Small Artery Heart Disease Clinical Trial

Condition: Coronary microvascular disease


Key Inclusion Criteria

  • Women and men with symptoms of myocardial ischemia and angina or angina equivalent (chest pain, abnormal stress testing, abnormal noninvasive testing)
  • No obstructive coronary artery disease performed within the previous 24 months
  • At least 18 years old
  • Competent to give informed consent

Key Exclusion Criteria

  • Obstructive CAD ≥ 50% luminal diameter stenosis in ≥ 1 epicardial coronary artery
  • Acute coronary syndrome
  • Primary valvular heart disease clearly indicating the need for valve repair or replacement
  • Patients with concurrent cardiogenic shock or requiring inotropic or intra-aortic balloon support
  • Prior or planned percutaneous coronary intervention or CABG or prior acute MI in prior 30 days
  • Prior non-cardiac illness with an estimated life expectancy < 4 years

Full Study Name

Coronary Microvascular Disease and Endothelial Function in Women and Men (IRB no. 08221)


The purpose of this study is to understand the mechanisms of heart disease in women and men who have chest pain in the presence of open coronary arteries. Researchers will examine functional abnormalities of the large and small arteries of the heart, as well as assess the effectiveness of using noninvasive tests such as peripheral artery tonometry and cardiac magnetic resonance imaging to aid in diagnosis and detection of abnormalities.

Principal Investigator

C. Noel Bairey Merz, MD


Raj Makkar, MD
Daniel Berman, MD


Barbra Streisand Women's Heart Center Research Staff