Gynecology Clinical Trials

With groundbreaking studies in minimally invasive surgery and other gynecologic issues, Cedars-Sinai is committed to research that leads to better treatments and healthier lives for women.

Questions? See the Clinical Trials FAQs.

Pending Gynecologic Surgery

Condition:

Pending Gynecologic Surgery  

Key Inclusion Criteria:

  • All women must be over the age of 18.
  • Blood and tissue donors:
    • Previously scheduled for gynecologic procedures that involve the removal of all or part of the female reproductive system
  • Follicular Fluid:
    • Patients being seen in the Cedars-Sinai’s OB/GYN–Reproductive Endocrinology Division
  • Blood samples collected only:
    • Patients of the study investigator who are routinely seen for gynecological cancers
  • Saliva samples:
    • Women 18 years or older
    • Seen at Cedars-Sinai for gynecologic evaluation or routine gynecologic care

Summary:

The purpose of the Gynecologic Tissue Bank is to identify genes and/or other markers that influence a woman’s risk of developing cancer or other diseases of the reproductive organs, as well as to discover new tests and treatments for gynecologic cancers and diseases. Researchers also aim to learn how individuals with a particular gynecologic disease will respond to treatments. Blood, tissue and other body fluids will be collected and studied together with clinical and family history information.

The Gynecologic Tissue Bank will collect materials from individuals who may have cancer or other diseases of the reproductive organs, or individuals who are having gynecologic surgery for benign reasons (healthy controls).

Hereditary Cancer

Condition/Intervention:

Prior genetic testing

Key Inclusion Criteria:

  • Individuals who have undergone genetic testing and have been documented as:
    • Having a known deleterious mutation or
    • A variant of unknown significance or
    • Are wild-type (mutation negative)
  • 18 years of age or older

Summary:

The purpose of this study is to identify factors that influence cancer risk and to better understand the precursors to cancer so that preventive steps can be employed for individuals with and without inherited genetic mutations. Researchers also aim to develop a better understanding about which modifiers (a gene that changes the effect produced by another gene) cause some individuals to be at higher risk for developing cancer.

The study will collect information about personal and family history of cancer, along with personal demographics, medical history, lifestyle habits, and quality of life.

Fibroids

Condition: 

Fibroids

Key Inclusion Criteria:

  • 18-70 years old
  • Have not yet signed surgical consent forms
  • Intend to undergo laparoscopic hysterectomy or myomectomy for uterine fibroids where morcellation (dividing and removing tissue) is anticipated to be needed for tissue extraction, but where other pathology is not suspected 

Summary:

This study focuses on patients who have elected to undergo surgery for uterine fibroids by a minimally invasive approach. The purpose of the study is to determine the type of patients who would benefit from video counseling before surgery for uterine fibroids. Researchers aim to determine whether video education counseling helps patients have a better understanding of the surgery they are about to undergo.

Patients will be asked if they wish to watch a short video that provides additional information and animations about their condition and surgery; watching this video is optional. Participants also will be asked to complete surveys.