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Women's Heart Clinical Trials

Cedars-Sinai is committed to research that leads to better treatments and healthier lives for women.

Questions? See the Clinical Trials FAQs.

Key Inclusion Criteria:

Normal Control and HypoE

  • Premenopausal, not on hormone therapy
  • Has missed three or more monthly menstrual cycles in a row or has normal monthly menstrual cycles
  • English speaking (for the purposes of complete self-assessments)
  • Able to give informed consent
  • Between 18-40 years old

Menopause

  • Recently menopausal (within three years of final menstrual period)
  • English speaking (for the purposes of complete self-assessments)
  • Able to give informed consent
  • 50 years of age or older
  • Has not taken hormone replacement therapy or estrogen since entering menopause

Summary:

The Barbra Streisand Women's Heart Center invites you to participate in a new study designed to evaluate the impact of estrogen on your heart health. We know that low estrogen levels are not healthy in young women, and we want to see if it will affect your heart health in the future.

Condition:

Takotsubo Cardiomyopathy

Key Inclusion Criteria (for Takotsubo cardiomyopathy patients):

  • Diagnosed with TTC
  • Fully understanding and willing to undergo study procedures

Summary:

This study is designed to explore the brain-heart connection in patients with Takotsubo cardiomyopathy. Takotsubo cardiomyopathy (TTC) is an acute, reversible form of stress-induced cardiomyopathy that has an increased prevalence in post-menopausal women. The syndrome is most often precipitated by an acute emotional or physical stressor, but the mechanism remains poorly understood.

Condition:

Coronary Artery Disease

Key Inclusion Criteria:

  • Participants enrolled and to be enrolled in Barbra Streisand Women’s Heart Center research studies 

Summary:

The purpose of this study is to collect long-term data and blood and urine samples to further understand heart artery disease. In so doing, researchers aim to identify biomarker and genetic factors that influence heart arteries. A biomarker is a biological molecule found in blood, other body fluids, or tissues that may be a sign of a condition or disease. Participants will be contacted annually to complete a phone interview about topics such as clinical symptoms, medications, quality of life, hospitalizations, myocardial infarction (heart attack) and stroke.

Condition:

Microvascular Coronary Dysfunction

Key Inclusion Criteria:

  • Women without signs and symptoms of myocardial ischemia (chest pain, abnormal stress testing, abnormal noninvasive testing)
  • No cardiac risk factors by Framingham/NCEP criteria, age and matched to the coronary microvascular dysfunction population
  • Normal exercise stress test

Summary:

The purpose of this study is to understand how to apply cardiac magnetic resonance imaging (CMR) to women with small artery heart disease by looking at the CMRs of women without heart disease. Women with no known heart disease or heart disease risk factors will be recruited for the study.

A Long-Term Safety Extension Study of Mavacamten in Adults Who Have Completed MAVERICK-HCM or EXPLORER-HCM

Condition: 

Hypertrophic Cardiomyopathy, Obstructive Hypertrophic Cardiomyopathy, Non-obstructive Hypertrophic Cardiomyopathy

A Phase 2 Study of Mavacamten in Adults With Symptomatic Non-Obstructive Hypertrophic Cardiomyopathy (nHCM) (MAVERICK-HCM)

Condition: 

Non-obstructive Hypertrophic Cardiomyopathy

Condition:

Preeclampsia, Gestational Hypertension

Key Inclusion Criteria:

  • Pregnant women who received obstetrics care or are receiving cardiac care at Cedars-Sinai
  • Women with single pregnancies diagnosed with gestational hypertension and preeclampsia
  • Healthy women with single pregnancies (for comparison group)

Summary:

This study focuses on women who were diagnosed with gestational high blood pressure or preeclampsia during their recent pregnancy, or who are healthy and will be part of the comparison group. The purpose of the study is to evaluate whether gestational hypertension (high blood pressure) and preeclampsia (high blood pressure and protein in urine) causes heart problems after delivery. Heart function will be evaluated by conducting magnetic resonance imaging (MRI), in addition to other tests. The study will also measure biomarkers of heart function in the blood. A biomarker is a biological molecule found in blood, other body fluids, or tissues that may be a sign of a condition or disease.

Condition:

Coronary Microvascular Disease

Key Inclusion Criteria:

  • Women and men with symptoms of myocardial ischemia and angina or angina equivalent (chest pain, abnormal stress testing, abnormal noninvasive testing)
  • No obstructive coronary artery disease performed within the previous 24 months
  • At least 18 years old
  • Competent to give informed consent

Summary:

The purpose of this study is to understand the mechanisms of heart disease in women and men who have chest pain in the presence of open coronary arteries. Researchers will examine functional abnormalities of the large and small arteries of the heart, as well as assess the effectiveness of using noninvasive tests such as peripheral artery tonometry and cardiac magnetic resonance imaging to aid in diagnosis and detection of abnormalities.

Condition:

Takotsubo Syndrome

Key Inclusion Criteria:

  • Diagnosis of Takotsubo syndrome
  • Submission of required medical records

Summary:

The goal of this registry is to understand how widespread Takotsubo is and to determine which individuals are at risk of experiencing additional Takotsubo events or other health problems. Registry participants will also be invited to provide a blood sample which will undergo proteomics analysis (study of proteins in the blood). Analysis of the registry's medical information and proteomics findings will enable researchers to study Takotsubo's effects on the body and determine potential treatment targets that can lead to new therapeutic strategies.

Condition:

Cardiovascular Disease

Key Inclusion Criteria:

For women undergoing invasive coronary angiography:

  • At least 18 years old
  • Symptomatic angina or anginal equivalent

For women and men with HFpEF:

  • At least 18 years old
  • Symptoms of heart failure
  • Preserved ejection fraction, left ventricular ejection fraction ≥45% prior to study entry

Summary:

This study focuses on women undergoing clinically-ordered coronary angiography for suspected coronary microvascular dysfunction (small vessel disease), or men or women with heart failure with preserved ejection fraction (HFpEF). Researchers aim to better understand HFpEF (inadequate heart muscle function in the setting of preserved muscle pumping) for therapeutic strategy development and optimized noninvasive cardiac MRI for the diagnosis and management of coronary microvascular dysfunction and HFpEF.

Women's Heart Attack Research Program—Imaging Study (HARP)

Condition:

Myocardial Infarction

Condition: 

Ischemia (inadequate blood flow to an organ), chest pain

Key Inclusion Criteria:

  • Have signs and symptoms of chest pain that prompted further evaluation by either a heart angiogram or a scan of the heart (coronary CT angiogram) within the previous 5 years  
  • 18 years of age or older
  • Non-obstructive coronary artery disease or have been told that heart arteries are not blocked or have blockages that are less than 50%

Summary:

This study is designed to determine whether intensive medical therapy provided as part of the study is better than usual care in women who have chest pain but who have been told they have no significant blockages of their coronary arteries.