DCM Research Project: DCM-CMR Ancillary Study

Condition: Dilated cardiomyopathy

Eligibility

Key Inclusion Criteria:

  • Individuals with dilated cardiomyopathy (DCM) or family members of individuals with DCM must also be enrolled in one of the partner studies (Precision Medicine or Discovery Study), and the patient or family member has one of the following conditions:
    • DCM of unknown cause (idiopathic DCM)
    • Cancer chemotherapy-associated DCM
    • Peripartum cardiomyopathy
    • Ischemic DCM
    • Cardiomyopathy associated with heart failure with preserved ejection fraction
    • Conditions that may lead to DCM
  • Healthy participants will be volunteers recruited from a DCM Consortium site. Control participants will be selected based on the demographics of study participants with a personal or family history of DCM.

Full Study Name

Dilated Cardiomyopathy Research Project: Cardiac Magnetic Resonance (DCM-CMR) Ancillary Study (IRB no. 00001212)

Summary

The Dilated Cardiomyopathy Research Project is a program seeking to better understand the genetics of dilated cardiomyopathy (DCM). DCM is a disease of the heart muscle that can occur in families; patients with DCM have an abnormally enlarged heart. The study focuses on patients whose dilated cardiomyopathy (DCM) is likely caused by a genetic change. The purpose of the Cardiac Magnetic Resonance (DCM-CMR) Ancillary Study is to understand the structural and functional cardiac phenotype (observable traits) in known or suspected dilated cardiomyopathy and related cardiac conditions by leveraging cardiac magnetic resonance (CMR) imaging to detect earliest findings of DCM in the at-risk family members enrolled into the parent study. Researchers aim to identify early clinical evidence of DCM and related conditions that can provide a more detailed evaluation of the heart and tissue changes that may lead to DCM.

Participants may also be healthy individuals without known cardiovascular disease who can help provide clinical information related to normal changes that occur in the heart to compare with those at risk for DCM.

Principal Investigator

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