusion Criteria:

  • At least 18 years old
  • Has a suspected or confirmed infection
  • Sepsis-induced hypotension defined as systolic blood pressure <100 mmHg or mean arterial pressure (MAP) <65 mmHg, or receiving a vasopressor infusion after a minimum of at least 1 liter of fluid

Key Exclusion Criteria:

  • More than 4 hours elapsed since meeting inclusion criteria
  • More than 24 hours elapsed since presentation to the hospital
  • Already received more than 3 liters of intravenous fluid

Full Study Name

Crystalloid Liberal or Vasopressors Early Resuscitation in Sepsis (IRB no. PRO00056937)

Summary

This study focuses on individuals diagnosed with low blood pressure due to sepsis (a serious infection) and whose blood pressure has stayed low after receiving fluid. The purpose of the study is to evaluate methods of using intravenous fluids (fluids given through a small tube placed in the vein) and vasopressors (medicines used to raise blood pressure) in the treatment of sepsis.

Specifically, researchers aim to determine which method is more effective: starting medicines to raise blood pressure first and then giving more fluids (if needed), or giving a larger amount of fluids first and then giving medicines to raise blood pressure if needed. Currently, the choice of approach to raise low blood pressure caused by sepsis is left to doctors. The treatment part of the study will last for 24 hours, after which patients will be evaluated until they return home.

Principal Investigator

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