Microbiome and NAFLD HCC Study

Condition: Nonalcoholic fatty liver disease, cirrhosis

Eligibility

Key Inclusion Criteria

  • At least 18 years old
  • History of nonalcoholic fatty liver disease with or without cirrhosis or hepatocellular carcinoma diagnosed within the last 6 months

Key Exclusion Criteria

  • Previous organ transplantation
  • Any known etiology (cause) for liver disease other than fatty liver (such as hepatitis C virus or hepatitis B virus positive; excess alcohol consumption; Wilson's disease)

Full Study Name

The Microbiome and Nonalcoholic Fatty Liver Disease-Related Hepatocellular Carcinoma (NAFLD HCC) Study (IRB no. 51810)

Summary

This study focuses on patients from Cedars-Sinai and Veteran's Administration Greater Los Angeles Healthcare System who have liver disease. Researchers believe that differences in gut bacteria and the products of these bacteria, together with other factors such as diet and body composition, may help to explain why some people with nonalcoholic liver disease progress to liver cirrhosis or cancer. In this study, researchers will evaluate the differences between biomarkers measured in participants' specimens, clinical data, and questionnaire data to learn more about why nonalcoholic fatty liver disease progresses in some people.


Principal Investigator

Shehnaz Hussain, PhD

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