Amenorrhea Related Cardiovascular Health (ARCH)

Condition: Hypothalamic amenorrhea, cardiovascular disease


Key Inclusion Criteria:

  • 3 or more months of no period and/or a diagnosis of hypothalamic amenorrhea
  • 18-40 years old
  • Premenopause status

Key Exclusion Criteria:

  • Other causes of secondary amenorrhea, polycystic ovarian syndrome, untreated thyroid disorder, prolactinoma, pregnancy
  • Psychotropic or illicit drug use
  • Medical, neurological or major psychological disorders (other than depression and anxiety)
  • Childbirth/lactating in the last 6-12 months
Study Name

Hypothalamic Amenorrhea as a Fertility Status Marker for Cardiovascular Health (IRB no. 00001449)


This study focuses on premenopausal women with hypothalamic amenorrhea (HA). HA is a condition related to stress, intense physical activity, and weight loss/undereating that results in continuous months without a menstrual period, low estrogen levels, and infertility.

The purpose of the study is to identify young women at risk for cardiovascular disease (CVD) based on a specific set of HA-related characteristics. Understanding HA characteristics that can predict CVD is an important next step in identifying women that are at risk and taking preventive action to improve overall cardiovascular health.

This is an observational study; researchers will monitor participants’ health and collect information. The main procedures of the study are blood draws, questionnaires, small blood vessel function testing (peripheral arterial tonometry), and remote patient monitoring (using Fitbit watch and scale).

Principal Investigator