Ke-to Liver Health Study

Condition: Nonalcoholic fatty liver disease

Eligibility

Key Inclusion Criteria

  • At least 18 years old
  • Diagnosis of NAFLD
  • Confirmed negative pregnancy test

Key Exclusion Criteria

  • Prior diagnosis of chronic liver disease other than NAFLD
  • Prior diagnosis of liver cirrhosis
  • History of liver transplantation

Full Study Name

A Randomized, Controlled Trial to Study the Effects of a 28-day Ketogenic Dietary Intervention on Nonalcoholic Fatty Liver Disease Progression (IRB no. 55577)

Summary

This study focuses on patients who have been diagnosed with nonalcoholic fatty liver disease (NAFLD). NAFLD is a condition in which excess fat is stored in the liver; this buildup of fat is not caused by alcohol use. Researchers aim to determine whether a low-carbohydrate diet (also known as the ketogenic diet or keto diet) will slow the progression of NAFLD compared to a standard, weight-loss diet in patients with NAFLD. Weight loss with a lower-calorie diet is widely recommended for NAFLD treatment; however, it is unknown whether specific types of food are more beneficial. Meals will be provided to all study participants by a prepared meal delivery service.

Participants will be randomly assigned to one of two treatment groups: the Low Carbohydrate Diet group will receive a ketogenic meal plan that restricts carbohydrate intake to less than 20 grams per day, and the Weight Loss Diet group will receive a standard, weight-loss meal plan.

Principal Investigator

Shehnaz Hussain, PhD

Contact