Ke-to Liver Health Study

Condition: Nonalcoholic fatty liver disease


Key Inclusion Criteria

  • At least 18 years old
  • Diagnosis of NAFLD
  • Confirmed negative pregnancy test

Key Exclusion Criteria

  • Prior diagnosis of chronic liver disease other than NAFLD
  • Prior diagnosis of liver cirrhosis
  • History of liver transplantation

Full Study Name

A Randomized, Controlled Trial to Study the Effects of a 28-day Ketogenic Dietary Intervention on Nonalcoholic Fatty Liver Disease Progression (IRB no. 55577)


This study focuses on patients who have been diagnosed with nonalcoholic fatty liver disease (NAFLD). NAFLD is a condition in which excess fat is stored in the liver; this buildup of fat is not caused by alcohol use. Researchers aim to determine whether a low-carbohydrate diet (also known as the ketogenic diet or keto diet) will slow the progression of NAFLD compared to a standard, weight-loss diet in patients with NAFLD. Weight loss with a lower-calorie diet is widely recommended for NAFLD treatment; however, it is unknown whether specific types of food are more beneficial. Meals will be provided to all study participants by a prepared meal delivery service.

Participants will be randomly assigned to one of two treatment groups: the Low Carbohydrate Diet group will receive a ketogenic meal plan that restricts carbohydrate intake to less than 20 grams per day, and the Weight Loss Diet group will receive a standard, weight-loss meal plan.

Principal Investigator

Shehnaz Hussain, PhD