The RESPOND Study
Condition: Sphincter of Oddi Dysfunction, pancreatitis
Key Inclusion Criteria:
- At least 18 years old
- Indication for endoscopic retrograde cholangio-pancreatography (ERCP) procedure (either or both of the following):
- Suspected sphincter of Oddi dysfunction (SOD)
- Idiopathic, recurrent acute pancreatitis
Key Exclusion Criteria:
- Prior endoscopic sphincterotomy before enrollment
- No plan to undergo ERCP
- Known chronic calcific pancreatitis
Results of ERCP in Sphincter of Oddi Dysfunction: The RESPOND Study (IRB no. 0000560)
This study focuses on patients at Cedars-Sinai who are suspected to have sphincter of Oddi dysfunction (SOD) or unexplained episodes of acute pancreatitis and are recommended to undergo endoscopic retrograde cholangio-pancreatography (ERCP) procedure. The purpose of the study is to examine how beneficial ERCP is for the treatment of SOD or unexplained episodes of acute pancreatitis. SOD is a disorder that involves the circular muscle that surrounds the drainage opening through which bile and pancreatic juices flow from the liver and pancreas into the duodenum (small intestine).
The main procedures of the study include a standard-of-care ERCP (commonly used to treat problems in the bile ducts, and pancreas) and follow-up assessments via questionnaires to assess participants’ progress and outcomes of the procedure. ERCP combines the use of X-rays and an endoscope, which is a long, flexible, lighted tube. Pain levels and use of medication will be evaluated and documented with questionnaires.