Women's Heart Clinical Trials

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Condition:

  • Takotsubo cardiomyopathy

Key Inclusion Criteria:

  • Diagnosed with TTC
  • Fully understanding and willing to undergo study procedures

Summary:

This study is designed to explore the brain-heart connection in patients with Takotsubo cardiomyopathy. Takotsubo cardiomyopathy (TTC) is an acute, reversible form of stress-induced cardiomyopathy that has an increased prevalence in post-menopausal women. The syndrome is most often precipitated by an acute emotional or physical stressor, but the mechanism remains poorly understood.

Subjects will participate in single photon emission computed tomography (SPECT) cardiac scans and magnetic resonance imaging (MRI) of the brain, among other procedures, during rest, exercise, and mental stress. Researchers will compare women with TTC to control subjects (healthy participants who do not have TTC).

Condition/Intervention:

  • Microvascular coronary dysfunction

Key Inclusion Criteria:

  • Women with symptomatic angina or angina equivalent
  • At least 18 years old
  • No obstructive coronary artery disease at coronary angiography (performed within the previous 24 months)
  • Competent to give informed consent

Summary:

The purpose of this study is to investigate how the heart reacts to mental stress and to understand more about the cardiac nervous system in women with microvascular coronary dysfunction (MCD). MCD occurs when there are abnormities in small blood vessels/arteries in the heart and symptoms of persistent chest pain.

Participants will be assigned to one of these three groups: chest pain subjects with MCD by abnormal coronary reactivity testing (CRT), chest pain subjects with no MCD, and a normal control group.

Condition/Intervention:

  • Microvascular coronary dysfunction

Key Inclusion Criteria:

  • Women without signs and symptoms of myocardial ischemia
  • No cardiac risk factors
  • Normal exercise stress test

Summary:

The purpose of this study is to understand how to apply cardiac magnetic resonance imaging (CMR) to women with small artery heart disease by looking at the CMRs of women without heart disease. Women with no known heart disease or heart disease risk factors will be recruited for the study.

Key Inclusion Criteria (Normal Control and HypoE):

  • Premenopausal, not on hormone therapy
  • Has missed three or more monthly menstrual cycles in a row or has normal monthly menstrual cycles
  • English speaking (for the purposes of complete self-assessments)
  • Able to give informed consent
  • Between 18-40 years old

Key Inclusion Criteria (Menopause):

  • Recently menopausal (within three years of final menstrual period)
  • English speaking (for the purposes of complete self-assessments)
  • Able to give informed consent
  • 50 years of age or older
  • Has not taken hormone replacement therapy or estrogen since entering menopause

Summary:

The Barbra Streisand Women’s Heart Center invites you to participate in a new study designed to evaluate the impact of estrogen on your heart health. We know that low estrogen levels are not healthy in young women, and we want to see if it will affect your heart health in the future. We are looking to compare three groups of women:

  1. women 18-40 years old who have missed three or more periods in a row
  2. women 18-40 years old who have regular monthly periods
  3. women 50 years or older and recently in menopause (less than three years)

Each woman will undergo blood draws and blood vessel function testing. Parking will be validated, and you will receive compensation upon completion of the study.

Condition/Intervention:

  • Coronary microvascular disease

Key Inclusion Criteria:

  • Women and men with symptoms of myocardial ischemia and angina or angina equivalent (chest pain, abnormal stress testing, abnormal noninvasive testing)
  • No obstructive coronary artery disease performed within the previous 24 months
  • At least 18 years old
  • Competent to give informed consent

Summary:

The purpose of this study is to understand the mechanisms of heart disease in women and men who have chest pain in the presence of open coronary arteries. Researchers will examine functional abnormalities of the large and small arteries of the heart, as well as assess the effectiveness of using noninvasive tests such as peripheral artery tonometry and cardiac magnetic resonance imaging to aid in diagnosis and detection of abnormalities.

WARRIOR Trial

C. Noel Bairey Merz, MD, talks about a new clinical trial that's underway to learn more about angina and close in on the current knowledge gap about it. 

More information can be found by watching the video from Dr. Bairey Merz, or by emailing the trial coordinator, Michael Elliott at michael.elliott@cshs.org.