Magnetic Resonance Imaging for Global Atherosclerosis Risk Assessment

Condition: Atherosclerosis

Eligibility

Key Inclusion Criteria

  • Recent myocardial infarction, ischemic stroke, or onset of symptomatic lower extremity peripheral artery disease less than 3 months before study enrollment
  • Recent or planned prescription of statin and antiplatelet therapy within 3 months of study recruitment

Key Exclusion Criteria

  • Less than 18 years old
  • Contraindications to MRI, including magnetically activated implanted devices or untreatable claustrophobia
  • Pregnancy

Full Study Name

Magnetic Resonance Imaging for Global Atherosclerosis Risk Assessment (IRB no. 47460)

Summary

This study focuses on patients who have recently had a heart attack, stroke or symptomatic peripheral artery disease. The purpose of the study is to measure plaque in multiple arteries in the body and evaluate their characteristics. Researchers will obtain these measurements to examine the ability of magnetic resonance imaging (MRI) to assess cardiovascular risk. Participants will undergo MRI of the carotid, coronary and femoral arteries; pulse wave analysis (a noninvasive clinical test) to measure stiffness of the blood vessels; and blood collection. They will also be asked to complete questionnaires.

Researchers will evaluate cardiovascular risk in combination with the imaging study by measuring cholesterol levels and other cardiovascular biomarkers. A biomarker is a biological molecule found in blood, other bodily fluids, or tissues that may be a sign of a condition or disease.


Principal Investigator

Janet Wei, MD

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