Interventional Cardiology Clinical Trials
As a patient at Cedars-Sinai, you will have access to the latest clinical trials and research for interventional cardiology. Backed by a respected team of specialists and researchers, our clinical trials aim to further the advancement of diagnosing and treating your condition.
Questions? See the Clinical Trials FAQs.
Assessment of the WATCHMAN™ Device in Patients Unsuitable for Oral Anticoagulation (ASAP-TOO)
Condition:
Stroke
Condition:
Coronary artery disease, peripheral vascular disease, cancers
Key Inclusion Criteria:
- At least 18 years old with body mass index less than 30
- Diagnosed with or undergoing evaluation for cardiovascular, nervous system diseases or solid-organ cancers
Summary:
Using the hybrid Siemens Biograph mMr (PET-MR) scanner, researchers simultaneously acquire MR and PET data across the whole body. Biomedical Imaging Research Institute scientists focus on developing new imaging techniques to answer a wide array of research and clinical questions, where producing a single scan that reveals both functional and anatomical information would create a more complete diagnostic tool. In collaboration with medical specialists, pulse sequences (software) are validated in patients undergoing evaluation for numerous diseases, including many types of heart disease, peripheral and intracranial (brain) neurological diseases, cancers, spine problems, urology and other nervous system disorders. The long-term goal of this study is to develop new techniques that would translate to clinical significance.
Caisson Transcatheter Mitral Valve Replacement (TMVR) System Early Feasibility Study (PRELUDE)
Condition:
Mitral Valve Regurgitation
Condition:
Cardiac Imaging
Key Inclusion Criteria:
- Patients undergoing a self-referred or physician-referred cardiac imaging procedure for any standard clinical indication
Summary:
The purpose of this research registry is to develop an organized system of information (demographic, historical, clinical, imaging and outcomes) from patients undergoing cardiac imaging procedures for use in ongoing and future research. The registry will allow qualified investigators at Cedars-Sinai to conduct analyses and write manuscripts that are critical in improving the ability to detect, accurately assess, and possibly prevent adverse outcomes of heart disease.
Clinical Trial to Evaluate the Safety and Effectiveness of Using the Tendyne Mitral Valve System for the Treatment of Symptomatic Mitral Regurgitation (SUMMIT)
Condition:
Mitral Regurgitation, Mitral Insufficiency, Mitral Valve Insufficiency, Cardiovascular Diseases, Valve Disease (Heart), Heart Valve Diseases, Functional Mitral Regurgitation, Degenerative Mitral Valve Disease
Condition:
Atherosclerotic cardiovascular disease, hypercholesterolemia
Key Inclusion Criteria:
- Evidence by cardiac computed tomography angiography of noncalcified coronary artery plaque and thoracic aorta atherosclerosis
- Indications for evolocumab treatment
Summary:
This study focuses on patients who have clinical atherosclerotic cardiovascular disease (ASCVD) or high cholesterol levels and are allergic to statins, or who have been diagnosed with primary hypercholesterolemia or homozygous familial hypercholesterolemia (genetic disorder causing high cholesterol levels and early heart disease). The purpose of the study is to evaluate the changes, if any, in coronary plaque volumes and its composition in patients who are treated with a drug called evolocumab. To help evaluate the effect of evolocumab, researchers will ask patients who are scheduled to start taking evolocumab plus another cholesterol-lowering medication (such as a statin) to undergo diagnostic testing, including non-invasive coronary computed tomography angiography scans and positron emission tomography (PET) scans.
Evaluate the Long-Term Safety and Efficacy of Evinacumab in Patients With Homozygous Familial Hypercholesterolemia
Condition:
Homozygous Familial Hypercholesterolemia
Evaluation of Treatment Strategies for Severe CaLcIfic Coronary Arteries: Orbital Atherectomy vs. Conventional Angioplasty Technique Prior to Implantation of Drug-Eluting StEnts: The ECLIPSE Trial (ECLIPSE)
Condition:
Coronary Artery Disease, Ischemic Heart Disease, Non ST Segment Elevation Myocardial Infarction
Evaluation of Treatment With Abbott Transcatheter Clip Repair System in Patients With Moderate or Greater Tricuspid Regurgitation (TRILUMINATE)
Condition:
Tricuspid Valve Insufficiency
HDL Acute Lipid Optimization in Homozygous Familial Hypercholesterolemia
Condition:
Homozygous Familial Hypercholesterolemia, HoFH
Investigational Device Evaluation of the WATCHMAN FLX™ LAA Closure Technology (PINNACLE FLX)
Condition:
Atrial Fibrillation
Safety and Potential Bioactivity of CLBS14 in Patients With Coronary Microvascular Dysfunction and Without Obstructive Coronary Artery Disease
Condition:
Coronary Microvascular Dysfunction
Study of Evinacumab (REGN1500) in Participants With Persistent Hypercholesterolemia
Condition:
Hypercholesterolemia
Transcatheter Mitral Valve Replacement With the Medtronic Intrepid™ TMVR System in Patients With Severe Symptomatic Mitral Regurgitation (APOLLO)
Condition:
Mitral Valve Regurgitation