Indicators and Causes of Bladder Hypersensitivity Syndromes

Interstitial cystitis/painful bladder syndrome and overactive bladder
Key Inclusion Criteria
  • Women who are at least 21 years old
  • Has symptoms of IC/PBS or OAB that are clinically diagnosed
  • "Normal" control subjects (without lower urinary tract symptoms)
Key Exclusion Criteria
  • Men
  • Children
Full Study Name

Inflammatory Etiology of IC/PBS and OAB in Women (IRB no. 46154)


The purpose of this study is to examine interstitial cystitis/painful bladder syndrome (IC/PBS) and overactive bladder (OAB) in women. The study focuses on women who have expressed pain or discomfort with their bladder (IC/PBS) or feel a sudden urge to urinate that is difficult to control, experience urge incontinence, frequent urination or nocturia (excessive urination at night). Participants may also be part of the "normal control" group with neither OAB or IC/PBS, or a control group with only OAB. (A "normal control" means that the participant does not have the condition that is being studied.) Participants will be asked to give a urine sample, among other samples, and complete questionnaires

Interstitial cystitis is very similar to overactive bladder, with urge to go to the bathroom, frequent urination, or nighttime urination, but overactive bladder does not have bladder pain. Researchers hope that the information on fungal and bacterial species examined in this study may support the development of diagnostic procedures and a better understanding of these diseases in the future.

Principal Investigator

A. Lenore Ackerman, MD


James Ackerman
Phone: 610-216-0684