Celltrion: CT-G20 in oHCM

Condition: Obstructive hypertrophic cardiomyopathy


Key Inclusion Criteria:

  • 18-70 years old
  • Established diagnosis of hypertrophic cardiomyopathy
  • Body mass index ≥18.0 to ≤36 kg/m2

Key Exclusion Criteria:

  • History of cardiac disease
  • History of clinically significant allergic reactions
  • Presence of gastrointestinal, renal, hepatic, hematological, metabolic, neurologic or pulmonary diseases
Study Name

A Randomized, Double-Blind, Placebo-Controlled, Sequential, Phase I Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of CT-G20 in Subjects With Hypertrophic Obstructive Cardiomyopathy (IRB no. 00000822)


This study focuses on adults (18-70 years old) who have been diagnosed with obstructive hypertrophic cardiomyopathy (oHCM). The purpose of the study is to determine the safety and tolerability of an investigational drug called CT-G20 in people with oHCM. The study will also determine how the drug is distributed within the body and its effects on the body. Obstructive hypertrophic cardiomyopathy is a condition in which heart muscle becomes abnormally thick, and blood flow out of the left ventricle is blocked.

Participants will be randomly assigned to receive either CT-G20 or placebo (inactive substance). CT G20 consists of an antiarrhythmic medication (medication used to treat irregular heartbeat) that improves the function of the left ventricle of the heart.

Principal Investigator