Myocardial Steatosis in Women With CMD

Condition: Coronary microvascular dysfunction

Eligibility

Key Inclusion Criteria:

  • Women who are at least 18 years old
  • Chest discomfort or shortness of breath
  • Diagnosed with coronary microvascular dysfunction (CMD)
  • Left ventricular ejection fraction ≥50%

Key Exclusion Criteria:

  • Pregnant or breastfeeding
  • Active infectious/inflammatory condition or systemic rheumatologic disorder, primary valvular heart disease clearly indicating the need for valve repair or replacement
  • Acute myocardial infarction
Study Name

Myocardial Steatosis in Women With Coronary Microvascular Dysfunction: Defining the Pathway to Heart Failure With Preserved Ejection Fraction (HFpEF) (IRB no. 00001247)

Summary

This study focuses on women with angina (chest pain) who have been diagnosed with coronary microvascular dysfunction (CMD, abnormal function of the small microvessels within the heart). The purpose of the study is to understand the relationship between myocardial steatosis (fat accumulation within the heart), coronary microvascular dysfunction, and heart failure with preserved ejection fraction (HFpEF, heart failure despite normal pumping function). HFpEF and CMD are prevalent conditions that predominantly impact women; CMD can cause insufficient delivery of blood and oxygen to the heart muscle.

Participants will be asked to visit Cedars-Sinai up to 3 times for study assessments (blood samples, 48-hour electrocardiogram monitoring, cardiac magnetic resonance imaging, and optional cardiac positron emission tomography scan to assess inflammation), in addition to completing questionnaires about their health. Researchers aim to test the hypothesis that chronic CMD-related ischemia results in myocardial steatosis and pre-HFpEF traits.

Principal Investigator