Cedars-Sinai in the News

CEOs Size Up Site-Neutral Pay Amid Tightening Financial Picture | Becker's Hospital Review
Peter L. Slavin, MD 

Foodborne Illnesses Can Lead to Long-Term Gut Issues | The New York Times
Mark Pimentel, MD 

Orbital Alchemy | Science
Arun Sharma, PhD, and Dhruv Sareen, PhD

Medical Experts Say Young Athletes Are More at Risk of Heat-Related Illnesses | CBS Los Angeles
Carlos Uquillas, MD 

What Are Compounded Medications? 8 Things Older Adults Should Know | AARP
Steven Simons, MD

Smart Toilets Are Scanning Poop and Urine for Health Clues. Should You Trust Them? | Miami Herald
Brennan Spiegel, MD, MSHS

What You Can Do To Slow Hearing Loss as You Age, According to Experts | Health
Yu-Tung Wong, MD 

How Modern Sports Medicine Is Prolonging Careers of Professional Athletes | CBS Los Angeles
Michael Banffy, MD

Good Medicine: Treating mCRPC | HealthCentral
Adam Weiner, MD

Lindsay Clancy Trial: A Closer Look at Postpartum Disorders | ABC 7 Los Angeles
Olusinmi Bamgbose, MD

The Risk of High Blood Pressure in Pregnancy Is Rising—and the Damage Can Be Life-Changing | Scientific American
Sarah Kilpatrick, MD, PhD

Faculty Publications

Anesthesiology

Obesity and Age Increase Hypoxia Risk During Esophagogastroduodenoscopy Under Monitored Anesthesia Care: Risk Stratification and Evaluation of a Procedural Oxygen Mask. Bonge, Sam, Maaz Majid, James M. Mirocha, Theodore Stein, Deena Midani, Derek Cheng, David Padua, Joshua Levy, and Megumi Nakamura. BMC Anesthesiology 26 (1): 534.

Biomedical Sciences

All-Cause and Cause-Specific Mortality in Chronic Pancreatitis: A Systematic Review. Jiang, Yi, Esther A. Adeniran, Wenmo Hu, Yanna Cai, Drew Fletcher, Zijin Lin, Yuan Li, Ali Badaoui, Jianing Li, Judy Tan, and Stephen J. Pandol. Therapeutic Advances in Gastroenterology 19: 17562848261483780.

Beyond Stenosis: Imaging Phenotyping and Risk Stratification in Nonobstructive Coronary Artery Disease. Piña, Pamela, Annalisa Filtz, Daniel Lorenzatti, Ankur Srivastava, Jaideep Singh Bhalla, Piotr J. Slomka, Daniel S. Berman, Damini Dey, and Leandro Slipczuk. Current Opinion in Cardiology, September.

Vitamin K2 and D3 Supplementation in Patients With Severe Coronary Artery Calcification: The DANCODE Trial. Hasific, Selma, Kristian Altern Øvrehus, Anna Mejldal, Susanne Hosbond, Jess Lambrechtsen, Preman Kumarathurai, Damini Dey, Emil Johannes Ravn, Lars Melholt Rasmussen, Oke Gerke, Hans Mickley, and Axel Diederichsen. Circulation, August.

Cardiac Surgery

Challenges of Using Fitness Trackers in Critical Care. Kazerouni, Stephanie, Xiaoyu Liu, Tao Shen, Michael Nurok, Abirami Kumaresan, Anahat Dhillon, and Jill Yaung. AACN Advanced Critical Care 37 (3): 287–91.

Cardiology

Aficamten for Symptomatic Nonobstructive Hypertrophic Cardiomyopathy. Masri, Ahmad, Martin S. Maron, Ankit Bhatia, Maria Luisa Peña-Peña, Mark V. Sherrid, Estevao Lanna Figueiredo, Michael Arad, Roberto Barriales-Villa, Lubna Choudhury, Brian L. Claggett, Caroline J. Coats, Edileide de Barros Correia, Juan Pablo Costabel, Perry M. Elliott, Jorge E. Silva Enciso, Pablo Garcia-Pavia, Junbo Ge, Sheila M. Hegde, Gregory D. Lewis, Renato D. Lopes, Matthew W. Martinez, Mathew S. Maurer, Zi Michael Miao, Michelle Michels, Sumeet S. Mitter, Jesus E. Pino Moreno, Iacopo Olivotto, Anjali T. Owens, Steen H. Poulsen, Florian Rader, Ethan J. Rowin, P. Christian Schulze, Robert Sepp, Nikhil Sikand, Scott D. Solomon, John A. Spertus, Charles Teale, Xiaoyan Zhao, Punag H. Divanji, Stephen B. Heitner, Daniel L. Jacoby, Stuart Kupfer, Fady I. Malik, Joel Salazar-Mendiguchía, Amy Wohltman, Shu Zhuo, Carolyn Y. Ho, and ACACIA-HCM Investigators. The New England Journal of Medicine, August.

Association of Eicosanoids and Eicosanoid-Related Metabolites With Obesity and Cardiometabolic Traits. Chitsazan, Mandana, Juhi K. Parekh, Amanda L. Grundmann, Emily S. Lau, Mona Alotaibi, Bing Yu, Casey M. Rebholz, Elizabeth Selvin, Norrina B. Allen, Matthew A. Allison, Mohit Jain, Susan Cheng, and Jennifer E. Ho. Diabetes, Obesity & Metabolism, September.

Beyond Lactate: Proteomic Prediction of Primary Graft Dysfunction in DCD Donor Hearts. Khush, Kiran K., and Jon A. Kobashigawa. JACC. Heart Failure, August, 103320.

Care Models for the Genetic Evaluation of Dilated Cardiomyopathy at Sites of the DCM Consortium. Jordan, Elizabeth, Tia Moscarello, Hibatallah Khafagy, Patricia Parker, Phoenix Grover, Simone Weinmann, Joseph Liu, Alberta Nomo, Naomi Barker, Emily E. Brown, Akos Berthold, Jessica Chowns, Ray E. Hershberger, et al. Circulation. Heart Failure, September, e014544.

Completeness of Revascularization in Coronary Three-Vessel Disease and Outcomes in the FAME 3 Trial. Otsuki, Hisao, Kuniaki Takahashi, Yuhei Kobayashi, Frederik M. Zimmermann, Mohamed El Farissi, Lennert Minten, Tatsunori Takahashi, Oskar Angerås, Steve E. S. Miner, Jaydeep Sarma, Evald H. Christiansen, Rana Sayeed, Kreton Mavromatis, Filip Casselman, Alan C. Yeung, Nico H. J. Pijls, Bernard De Bruyne, William F. Fearon, and FAME 3 Trial Investigators. European Heart Journal, August, ehag630.

Effect of Aficamten on Cardiac Structure and Function in Patients With Symptomatic Nonobstructive Hypertrophic Cardiomyopathy. Hegde, Sheila M., Xiaowen Wang, Ankit Bhatia, Maria Luisa Peña-Peña, Mark V. Sherrid, Estevao Lanna Figueiredo, Michael Arad, Roberto Barriales-Villa, Lubna Choudhury, Brian L. Claggett, Caroline J. Coats, Edileide de Barros Correia, Juan Pablo Costabel, Perry M. Elliott, Jorge E. Silva Enciso, Pablo Garcia-Pavia, Junbo Ge, Carolyn Y. Ho, Neal K. Lakdawala, Gregory D. Lewis, Martin S. Maron, Matthew W. Martinez, Ahmad Masri, Mathew S. Maurer, Michelle Michels, Sumeet S. Mitter, Jesus E. Pino Moreno, Viktória Nagy, Iacopo Olivotto, Anjali T. Owens, Steen H. Poulsen, Florian Rader, Ethan J. Rowin, Maria Ruda, P. Christian Schulze, Nikhil Sikand, John A. Spertus, Xiaoyan Zhao, Punag H. Divanji, Stephen B. Heitner, Daniel L. Jacoby, Stuart Kupfer, Fady I. Malik, Joel Salazar-Mendiguchía, Amy Wohltman, Shu Zhuo, Scott D. Solomon, and ACACIA-HCM Investigators. Circulation, August.

Eplontersen for Transthyretin Amyloid Cardiomyopathy. Fontana, Marianna, Ahmad Masri, Scott D. Solomon, Francesco Cappelli, Margot K. Davis, Pablo García-Pavía, Julian D. Gillmore, Mazen Hanna, Laura Obici, Brett W. Sperry, Nobuhiro Tahara, Márcia Waddington-Cruz, Olga Azevedo, Thibaud Damy, Edileide de Barros Correia, Michel G. Khouri, Andriana P. Nikolova, Stefan Störk, Tom Conrad, Qingqing Yang, Brian L. Claggett, Jersey Chen, Gary T. Brice, Sotirios Tsimikas, Mathew S. Maurer, and CARDIO-TTRansform Investigators. The New England Journal of Medicine, August.

Global Efficacy of Aficamten in Nonobstructive Hypertrophic Cardiomyopathy: Results From ACACIA-HCM. Maron, Martin S., Ahmad Masri, Ankit Bhatia, Maria Luisa Peña-Peña, Mark V. Sherrid, Estevao Lanna Figueiredo, Michael Arad, Lubna Choudhury, Brian L. Claggett, Caroline J. Coats, Edileide de Barros Correia, Juan Pablo Costabel, Perry M. Elliott, Jorge E. Silva Enciso, Junbo Ge, Carolyn Y. Ho, Ian Kulac, Gregory D. Lewis, Matthew W. Martinez, Mathew S. Maurer, Michelle Michels, Sumeet S. Mitter, Jesus E. Pino Moreno, Iacopo Olivotto, Anjali T. Owens, Steen H. Poulsen, Florian Rader, Ethan J. Rowin, P. Christian Schulze, Robert Sepp, Nikhil Sikand, Scott D. Solomon, John A. Spertus, Xiaoyan Zhao, Punag H. Divanji, Stephen B. Heitner, Daniel L. Jacoby, Stuart Kupfer, Fady I. Malik, Joel Salazar-Mendiguchía, Amy Wohltman, Shu Zhuo, Roberto Barriales-Villa, and ACACIA-HCM Investigators. Circulation, August.

Long-Term Effects of Acoramidis on Mortality in Variant Transthyretin Amyloid Cardiomyopathy, Including p.Val142Ile: Findings From the Open-Label Extension of ATTRibute-CM. Ruberg, Frederick L., Margot K. Davis, Sarah A. M. Cuddy, Lily K. Stern, Olakunle Akinboboye, Keyur Shah, Nitasha Sarswat, Michel G. Khouri, Daniel P. Judge, Jan M. Griffin, Justin L. Grodin, Souhiela Fawaz, Bret Zeldow, Jean-François Tamby, Adam Castaño, Uma Sinha, Marianna Fontana, Julian Gillmore, and Kevin M. Alexander. European Journal of Heart Failure, August, xuag258.

Noninvasive Thrombus Imaging in Patients With Ischemic Stroke. Whittington, Beth, Craig Balmforth, Alessandro Giaj Levra, Laura Clark, Neil Craig, Audrey White, Krithika Loganath, Evangelos Tzolos, Allison Winarski, Rachael O. Forsythe, Michael McDermott, Tariq Ramtoola, Phyo H. Khaing, Sphamandla Ntshangase, Mark G. Macaskill, Stefan Veizades, Mairi Brittan, Tim Clark, Michelle Rooney, Christophe Lucatelli, Piotr J. Slomka, Norman Koglin, Andrew W. Stephens, Iris Hardewig, Edwin J. R. van Beek, Marc R. Dweck, Joanna Wardlaw, Michelle C. Williams, William N. Whiteley, and David E. Newby. Circulation, September.

Percutaneous Epicardial Entry With a Novel Videoscope-Guided Epicardial Access Device: Initial Multicenter Experience. Ehdaie, Ashkan, Henry D. Huang, Jackson J. Liang, Ammar M. Killu, Alan Sugrue, Eric D. Braunstein, and Michael Shehata. JACC. Clinical Electrophysiology, August, S2405-500X(26)00743-7.

Platelet Activation and Thrombosis in Microvascular Obstruction. Balmforth, Craig, Alessandro Giaj Levra, Beth Whittington, Aidan Morgan, Mark G. Macaskill, Evangelos Tzolos, Alex J. Jordan, Tariq Ramtoola, Tim Clark, Michelle Rooney, Christophe Lucatelli, Edwin J. R. van Beek, Piotr J. Slomka, Stephanie L. Sellers, Norman Koglin, Andrew W. Stephens, Iris Hardewig, David E. Newby, Michelle C. Williams, and Marc R. Dweck. European Heart Journal. Cardiovascular Imaging, August, jeag225.

Short-, Medium-, and Long-Term Temperature and Sudden Cardiac Death in a Cohort of US Women. Borchert, William, Rachel C. Nethery, Christine M. Albert, Jochem O. Klompmaker, Charlotte Roscoe, Grete E. Wilt, Francine Laden, and Jaime E. Hart. Journal of the American Heart Association, August, e033829.

The Return of Thallium-201 for American Patients: History, Radiopharmaceutical Features, and Current Applications. Einstein, Andrew J., Daniel S. Berman, Yosef A. Cohen, Richard Green, Joshua Mailman, and Vasken Dilsizian. Current Cardiology Reports 28 (1): 86.

Transcatheter Aortic Valve Replacement for Severe Bicuspid Aortic Valve Stenosis: A Systematic Review and Meta-Analysis. Kumar, Sant, Jung-Min Ahn, Euihong Ko, Gossadi Mohammed, Kentaro Hayashida, Wei-Hsian Yin, Hasan Jilaihawi, Raj Makkar, Won-Keun Kim, Tullio Palmerini, Christine J. Chung, David Elison, Soo Yeon An, Ju Hyeon Kim, Do-Yoon Kang, Joon Bum Kim, David J. Cohen, Davide Capodanno, Duk-Woo Park, and Seung-Jung Park. JACC. Advances 5 (8): 103052.

Computational Biomedicine

Audience-Customized Translation of Rule-Based Evidence With Large Language Models Across Multiplexer Benchmarks. Bandhey, Harsh, Gabriel Lipschutz-Villa, Khoi Dinh, Malek Kamoun, and Ryan J. Urbanowicz. Genetic and Evolutionary Computation Conference: [Proceedings]. Genetic and Evolutionary Computation Conference 2026 (Companion): 1175–83.

Phase-Alternation and Tree-Initialization to Facilitate Interpretable Rule-Based Machine Learning. Lipschutz-Villa, Gabriel, Harsh Bandhey, Khoi Dinh, Michael Heider, Malek Kamoun, and Ryan J. Urbanowicz. Genetic and Evolutionary Computation Conference: [Proceedings]. Genetic and Evolutionary Computation Conference 2026: 300–309.

ScaleBarOn and Muad’Data: Simple Python Tools for Elemental Imaging Data Visualization and Comparative Scaling. Punshon, Tracy, Brian P. Jackson, and Joshua Levy. Journal of Analytical Atomic Spectrometry, August.

Survival-LCS: Rule-Based Survival Analysis Without Proportional Hazard Assumptions. Woodward, Alexa A., Harsh Bandhey, Jason H. Moore, and Ryan J. Urbanowicz. ACM Transactions on Evolutionary Learning and Optimization 6 (2): 13.

Medicine

Advancing Equity and Patient Partnership in Clinical Trials for Inflammatory Bowel Disease: A Model for Inclusive Trial Design. Rubin, David T., Andres Yarur, Renika Wood, Brian Po-Han Chen, Lisa E. Young, Megan Gower, and Vijay Yajnik. Clinical and Experimental Gastroenterology 19: 603005.

Black Race Predicts Poor Compliance and Higher Prostate Cancer Risk in a Multinational Repeat Biopsy Cohort: Secondary Analysis From the Reduction by Dutasteride of Prostate Cancer Events (REDUCE) Clinical Trial. Freedland, Alexis R., Daniel M. Moriera, Jun Gong, and Stephen J. Freedland. The Prostate, August.

Comparative Efficacy of Herbal Products on Metabolic Parameters in Metabolic-Dysfunction Associated Liver Disease: A Systematic Review and Network Meta-Analysis. Sairaj, Revathi Thirumushi, Alejandro Chen Liang, Yeison Cruz Castillo, Mariela Denise Fermin Madera, Jose Medina, Tatiana Alexandra Moreno Díaz, Gabriela Flores Monar, Supritha Chintamaneni, Camila Sanchez Cruz, Rashmi Advani, Sushovan Guha, and Ernesto Calderón-Martinez. Gastro Hep Advances 5 (10): 101040.

Driver Genomic Lesions in MDM2, CDK4, and JUN Co-Opt Targetable Super-Enhancer Networks to Impose Liposarcomagenic Core Regulatory Circuitry. Chen, Ye, Ying Zhang, Long Xie, Xiaorui Fan, Jiyang Liu, Tuan Zea Tan, Zhengming Yang, Pushkar Dakle, Suya Zheng, Nan Li, Chenying Wang, Victor Kwanmin Lee, Lingwen Ding, Qiaoyang Sun, Wen Yi, H. Phillip Koeffler, and Liang Xu. Journal of Advanced Research, August, S2090-1232(26)00687-9.

L-Glutamine in Combination With First-Line Gemcitabine and Nab-Paclitaxel in Advanced Pancreatic Ductal Adenocarcinoma: An Open-Label, Single-Arm, Phase 1 GlutaPanc Trial. Gong, Jun, Hayato Muranaka, So Yung Choi, Mourad Tighiouart, Shrikant Bhute, Ezinne R. Aja, Jonathan P. Jacobs, Aleksandr Stotland, Jennifer Van Eyk, Omer H. M. Elmadbouh, Mouad Edderkaoui, Sunao Tanaka, Hideki Furuya, Arsen Osipov, Jeremy Lorber, Sandrine Billet, Alexzandra Morris, Johanna Ten Hoeve-Scott, Thomas Graeber, Stephen J. Pandol, Andrew Hendifar, and Neil A. Bhowmick. Nature Cancer, August.

Nirmatrelvir-Ritonavir Targeting Viral Persistence in Post-COVID-19 Condition (Long COVID) in the USA (RECOVER-VITAL): A Randomised, Double-Blind, Placebo-Controlled, Phase 2 Trial. Baden, Lindsey R., Nirav S. Shah, Sean T. H. Liu, Jonathan Cohen, James Moy, Andre Kumar, Grace A. McComsey, Peter Chen, Michelle Floris-Moore, Nora G. Singer, Inti Fernandez, Alex J. Slandzicki, RECOVER-VITAL Clinical Trial Group, et al. The Lancet. Infectious Diseases, August, S1473-3099(26)00406-8.

Noninvasive Positive Airway Pressure for Hypoxemia Prevention During Sedated Gastrointestinal Endoscopy in Adults With Obesity: A Systematic Review and Meta-Analysis. Pérez, Jariel Abreu, Valeria Esther Acosta Casana, Carlos Josue Alfaro Lazo, Valentina Alonzo, Carla Daniela Calizaya Baldellon, Alejandro Chen Liang, Macarena Chalbaud, Edgar Lozano, Suleen Daniela Barrera Mosquera, Alejandra Anez Gonzalez, Alexander Vega, Rashmi Advani, and Ernesto Calderón Martínez. Gastrointestinal Endoscopy, September, S0016-5107(26)07018-5.

Remission Rates of Patients With Axial Spondyloarthritis in a Tertiary Care Center. Kluempers, Franziska, Imke Redeker, Abin P. Puravath, Omar Javier Calixto, Styliani Tsiami, David Kiefer, Xenofon Baraliakos, and Uta Kiltz. The Journal of Rheumatology, September, jrheum.2025-1143.

The Cognitive Effects of Creatine Supplementation in Older Adults and Preclinical Models of Dementia: A Scoping Review. Whitford, Tobias, Christian Donlon, Aidan Pech, Chase Goldberg, Harris Whiteson, and Mill Etienne. Ageing Research Reviews, August, 103317.

Waist-to-Height Ratio as a Practical Indicator for Screening Pediatric Metabolic Dysfunction-Associated Steatotic Liver Disease in Diverse Populations and Genetic Backgrounds. Liu, Yun-Fei, You-Xin Wang, Li Li, Di Shi, Maike Wolters, Ping-Ping Zhang, Jia-Jia Dang, Shan Cai, Tian-Yu Huang, Ya-Qi Wang, Jie-Yu Liu, Ming-Yue Wang, Yu-Ying Wu, Enkar Nur, Wen-Jia Lian, Li-Po Guo, Yuan-Yuan Li, Jie-Yun Song, Jing Li, Yan-Hui Dong, Yan-Chun Cui, Antje Hebestreit, Yee Hui Yeo, Susan M. Sawyer, Hui Wang, and Yi Song. World Journal of Pediatrics: WJP, August.

Neurology

No Evidence for Modulation of the Readiness Potential by Respiratory Phase During Natural Breathing. Jeay-Bizot, Lucas, Raniyah Chishti, Uri Maoz, and Aaron Schurger. PLoS Biology 24 (9): e3003982.

Priorities for Advancing Palliative Care for Amyotrophic Lateral Sclerosis: A Consensus Report From a Palliative Care for ALS Working Group in the United States. Bischoff, Kara E., Yaowaree L. Leavell, Jessica M. Besbris, Christi Lero, Kelsey Noble, Astrid Grouls, Jerome Kurent, Benzi M. Kluger, Steven Z. Pantilat, Ambereen K. Mehta, and International Neuropalliative Care Society’s Palliative Care for ALS Working Group. Muscle & Nerve, August.

Neurosurgery

Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer’s Disease Severity. Rentsendorj, Altan, Jean-Philippe Vit, Alexandre Hutton, Yosef Koronyo, Saba Shahin, Edward Robinson, Ernesto Barron, Anthony Rodriguez, Ousman Jallow, Julia Sheyn, Bhakta Prasad Gaire, Lalita Subedi, Miyah R. Davis, Barathan Gnanabharathi, Alexander V. Ljubimov, Stuart L. Graham, Vivek K. Gupta, Mehdi Mirzaei, Debra Hawes, Katlin Silm, Keith L. Black, Lon S. Schneider, Alfredo A. Sadun, Jesse G. Meyer, Dieu-Trang Fuchs, and Maya Koronyo-Hamaoui. Advanced Science, August, e00020.

Predicting Craniospinal Surgery in Pediatric Achondroplasia: Benchmarking Statistical Inference and Explainable AI Under Rare-Disease Constraints. Gholampour, Seifollah, Jesse Huang, Dylan Keusch, Carolina Lopes, Aseel Masarwy, James Obayashi, Marcella Ruppert-Gomez, Christina M. Sayama, Lissa C. Baird, Moise Danielpour, and David F. Bauer. Annals of Biomedical Engineering, September.

Refining the Posterior Compartment of the Cavernous Sinus: A Detailed Reappraisal of Surgical Anatomy and Techniques for Invasive Pituitary Adenoma Resection. Xu, Yuanzhi, Tatsuya Uchida, Erik Burgos-Sosa, Ana Sofia Alvarez, Mariano Rinaldi, Taishi Nakase, Matei Alexandru Banu, Ludovico Agostini, Limin Xiao, Vera Vigo, Peyton L. Nisson, Simon A. Menaker, Aaron A. Cohen-Gadol, and Juan C. Fernandez-Miranda. Journal of Neurosurgery, August, 1–13.

Nursing

Artificial Intelligence, and the Future of Nursing Leadership: From Innovation to Stewardship. Marshall, David, and Nancye R. Feistritzer. Nursing Administration Quarterly 50 (4): 177–78.

Critical Care Nurses in Organ Donation and Transplantation, Part 2. Coleman, Bernice, and Linda Ohler. AACN Advanced Critical Care 37 (3): 293–94.

System-Level AI Governance in Nursing: A Practical Framework for Safe and Scalable Adoption. Wang, Jing, Yijiong Yang, David Marshall, Patricia Shucoski, Tera Gross, Ryannon Frederick, and Sharon Pappas. Nursing Administration Quarterly 50 (4): 208–13.

OBGYN

Seeing But Not Foreseeing: O-RADS Stratification and Surgical Outcomes in Benign Ovarian Cysts Engel, O., M. Weiss, R. Meyer, M. Tenne, N. Paul, O. Markovitch, Y. Dykan, Z. Klein, R. Schonman, and Y. Yagur. Ultrasound in Obstetrics & Gynecology 68 Suppl 1 (September): 99.

Orthopaedics and Sports Medicine

Decompression and Dynamic Sagittal Tether Stabilization for Degenerative Spondylolisthesis: Primary Outcomes of a Multicenter FDA IDE Trial. Sasso, Rick C., Hyun Bae, Ivan Cheng, Jeffrey L. Gum, Alan T. Villavicencio, Mick Perez-Cruet, S. Tim Yoon, William F. Lavelle, Kee D. Kim, Michael Y. Wang, Ravinder S. Bains, Calvin C. Kuo, Harvinder S. Sandhu, Michael P. Stauff, Dennis G. Crandall, Sigurd H. Berven, Harel Deutsch, Jeffrey S. Fischgrund, Adam L. Shimer, Khalid Sethi, Wilson Z. Ray, Matthew J. Mermer, Reginald J. Davis, Elizabeth Yu, Todd F. Alamin, Louis C. Fielding, Jens R. Chapman, Richard D. Guyer, and William C. Welch. Spine, August.

Trends in the Distribution of Skeletal Compensation Based on Severity and Correction in Adult Spinal Deformity Patients. Onafowokan, Oluwatobi O., Mohammad Daher, Renaud Lafage, Virginie Lafage, Justin S. Smith, D. Kojo Hamilton, Max R. Fisher, Bassel G. Diebo, Alan H. Daniels, Robert Eastlack, Gregory Mundis, Breton G. Line, Pierce Nunley, Neel Anand, Themistocles Protopsaltis, David O. Okonkwo, Khaled M. Kebaish, Justin K. Scheer, Praveen V. Mummaneni, Dean Chou, Han Jo Kim, Richard Hostin, Munish Gupta, Douglas Burton, Christopher P. Ames, Frank Schwab, Christopher I. Shaffrey, Shay Bess, Lawrence Lenke, and Peter G. Passias. Journal of Neurosurgery. Spine, August, 1–8.

Pathology and Laboratory Medicine

Examining Inflammatory Effects of Reticulocyte Erythrophagocytosis in Human Macrophage Cultures. Hernández-Armengol, Rosario, Kausik Paul, Che-Yu Chang, June Young Lee, Krystalyn E. Hudson, and David R. Gibb. Methods in Molecular Biology 3053: 641–58.

Lessons Learned From the Validation of a Machine Learning-Based Colorectal Carcinoma Screening Pipeline in Sub-Saharan Africa. Githuka, Alfred, Ulysses G. J. Balis, Ye Chan Kim, Eileen M. Weinheimer-Haus, Christopher L. Williams, Jerome Y. Cheng, Kelou Yao, John Blau, Jessica A. Baker, Priscilla Njenga, Winny Chepkemoi, Robert K. Parker, Akbar K. Waljee, Shahin Sayed, and Mansoor N. Saleh. Journal of Pathology Informatics 22 (August): 100691.

Pediatrics

Analysis of Neonatal Resuscitation Debriefings: Mixed-Methods Results From a Multicenter Pilot Study. Dadiz, Rita, Louis P. Halamek, Julie E. Riccio, Daniel Chiou, Michelle Olech Smith, Len Y. Tanaka, Debra L. Weiner, American Academy of Pediatrics WHiCED Task Force, and Theodora A. Stavroudis. Journal of Perinatology, August.

Mechanistic Characterization and Inhibition of PAD4-Dependent NETosis Following Experimental Neonatal Hypoxic-Ischemic Brain Injury. Bremer, Anna-Sophie, Maria Eugenia Bernis, Hannah Burkard, Elke Maes, Aimee S. Wilson, Zhaoyang Xu, David H. Rowitch, Waqar Hanif, Riki Kawaguchi, Thomas Ulas, and Hemmen Sabir. Experimental Neurology 406 (August): 115994.

Randomized Controlled Trials Evaluating Exercise Interventions for Plantar Fasciopathy Pain: A Systematic Review and Meta-Analysis. Gonçalves, Irenilde F., Thacyana T. Carvalho, Kamila Grandolfi, Juliano Casonatto, and Sergio M. Borghi. Musculoskeletal Science & Practice 86 (August): 103644.

Sequential Patterning of Photoresponsive Hydrogels Directs Crypt Fission and Reveals the Role of Epithelial Curvature on Fission Symmetry. McNally, Delaney L., Kaustav Bera, Nolan R. Petrich, Alex Khang, Marilyne Coulombe, David Castillo-Azofeifa, Ophir D. Klein, Peter J. Dempsey, and Kristi S. Anseth. Advanced Science, August, e77397.

Surgery

AI-Based Tools for Predicting and Early Diagnosis of Graft Rejection in Solid Organ Transplantation - a Systematic Review. Henderson, Douglas, Tobias Niederegger, Robert Munzinger, Emre Karakas, Jonas Hildinger, Jasper Iske, Max Heiland, Curtis L. Cetrulo, Alexandre G. Lellouch, and Leonard Knoedler. Transplantation Reviews 40 (4): 101054.

Efficacy and Safety of Local Tranexamic Acid in... : Plastic and Reconstructive Surgery - Global Open. Mokhtar, Jonathan, Marwa Hadi, Kreutz-Rodrigues Lucas, Kevin Sadati, Krishna S Vyas, Curtis L Cetrulo, and Alexandre G Lellouch. Plastic and Reconstructive Surgery - Global Open, August.

Generative AI and Clinicians Show Comparable Prognostic Reasoning From Clinical Narratives in Biologic-Treated CRSwNP. Hack, Sholem, Chase Kahn, Ainhoa Garcia-Lliberos, Cristina Rodriguez-Prado, Ameen Biadsee, Maxime Fieux, Mark Liu, Eran Glikson, Masayoshi Takashima, Omar G. Ahmed, Raj Sindwani, Dennis M. Tang, and Christopher R. Roxbury. World Journal of Otorhinolaryngology - Head and Neck Surgery, August.

HSV-1 LAT Promotes Ocular Diseases in the Absence of Type I IFN Responses in Sensory Neurons. Wang, Shaohui, Ujjaldeep Jaggi, Jay J. Oh, Deepak Arya, and Homayon Ghiasi. Journal of Virology, August, e0096026.

Mapping Structural Aging Across Human Tissues Reveals Tissue-Specific Trajectories and Coordinated Deterioration. Yadav, Anamika, Kyle Alvarez, Anna Chechenina, Kevin Y. Yip, Eytan Ruppin, Alexandre Colas, Jacqueline C. Yano Maher, Veronica Gomez-Lobo, Caroline Kumsta, and Sanju Sinha. Nature Aging, August.

Precision Oncology in Pediatric Cancer Surgery. Lee, William G., and Eugene S. Kim. Hematology/Oncology Clinics of North America 40 (5): 895–931.

Primary Resection and Metastasectomy for Well-Differentiated Grade 3 Gastro-Entero-Pancreatic Neuroendocrine Tumors: A National Cancer Database Analysis. Sutton, Thomas L., Marco Ventin, Teodora Dumitra, Shahrzad Arya, Lara Schwieger, Cristina R. Ferrone, Andrew E. Hendifar, and Alexandra Gangi. Annals of Surgical Oncology, August.

Real-World Use of Normothermic Machine Perfusion in Liver Transplantation: A Multi-Institutional Experience From the National Organ Perfusion Registry. Cortez, Alexander R., Wei San Loh, Sarah Sheskey, Hillary J. Braun, Aashna Mehta, Christopher Connelly, Austin Schenk, Musab Alebrahim, Raj Patel, Lori A. McLamb, Andrew Barbas, Steven A. Wisel, Garrett R. Roll, and Kyle H. Sheetz. Clinical Transplantation 40 (9): e70664.

Reconstructing the Anterior Skull Base After Oncologic Resection: A Comprehensive Systematic Review of Open Techniques and Outcomes. Cardoso, Leonardo Januário Campos, Márcio Yuri Ferreira, Murtaja Satea, Paulo Vitor Marques Xavier, Lidia Cheidde, Benjamin Marc Daniels, Danil Ratnikov, Felix Schumacher, Gustavo Vieira Rennó, Anderson Matheus Pereira da Silva, Haizam Oubari, Alexandre G. Lellouch, and Netanel Ben-Shalom. The Journal of Craniofacial Surgery, August.

Urology

Robotic Versus Open Post-Chemotherapy Retroperitoneal Lymph Node Dissection: A Propensity Score Matched Study Across 11 Academic Medical Centers. Chavarriaga, Julian, Alireza Ghoreifi, Eshetu G. Atenafu, Ahmad Mousa, Lynn Anson-Cartwright, Sanchit Kaushal, Farshad Sheybaee Moghaddam, Anirban P. Mitra, Ashish Khanna, Amitabh Singh, Sol C. Moon, Ahmed Saeed Goolam, Ryan Chuang, Jordan Rich, Fady Baky, Mathew Ho, Jacob Roberts, Inderbir S. Gill, Reza Mehrazin, John Sfakianos, James Porter, Soroush Rais-Bahrami, Aditya Bagrodia, Nariman Ahmadi, Scott Eggener, Jacob Tallman, Sudhir Rawal, John F. Ward, Michael Jewett, Hooman Djaladat, and Robert J. Hamilton. World Journal of Urology 44 (1): 612.

Cedars-Sinai Health Sciences University is advancing groundbreaking research and educating future leaders in medicine, biomedical sciences and allied health sciences. Learn more about the university.

A new study led by Cedars-Sinai Health Sciences University investigators found that prostate-specific antigen (PSA) levels in the blood, which are used to track the effectiveness of prostate cancer treatment, need to be 10 times lower than most physicians generally target for the best patient outcomes.

The study, published in Cancer, could help doctors better manage treatment of prostate cancer patients, maximizing patients’ chances of survival.

“PSA levels drop dramatically when patients receive hormone therapy,” said Stephen Freedland, MD, professor of Urology and director of the Center for Integrated Research in Lifestyle and Cancer at Cedars-Sinai, and first author of the study. “Our study found that the optimal PSA level was less than 0.2 nanograms per milliliter of blood. However, fewer than half of patients given hormone therapy alone reached that optimal level for overall survival.”

Investigators reviewed Veterans Health Administration data on 4,090 prostate cancer patients. They found that even if PSA dropped 90%, if it did not get below 0.2 nanograms per milliliter of blood, outcomes were not good.

Importantly, the study found that if doctors added drugs called androgen receptor pathway inhibitors to their hormone therapy, patients were much more likely to reach PSA levels below 0.2 nanograms per milliliter of blood.

“Many physicians don’t offer patients additional treatment because hormone therapy alone lowers their PSA levels below 2 nanograms per milliliter, which we previously showed was many physicians’ target level,” Freedland said. “We hope these data will change that practice.”

Additional authors include Wei Gao, PhD; Maëlys Touya, PharmD, MSc; Hongbo Yang, PhD; David Russell, MD, FACS; Jingyi Chen, MS; Grace Chen, MS; and Jasmina I. Ivanova, MA.

Funding: Sponsored by Pfizer Inc. and Astellas Pharma Inc.

Disclosures: Stephen J. Freedland reports consulting or advisory roles with Astellas Pharma Inc., AstraZeneca, Bayer, Candel, Eli Lilly, Johnson & Johnson Innovative Medicine (formerly Janssen), Merck, Novartis, Pfizer Inc., Sanofi, Sumitomo Pharma America, Inc. (formerly Myovant Sciences), and Tolmar.

New Tool Measures Thyroid Cancer Patients’ Anxiety

A new tool created by Cedars-Sinai Health Sciences University investigators is the first to measure anxiety in patients with thyroid cancer. Described in Thyroid, the Thyroid Cancer Modified Anxiety Scale (TC-MAX) could help doctors clarify patients’ expectations, better match their treatment to their needs, and improve patient outcomes.

“A patient’s distress greatly influences which thyroid cancer treatment the patient prefers and what their doctor recommends,” said Allen Ho, MD, professor of Surgery, co-director of the Thyroid Cancer Program at Cedars-Sinai Cancer and senior author of the study. “We found that our tool effectively assesses patient concerns to help doctors better determine the best course of treatment. This is especially important when the treatment options have similar likely outcomes but patient preferences vary widely.”

The tool includes 18 questions that measure a patient’s general cancer-related anxiety, their anxiety around ultrasound testing, which is used to monitor thyroid cancer progression, and their fear about whether their cancer will progress or come back. Investigators created TC-MAX in collaboration with Thyroid Cancer Survivors’ Association, the world’s largest thyroid cancer patient consortium. They relied on medical literature, physician expertise and the perspectives of more than 1,000 thyroid cancer patients.

The study showed that the extent of each patient’s anxiety mirrored the extent of surgery they chose, Ho said. When active surveillance, partial thyroid removal and total thyroid removal were all options, patients with the highest TC-MAX anxiety scores chose to have their entire thyroid removed, while those with lower average TC-MAX scores generally selected partial thyroid removal. Patients with the lowest scores chose active surveillance.

Ho said that the tool is now ready for use in clinical trials and patient care.

Additional Cedars-Sinai authors include Amanda J. Bastien MD, Sungjin Kim MS, Cynthia Zalt, Iris Cong PhD, Jewel Ng, Caroline Marshall, Christopher V. Almario MD MSHPM, Omer Liran MD, Brennan M.R. Spiegel MD, MSHS, Jon Mallen-St. Clair MD, PhD, Evan Walgama MD, Kevin S. Scher MD, Julie K. Jang MD, Yufei Chen MD, Samuel Zhang MD, Linnea Peterson MD, Wendy L. Sacks MD, and Zachary S. Zumsteg MD.

Other authors include Gary Bloom and Michelle M. Chen MD.

Funding: AAOHNS CORE Grant; Cedars-Sinai Jim and Eleanor Randall Department of Surgery Research Award.

Reducing Unnecessary Fluid Testing Could Lower Cancer Care Costs

Doctors might be able to safely reduce healthcare costs by skipping unnecessary laboratory tests for patients with advanced gynecologic cancers, according to a Cedars-Sinai Health Sciences University study. The paper, published in JAMA Network Open, examined testing on fluid drained from the abdomen or around the lungs.

Patients with advanced gynecologic cancer often experience fluid buildup in these areas. Draining the fluid helps relieve pain, pressure and other symptoms, but the investigators found that laboratory testing of the fluid is frequently unnecessary.

Cedars-Sinai gynecologic oncology fellow Yingao Zhang, MD, and obstetrics and gynecology resident Olivia Foy, MD, are co-first authors of the study.

“We undertook this study to determine how often unnecessary tests may be safely skipped, and to estimate how much this would help reduce healthcare costs,” Zhang said.

Investigators reviewed 976 fluid-draining procedures performed on gynecologic cancer patients at one hospital over 10 years. Laboratory testing was ordered in 40% of cases, a common practice done to rule out infection, check for the presence of cancer cells, and determine the cause of fluid buildup.

Nearly 80% of those orders included at least one test the researchers determined was likely unnecessary—either because a cancer diagnosis had already been confirmed or a patient had no symptoms that would prompt further fluid testing. The estimated cost of these tests was roughly $1million over 10 years.

The investigators found that unnecessary tests were more likely to be ordered in the emergency department or for hospitalized patients than in outpatient clinics. They also found that non-oncology care providers were more likely to order unneeded fluid tests than oncologists.

“Avoiding automatic lab testing on fluid from patients with known cancer diagnoses represents a low-risk opportunity to reduce healthcare costs,” Foy said.

The investigators identified clinician education as a way to reduce unnecessary testing and related costs, and suggested that similar analyses in other cancer types and other institutions could uncover additional cost-reducing opportunities.

Additional Cedars-Sinai authors include Grace Pipes, MD; and Margaret I. Liang, MD, MSHPM.

Funding: The Cedars-Sinai Honest Enterprise Research Broker (HERB) Committee, which assisted with cohort building, is supported by the NIH National Center for Advancing Translational Science (NCATS) UCLA CTSI Grant Number UL1TR001881.

Disclosures: Dr. Liang reported grants from Merck, grants from Foundation for Women’s Cancer, and personal fees from Association of Cancer Care Centers outside the submitted work.

How Your Brain Stays Focused on a Goal

Cedars-Sinai Health Sciences University investigators have discovered how the brain maintains focus when a person is working toward a goal. The study, published in Nature Human Behaviour, sheds light on how a person’s brain actively maintains task goals in working memory while that person responds to changes in their environment.

“Our findings show that the brain maintains memories of task goals by keeping certain neurons persistently active over minutes,” said Ueli Rutishauser, PhD, professor of Neurosurgery, at Cedars-Sinai and senior author of the study. “The two different brain regions we studied maintained such memories in two different formats, thereby giving people the flexibility to adapt while continuing to pursue the same goal.”

The study concentrated on two brain regions: the medial frontal cortex, which supports planning, decision-making and long-term goal achievement, and the hippocampus, which plays an important role in learning and memory.

Investigators recorded the activity of individual brain cells while study participants completed tasks designed to test how the brain remembers goals over many minutes without reminders.

By analyzing activity patterns in different brain regions, investigators found that task goals are stably and persistently represented by brain cells in the medial frontal cortex many minutes after instructions were given to the participants. In contrast, the hippocampus continuously updated task goal information as circumstances changed on the timescale of seconds. This allows a person to adapt quickly to change without losing sight of a desired long-term outcome.

Additional Cedars-Sinai authors include Hristos Courellis, Michael Kyzar, Juri Minxha and Adam Mamelak.

Other authors include Araceli R. Cardenas, Taufik Valiante and Ralph Adolphs.

Funding: This work was supported by the BRAIN Initiative through the NIH Office of the Director (U01NS117839 to U.R.), the Simons Foundation Collaboration on the Global Brain (to U.R. and R.A.), and by a merit scholarship from the Josephine De Karman Fellowship Trust (to H.S.C.).

Small Bowel Microbiome Offers Clues to Women’s Health        

A new study by investigators at Cedars-Sinai Health Sciences University has identified differences in the makeup and organization of the small bowel microbiome between women and men. The findings, published in iScience, could offer new insights into why some conditions are more prevalent in women.

The small bowel microbiome comprises a community of microorganisms that coexist in this part of the digestive tract and play vital roles in immune function, metabolism and hormonal regulation.

“One intriguing finding was a bacterial community containing Granulicatella, which we found only in women,” said Ruchi Mathur, MD, director of Clinical Research and Clinical Operations for the Medically Associated Science and Technology (MAST) Program at Cedars-Sinai and corresponding author of the study. “Bacteria in this community appear at increased levels in women with polyendocrine metabolic ovarian syndrome, formerly known as polycystic ovary syndrome.”

Investigators also found sex differences related to how small bowel microbes produce fructans, complex carbohydrates known for triggering digestive symptoms in irritable bowel syndrome (IBS), a condition far more common in women than men.

“Our findings show that biological sex is a critical variable in the small bowel microbiome,” said Mathur, also a professor of Medicine. “We must consider it as we move toward more personalized approaches to understanding and treating disease.”

Other Cedars-Sinai authors include Mohamad Rashid, Gabriela Leite, Gillian M. Barlow, Ava Hosseini, Daniel Brimberry, Dilara Flor, Gonzalo Parodi, Maritza Sanchez, Ignacio Rivera, Angel Trujillo, Maria Jesus Villanueva-Millan, Walter Morales, Stacy Weitsman and Mark Pimentel.

Funding: This study was supported by the Monica Lester Charitable Trust and the Elias, Genevieve and Georgianna Atol Charitable Trust in support of Ruchi Mathur’s research, and the National Philanthropic Trust in support of Mark Pimentel’s research.

Boosting the Accuracy of Disease Risk Prediction From Genetic Data

Investigators at Cedars-Sinai Health Sciences University have developed a new computational framework for improving how genetic data is used to estimate the inherited risk that an individual will develop conditions like Alzheimer's disease, Type 2 diabetes, high blood pressure and breast cancer.

The framework, called Adaptive Boosting of Pre-trained Polygenic Risk Scores (AB-PRS) and described in Nature Communications, builds on existing polygenic risk scores, tools that estimate disease risk based on many genetic variants across the genome, and identifies additional genetic signals that may not be fully captured by current scoring methods.

"As more people undergo genetic testing, it's becoming increasingly important to make the best use of that information," said Ruowang Li, PhD, co-corresponding author of the study and assistant professor of Computational Biomedicine at Cedars-Sinai. "Our findings aim to improve the accuracy of genetic risk prediction, allowing us to better predict disease risk and guide more personalized care."

Polygenic risk scores are increasingly used in research and clinical settings to estimate genetic susceptibility to common diseases, but their accuracy varies across diseases, datasets and populations. Investigators trained AB-PRS to identify genetic signals that existing risk scores may miss. They tested the approach using genetic data from the UK Biobank and validated the findings in three independent biobanks. The method consistently matched or outperformed existing polygenic risk scores across multiple diseases. The researchers say additional validation, particularly in more diverse populations, will be needed before the approach can be widely used in clinical care.

Additional Cedars-Sinai authors include Raelynn Chen, Olivia Wu, Okan Bilge Ozdemir, Zaldy Tan.

Other authors include Jie Hu, Maxwell Salvatore, Yiwen Lu, Shawn Murphy, Elizabeth Karlson, Atlas Khan, Krzysztof Kiryluk, Iftikhar Kullo, Johanna Smith, Eimear Kenny, Yuan Luo, William G. La Cava, Marylyn D. Ritchie and Yong Chen.

Funding: J.H. and Y.C.’s efforts were supported in part by National Institutes of Health

(U01TR003709, RF1AG077820, R01AG073435, R01DK128237). R.L. is supported

by the National Institutes of Health grants R01 AG094962, P30 AG094848 and U01 AG066833 and in part by Cedars-Sinai Department of Neurology/Jona Goldrich Center for Alzheimer’s & Memory Disorders. R.C. and O.B.O. are supported by the Department of Computational Biomedicine, Cedars-Sinai.

Cedars-Sinai Health Sciences University is advancing groundbreaking research and educating future leaders in medicine, biomedical sciences and allied health sciences. Learn more about the university.

Cedars-Sinai in the News

GLP-1 Health Benefits May Go ‘Far Beyond’ Weight Loss. Here’s What’s Exciting Doctors | TODAY
Nicolas Musi, MD 

STI Rates Fall by Two Thirds After Implementation of DoxyPEP Prescribing at Southern US Clinic | Medscape
Christopher Foltz, MD 

Cases of ‘Scromiting’ Condition Tied to Cannabis Use Spike Among Teens, Young Adults: New Study | The Hill
Sam Torbati, MD 

The Lifesaving Case for CPR Dummies With Breasts | Vox
Pooja Nawathe, MD

Managing IBD Patients With Few Options Left | Gastroenterology & Endoscopy News
Gil Melmed, MD 

Cedars-Sinai Study Links Daily Coffee to Reduced Liver Scarring | Los Angeles Times
Hyunseok Kim, MD, MPH, PhD, and Shelly Lu, MD 

Are Fermented Foods More Than a Wellness Trend? | The Advisory Board
Suzanne Devkota, PhD

AI System Links Surgical Gestures With Postoperative Outcomes | Urology Times
Andrew J. Hung, MD

Faculty Publications

Biomedical Sciences

PTEN-AKT2 Regulates Mixed Lineage Liver Cancer Development and Sensitizes Cancer Cells to TGFβ Treatment. Tang, Qi, Ielyzaveta Slarve, Jingyu Chen, Ni Zeng, Yiwei Gu, Lina He, Shunan Hu, Diala Alhousari, Zifei Xu, Brittney Hua, Guo Zhang, Phillip Nguyen, Mario Alba, Ajay Bharadwaj, Jihyeon Lee, Simion Kreimer, Jian Xu, Baoan Ji, Shelly C. Lu, Jennifer Van Eyk, Shefali Chopra, Gary Kanel, Liyun Yuan, and Bangyan L. Stiles. Oncogene, August.

Cardiac Surgery

The Impact of Preoperative Mechanical Support on Long-Term Survival Following Early Lung Re-Transplantation for Graft Failure. Krishna, Vikram, Allen A. Razavi, Brian Lim, Zachary Brennan, Qiudong Chen, Joanna Chikwe, Michael E. Bowdish, Laura DiChiacchio, Reinaldo Rampolla, Dominick Megna, and Pedro Catarino. JHLT Open 14 (November): 100626.

Cardiology

Artificial Intelligence-Derived Fractional Flow Reserve in Routine Clinical Practice: An International Multicenter Retrospective Study. Ben-Assa, Eyal, Bruce A. Samuels, Ehtisham Mahmud, Carlos Cafri, Ariel Roguin, Yair Feld, Eli Lev, Emanuel Harari, Tali Ben-Yehuda, Hector M. Garcia-Garcia, and Gregg W. Stone. Journal of the Society for Cardiovascular Angiography & Interventions 5 (8): 105451.

Associations Between Symptoms of Depression and Anxiety With Left Ventricular Hypertrophy Among Hispanic and Latino Participants of the Hispanic Community Health Study/Study of Latinos. Andrade-Bucknor, Sharon N., Robert A. Mesa, Christina Cordero, Neil Schneiderman, Alvin Mathew, Barry E. Hurwitz, Carlos J. Rodriguez, Linda C. Gallo, Carlos E. Rosas, Sara Gonzalez, Scott D. Solomon, Susan Cheng, Martha Daviglus, Mayank M. Kansal, Krista M. Perreira, Frank J. Penedo, and Tali Elfassy. Journal of the American Heart Association, August, e048867.

Conduction Disturbances and Pacing After Transcatheter Aortic Valve Replacement: Mechanisms, Risk Stratification, and Management. AlBadri, Ahmed, Stephanie Wang, Cesar Egoavil, and Hasan Jilaihawi. Interventional Cardiology Clinics 15 (4): 623–35.

Device Shifting and Embolization of a New Generation Percutaneous Left Atrial Appendage Occluding Device. Novel Insights on Watchman FLX PRO. Bahbah, Ali, Ehab Aboelsoud, Mai Badr, Kerollos Abdelsayed, John Ambrose, Chandra K. Katikireddy, Robert Hauser, and Michael Shehata. Cardiovascular Revascularization Medicine: Including Molecular Interventions, August, S1553-8389(26)00370-2.

Early Multicenter Outcomes of Dedicated Transcatheter Aortic Valve Replacement for Left Ventricular Assist Device-Associated Pure Aortic Regurgitation. Hinkov, Hristian, Sara Yousefzada, Isabell A. Just, Christoph Klein, Evgenij Potapov, Santiago Garcia, Dhairya Patel, Lauren S. Ranard, Arseniy Goncharov, Dean J. Kereiakes, Raj R. Makkar, Torsten P. Vahl, Tanja K. Rudolph, and Axel Unbehaun. Artificial Organs, August.

Health Status Relationship to Ischemia and Coronary Artery Disease Severity in the ISCHEMIA Trial. Phillips, Lawrence M., Philip G. Jones, Leslee J. Shaw, Daniel B. Mark, Daniel S. Berman, Raymond Y. Kwong, Michael H. Picard, Bernard R. Chaitman, James K. Min, Jelena Celutkiene, Gregg W. Stone, Joao Vitola, Nagaraja Moorthy, Philippe Gabriel Steg, Peter Ong, Whady A. Hueb, Paulo C. Rezende, Judith S. Hochman, David J. Maron, Harmony R. Reynolds, John A. Spertus, and ISCHEMIA Research Group. American Heart Journal, August, 107586.

Impaired CD4+ T Cell Response to Apolipoprotein B-100 Peptide P210 in Atherosclerotic Cardiovascular Disease Is Reversed by P210-Conjugated Nanoparticles. Dimayuga, Paul C., Jianchang Zhou, Xiaoning Zhao, Janet Wei, Noah Trac, Karla Lambaren, Eun Ji Chung, Bojan Cercek, Prediman K. Shah, and Kuang-Yuh Chyu. American Journal of Physiology. Heart and Circulatory Physiology, August.

Mitral Transcatheter Edge-to-Edge Repair in Younger Adults. Guo, Yuchao, Vivek Patel, Jair Basantes de la Calle, Takashi Nagasaka, Kazuki Suruga, Hidemasa Shitan, Dhairya Patel, Tarun Chakravarty, Mamoo Nakamura, Aakriti Gupta, Moody Makar, Sabah Skaf, Mitch Gheorghiu, Wen Cheng, Hasan Jilaihawi, and Raj Makkar. Journal of the American Heart Association, August, e043262.

Prenatal Diagnosis of Aorto-Left Ventricular Tunnel. Le, Tuyen Kim, Truong Huy Hoang, and Mark S. Sklansky. CASE 10 (8): 342–45.

Pulmonary Primary Oxysterol and Bile Acid Synthesis as a Predictor of Outcomes in Pulmonary Arterial Hypertension. Alotaibi, Mona, Lloyd D. Harvey, William C. Nichols, Anna Hemnes, Wei Sun, Arjana Begzati, Tao Long, Aki S. Havulinna, Teemu J. Niiranen, Ankit A. Desai, Susan Cheng, Mohit Jain, and Stephen Y. Chan. American Journal of Respiratory and Critical Care Medicine, August, aamag383.

Racial and Ethnic Differences in Dietary Intake and Metabolic Profiles Among Adults With Heart Failure, Type 2 Diabetes, and Overweight or Obesity: A Secondary Analysis of the Pro-HEART Trial. Evangelista, Lorraine S., Angelina P. Nguyen, Jennifer Kawi, Rebecca Meraz, Kelly L. Wierenga, Alona D. Angosta, Michele A. Hamilton, and Gregg C. Fonarow. Nutrients 18 (16): 2737.

Redo-TAVR With Evolut: The Second Valve Is Only Half the Story. Chakravarty, Tarun, Christopher Rajkumar, and Raj R. Makkar. JACC. Cardiovascular Interventions 19 (16): 2217–19.

Sleep Deprivation as a Modulator of Thyroid Function: A Systematic Review and Meta-Analysis. Jain, Sharon Philip, Laurentia Fidella Averina Setia Santoso, Niharika Ikkurthy, Shervinchris Philip Jain, and Gilda Silven. Journal of Endocrinological Investigation, August.

Stability of Compounded Intracoronary Acetylcholine and Implications for Beyond-Use Dating. Takahashi, Tatsunori, Janet Wei, Allen Ahn, Heidi Hagena, C. Noel Bairey Merz, and Bruce A. Samuels. Circulation. Cardiovascular Interventions, August, e017021.

Statins and Frailty in Older Adults: From Cardioprotection to Geroprotection. Ji, Hongwei, Elaine Luterstein, and Susan Cheng. European Heart Journal, August, ehag640.

The Neglected Role of Lethal Arrhythmia in the Sudden Death of Stroke Survivors. Kadiyala, Vishnu, Kyndaron Reinier, and Sumeet S. Chugh. Nature Cardiovascular Research, August.

Computational Biomedicine

A Novel Approach for Analyzing Non-Proportional Hazards With Long-Term Survivors: The Defective Yang-Prentice Model. Calsavara, Vinicius F. Biometrical Journal. Biometrische Zeitschrift 68 (5): e70158.

Emergency Medicine

VenoArterial Extracorporeal Membrane Oxygenation in Cardiac Arrest Suspected Due to Massive Pulmonary Embolism: A Case Report. Chopra, Tananshi, Lea Dahlke, Nancy Salinas, Moizza Shabbir, Tyler Gunn, and Sam Torbati. Clinical Practice and Cases in Emergency Medicine 10 (3): 358–62.

Medicine

A Dosimetric Reappraisal of the Photobiomodulation Literature Assessing Animal Safety and Phototoxicity Evidence for Photobiomodulation in Oncology: Phantom Dangers. Cronshaw, Mark, Steven Parker, James D. Carroll, Joel B. Epstein, Kinga Grzech-Leśniak, and Michael R. Hamblin. Biomedicines 14 (8): 1859.

A Single Question on Quality-of-Life Improvement Identifies Treatment Satisfaction in Irritable Bowel Syndrome. Clark, Allistair, Rongsen Li, Brennan M. R. Spiegel, and Christopher V. Almario. Clinical Gastroenterology and Hepatology, August, S1542-3565(26)00629-4.

Anakinra Prophylaxis for Recurrent Severe ICANS Associated With Tarlatamab in Small Cell Lung Cancer: Case Report. Shia, David W., Suwicha Limvorasak, Karen L. Reckamp, and Kamya Sankar. JTO Clinical and Research Reports 7 (9): 101025.

Beyond ADCs: Antibody-Encapsulated Drug for Targeted Cancer Therapy. Li, Linrong, Armando Giuliano, Qiang Sun, Xiaojiang Cui, and Yuan Yuan. Cell Investigation 2 (3): 100087.

Cross-Cultural Validation of the 11-Item Frommelt Attitude Toward the Care of the Dying Scale Among U.S. Preclinical Medical Students. Miniotti, Marco, Barbara Loera, Giorgia Molinengo, Michael Lee, Amy Hayton, Julio Silvestre, and Paolo Leombruni. Journal of Cancer Education, August.

Elacestrant in Combination With Everolimus for Estrogen Receptor-Positive, HER2-Negative Previously Treated Advanced Breast Cancer: Results From ELEVATE. Rugo, Hope S., Sara M. Tolaney, Nancy Chan, Giuliano Borges, Rinat Yerushalmi, Marina N. Sharifi, Wassim McHayleh, Thaddeus Beck, Neelima Vidula, Erika Hamilton, Kristine J. Rinn, Joyce O’Shaughnessy, Giuseppe Curigliano, Javier Cortés, Isabel Garcia-Fructuoso, Philippe Aftimos, Begoña Bermejo de Las Heras, Pablo Tolosa, Yuan Yuan, Vicente Valero, Marla Lipsyc-Sharf, Paula Muñoz Romero, Faten Koraichi Auriol, Alessandro Paoli, Jennifer A. Crozier, Tomer Wasserman, and Virginia Kaklamani. Clinical Cancer Research, August.

Epigenetic Aging of Colorectal Mucosa in Cancer Development. Hardikar, Sheetal, Biljana Gigic, Jacob K. Kresovich, Victoria Damerell, Caroline Himbert, Jennifer Ose, Adetunji T. Toriola, David Shibata, Christopher I. Li, Jane C. Figueiredo, Doratha A. Byrd, Erin M. Siegel, Christoph Kahlert, Alexander Brobeil, Peter Schirmacher, Cornelia M. Ulrich, and Timothy M. Barrow. Journal of the National Cancer Institute, August, djag297.

Genetic Testing in Pituitary Adenomas: A Pituitary Society International Consensus Statement. De Sousa, Sunita M. C., Cynthia L. Andoniadou, Adrian F. Daly, Mônica Gadelha, Federico Gatto, Peter Kamenický, Pedro Marques, Martin Reincke, Frederique Ruf-Zamojski, Roberto Salvatori, Yutaka Takahashi, Christina Tatsi, Takako Araki, Sabrina Chiloiro, Laura Dichtel, Adriana G. Ioachimescu, Susana Mallea-Gil, Dan A. Niculescu, Alberto M. Pereira, Ilan Shimon, John Wass, Gabriel Zada, Maria Fleseriu, and Shlomo Melmed. Nature Reviews. Endocrinology, August.

Insights on Supplement Use During Cancer Care From Online Reddit Conversations. Waissengrin, Barliz, Karen O’Connor, Celina H. Shirazipour, Flores Amaro Ivan, Karen L. Reckamp, Graciela Gonzalez-Hernandez, and Jane C. Figueiredo. BMC Complementary Medicine and Therapies 26 (1): 256.

Pain Prescription Trends and Opioid Disorder Risk in Chronic Pancreatitis: A Real-World Data Analysis From 2015 to 2024. Cai, Yanna, Jianing Li, Niwen Kong, Walter G. Park, Yan Bi, Stephen Pandol, and Yi Jiang. Pancreatology, August, S1424-3903(26)00896-3.

Reply: The Simplest Hepatoprotective Intervention? Coffee in the Era of Precision Hepatology. Celtik, Derin, Hyun-Seok Kim, and co-authors. Clinical Gastroenterology and Hepatology, August, S1542-3565(26)00632-4.

The International Chinese Young Scholars Alliance for the Study of the Liver: Facilitating Global Collaboration. Li, Wenhao, Zhujun Cao, Yee Hui Yeo, Ying Shang, Kaina Chen, and Xiaolong Qi. Nature Reviews. Gastroenterology & Hepatology, August.

Timing-Dependent Clearance of P16-Positive Cells Mitigates Radiation-Induced Accelerated Aging. Valdivieso, Karla, Melanie Weigand, Daniela G. Costa, Gung Lee, Nick Pirius, Helene Martini, Shivangi Oberai, Christina Inman, Yi Zhu, Thomas von Zglinicki, Sundeep Khosla, Nathan LeBrasseur, João F. Passos, Tamara Tchkonia, James L. Kirkland, and Diana Jurk. Aging Cell 25 (9): e70693.

Neurosurgery

Disruption of Hippocampal Upstream Regulators of mTOR and Insulin Pathways in Down Syndrome With Alzheimer’s Disease Neuropathology: Preliminary Observations. Nordbeck, Abigail J., Mitchell Martá-Ariza, Henric Ek Olofsson, Evgeny Kanshin, Beatrix Ueberheide, Ken Jones, Bridget Sanford, Eric D. Hamlett, Elizabeth Head, Elliott J. Mufson, Sylvia E. Perez, Thomas Wisniewski, Samuel Guzman, and Ann-Charlotte Granholm. Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association 22 (8): e71776.

Socioeconomic and Sociodemographic Factors and Utilization of Revascularization Surgery in Moyamoya Disease: A Systematic Review and Meta-Analysis. Wijaya, Jeremiah Hilkiah, Miguel David Quintero Consuegra, Daniela A. Perez-Chadid, Aafreen Azmi, Juan Pablo Avila Madrigal, Abdelrahman Ramadan Elashry, Mohamed Lemine Sidi, Kerry A. Vaughan, Shane Shahrestani, Anil Nanda, and Nestor Gonzalez. Journal of Stroke and Cerebrovascular Diseases, August, 108735.

The Impact of Testosterone Replacement Therapy on Clinical Outcomes After Anterior Cervical Discectomy and Fusion: A Propensity-Matched Cohort Study. Ferdon, Robert J., Jacob Peller, Sohaib Z. Hashmi, J. Patrick Johnson, Robert A. Ravinsky, Charles A. Reitman, and Jason Silvestre. European Spine Journal, and the European Section of the Cervical Spine Research Society, August.

Orthopaedics and Sports Medicine

Charcot-Marie-Tooth Cavovarus Foot: Current Concepts and Emerging Strategies for Deformity Correction. Moon, Sung Jun, Young Ki Min, Glenn B. Pfeffer, Byung Ki Cho, Chan Kang, Yea Eun Kang, Woo Jin Shin, and Jae Hwang Song. Journal of Clinical Medicine 15 (16): 6474.

Clavicle Length and Scapulothoracic Angle in Young Children With Internal Rotation Contracture Secondary to Brachial Plexus Birth Palsy: A Bilateral MRI Study. Meltzer, Jourdan H., and Michael L. Pearl. JSES Reviews, Reports, and Techniques 6 (4): 100823.

Pathology and Laboratory Medicine

Improving the Histologic Classification of Advanced Diabetic Nephropathy Based on the Transformative Research in Diabetic Nephropathy (TRIDENT) Findings. Mohandes, Samer, Cynthia C. Nast, Amy Mottl, Julia Scialla, Salem Almaani, Randy Luciano, Tamara Isakova, Carla Ellis, Shweta Bansal, Christos Argyropoulos, J. Charles Jennette, Adil Gasim, Isaac E. Stillman, Kirk N. Campbell, Amin Abedini, Gaia Coppock, TRIDENT Consortium, Katalin Susztak, and Matthew B. Palmer. Kidney International, August, S0085-2538(26)00716-7.

Pediatrics

Advancing Neonatal Drug Development Through Industry-Academic Collaboration. Ramanathan, Rangasamy, Jacob V. Aranda, Daniele De Luca, and Victoria Niklas. Journal of Clinical Pharmacology 66 (8): e70273.

Breastfeeding and Viral Infections in Preterm Infants: A Multicenter Cohort Study. Kamiya, Yusaku, Akihito Takeuchi, Kazue Nakamura, Takahiro Namba, Kei Tamai, Makoto Nakamura, Misao Kageyama, Takashi Yorifuji, and Noriko Sugino. Pediatric Research, August.

Development and Validation of Temperature Trajectory-Based Phenotypes in Pediatric Sepsis: A Multicenter Retrospective Cohort Study, 2012-2018. Brown, Stephanie R., L. Nelson Sanchez-Pinto, Jocelyn R. Grunwell, Xiao Hu, Craig M. Coopersmith, Mihir R. Atreya, Colin M. Rogerson, Alon Geva, Tellen D. Bennett, Grace Chong, Sareen S. Shah, Mark W. Hall, and Sivasubramanium V. Bhavani. Pediatric Critical Care Medicine: A Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, August.

Shared Genetic Basis and Structure of Syndromic and Normal Facial Variation. Aponte, J. David, Cassidy Da Silva, Hanne Hoskens, Seppe Goovaerts, Michiel Vanneste, Jay Devine, Katherine Caine, Alexander Buchner Beaudet, H. Artee Luchman, Seth M. Weinberg, Hilde Peeters, Ophir D. Klein, Ralph S. Marcucio, A. Micheil Innes, Peter Claes, Richard A. Spritz, Francois P. Bernier, and Benedikt Hallgrímsson. American Journal of Human Genetics, August, S0002-9297(26)00280-6.

Radiation Oncology

Association of Pulmonary Artery Radiation With Pulmonary Hypertension After Lung Cancer Radiotherapy. Atkins, Katelyn M., Samuel C. Zhang, Christopher E. Kehayias, Christian Guthier, Katrina D. Silos, Olivia Peony, Andrew Warrington, Mina Bakhtiar, Maria Oorloff, Cosmin Ciausu, Asneh Singh, John He, David E. Kozono, David C. Christiani, Cody Ramin, Anju Nohria, Andriana P. Nikolova, Aaron B. Waxman, and Raymond H. Mak. Thorax, August, thorax-2025-224178.

Thymic Radiation Is Associated With Worse Outcomes in Patients With NSCLC. Prudente, V., S. Bernatz, S. Pai, K. M. Atkins, F. Pecci, E. Garbo, K. Bressem, C. V. Guthier, A. Warrington, M. Tonneau, C. Ciausu, S. Yu, L. Thompson, E. Mannarino, A. K. Attermann, L. Nuernberg, C. E. Kehayias, C. Abbosh, C. Swanton, M. Jamal-Hanjani, B. Ricciuti, N. J. Birkbak, R. H. Mak, and H. J. W. L. Aerts. Annals of Oncology, December, S0923-7534(26)00997-X.

Surgery

Cellularized Skin Substitute Bioengineering for Regenerative Medicine: Cell Sources, Culture Strategies, and Transition Toward Defined, Xeno-Free Culture Systems. Lemaître, Gilles, Marina Trouillas, Tatiana Vinasco-Sandoval, Cécile Giordano, Alexandre G. Lellouch, Walid Rachidi, Jean-Jacques Lataillade, and Nicolas O. Fortunel. Advanced Healthcare Materials, August, e71630.

Development and Reliability Testing of the Sinonasal Assessment of Reepithelialization, a Novel Wound Healing Scale to Assess Postoperative Healing. Bellary, Rohan, Zakaria Dairi, Niraj Rama, Jennifer Kreinik, Thomas S. Higgins, Taylor Carle, Arthur W. Wu, Dilpreet Mann, Jennifer K. Mulligan, Brian Lobo, Christopher Ito, Elisa A. Illing, Satyan B. Sreenath, Martin J. Citardi, Christopher Roxbury, Raj Sindwani, Edward McCoul, Jeffrey Suh, Daniel Beswick, Philip G. Chen, and Dennis M. Tang. International Forum of Allergy & Rhinology, August.

Neoadjuvant Chemotherapy With or Without Radiotherapy in Resected Pancreatic Ductal Adenocarcinoma. De Stefano, Federico, Nathaniel F. Wu, Giulio Belfiori, Hannah J. Roberts, Cristina Ferrone, Francesca Aleotti, Jill N. Allen, Gianpaolo Balzano, Lawrence S. Blaszkowsky, Jeffrey W. Clark, Francesco De Cobelli, Peter J. Fagenholz, Giulia Gasparini, Jon M. Harrison, Theodore S. Hong, Nicole A. Lester, Diego Palumbo, Priyadarshini S. Pathak, Nicolò Pecorelli, Marco Schiavo Lena, Rebecca Tang, Domenico Tamburrino, Colin D. Weekes, Motaz Qadan, Stefano Partelli, Keith D. Lillemoe, David P. Ryan, Jennifer Y. Wo, Stefano Crippa, Massimo Falconi, and Carlos Fernández-Del Castillo. JAMA Surgery, August.

Physical Activity Changes Following Sinus Surgery: A Multi-Center Apple Health Wearable Technology Pilot Study. Varghese, Justina R., Aakash Agarwal, Akshay R. Prabhakar, Cameron Keehn, Corinne Negvesky, Raffaello Cutri, Linda Liu, Stephanie Camey, Roger Neuberger, Renjie Hu, Ron L. Moses, Masayoshi Takashima, Arthur Wu, Dennis Tang, and Omar G. Ahmed. International Forum of Allergy & Rhinology, August.

Practice Patterns in the Surgical Management of Hinchey III and IV Diverticulitis: Results of a National Survey. Cripps, Michael W., Patricia Sylla, Robert Lim, Mark Whiteford, Mike Truitt, Marylise Boutros, Sara Hennessy, Dale Butler, Matthew Bloom, Shane Urban, and Caroline Reinke. Surgical Endoscopy, August.

Resolution of Painful Refractory Soft Palate Mucoceles Following Post-Surgical Onset of Satellite Lesions: A Rare Three-Year Course. Ellis, Collin L., Ankona Ghosh, and Joel B. Epstein. International Journal of Clinical and Experimental Pathology 19 (7): 346–51.

The Value of Multidisciplinary Aerodigestive Evaluation in Pediatric Vascular Ring and Sling Management: A Retrospective Cohort Study. Risbud, Adwight, Ethan D. Frank, Heather Y. Sun, Aparna Rao, Z. Jason Qian, Matthew T. Brigger, Soma Kumar, Virginia Floco, Elizabeth E. LaSalle, Kimberly Morris, Lisa Horvay, and Tzyynong L. Friesen. International Journal of Pediatric Otorhinolaryngology 209 (August): 112990.

Urology

Insulin-like Growth Factor Signaling Promotes Corneal Myofibroblast Survival and Sustains Corneal Fibrosis. Hwang, Yunjeong, Kyung-No Son, Manoj Chaudhary, Eunbee Lee, Minhyung Kim, Sungyong You, Terry J. Smith, Vinay Kumar Aakalu, and Kyu-Yeon Han. International Journal of Molecular Sciences 27 (16): 7320.

Cedars-Sinai Health Sciences University is advancing groundbreaking research and educating future leaders in medicine, biomedical sciences and allied health sciences. Learn more about the university.

Danovitch and Murphy can discuss:

• How social media engages the brain and whether compulsive use shares characteristics with substance-related and other addictive disorders
• What research shows about the relationship between social media use and mental health, self-esteem and self-worth
• Why children and adolescents may be more vulnerable than adults to the potential harms of social media
• How performing for a constant online audience can influence identity development during adolescence
• How frequent social media use may affect young people’s ability to sustain attention, tolerate boredom and focus on tasks that require deep concentration
• Practical steps parents can take to encourage healthier social media habits and protect young users
   

Media Contact

To schedule an interview with a Cedars-Sinai behavioral health expert, contact Kristin Reynolds at marykristin.reynolds@cshs.org or 424-241-8108.

Cedars-Sinai in the News

Doctor and Survivor Discuss how CPR Saved the Dancer’s Life After Cardiac Arrest | CBS News LA
Laura Dichiacchio, MD, PhD 

Q&A: Expert Consensus Pathway Outlines ‘Explosion of Therapies’ now Available for HFpEF | Healio Cardiology Today
Michelle Kittleson, MD, PhD 

Beta-Blockers for Anxiety: What Older Adults Should Know | AARP
Nathalie Murphy, MD 

HCM Care Is Evolving Thanks to Better Data, New Treatments | Cardiovascular Business
Florian Rader, MD 

The Impact of AI on Clinical Practice and Care—Insights From Dr. Melissa Wong | Clinical Pain Advisor
Melissa Wong, MD 

Shigella Growing ‘More Resistant’ to Antibiotics as Adult Men Shoulder Burden of New Cases | Healio Gastroenterology Today
Ali Rezaie, MD  

Patient Warning: Bariatric Surgery Can Get Them Drunk Faster | Medscape
Albert Abayev, RD 

New Research Explores the Earliest Stages of Coronary Plaque Inflammation | Cardiovascular Business
Sarah Parker, PhD 

Mass Spec Roundup: Protein Landscapes and Adaptive Analysis | The Analytical Scientist
Katlin Silm, PhD 

AI-Powered Opportunistic Screening Could Help Find Patients With Undetected Aortic Stenosis | Cardiovascular Business
Ofir Koren, MD

Faculty Publications

Biomedical Sciences

Assessment of Coronary Plaque Burden Using Non-Contrast T1-Weighted Cardiovascular MR: Comparison With Coronary CT Angiography. Pedersen, Alexandra Amalie Uglebjerg, Gregory Wood, Andreas Kabel, Damini Dey, Erik Thorlund Parner, Jesper Møller Jensen, Martin Bødtker Mortensen, Karl P. Kunze, Claudia Prieto, René M. Botnar, Bjarne Linde Nørgaard, and Won Yong Kim. Journal of Cardiovascular Magnetic Resonance, August, 102788.

Retrieval-Augmented Claude Opus 4.7 and GPT-5.5 Surpass Human Performance on the Nuclear Cardiology Board Preparation Exam (and Claude Drafts a Paper About It). Killekar, Aditya, Aakash Shanbhag, Robert J. H. Miller, Damini Dey, Paul B. Kavanagh, Jamieson M. Bourque, Lawrence M. Phillips, Panithaya Chareonthaitawee, and Piotr J. Slomka. Journal of Nuclear Cardiology, August, 102946.

South Asian Cardiovascular Risk: Role of Coronary Artery Calcium Scoring and Computed Tomography Angiography. Kalra, Dinesh K., Deepak Vedamurthy, Nisha Hosadurg, Abhinav Goyal, Milan Gupta, Neha Pagidipati, Leandro Slipczuk, Damini Dey, Anurag Mehta, Parag Joshi, Lohendran Baskaran, Nathan Wong, and Salim S. Virani. JACC. Asia 6 (8 Pt 2): 1657–77.

Cardiac Surgery

Outcomes After Lung Retransplantation for Restrictive Allograft Syndrome Have Not Improved Over 2 Decades. Krishna, Vikram, Allen A. Razavi, Brian Lim, Zachary Brennan, Qiudong Chen, Laura DiChiacchio, Dominick Megna, Joanna Chikwe, Michael E. Bowdish, and Pedro Catarino. JTCVS Open 32 (August): 101862.

Cardiology

A National Institute on Aging Workshop on Sex Differences in Health Across the Lifespan. Pea, Jeffrey, Siobhan Addie, Fabrisia Ambrosio, Rozalyn M. Anderson, C. Noel Bairey Merz, Elizabeth Barr, Stacy Carrington-Lawrence, Rafael de Cabo, Patrice Desvigne-Nickens, Dena B. Dubal, Chelsea Haakenson, Passley Hargove-Grimes, Emily G. Jacobs, Mihoko Kai, Maja Maric, Sunila G. Nair, Kristy Nicks, Jennifer L. Pluznick, Kimberlee Potter, Mercy R. Prabhudas, Marta Rodriguez-Garcia, Michael B. Stout, Barbara E. Stranger, Susan Taymans, Dan Theodorescu, John P. Williams, Fei Wang, Xin Yuan, Viviana I. Perez, and Francesca E. Duncan. Nature Aging, August.

Bone Mineral Density in Women With Functional Hypothalamic Amenorrhea Compared to Eumenorrheic Controls and Recently Menopausal Women. Safwan, Nancy, Regina Castaneda, Erin R. Uddenberg, Maria D. Hurtado Andrade, Jenna Maughan, Mariam Saadedine, Stephanie S. Faubion, Sarah L. Berga, Margareta D. Pisarska, C. Noel Bairey Merz, and Chrisandra L. Shufelt. Frontiers in Endocrinology 17: 1897514.

Game-Changers: Using Simulation Gaming to Strengthen Charge Nurse Leadership Development. Rodriguez, Krystal, Lucía Floríndez-Cox, Byunghyun Kim, Marisela Rosales, and Margo Minissian. Nurse Leader 0 (0).

Is Menopause a Driver of Cardiovascular Disease? Bairey Merz, C. Noel. Circulation. Population Health and Outcomes, August, e013944.

Pharmacokinetics of Oral Bromocriptine in Postpartum Patients. Sinkey, Rachel, Yuanfan Ye, Kevin J. Ryan, Jeff M. Szychowski, Natalie A. Bello, Karen Sliwa, Edward P. Acosta, and Alan Tn Tita. Pregnancy 2 (1): e70199.

Physics-Informed Reconstruction of Transmural Myocardial Deformation From 3D Echocardiography: Validation Against Cardiac MRI. Pradhan, Satya Prakash, Arash Yavari, Issac D. Lindley, Nader Binesh, Yuri P. Matusov, Kambiz Ghafourian, Gianni Pedrizzetti, and Arash Kheradvar. Annals of Biomedical Engineering, August.

Prophylactic Implantation of Implantable Cardioverter-Defibrillator for the Primary Prevention of Sudden Cardiac Death After Myocardial Infarction: Protocol for Systematic Review and Meta-Analysis of Randomised Controlled Trials. Amarasekera, Anjalee Thanuja, Anoja W. Gunaratne, Joshua G. Kovoor, Aravinda Thiagalingam, Clara Chow, Sarah Zaman, Gopal Sivagangabalan, Matthew Kuang Yu Tung, Martin Stiles, Ian Crozier, Keng Tat Koh, Christian Sticherling, Tobias Reichlin, Jerzy Krzysztof Wranicz, Dimitrios Avramides, Konstantinos Tsioufis, Oliver Ritter, Kerstin Bode, Oholi Tovia-Brodie, Karin Chia, Robert E. Park, Karin Nentwich, Yoav Michowitz, Martin Svetlosak, Robert Hatala, Markus Zabel, Vivien Klaudia Nagy, Béla Merkely, Andrew Taylor, Laurent Billot, Pramesh Kovoor, and PROTECT-ICD Study Investigators. BMJ Open 16 (8): e107134.

Short-Interval Coronary Plaque Remodeling Assessed by Serial AI-Quantified Coronary CTA During Intensive Plaque-Directed Therapy. Karlsberg, Ronald P., Abhinav R. Thummala, Francisco X. Elisarraras, Ilana S. Golub, and Geoffrey W. Cho. Journal of Cardiovascular Computed Tomography, August, S1934-5925(26)00427-2.

The Opportunities and Challenges in AI Opportunistic Disease Detection in General Populations. Sahashi, Yuki, Jacob Mishell, and David Ouyang. Journal of the American College of Cardiology 88 (7): 765–67.

What Makes a Meta-Analysis Believable? Lee, Matthew M. Y., Sanjay Kaul, Harlan M. Krumholz, Stuart J. Pocock, Carolyn S. P. Lam, and Faiez Zannad. Lancet, August, S0140-6736(26)01087-1.

Computational Biomedicine

Characterizing Primary Care in Breast Cancer Survivors After Completion of Cancer Therapy. Kay, Kendall, Yancen Pan, Jessica Li, Lan Zhang, Vanessa N. Torres, Yelba Castellon-Lopez, Meng-Han Tsai, Geetanjali D. Datta, Jennifer Henry, and Cody Ramin. Cancer Causes & Control: CCC 37 (9): 146.

Emergency Medicine

Time to Inpatient Management for Boarding Emergency Department Patients. Janke, Alexander T., Adrian D. Haimovich, Meaghan Cussen, Christopher M. Fung, Margaret E. Samuels-Kalow, DaMarcus E. Baymon, Yosef Berlyand, Laura G. Burke, Brian W. Patterson, Daniel J. Hekman, Martin S. Copenhaver, Joshua D. Niforatos, Amber K. Sabbatini, M. Kennedy Hall, Ula Hwang, Natalia Sifnugel, Rohit B. Sangal, Arjun K. Venkatesh, George Glass, Richard Andrew Taylor, Rachel M. Skains, Russell L. Griffin, Peter S. Antkowiak, Seth Gemme, Michael Gottlieb, Eric Moyer, Carl T. Berdahl, Sam S. Torbati, Larry A. Nathanson, Evan L. Leventhal, Molly M. Jeffery, Brendan M. Carr, Tehreem Rehman, Samuel E. Sondheim, Kenneth M. Lee, Theodore J. Iwashyna, and Ari B. Friedman. JAMA, August, e2613302.

Medicine

A Deep Learning Approach for Noise Suppression in Cardiac-Gated SPECT Studies. Zhang, Xirang, Yongyi Yang, Jovan G. Brankov, Janusz K. Kikut, Piotr J. Slomka, and Michael A. King. Journal of Nuclear Cardiology, August, 102944.

Cryptogenic Steatotic Liver Disease Reveals Hidden Liver Risk in Metabolically Silent Lean Individuals. Danpanichkul, Pojsakorn, and Ju Dong Yang. Gut, August, gutjnl-2026-339978.

Diagnostic Performance of the Nine-Item ARFID Screen in Patients With Disorders of Gut-Brain Interaction. Wang, Yingxin, Adeline Answine, Michigan Medicine ARFID Working Group, William D. Chey, Jessica P. Naftaly, Allen Lee, and Prashant Singh. Clinical Gastroenterology and Hepatology, August, S1542-3565(26)00592-6.

Endpoint Discordance in IBS-C: Bloating as a Partially Uncaptured Therapeutic Signal. Busam, Jonathan A., and Mark Pimentel. Clinical Gastroenterology and Hepatology, August, S1542-3565(26)00591-4.

Primary Care Referrals and Abdominal Imaging in People With New-Onset Diabetes and Weight Loss: Cohort Study Using the English National Sentinel Network Database. Lemanska, Agnieszka, Hugh Claridge, Claire A. Price, Jessica Abell, Eithne Costello, Georgina Evans-Lilley, Stephen Pandol, Poppy Richards, Rachael Z. Stolzenberg-Solomon, and Simon de Lusignan. BMJ Open 16 (8): e119662.

Protocol for the CLOCKS Study: A 4-Arm Randomized Controlled Trial Testing the Independent and Combined Effects of 2 Chronotherapies-Early Time-Restricted Eating and Daytime Bright Light Therapy-in Adults With Type 2 Diabetes. Steger, Felicia L., Sarah-Jeanne Salvy, T. Brooks Vaughan, Catherine Lowry, Joshua S. Richman, Karen L. Gamble, W. Timothy Garvey, Frank A. J. L. Scheer, and Courtney M. Peterson. Nutrition Research 153 (July): 142–59.

Safety and Efficacy of Intratumoral MEDI1191, an IL-12 mRNA Lipid Nanoparticle, Plus Intravenous Durvalumab in Patients With Advanced Solid Tumors: A First-in-Human Study. Carneiro, Benedito A., Thomas Marron, Dmitriy Zamarin, Eduardo Castañón, Sandip Pravin Patel, Vivek Subbiah, Inderjit Mehmi, Anthony El-Khoueiry, Arjun Oberoi, Michael Abadier, Emily C. Jennings, Vincent Dubois, Zhongying Chen, Xiaoru Chen, Nairouz Elgeioushi, Nicholas M. Durham, Benjamin Ridgway, Paula G. Fraenkel, Analia Azaro, and Omid Hamid. Clinical Cancer Research, August.

September 2026 Issue First Authors. Akinsola, Rasaq, Sofia Nasini, Hanyuan Zheng, and Andrea Villatore. Trends in Pharmacological Sciences, August, S0165-6147(26)00200-2.

The Role of Glucagon-like Peptide 1 Receptor Agonists in the Management of Patients With Inflammatory Bowel Diseases. Beniwal-Patel, Poonam, Sami Samaan, Maria T. Abreu, Parakkal Deepak, and Andres J. Yarur. Inflammatory Bowel Diseases, August, izag151.

Neurology

Generative Artificial Intelligence in Manuscript Writing and Peer Review for the Journal of Neuroimmunology. Wu, Gregory F., Robyn S. Klein, Ashutosh K. Mangalam, Kristen E. Funk, Hanane Touil, Qiang Liu, Ralf Gold, and Laura Piccio. Journal of Neuroimmunology, July, 579042.

Neurosurgery

Neural Dynamics Underlying Minute-Timescale Persistent Behaviour in the Human Brain. Courellis, Hristos S., Michael Kyzar, Juri Minxha, Araceli R. Cardenas, Taufik A. Valiante, Adam N. Mamelak, Ralph Adolphs, and Ueli Rutishauser. Nature Human Behaviour, August.

OBGYN

Cost-Effectiveness of Implementing a Multidisciplinary Team Approach in the Management of Placenta Accreta Spectrum. Luu, Binh T., Megha Arora, Ava D. Mandelbaum, Andrew H. Chon, Tania F. Esakoff, Deirdre J. Lyell, and Aaron B. Caughey. Pregnancy 2 (4): e70323.

Hypertension-Related Morbidity After Delivery Discharge: A Comparison of Nifedipine Versus Labetalol. Fabricant, Sonya, Matthew Cervantes, Glenda Marshall, Natalie Bello, Emily Seet, Sarah Kilpatrick, and Mariam Naqvi. Pregnancy 2 (4): e70357.

Impact of a Substance Use Screening Program on Racial Disparities in Urine Toxicology Testing. Naqvi, Mariam, Amin Tavakoli, Camelita S. Thrift, Allison Henry, Jennifer Astasio, Farnaaz Kia, Naomi Greene, and Sarah J. Kilpatrick. Pregnancy 2 (2): e70247.

Interdisciplinary Management of a Viable Term Abdominal Ectopic Pregnancy. Hayer, Sarena, Natasha Q. McGlaun, Katerina A. Furman, Michael R. Manuel, Gouri B. Sadananda, Daniel Manzoor, Swati Bhardwaj, Tanu Patel, Sara Dayanim, and John A. Ozimek. Pregnancy 2 (4): e70336.

Polyendocrine Metabolic Ovarian Syndrome (PMOS)/Polycystic Ovary Syndrome (PCOS): Current and Future Trends. Chan, Jessica L., Irene Masini, and Margareta D. Pisarska. The Journal of Clinical Investigation 136 (12): e202824.

Uterine Weight and Postoperative Outcomes by Surgical Route in Minimally Invasive Hysterectomy. Yagur, Yael, Kacey M. Hamilton, Ogechukwu Ezike, Maya Shats, Connie Liao, Katharine Ciesielski, Rebecca Schneyer, Yair Daykan, Gabriel Levin, Matthew T. Siedhoff, Kelly N. Wright, and Raanan Meyer. Journal of Minimally Invasive Gynecology, August, S1553-4650(26)00442-5.

Orthopaedics and Sports Medicine

Administration of Preoperative Cryoneurolysis Is Associated With Continued and Persistent Opioid Reduction and Improved Outcomes in Primary Total Knee Arthroplasty. Ng, Mitchell K., Jennifer H. Lin, Andrew I. Spitzer, Vinod Dasa, Adam Rivadeneyra, David Rogenmoser, Andrew L. Concoff, Paul G. Mastrokostas, Mary DiGiorgi, Joshua Urban, William M. Mihalko, and Michael A. Mont. The Journal of Arthroplasty, August, S0883-5403(26)00871-5.

Age-Related Differences in Radiologic and Clinical Presentation of Charcot-Marie-Tooth Foot Deformity: Insights From WBCT and PROMIS Analysis. Song, Jae Hwang, Max P. Michalski, Giselle Moriah Porter, Andy Tong, and Glenn B. Pfeffer. Foot and Ankle Surgery, August, S1268-7731(26)00212-2.

Injectable Thermoresponsive Microgels Encapsulate and Precondition Nucleus Pulposus Cells for Intervertebral Disc Regeneration. Jiang, Wensen, Namdev More, Melissa Chavez, Jacob T. Wechsler, Sarah Mohyeddinipour, Tiffany Lee, Wei Huang, Giselle Kaneda, Lei Mou, Thomas Spaeter, Julia Sheyn, Changlu Xu, Victoria Yu, Chloe Castaneda, Ethan Ha, Wafa Tawackoli, Linda Ea Kanim, Oksana Shelest, Hyun W. Bae, Samad Ahadian, Mehmet R. Dokmeci, Ali Khademhosseini, Dror Seliktar, and Dmitriy Sheyn. ACS Applied Bio Materials 9 (16): 7398–7408.

Quantifying Influence: The Orthopaedic PAC’s Impact Explored Through Analysis of FEC Data. Nadarajah, Vidushan, Miranda Barnes, Jonathan Belding, Basilia O. Nwankwo, Susan E. Stephens, A. Bobby Chhabra, and Matthew J. Deasey. Journal of the American Academy of Orthopaedic Surgeons. Global Research & Reviews 10 (8): e26.00257.

Representation of Hispanic and Latino Orthopaedic Surgery Trainees and Attendings in the United States: A Demographical Analysis. Brito, Emmanuel, Nathan Sherman, and Guy Paiement. JB & JS Open Access 11 (3): e25.00349.

Pathology and Laboratory Medicine

Fatal Outcome of Widespread Cranial Basal Cell Carcinoma Due to Intraparenchymal Brain Extension in a Setting of Local Recurrences. Gant, Tayler, Serguei Bannykh, and David Frishberg. Cureus 18 (7): e112885.

Longitudinal Associations Between Albuminuria and Renal Function and Annual Brain Volume Changes: The Ohasama Study. Nakayama, Shingo, Michihiro Satoh, Satoshi Yamaguchi, Ayana Saito, Hiroki Nobayashi, Megumi Tsubota-Utsugi, Yukako Tatsumi, Takahisa Murakami, Takahito Yagihashi, Maya Toyama, Takuo Hirose, Azusa Hara, Takefumi Mori, Kei Asayama, Naoko Mori, Masahiro Kikuya, Kyoko Nomura, Hirohito Metoki, and Takayoshi Ohkubo. Clinical and Experimental Nephrology, August.

Scalable, Modular Whole-Slide Imaging Pipelines for Low-Resource Settings: A Practical Framework and Open Notebook Implementation. Githuka, Alfred, Ulysses G. J. Balis, Ye Chan Kim, Eileen M. Weinheimer-Haus, Christopher L. Williams, Jerome I. Cheng, Kelou Yao, John Blau, Jessica A. Baker, Priscilla Njenga, Winny Chepkemoi, Robert K. Parker, Akbar K. Waljee, Shahin Sayed, and Mansoor N. Saleh. Journal of Pathology Informatics 22 (August): 100692.

Pediatrics

Cancer Control After Pausing Treatment With Larotrectinib in Responding Children With Sarcoma and a TRK Fusion: A Plain Language Summary. Mascarenhas, Leo, Christopher Ollis, Yuvraj Singh, Linet Menachery, Domnita-Ileana Burcoveanu, Esther De La Cuesta, Cornelis M. van Tilburg, and Theodore W. Laetsch. Future Oncology, August, 1–10.

Donor-Derived Cell-Free DNA in Stable Pediatric Kidney Transplant Recipients: Influence of Donor Obesity and Recipient Size. Steinke, Julia, Lyndsay Harshman, Kelly Kirshner, Arundhati Kale, Erica Winnicki, Daniel Ranch, Jayanthi Chandar, Helen Pizzo, Arshdeep Kaur, Paul Hanson, Zunqiu Chen, Ling Shen, and Dechu Puliyanda. Pediatric Transplantation 30 (8): e70416.

Radiation Oncology

Stereotactic Body Radiotherapy vs Moderately Hypofractionated IMRT for Localized Intermediate-Risk Prostate Cancer: A Randomized Clinical Trial. Ellis, Rodney J., Stephanie L. Pugh, James B. Yu, Felix Y. Feng, Andre A. Konski, Robert L. Grubb, Robert E. Wallace, David J. Gladstone, Cynthia Ménard, Joseph A. Miccio, Arthur J. Frazier, J. Daniel Pennington, Jeff M. Michalski, Daniel E. Spratt, Alvaro Martinez, Scott C. Morgan, Alina Mihai, Abhishek Ashok Solanki, Asim Amjad, Michael W. Straza, Guila Delouya, Thomas M. Schroeder, David T. Marshall, Nirav Kapadia, Akshar N. Patel, Terrence P. Cescon, Ali El-Gayed, Harold A. Yoon, Rebecca Paulus, Howard M. Sandler, and NRG-GU005 Collaborative Authors. JAMA, August, e2612627.

Surgery

Clustering and Predicting VCA Patient Populations - a Machine Learning Approach Into Vascularized Composite Allotransplantation. Knoedler, Leonard, Tobias Niederegger, Thomas Schaschinger, Carsten Stahl, Jule Brandt, Curtis L. Cetrulo, Max Heiland, Gabriel Hundeshagen, Jan O. Voss, and Alexandre G. Lellouch. Frontiers in Immunology 17 (August).

Comparative Clinical Effectiveness and Operating Efficiency of Different Ultrasonic Devices for Performance of Sleeve Gastrectomy. Monali, Misra, I.-Wen Pan, Zasim Azar Siddqui, Frank Bisceglie, and Matthew Kroh. Obesity Surgery, August.

Development of Cecal Volvulus After Redo Pancreas Transplantation. Voidonikolas, Georgios, Nicolas Melo, Steven A. Wisel, Justin A. Steggerda, Manaf Alsudaney, Tsuyoshi Todo, Irene K. Kim, and Todd V. Brennan. Journal of Surgical Case Reports 2026 (8): rjag703.

Early vs Late Surgical Intervention for Morel-Lavallée Injuries: A Pacific Coast Surgical Association Prospective Multicenter Study. Smith, Maren B., Areg Grigorian, Jarrett E. Santorelli, Joshua C. Dilday, Daniel J. Stephens, Karen G. Minoza, Walter L. Biffl, Raul Coimbra, Areti Tillou, Jeffry Nahmias, and Morel Lavallée Study Group. Journal of the American College of Surgeons 243 (3): 651–59.

Facial Vascularized Composite Allotransplantation: Mapping Global Research Trends and Scientific Impact. Alves, André S., Tobias Niederegger, Leonard Knoedler, Curtis L. Cetrulo, and Alexandre G. Lellouch. JPRAS Open 0 (0).

Performance of Large Language Models in Answering Otolaryngology Clinical Questions in Non-English Languages. Oh, Eugene, Arthur W. Wu, Laura Garcia-Rodriguez, Zhen-Xiao Huang, Wei-Chung Hsu, Jeongkyou Kim, Young Chul Kim, Yi-Tsen Lin, Hae Chan Park, Hector Andres Perez, Juan San Juan, Gene Liu, Matthew Lee, and Dennis M. Tang. World Journal of Otorhinolaryngology - Head and Neck Surgery, August.

Survival and Outcomes After Nonoperative Management of Operable Non-Small Cell Lung Cancer. Rocco, Raffaele, Ralf Martz Sulague, Vikram Krishna, Clark B. Fuller, Philicia Moonsamy, Andrew R. Brownlee, and Harmik J. Soukiasian. JTCVS Open 32 (August): 101920.

The Regenerative Potential of GHK-Cu in Aesthetic Medicine. Mokhtar, Jonathan, Basel Mohamad, Jewel Haddad, Alma Said, Arya Menon, Lucas Kreutz-Rodrigues, Krishna S. Vyas, Curtis L. Cetrulo, and Alexandre G. Lellouch. Aesthetic Surgery Journal, August, sjag169.

The Superficial Musculoaponeurotic System Versus Deep Plane Facelift Debate in the Instagram and TikTok Era. Lu, Richard, and Babak Azizzadeh. Facial Plastic Surgery & Aesthetic Medicine, August, 26893614261479874.

Urology

Evaluation of AI Chatbot Responses to Pediatric Urology Frequently Asked Questions. Mazhari, Najva, Andrew Freedman, Nadine Friedrich, Timothy Daskivich, and Paul Kokorowski. Urology, August, S0090-4295(26)00517-0.

Prospective Multicenter Validation of a Urine-Based Multiplex Assay for Risk Stratification of Patients Presenting With Gross Hematuria. Lotan, Yair, Amit Gupta, Makito Miyake, Satoshi Anai, Michael Luu, Michael Ahdoot, Edward Messing, Garry Peers, Arnold I. Chin, Menghan Liu, Sergei Tikhonekov, Toru Sakatani, Takuto Shimizu, Ian Pagano, Yingye Zheng, Zhen Zhang, Howard Kim, David Josephson, Hideki Furuya, and Charles J. Rosser. Journal of the National Cancer Institute, August, djag282.

Cedars-Sinai Health Sciences University is advancing groundbreaking research and educating future leaders in medicine, biomedical sciences and allied health sciences. Learn more about the university.

The promotions of Jennifer Blaha, MBA; Clare Lee, MBA; Lisa Maqueira; and Alen Voskanian, MD, MBA, represent an intentional investment in leadership capacity to meet Cedars-Sinai’s core mission of delivering the highest-quality care to patients in Los Angeles and beyond.

“These four leaders exemplify the operational excellence and strategic acumen required to deliver on our care vision,” said Peter L. Slavin, MD, president and CEO of Cedars-Sinai Medical Center and Cedars-Sinai Health System. “Collectively, these promotions expand the portfolio of responsibilities held by leaders who have shown, time and again, that operational excellence and exceptional patient care are complementary priorities.”

Blaha, senior vice president of Surgical Services, joined Cedars-Sinai 17 years ago from GE Healthcare, where she served as a senior consultant, and has since risen through senior operational roles across the institution before being named vice president of Operations in 2018.

In her new role, she will oversee the service lines of Neurosurgery, Neurology, Orthopaedics, Surgery, Transplant and Urology, along with Peri-Procedural Services, including Anesthesia and OR Operations.

Blaha has built a strong record of improving clinical quality, patient satisfaction and operational efficiency across the surgical service lines she now leads. She was one of 22 healthcare leaders selected nationally for the Carol Emmott Fellowship, a competitive program advancing women in healthcare leadership.

Lee, senior vice president of Medical Services, brings 34 years of healthcare experience, including 21 years at the executive level, to her new role. She joined Cedars-Sinai in 2018 as vice president of Operations. Prior to Cedars-Sinai, Lee was chief operating officer at Dignity Health Mercy General Hospital in Sacramento and vice president of Operations at Houston Methodist.

In her new role, she will oversee the service lines of Medicine, OB/GYN, Pediatrics and Psychiatry, along with Imaging, Lab and Pathology, and Emergency Services. Over her career, she has transformed clinical operations within the service lines under her purview, cultivating strong leaders and driving significant improvements across clinical and operational areas.

Maqueira, senior vice president of Finance and chief revenue cycle officer, joined Cedars-Sinai in 2011 as director of Professional Billing and Revenue Cycle Services, leading the transformation of professional billing operations. She was promoted to vice president of Revenue Cycle and Managed Care Operations in 2016, taking on expanded responsibility for managed care operations and contracting, professional compliance, government incentives, and centralized scheduling for Cedars-Sinai Medical Network.

Maqueira was named vice president of Finance and chief revenue cycle officer in 2022, leading the organization’s integrated revenue cycle strategy across hospitals and physician networks. With 33 years of revenue cycle experience, she has consistently delivered stronger collections, improved charge capture and greater operational efficiency. In her new role, she is accountable for setting and executing a strategic vision to advance exceptional patient and provider experience while strengthening financial performance.

Voskanian, senior vice president and chief operating officer of Ambulatory Clinics, joined Cedars-Sinai in 2018 from VITAS Healthcare, where he was regional medical director. He served as medical director of Cedars-Sinai Medical Group and later as vice president and chief operating officer of Cedars-Sinai Medical Network.

A practicing physician who continues to care for patients, Voskanian has helped lead ambulatory strategy and the growth and integration of specialty practices, contributing to substantial growth in weekly patient volumes during his tenure as chief operating officer. Working closely with clinical and administrative leaders, he has also advanced a dyad leadership model that strengthens collaboration, improves operational performance and supports physicians and staff in delivering high-quality care.

Read more from Cedars-Sinai Stories and Insights: New Cedars-Sinai CEO Shares Vision for Growth and Priorities

Cedars-Sinai in the News

Body Image and Eating Disorder Concerns | CBS LA
Itai Danovitch, MD 

3 Easy Ways to Reduce Stress When You Have IBS | Everyday Health
Brennan Spiegel, MD, MSHS 

Los Angeles Schools Limit Classroom Screen Time Amid Concerns About Child Development | Consumer Affairs
Jane Tavyev Asher, MD 

How Will the Commanders Replace Laremy Tunsil—and Could He Return This Season? | The New York Times
Brian Lee, MD 

Warning Symptoms, Clinical History Can Predict Sudden Cardiac Arrest | HealthDay
Sumeet Chugh, MD 

Inconclusive BRCA Results Linked to Higher Breast Cancer Risk | Medscape
Fahima Dossa, MD, PhD

How Urinary Tract Infections Trigger Delirium in People With Dementia | Being Patient
Shouri Lahiri, MD

Faculty Publications

Biomedical Sciences

Let Distortion-Guided Restoration: A Physics-Informed Learning Framework to Correct Prostate Diffusion MRI Artifacts. Long, Ziyang, Nader Binesh, Lixia Wang, Archana Vadiraj Malaji, Chia-Chi Yang, Haoran Sun, Rola Saouaf, Timothy Daskivich, Hyung Kim, Yibin Xie, Debiao Li, and Hsin-Jung Yang. Radiology Advances 3 (4): umag031.

Metabolic Reprogramming of Brain Microglia: Implications for Aging and Aging-Associated Neurodegenerative Diseases. Kang, Seokjo, and Helen S. Goodridge. Aging Cell 25 (8): e70660.

Nepal’s Vulnerability to Nipah Virus Transmission: An Urgent Call for Preparedness. Lama, Bhupendra, Uday Narayan Yadav, Gopiram Syangtan, Alaka Bhandari, Binod Gc, Mukesh Rai, Martyn D. Kirk, and Binod Rayamajhee. Sustainable Microbiology 3 (2): qvag015.

Cardiac Surgery

A New Era for the Surgical Treatment of Atrial Fibrillation: Evolving Surgical Techniques and Clinical Considerations. Kiankhooy, Armin, Adam Eqbal, Richard P. Whitlock, T. Jared Bunch, Ali J. Khiabani, Ralph J. Damiano, Graham Peigh, Rod S. Passman, Patrick M. McCarthy, J. Hunter Mehaffey, and Arnar Ingason. The Annals of Thoracic Surgery, August, S0003-4975(26)00817-9.

Baseline Lung Allograft Dysfunction: Definition, Timing, and Implications for Outcomes-an ISHLT Consensus Document. Gottlieb, Jens, Tereza Martinu, Merel Hellemons, David R. Darley, Laurie Snyder, Laura DiChiacchio, Miranda Paraskeva, Christian Benden, Berta Saez-Gimenez, Anoop Mohandas, Letizia Corinna Morlacchi, Joshua M. Diamond, Saskia Bos, Erika D. Lease, Geert Verleden, Allan Glanville, and Kieran Halloran. The Journal of Heart and Lung Transplantation, June, S1053-2498(26)01945-5.

Donor Diabetes Status Impacts Long-Term Survival in Diabetic Heart Transplant Recipients. Lim, Brian, Allen A. Razavi, Aminah Sallam, Vikram Krishna, Federico Sertic, Dominic Emerson, Dominick Megna, Pedro Catarino, Michael E. Bowdish, Lawrence Czer, Jon Kobashigawa, Fardad Esmailian, Joanna Chikwe, and Laura DiChiacchio. JHLT Open 14 (November): 100631.

Cardiology

Aspirin-Free P2Y12 Inhibitor Monotherapy Post-Stenting in Acute Coronary Syndromes. Kaul, Sanjay, and James M. Brophy. European Heart Journal, August, ehag620.

Dual Inhibition of SGLT 1 and 2 by Sotagliflozin Alleviates Intracellular Sodium Overload and Improves Cardiometabolic Remodelling in Uraemic Cardiomyopathy. Young, Megan, Anja Karlstaedt, Sanushi Dambure, Jack J. J. J. Miller, Tong Guo, Xin Zhou, Zenouska Ramchunder, Jair Gonzalez Marques Junior, Muriel Nobles, Andrew Tinker, Kyuongmin Kim, Amanda R. Purcell, Sarah J. Glastras, Fenn Cullen, Thomas R. Eykyn, Alex Von Kriegsheim, Blanca Rodriguez, Michelangelo Campanella, Michael J. Shattock, Nay Aung, Claudia P. Cabrera, Magdi M. Yaqoob, and Dunja Aksentijevic. Cardiovascular Research, August, cvag167.

Prediction of Left Main Coronary Artery Disease by ECG Exercise Stress Testing: Ready for Clinical Implementation? Bairey Merz, C. Noel. European Heart Journal, August, ehag605.

Predictors of Target Lesion Failure in Patients With In-Stent Restenosis: Insights From the AGENT IDE Trial. Abbott, J. Dawn, Nicholas Kassis, Azeem Latib, Richard A. Shlofmitz, Jeffrey W. Moses, William B. Bachinsky, Suhail Dohad, Steven G. Rudick, Robert C. Stoler, Brian K. Jefferson, William J. Nicholson, John D. Altman, Cinthia T. Bateman, Amar Krishnaswamy, Rafael Cavalcante, Robert W. Yeh, and Ajay J. Kirtane. Circulation. Cardiovascular Interventions, August, e016289.

The Current and Future in Transcatheter Treatment of Aortic Stenosis: From the ‘Beyond the Guidelines’ Session at Cardiovascular Research Technologies. Ha, Edward T., Holger Thiele, Michael Joner, Howard C. Herrmann, Hasanian A. Jilaihawi, Gilbert H. L. Tang, Isaac George, Thomas E. MacGillivray, and Ron Waksman. Cardiovascular Revascularization Medicine: Including Molecular Interventions, July, S1553-8389(26)00326-X.

Computational Biomedicine

Impact of Surveillance Colonoscopy on Colorectal Cancer Incidence and Mortality in Lynch Syndrome: A National Observational Cohort Study of Patients in the English NHS 2010-2022. Huntley, Catherine, Lucy Loong, Corinne Mallinson, Tameera Rahman, Beth Torr, Sophie Allen, Isaac Allen, Hend Hassan, Yvonne Walburga Joko Fru, Daniela Tataru, Lizz Paley, Sally Vernon, Richard S. Houlston, David Muller, Fiona Lalloo, Adam C. Shaw, John Burn, Eva J. A. Morris, Marc Tischkowitz, Antonis C. Antoniou, Paul D. P. Pharoah, Kevin Monahan, Steven Hardy, and Clare Turnbull. Gut, August, gutjnl-2025-337379.

Emergency Medicine

Conversational Artificial Intelligence and Neuropsychiatric Risk: A Narrative Review and Case-Based Synthesis Proposing a Delusional Feedback Loop. Abesadze, Nino, Abigale Fernandes, and Elizabeth Rubin. Cureus 18 (7): e112306.

Small Doses, Big Problems: Antidote Shortages. Laub, Daniel Ascher, Maryann Mazer-Amirshahi, Michelle Burns, and Erin R. Fox. The Journal of Pediatric Pharmacology and Therapeutics: JPPT, 31 (4): 574–76.

Imaging

Coronary Plaque Phenotype in Ischemic Stroke Survivors: A Quantitative Coronary CT Angiography Comparison With Acute Myocardial Infarction and Stable Chest Pain. Muthalaly, Rahul G., Julian Giovannucci, Andrew Lin, Sean Tan, Nitesh Nerlekar, Adam J. Nelson, Damini Dey, Thanh Phan, Henry Ma, and Stephen J. Nicholls. Radiology. Cardiothoracic Imaging 8 (4): e260039.

Medicine

Association Between Diabetic Control and Progression of Monoclonal Gammopathy of Undetermined Significance to Multiple Myeloma. Liu, Lawrence, Byron Sigel, Mei Wang, Nikhil Grandhi, Martin W. Schoen, Kristen M. Sanfilippo, Kenneth R. Carson, Murali Janakiram, Tzeyu L. Michaud, Graham A. Colditz, Theodore S. Thomas, and Su-Hsin Chang. Blood Cancer Journal 16 (1): 135.

Association of High Birth Weight With Risk of Early-Onset Colorectal Cancer. Mukherjee, Amrita, Lanfang Xu, Darios Getahun, Jessica Chubak, Jane C. Figueiredo, Kimberly L. Cannavale, Alec D. Gilfillan, Bechien U. Wu, and Chun R. Chao. Cancer Epidemiology, Biomarkers & Prevention: A Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology, August.

Belzutifan Plus Lenvatinib Versus Cabozantinib in Patients With Previously Treated Advanced Renal Cell Carcinoma (LITESPARK-011): An Open-Label, Randomized, Controlled, Phase 3 Trial. Motzer, Robert J., Ray McDermott, Se Hoon Park, Mauricio Burotto, Roberto Iacovelli, Elena Verzoni, Cristina Suárez, Masatoshi Eto, Hernan J. Cutuli, Camillo Porta, Ray Manneh Kopp, Sylvie Rottey, Guillermo de Velasco, Begoña P. Valderrama, Arun A. Azad, Ugo De Giorgi, Michel Pavic, Piotr Tomczak, Robert Figlin, Hans M. Westgeest, Annalisa Guida, Andrea Necchi, Fabio A. Schutz, Britt B. M. Suelmann, John B. A. G. Haanen, Sammy Shuai Yuan, Rodolfo F. Perini, Ding Wang, Daniel Y. C. Heng, Manuela Schmidinger, and LITESPARK-011 Investigators. Lancet, August, S0140-6736(26)01089-5.

Beyond Calprotectin: Where Leucine-Rich Α2-Glycoprotein May Fit in Small Bowel Crohn Disease Monitoring. Anand, Rajsavi, and Andres J. Yarur. Inflammatory Bowel Diseases, August, izag165.

Early Consideration of Automated Insulin Delivery in Type 2 Diabetes: A Critical Review. Tariq, Zunera, Grazia Aleppo, Anders L. Carlson, David Kayne, Davida F. Kruger, Yogish C. Kudva, Eden Miller, Katelyn O’Brien, Sean M. Oser, Ruth S. Weinstock, and Viral N. Shah. Endocrine Practice, August, S1530-891X(26)01105-5.

Fstl1 Determines Luminal Size of Mouse Trachea Through Negative Regulation of BMP4 Signaling. Jin, Yueyue, Yue Zhang, Yingying Liu, Maolin Yao, Chenjie Zhang, Shuzi Li, Yibo Ding, Zhuan Niu, Yue Han, Yan Geng, Lian Li, Xue Liu, and Wen Ning. iScience 29 (8): 116972.

Liver Transplantation at the Extreme: Analysis of Outcomes and Predictors of Futility in Acute-on-Chronic Liver Failure Grade 3 Patients on Maximal Life Support. Melehy, Andrew, Asara Thepbunchonchai, Benjamin V. Tran, Ruben Hernaez, Dominic Amara, Samer Ebaid, Daniela Markovic, Fady M. Kaldas, Igor Barjaktarevic, Victor Xia, Constantine J. Karvellas, Saro Khemichian, Lance L. Stein, Kirti Shetty, Christina C. Lindenmeyer, Justin R. Boike, Douglas A. Simonetto, Robert S. Rahimi, Prasun K. Jalal, Manhal Izzy, Michael S. Kriss, Gene Y. Im, Ming V. Lin, Janice H. Jou, Brett E. Fortune, George Cholankeril, Alexander Kuo, Vinay Sundaram, Multi-Organ Dysfunction and Evaluation for Liver Transplantation (MODEL) Consortium, Ronald W. Busuttil, Douglas G. Farmer, and Vatche G. Agopian. JHEP Reports: Innovation in Hepatology, August, 101959.

Novel Topical Treatment for Dysgeusia/Ageusia: A Case Series Report. Epstein, Joel B., Arezou Petrie, Geena L. Epstein, and Andrei Barasch. Supportive Care in Cancer, 34 (9): 845.

STAT3 Signaling Inhibitors for Cancer Treatment. Akinsola, Rasaq, Jing Xian, and James Turkson. Trends in Pharmacological Sciences, August, S0165-6147(26)00173-2.

Neurosurgery

Cross-Region Neuron Co-Firing Mediated by Ripple Oscillations Supports Distributed Working Memory Representations. Verzhbinsky, Ilya A., Jonathan Daume, Sophia Cheng, Ueli Rutishauser, and Eric Halgren. Nature Neuroscience, August.

Dorsal Spinal CSF Leaks in Patients With Spontaneous Intracranial Hypotension: A Radiologic-Anatomic Study. Schievink, Wouter I., Marcel M. Maya, Kim T. Giang, Rachelle B. Taché, Ravi S. Prasad, and Vikram Wadhwa. AJNR. American Journal of Neuroradiology, August, ajnr.A9572.

Inferring Brain-Wide Interactions Using Data-Constrained Recurrent Neural Network Models. Perich, Matthew G., Charlotte Arlt, Sofia Soares, Siyan Zhou, Manuel Beiran, Aaron S. Andalman, Tyler Benster, Megan E. Young, Clayton P. Mosher, Juri Minxha, Eugene Carter, Ueli Rutishauser, Peter H. Rudebeck, Christopher D. Harvey, Karl Deisseroth, and Kanaka Rajan. Neuron, August, S0896-6273(26)00571-4.

Orthopaedics and Sports Medicine

Achilles Tendon Injuries in Major League Soccer: A 10-Year Analysis of Injury Rate, Return to Play, and Performance Metrics. Forsythe, Brian, Catherine Hand, Francis Hand, Henry Eilen, Matthew Varano, Jared Sasaki, Camden Bohn, Anne Timmermann, Lauren Fertig, Eric Giza, Robert H. Brophy, Bert Mandelbaum, and Kirk McCullough. Orthopaedic Journal of Sports Medicine 14 (8): 23259671261449641.

Smart Implantable Device Use Is Associated With Decreased Post-Discharge Hospital Utilization in Total Knee Arthroplasty Patients Who Have Metabolic Syndrome: A Propensity Score-Matched Analysis. Nakla, Andrew, Patrick M. Aubin, Samuel Ademisoye, Rebecca G. Burr, Sean S. Rajaee, and Mark Wu. The Journal of Arthroplasty, August, S0883-5403(26)00843-0.

Pathology and Laboratory Medicine

Reproductive Factors and Brain Volume in Community-Dwelling Individuals: The Ohasama Study. Saito, Ayana, Kyoko Nomura, Michihiro Satoh, Satoshi Yamaguchi, Azusa Hara, Melanie Griffith-Quintyne, Hiroaki Shimizu, Shingo Nakayama, Megumi Tsubota-Utsugi, Takahisa Murakami, Yukako Tatsumi, Takuo Hirose, Tomoko Totsune, Naoko Mori, Kei Asayama, Masahiro Kikuya, Hirohito Metoki, Atsushi Hozawa, and Takayoshi Ohkubo. Environmental Health and Preventive Medicine 31: 52.

Unmasking Additional Mutations: A Single Institution Study in Myeloproliferative Neoplasms. Tizro, Parastou, Eric Vail, Manoj Sapkota, Matthew G. Gayhart, and Celeste C. Eno. Cancers 18 (15): 2458.

Pediatrics

Alemtuzumab Induction via Intravenous vs. Subcutaneous Administration in Pediatric Kidney Transplantation. Pizzo, H., A. Barbera, K. Westreich, M. E. Seifert, J. Mirocha, K. Kirshner, and D. Puliyanda. Pediatric Transplantation 30 (8): e70424.

Whole Genome Sequencing in Cerebral Palsy: A UK Paediatric Pilot Study. Ratnaike, Thiloka E., Heather H. Pierce, Alison J. Coffey, Joao M. L. Dias, Iain R. L. Kean, Emily Li, Ravi P. More, Dulika S. Sumathipala, Maya Bajracharya, Zoya Kingsbury, Taksina Newington, Anthony S. Rogers, Isabelle Delon, Kate Downes, Yasmin de Alwis, Anna P. Basu, Manal Issa, Catherine Kearney, Amjad H. Khan, Benjamin P. Marlow, Alison Sansome, JooWook Ahn, A. Yee Than, Tracy Lau, David R. Bentley, Sarah Bowdin, Evan Reid, Henry Houlden, Sean Humphray, and David H. Rowitch. The Lancet Regional Health. Europe 68 (September): 101786.

Surgery

‘I Don’t like Fitting a Box, Except the Box I Am’: Genderqueer and Nonbinary (GQNB) Patient Strategies for Navigating Healthcare. Sidhu, Shanaya, Jennifer T. Anger, Victor Trasvina, Falisha Kanji, Kyle Okamuro, Sunny Mangiameli, Alan J. Card, Tara Cohen, Hanna J. Barton, and TRANS-SAFE Author Group. International Journal for Equity in Health 25 (1): 194.

Incidental Mass Found on Screening Colonoscopy. Amedi, Alan, Serhat Suzer, Jesse Zuckerman, and Eiman Firoozmand. Journal of Surgical Case Reports 2026 (8): rjag684.

Prediction of Blunt Trauma Outcomes With Pulmonary Contusion Quantification. Jain, Ashwin, Erik DiGiacomo, Pedro V. Staziaki, Matthew Diamond, Donghoon Shin, Celina L. Duran, Oam Bhate, Myoung Jin Kim, Stephan W. Anderson, Tejal S. Brahmbhatt, and Christina A. LeBedis. Emergency Radiology, August.

Predictive Models for Toxicities after CAR T-Cell Therapy: Challenges and Opportunities. Ma, Julie, August Culbert, Tian-Gen Chang, Mark L. Solter, Eytan Ruppin, Kai Rejeski, and Nirali N. Shah. Blood Cancer Discovery, August, OF1–23.

Reply to: When Guidelines Meet Reality: Implementing the 2025 ATA Recommendations for Differentiated Thyroid Cancer in Limited-Resource Settings. Ho, Allen S., Matthew D. Ringel, Julie Ann Sosa, Julie H. Johnson, and Ellen Marqusee. Thyroid, August, 10507256261478396.

Surviving the Nucleus Pulposus Desert: Next-Generation Strategies for Intervertebral Disc Cell Therapy. Hamidouche, Tynhinane, Namdev More, Tiffany Lee, Mia Orr, Anne Camus, Devina Purmessur, Sarah E. Gulbrand, Nadeen O. Chahine, Lara Silverman, and Dmitriy Sheyn. JOR Spine 9 (3): e70207.

The Thyroid Cancer Modified Anxiety Scale (TC-MAX): Development and External Validation of a Thyroid Cancer Distress Instrument. Bastien, Amanda J., Sungjin Kim, Cynthia Zalt, Iris Cong, Jewel Ng, Caroline Marshall, Christopher V. Almario, Omer Liran, Brennan M. R. Spiegel, Jon Mallen-St Clair, Evan S. Walgama, Kevin S. Scher, Julie K. Jang, Yufei Chen, Samuel Zhang, Gary Bloom, Michelle M. Chen, K. Linnea Peterson, Wendy L. Sacks, Zachary S. Zumsteg, and Allen S. Ho. Thyroid, August, 10507256261475819.

Urology

How Low Do You Need to Go? Association Between Various Prostate-Specific Antigen Response Measures and Clinical Outcomes in Metastatic Castration-Sensitive Prostate Cancer in the Veterans Health Administration Data. Freedland, Stephen J., Wei Gao, Maëlys Touya, Hongbo Yang, David Russell, Jingyi Chen, Grace Chen, and Jasmina I. Ivanova. Cancer 132 (16): e70494.

Cedars-Sinai Health Sciences University is advancing groundbreaking research and educating future leaders in medicine, biomedical sciences and allied health sciences. Learn more about the university.

Cedars-Sinai is urging eligible Angelenos to donate blood this month amid a national blood supply crisis. Blood donation expert Armando Romero is available for interviews to discuss the current shortage, why summer is a challenging time for maintaining the blood supply and how donating blood saves lives.  

WHO

Armando Romero, associate director of Transfusion Medicine at Cedars-Sinai, can discuss why blood donations are especially critical this summer, how the donation process works and who is eligible to donate.

WHY

Earlier this summer, the American Red Cross reported a four-year summer low and the second-ever national blood supply crisis. Because students are a significant percentage of the donor base and schools are not in session, summer is traditionally a time when blood donations decline. At the same time, it’s a busy travel season and extreme heat can discourage participation in community blood drives. Hospitals depend on blood supplies to save lives, and blood donations are especially critical during the summer, when traumatic injuries increase. Every two seconds, someone in the U.S. needs blood. At Cedars-Sinai, a Level 1 trauma center, patients need more than 60,000 units of blood each year.

WHEN

Armando Romero is available for immediate interviews.

WHERE

Cedars-Sinai Medical Center, 8700 Beverly Blvd., Los Angeles. Interviews also are available via Zoom.

TO ARRANGE AN INTERVIEW

Kristin Reynolds | 424-241-8108 | marykristin.reynolds@cshs.org

TO DONATE BLOOD

The public is invited to donate blood at Cedars-Sinai. Call 310-423-5346 to schedule an appointment or select a time here.

The mobile clinics provide school-required immunizations, including Tdap (tetanus, diphtheria and pertussis) and MMR (measles, mumps and rubella), at no cost. The program is aimed at helping families in underserved communities, where families can face barriers to preventive care.

“Preparing for a successful school year starts with protecting children’s health,” said Arthur Cho, MD, medical director of COACH for Kids. “Our Back-to-School immunization campaign brings recommended vaccines directly into the communities we serve, making it easier for families to get their children ready for the classroom.”

COACH for Kids delivers free medical services to children from birth through age 18 in underserved communities throughout Los Angeles.

COACH for Kids Mobile Medical Unit August Calendar

All clinics run from 9 a.m. to 3 p.m. and are closed from noon to 1 p.m.

Tuesday, Aug. 11
Charles Drew Middle School
8511 Compton Ave.
Los Angeles, CA 90001

Wednesday, Aug. 12
Edison Middle School
6500 Hooper Ave.
Los Angeles, CA 90001

Thursday, Aug. 13
Audubon Middle School
4120 11th Ave.
Los Angeles, CA 90008

Monday, Aug. 17
Gompers Middle School
234 E. 112th St.
Los Angeles, CA 90061

Tuesday, Aug. 18
Miramonte Elementary School
1400 E. 68th St.
Los Angeles, CA 90001

Wednesday, Aug. 19
Parmelee Avenue Elementary School
1338 E. 76th St.
Los Angeles, CA 90001

Thursday, Aug. 20
Alliance Virgil Roberts Leadership Academy & Alliance Renee and Meyer Luskin Academy High School
2941 W. 70th St.
Los Angeles, CA 90043

Monday, Aug. 24
74^th Street Elementary School
2112 W. 74th St.
Los Angeles, CA 90047

Tuesday, Aug. 25
93rd Street Elementary School
330 E. 93rd St.
Los Angeles, CA 90003

Wednesday, Aug. 26
Raymond Avenue Elementary School
7511 Raymond Ave.
Los Angeles, CA 90044

Thursday, Aug. 27
99th Street Elementary School
9900 Wadsworth Ave.
Los Angeles, CA 90002

Monday, Aug. 31
Nevin Avenue Elementary School
1569 E. 32nd St.
Los Angeles, 90011

MEDIA CONTACT

Media interested in attending a COACH for Kids clinic must coordinate in advance with Cedars-Sinai External Communications. Please contact: Melissa Vizcarra | melissa.vizcarra@cshs.org | 719-502-5001

Cedars-Sinai in the News

Why Hospitals Must Avoid ‘Pilot Purgatory’ | Chief Healthcare Executive
Peter L. Slavin, MD

Why Are More Young Women Developing Heart Disease? | The New York Times
C. Noel Bairey Merz, MD 

Woman Goes to Have 22-lb. Ovarian Tumor Removed. Then Doctors Discover a Full-Term Baby Hiding Behind It: ‘Miraculous’ | People
John Ozimek, DO 

Doctors Explain the Differences Between Alzheimer's Disease and Other Types of Dementia | Prevention
Zaldy S. Tan, MD, MPH 

How 7 Systems Divert Behavioral Health Patients From the ED | Becker’s Hospital Review
Itai Danovitch, MD 

Can Humans Live Forever? Study Puts a Cap on Life Span at 194 Years | Healthline
Bert Mandelbaum, MD

Data. Data. Data. How Can Wearables Really Help Us? | Forbes
Brennan Spiegel, MD, MSHS 

Women in Wellness: Natasha Trentacosta of Cedars-Sinai on the Five Lifestyle Tweaks That Will Help Support People’s Journey Towards Better Wellbeing | Medium/Authority Magazine
Natasha Trentacosta, MD 

Experts Weigh in on the Challenges of Managing Cannabinoid Hyperemesis Syndrome | Medscape
Sam Torbati, MD

4 Endocrinologists Share the Fruits They Eat Regularly for Better Blood Sugar | Verywell Health
Ruchi Mathur, MD 

Hidden Ways IBD Affects You Over a Lifetime | Podfollow/About IBD
Puja Khanna, MD

American Heart Association Now Recommends Blood Pressure Treatment to Reduce Dementia Risk | Forbes
Joseph Ebinger, MD

Faculty Publications

Cardiology

Arrhythmia Occurrence After Balloon-Expandable and Self-Expanding Transcatheter Pulmonary Valve Replacement. McCanta, Anthony C., Natalie A. Bello, Patrick Conley, Marissa Petralia, Maulin B. Shah, Evan M. Zahn, and Rose O. Tompkins. JACC. Clinical Electrophysiology 12 (3): 462–71.

Decoding Cardiovascular Disease Through Spatial Proteomics. Ma, Min, Yingyi Lian, Erfei Shang, Chao Xue, Maosheng Wei, Ming Zhang, Niveda Sundararaman, Sarah J. Parker, Jennifer E. Van Eyk, and Jun Qu. Circulation Research 139 (4): e327475.

Fast Skeletal Myosin Binding Protein-C Expression Exacerbates Dysfunction in Heart Failure. McNamara, James W., Taejeong Song, Perwez Alam, Akhil Baby, Aleksandra Binek, Kalyani Ananthamohan, Rohit R. Singh, Michelle L. Nieman, Marloes van den Berg, Brent M. Cernyar, Sheryl E. Koch, Malina J. Ivey, Thomas L. Lynch, James T. Pearson, Jack Rubinstein, J.-P. Jin, John N. Lorenz, Jennifer E. Van Eyk, Onur Kanisicak, and Sakthivel Sadayappan. Basic Research in Cardiology, August.

Modeling Individual Patient Outcomes After Interatrial Shunt Treatment in Heart Failure With Reduced and Preserved Ejection Fraction: The RELIEVE-HF Trial. Stone, Gregg W., JoAnn Lindenfeld, Michael R. Zile, Stefan D. Anker, Josep Rodés-Cabau, Clayton Snyder, Saibal Kar, Michael P. Pfeiffer, Antoni Bayes-Genis, Jeroen J. Bax, Alan J. Bank, Julio Núñez, Elizabeth C. Lee, Michal Laufer-Perl, Gil Moravsky, Sheldon E. Litwin, Richard Holcomb, Neal L. Eigler, William T. Abraham, and RELIEVE-HF Investigators. Circulation. Heart Failure, August, e014100.

National Impact of Optimal Implementation of Guideline-Directed Medical Therapy in Heart Failure With Reduced Ejection Fraction. Keykhaei, Mohammad, Alexander T. Sandhu, Priscilla Y. Hsue, Stephen J. Greene, Boback Ziaeian, Michelle Kittleson, MaryAnn Villarreal-Gonzalez, Shahin Hallaj, Mattheus Ramsis, Manyoo A. Agarwal, and Gregg C. Fonarow. JACC. Heart Failure, August, 103295.

Percutaneous Atrial Delivery of TBX18 Creates a Stable Supraventricular Biological Pacemaker in Porcine Sick Sinus Syndrome. Dawkins, James F., Thassio Mesquita, Kevin Holm, Takeshi Ijichi, Peter Kilfoil, Ralf Sulague, Lizbeth Sanchez, Asma Nawaz, Juan Cardenas, Jackelyn Valle, Eduardo Marbán, and Eugenio Cingolani. JACC. Clinical Electrophysiology, July, S2405-500X(26)00577-3.

Prolonged PPI-TCL in the Presence of a Slowly Conducting Retrograde Accessory Pathway: What Is the Mechanism? Sun, Yuanjun, Ashkan Ehdaie, Eugenio Cingolani, Eric Braunstein, Xunzhang Wang, Archana Ramireddy, and Michael Shehata. JACC. Clinical Electrophysiology, July, S2405-500X(26)00571-2.

Single Cell Proteomics to Spatial Multiomics in Cardiovascular Disease: Foundations, Technologies, and Biological Insights. Binek, Aleksandra, and Peggi M. Angel. Circulation Research 139 (4): e327684.

The Song Remains the Same: Genetic Testing in Advanced Heart Failure. Kransdorf, Evan P., and Luke Masha. JACC. Advances 5 (9): 103090.

Computational Biomedicine

Pre-Trained Knowledge Transfer With Application in Multisystem Inflammatory Syndrome Subphenotyping in Children. Liu, Xiaokang, Naimin Jing, Yiwen Lu, Jason H. Moore, Christopher B. Forrest, James Zou, and Yong Chen. Npj Health Systems 3 (1): 69.

Medicine

Bridging Evidence and Practice: International Multidisciplinary Consensus on Non-Metastatic NSCLC. Meyer, May-Lucie, Solange Peters, Hossein Borghaei, Tina Cascone, Sanja Dacic, Corinne Faivre-Finn, Natasha Leighl, Luis Paz-Ares, Joachim Aerts, Charu Aggarwal, Myung-Ju Ahn, Maria E. Arcila, Federico Cappuzzo, et al. Journal of Thoracic Oncology, July, 104111.

Defining Actionable Cell States in Cardiovascular Disease Through Single-Cell and Spatial Technologies. Parker, Sarah J., and Jennifer E. Van Eyk. Circulation Research 139 (4): e329382.

Delayed Hypersensitivity to Iodinated Contrast: A Rare Case of Iododerma and Successful Strategy for Readministration. Truong, Tiffany, Monica Tsai, Terrie S. Ahn, and Lorraine Anderson. Cureus 18 (7): e112105.

Determining the Minimal Important Change in Patient Reported Outcomes for Carpal Tunnel Syndrome. Harris, Alex H. S., Kristen Davis-Lopez, Andrea K. Finlay, Eric M. Schmidt, Catherine M. Curtin, Erika D. Sears, Ryu Yoshida, Donna Lashgari, Robin N. Kamal, and Teryl K. Nuckols. PM & R: The Journal of Injury, Function, and Rehabilitation, July.

Early-Onset Pancreatic Cancer Is Associated With Better Survival: A SEER Population-Based Analysis. Liengswangwong, Kaewkwan, and Stephen J. Pandol. Pancreas, July.

Inhaled LTI-03 for Idiopathic Pulmonary Fibrosis: A Randomized Dose Escalation Study. Molyneaux, Philip L., Nikhil A. Hirani, Collin C. K. Chia, Tejaswini Kulkarni, Tanzira Zaman, Robert J. Kaner, Ana Lucia Coelho, Yago Amigo Pinho Jannini-Sa, Brian Windsor, Sydney Kruger, Dale J. Christensen, Steven A. Shoemaker, Cory M. Hogaboam, BreAnne MacKenzie, and Andreas Günther. Nature Communications 17 (1): 7620.

IOIBD: The International Organization for the Study of Inflammatory Bowel Disease. Dotan, Iris, Marla C. Dubinsky, Corey A. Siegel, James Lindsay, Dermot McGovern, Matthieu Allez, Pär Myrelid, James Lewis, Bruce E. Sands, Laurent Peyrin-Biroulet, Silvio Danese, Vineet Ahuja, Gilaad G. Kaplan, Marischka Konings, Richard Gearry, Siew C. Ng, Vipul Jairath, Fernando Magro, Mark S. Silverberg, Dan Turner, Maria T. Abreu, Ailsa Hart, Axel Dignass, David T. Rubin, and International Organization for the Study of Inflammatory Bowel Diseases (IOIBD). Therapeutic Advances in Gastroenterology 19: 17562848261470923.

Large Language Model-Based Extraction of Rheumatoid Arthritis Clinical Disease Activity Index From Clinical Notes. Weisberg, Reid, Ruoqi Yang, Iram Kamdar, Justin Chestang, Joan Bathon, Jon T. Giles, Chunhua Weng, and Elizabeth Park. JAMIA Open 9 (4): ooag152.

Metabolic Dysfunction-Associated Steatotic Liver Disease Reprograms the Hepatic Metastatic Niche. Karabicici, Mustafa, and Ekihiro Seki. Seminars in Liver Disease, August.

Novel Explantation Protocol for Cardiac Recovery and Device Weaning Post-Left Ventricular Assist Device Therapy: A Single-Center Experience. Kumar, Aarti, Ashley J. Mitchell, Negeen Shahandeh, Darko Vucicevic, Murray H. Kwon, Pratyaksh K. Srivastava, Ali Nsair, and Megan Y. Kamath. ASAIO Journal, August.

Phase 1/2 Study of INCAGN01876, an Anti-GITR Agonist Monoclonal Antibody, Plus Immunotherapy for Advanced Cancers. Hamid, Omid, Frederic Forget, Melissa Johnson, Thomas J. George, Nawel Bourayou, Sonia Ioannidis, Feng Zhou, Hong Yang, Zhiwan Dong, and Martin E. Gutierrez. The Oncologist, July, oyag257.

Risk of HCC in Elderly Patients With MASLD: Proposal of an Effective Surveillance Strategy. Chon, Young Eun, Kyung-Do Han, Ju Dong Yang, Ju-Yeong Park, Hyun-Seok Kim, Hyung Woong Lee, Tae Seop Lim, and Beom Kyung Kim. Journal of Gastroenterology and Hepatology, August.

The Cost-Effectiveness of Biosimilar Denosumab in Postmenopausal Osteoporosis: Implications of Baseline Fracture Risk and Drug Price. Li, Edward, Fatemeh Mirzayeh Fashami, Sarah Kane, Rebecca McTavish, Marion Schauf, and Stuart Silverman. Osteoporosis International: A Journal Established as Result of Cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, July.

Therapeutic Application of Feeding Strategies in Chronic Pancreatitis: The Potential for Jejunal Feeding and Elemental Diet to Modulate Pancreatic Secretion to Alleviate Painful Symptoms. Cai, Mei, Niwen Kong, Baraa Abdelghne, Anna Evans Phillips, Sohail Z. Husain, Stephen J. Pandol, and Yi Jiang. Frontiers in Physiology 17: 1828606.

Neurosurgery

Effect of Time to Palliative Epilepsy Surgery on Outcomes. Crutcher, Robert M., David E. Horvat, Avery R. Caraway, Kristen H. Arredondo, Taylor J. Abel, Nitin Agarwal, Allyson L. Alexander, Dallas Michael Armstrong, Kurtis I. Auguste, Danilo Bernardo, Jeffrey Bolton, David Bonda, Dewi Frances Depositario-Cabacar, Krista Eschbach, William D. Gaillard, Aran Groves, Jason S. Hauptman, Pradeep K. Javarayee, Cemal Karakas, Andrew T. Knox, Jenny J. Lin, Patricia E. McGoldrick, Derryl J. Miller, Edward John Novotny, Adam P. Ostendorf, Pilar D. Pichon, Shilpa B. Reddy, Debopam Samanta, Rani K. Singh, Janelle L. Wagner, Steven M. Wolf, Lily C. Wong-Kisiel, Fernando N. Galan, M. Scott Perry, and Michael A. Ciliberto. Epilepsia, August.

Pediatric Neurosurgery Procedural Coding: Current Lay of the Land. Vessell, Meena, Ryan S. Chung, Randaline Barnett, Kristin Zieles, David Bonda, Benjamin Best, and Virendra R. Desai. Neurosurgery Practice 7 (4): e000254.

Response to Request for Modification of the 2026 AHA/ASA Acute Ischemic Stroke Guidelines: Endovascular Thrombectomy Imaging Selection in the 6- to 24-Hour Window. Gonzalez, Nestor R., Shyam Prabhakaran, Kori S. Zachrison, Enrique C. Leira, Mona Bahouth, Joe Broderick, and 2026 AHA/ASA Acute Ischemic Stroke Guideline Writing Group. Stroke, July.

Orthopaedics and Sports Medicine

Frailty and Surgical Invasiveness Are Independently Associated With Complications in Pediatric Spinal Deformity Surgery. Chan, Vivien, Andrea Simmonds, Luke Maclean, David Parsons, Michael G. Vitale, and David L. Skaggs. The Journal of Bone and Joint Surgery. American Volume, August.

Osteochondral Lesions of the Tibial Plafond (OLTPs): Proceedings of the International Consensus Meeting on Cartilage Repair of the Ankle. Rubin, Jared, Alexander Tham, James J. Butler, Paloma Gauthier, Davis Hedbany, John G. Kennedy, Jorge P. Batista, Stephen Bayer, Gregory C. Berlet, Roberto Buda, James D. F. Calder, Jari Dahmen, Alastair S. E. Younger, et al. Foot & Ankle Specialist, July, 19386400261471631.

Pathology and Laboratory Medicine

Sporadic Sarcoma Arising From a Previously Resected Benign Vestibular Schwannoma Without Neurofibromatosis or Radiosurgery: Illustrative Case. Menaker, Simon A., Michelot Michel, Catherine M. Garcia, Edward Robinson, Xuemo Fan, Gregory P. Lekovic, and John S. Yu. Journal of Neurosurgery. Case Lessons 12 (5): CASE251003.

Pediatrics

Ventricular Arrhythmias After Self-Expanding Transcatheter Pulmonary Valve Replacement: A Report From the SERVE Registry. Armstrong, Aimee K., Bryan H. Goldstein, Jamil Aboulhosn, David Balzer, Oliver M. Barry, Darren P. Berman, Brian A. Boe, Martin L. Bocks, Allison K. Cabalka, Hannah Fraint, Joshua Kanter, Britton Keeshan, Luke Lamers, R. Allen Ligon, Nicola Maschietto, William S. McMahon, Athar M. Qureshi, Shabana Shahanavaz, Ada C. Stefanescu Schmidt, Patcharapong Suntharos, Wendy Whiteside, Jenny E. Zablah, Evan Zahn, Jeffrey D. Zampi, Thomas Zellers, Julia Eazer, Victoria Shay, Chance Alvarado, V. Vivian Dimas, and Anna N. Kamp. JACC. Clinical Electrophysiology 12 (3): 446–58.

Psychiatry & Behavioral Neurosciences

Psychotherapy vs Antidepressants in Heart Failure: Impact of Adherence. IsHak, Waguih William, Michele A. Hamilton, Marcio A. Diniz, James Mirocha, Robert Chernoff, Rebecca Hedrick, Harriet Aronow, Tarneem Darwish, Gabrielle Messineo, Mia Pasini, Linda Olanisa, Ella Tetrault, Ankith Arun, Kaleab K. Tessema, John Gordon Harold, Michael K. Ong, Brennan Spiegel, Kenneth Wells, and Itai Danovitch. Journal of Affective Disorders, July, 122318.

Radiation Oncology

Patient-Provider Communication and Treatment Decision-Making Among Latino Men With Prostate Cancer: A Qualitative Study. Rodriguez, Victoria E., Briseyda Mendoza-Aguayo, Janet Rodriguez, Carla M. Ramirez, Daniel Soto, Jennifer B. Unger, Andre Luis Abreu, Rojine Ariani, Lourdes Baezconde-Garbanati, Leslie Ballas, and Mariana C. Stern. Journal of Racial and Ethnic Health Disparities, July.

Surgery

A Social Media Quality Review of Popular Ankyloglossia Videos on TikTok. Bellary, Rohan, Niraj Rama, Jennifer Kreinik, Michael DeMarcantonio, Christopher Roxbury, Thomas Higgins, Arthur Wu, and Dennis Tang. Otolaryngology--Head and Neck Surgery, August.

Artificial Intelligence in Plastic Surgery: A Bibliometric and Visual Analysis of the 100 Most-Cited English-Language Publications. Mokhtar, Jonathan, Meera Hallak, Michel Gabriel Cazenave, Lucas Kreutz-Rodrigues, Krishna S. Vyas, Curtis L. Cetrulo, and Alexandre G. Lellouch. Aesthetic Surgery Journal. Open Forum 8: ojag148.

Breast and Ovarian Cancer Among Individuals Undergoing BRCA1 and BRCA2 Testing. Dossa, Fahima, Kelly Metcalfe, Zharmaine Ante, Ning Liu, Jordan Lerner-Ellis, Andrea Eisen, and Nancy N. Baxter. JAMA Network Open 9 (7): e2626334.

Faculty and Resident Perceptions of Learning Activities During Surgery Residency. Rosenberg, David M., Cooper Nagaki, Christian de Virgilio, Farin F. Amersi, Lisa A. Cunningham, Karen J. Dickinson, E. Shields Frey, Henry R. Govekar, Jukes P. Namm, V. Prasad Poola, Edgardo S. Salcedo, Saad A. Shebrain, Anaar E. Siletz, Brian R. Smith, Brian T. Valerian, Steven D. Wexner, James X. Wu, and Alexander C. Schwed. JAMA Surgery, August.

How I Approach Median Arcuate Ligament Syndrome (MALS) and Superior Mesenteric Artery Syndrome (SMAS). Spiritos, Zachary, Daniel Shouhed, and Alexis Cutchins. The American Journal of Gastroenterology, August.

Management of Gastrointestinal Oncologic Emergencies for the Acute Care Surgeon: What You Need to Know. Huang, Raymond, and Galinos Barmparas. The Journal of Trauma and Acute Care Surgery, August.

Same-Surgeon Versus Separate-Surgeon Prophylactic Ureteral Catheterization in Colectomy and Proctectomy: A National Retrospective Cohort Study. Wu, George L., Matthew Zeller, Joseph Wetherell, Jessica Felton, Yosef Nasseri, and Joshua H. Wolf. Journal of Gastrointestinal Surgery, July, 102537.

The Multilevel Facial Anatomic Classification System: A Comprehensive Framework for Contemporary Facelift and Neck Rejuvenation Surgery. Azizzadeh, Babak, and Neal Deot. Facial Plastic Surgery & Aesthetic Medicine, July, 26893614261453792.

Cedars-Sinai Health Sciences University is advancing groundbreaking research and educating future leaders in medicine, biomedical sciences and allied health sciences. Learn more about the university.

Brain cells that release dopamine—a messenger chemical that drives motor control— package it into tiny membrane-bound sacs called synaptic vesicles. And these vesicles differ from vesicles used by brain cells that release other messenger chemicals, a study led by Cedars-Sinai Health Sciences University investigators shows.

The study, published in Science Advances, could lead to better understanding of Parkinson’s disease, a movement disorder that causes dopamine-releasing brain cells to progressively die. The death of these cells leads to the movement problems that characterize the disease.

“Our research sheds light on the different ways brain cells release chemical messengers, which the cells use to communicate with each other,” said Katlin Silm, PhD, assistant professor of Biomedical Sciences and Neurology and senior author of the study. “We identified key differences between brain cells that release dopamine and those that release other brain chemicals.”

Synaptic vesicles help brain cells to communicate by fusing with the cell membrane and releasing their contents into the space between cells. In the brains of laboratory mice, investigators found that dopamine-containing synaptic vesicles carry a distinct set of proteins compared to those containing other messenger chemicals.

“Our findings show that a vesicle’s composition is critical to determining how brain messenger chemicals are released,” said Silm, also a research scientist in the Board of Governors Regenerative Medicine Institute. “The differences we identified help explain the unique properties of dopamine release and lay the groundwork to explore how this affects the long-term stability of dopamine-producing brain cells.”

Additional Cedars-Sinai authors include Hrach Asmerian, Alexia J. Diaz, Jacob Alberts, Barathan Gnanabharathi, Anna M. Sanetra, and Noah Carr.

Other authors include Hongfei Xu, Juan A. Oses-Prieto, Poulomi Das, Alma L. Burlingame, and Robert H. Edwards.

Funding: This work was supported by The Larry L. Hillblom Foundation grant 2022-A-004-SUP (KS), Brain and Behavior Research Foundation grant 29845 (KS), National Institutes of Health grant R01NS138465 (KS), National Institutes of Health grant R01NS103938 (RHE), National Institutes of Health grant R01NS129803 (RHE). Mass spectrometry was performed at the Mass Spectrometry Resource at UCSF, which is supported by the Dr. Miriam and Sheldon G. Adelson Medical Research Foundation (JAO-P & ALB).

New Method Could Boost Blood Tests’ Colon Cancer Monitoring Value

Blood tests could become a more powerful tool for monitoring colon cancer progression and treatment response, based on a study led by Cedars-Sinai Health Sciences University investigators. Their findings, published in Experimental Hematology & Oncology, used single-cell profiling to analyze circulating tumor cells and noncancerous cells in patients’ blood.

“Our method looks beyond the tumor to also understand the patient’s response to the cancer,” said Jun Gong, MD, medical director of Colorectal Cancer at Cedars-Sinai and an author of the study. “It could help guide more personalized treatment decisions based on tumor behavior and patient condition.”

Investigators analyzed blood samples from patients with advanced colorectal cancer, looking at 10 different cellular characteristics and using single-cell analysis to refine their findings.

The method reveals important changes, such as tumor cells taking action to evade the immune system or normal cells showing inflammation. These changes would be missed with existing tests, Gong said.

If these findings are validated in larger studies, Gong said, this method would complement existing tools for cancer monitoring, including imaging and standard laboratory tests.

Additional Cedars-Sinai authors include Francesca Aguirre, MD; Lisa Zhou, BS; Aaron Denmark, BS; Rocio Alvarez, MsC; and Daniel M. Kim, MD.

Other authors include Gabriela Felix, PhD; and Megan P. Hitchins, PhD.

Funding: This study was funded in part by NCI grant R01CA252042 (MH), Cedars-Sinai Cancer Developmental Fund (MH) and the ASCO Conquer Cancer Career Development Award (JG).

Disclosures: J.G. reports receiving consulting fees and honoraria from the following companies: EMD Serono, Exelixis, Natera, Eisai, Janssen, Pfizer, Bayer, Taiho, Agenus, Seagen, and Caper Labs. G.F., J.G. and M.H. have a provisional patent application (Application No.: 64/039,184) related to the work described in this manuscript.

Hydrogen Sulfide Gas Linked to More Severe IBS Damage

Investigators at Cedars-Sinai Health Sciences University have identified how excess hydrogen sulfide gas produced by certain gut microbes alters gene activity in the small intestine. Their findings, published in mSystems, offer new insight into conditions associated with irritable bowel syndrome (IBS), one of the most common gastrointestinal disorders.

Small intestinal bacterial overgrowth (SIBO), intestinal methanogen overgrowth (IMO) and intestinal sulfide overproduction (ISO) are conditions in which gas-producing microbes over-multiply in the small intestine. The disorders are often connected to IBS. 

"Our results show that ISO, IMO and SIBO are biologically distinct conditions that will require different treatment approaches," said Mark Pimentel, MD, executive director of the Medically Associated Science and Technology (MAST) Program at Cedars-Sinai and corresponding author of the study. "The genes altered in these conditions are linked to a variety of symptoms and understanding these mechanisms will help us develop better therapies for patients."

Investigators analyzed small bowel tissues samples from patients and laboratory animals. They found the most extensive changes in gene activity in samples from patients with ISO, and more limited changes in SIBO and IMO samples.

The genetic changes affected immune activity, fluid absorption, movement of nutrients through the gut, antioxidant defenses and cellular energy production. These findings may help explain why hydrogen sulfide overproduction has been associated with diarrhea, abdominal pain and other severe gastrointestinal symptoms in patients with diarrhea-predominant IBS.

Pimentel said larger studies integrating breath testing and microbiome profiling are needed to further validate these findings and identify how they might inform new therapies.

Other Cedars-Sinai authors include Juliana de Freitas Germano, Gabriela Leite, Maria Jesus Villanueva-Millan, Daniel Brimberry, Mohamad Rashid, Ava Hosseini, Dilara Flora, Said Bogatyrev, Walter Morales, Stacy Weitsman, Maritza Sanchez, Ignacio Rivera, Cristina Moreno Fajardo, Victoria Murray, Gonzalo Parodi, Margie Parra, Gillian M. Barlow, Ali Rezaie and Ruchi Mathur.

Other authors include Zhe Lyu.

Funding: This study was primarily supported by the Medically Associated Science and Technology (MAST) Program at Cedars-Sinai Medical Center, Los Angeles, CA, and funded in part through private donations to the MAST Program.

Disclosures: Drs. Pimentel, Mathur and Rezaie report equity in APQ Health and have received licensing or consulting fees related to diagnostic breath-testing technologies from Gemelli Biotech and Brio-Medical. The remaining authors declare no competing interests.

Cedars-Sinai Health Sciences University is advancing groundbreaking research and educating future leaders in medicine, biomedical sciences and allied health sciences. Learn more about the university.

The designation from the condition’s oldest patient organization is awarded to programs with the infrastructure and experience needed to provide high-quality care to people with pulmonary hypertension, a type of high blood pressure that occurs in arteries of the lungs.

Pulmonary hypertension can make it difficult for blood to circulate through the lungs, forcing the heart to work harder. In severe cases, the condition can lead to heart failure. People with pulmonary hypertension often need care from several specialists.

The Cedars-Sinai Pulmonary Hypertension Clinic includes six physicians and one nurse practitioner. The pulmonary hypertension program combines cardiology and pulmonology, which allows patients to access multidisciplinary care from experts in the disease. Providers care for more than 250 patients each year and address multiple aspects of the disease, including diagnosis, medication management, symptom control and disease progression.

“At Cedars-Sinai, pulmonary hypertension specialists collaborate with colleagues in rheumatology, congenital heart disease, critical care medicine, lung transplantation and other specialties to create treatment plans tailored to patients,” said Yuri Matusov, MD, assistant professor of Medicine at Cedars-Sinai. “We are proud to care for an extraordinarily diverse patient population, some of whom come from very far away for their care.”

The association noted several outstanding aspects of the Cedars-Sinai Pulmonary Hypertension Clinic including:

• A team that collaborates and provides timely evaluation and management of people who are hospitalized and continues to provide consistent care when they leave the hospital.
• Monthly conferences with specialists in the Southern California region that allow for the review of complex pulmonary hypertension cases, knowledge-sharing and regional care coordination.
• For people with advanced disease, access to top-notch heart, lung and thoracic transplant programs.
• A research program led by doctors investigating potential treatments.

“We are honored for our clinic to have received this designation, the highest recognition available to pulmonary hypertension programs in the United States,” said Dael Geft, MD, assistant professor of Cardiology in the Smidt Heart Institute at Cedars-Sinai. “Ultimately, the greatest reward is helping our patients live longer, healthier and more fulfilling lives.”

Read more on the Cedars-Sinai Newsroom: Unique Cell-Based Approach for Pulmonary Arterial Hypertension Shown to Be Safe

تم إدراج Cedars-Sinai Medical Center ضمن قائمة الشرف للعام الحادي عشر على التوالي في تصنيف "Best Hospitals 2026-27" السنوي الصادر عن U.S. News & World Report .

تستند تصنيفات مجلة U.S. News، الصادرة يوم الثلاثاء، إلى نتائج المرضى، وتجاربهم، والقدرة على التعامل مع الحالات الطبية المعقدة ومجموعة متنوعة من التدابير الأخرى المتعلقة بالصحة.

تشير التصنيفات للمرضى الدوليين إلى أن Cedars-Sinai يلبي معايير صارمة للتميز السريري والبحث والابتكار، مما يوفر مزيدًا من الضمان بأن المرضى سيحصلون على رعاية عالمية المستوى من مؤسسة موثوقة ومعترف بها عالميًا.

وقال الدكتور Heitham Hassoun، الرئيس التنفيذي لـ Cedars-Sinai International: "إن تصنيفنا ضمن أفضل المستشفيات في الولايات المتحدة لمدة 11 عامًا متتالية يعكس التزامنا المستمر بتقديم رعاية سريرية متميزة للمرضى، وإتاحة الوصول إلى أبحاث تُحدث تحولاً حقيقيًا في مجال الرعاية الصحية. وسنواصل تقديم ابتكارات Cedars-Sinai ورعايته الطبية المصنفة ضمن الأفضل إلى مرضانا أينما كانوا حول العالم.".

تختار مجلة U.S. News المستشفيات الأفضل أداءً لقائمة الشرف بناءً على تصنيفاتها العالية وتصنيفاتها في تخصصات وإجراءات سريرية وحالات متعددة.

وقد أُدرجت عشرة تخصصات في Cedars-Sinai ضمن أفضل البرامج السريرية في الولايات المتحدة، وجاءت ثلاثة منها ضمن المراكز الخمسة الأولى:

طب أمراض القلب وجراحة القلب والأوعية الدموية •

طب أمراض وجراحة الجهاز الهضمي •

جراحة العظام •

وشملت التخصصات الأخرى المصنفة ضمن الأفضل في الولايات المتحدة ما يلي: السرطان؛ داء السكري والغدد الصماء؛ طب الشيخوخة؛ طب الأعصاب وجراحة الأعصاب؛ أمراض النساء والتوليد؛ أمراض الرئة وجراحة الرئة؛ والمسالك البولية.

وقال Peter L. Slavin, MD، رئيس ومدير عام Cedars-Sinai Medical Center وCedars-Sinai Health System ، "تُعد هذه النتائج المتميزة ثمرةً لجهود اختصاصيي الرعاية الصحية والموظفين المتفانين الذين يعملون يوميًا على تحقيق رسالتنا المتمثلة في العلاج، والاكتشاف، والتعليم، وخدمة المجتمع. ويقودنا التزام راسخ بتحسين صحة المرضى في لوس أنجلوس وفي مختلف أنحاء العالم."

Cedars-Sinai Medical Center가 11년 연속으로 명예의 전당에 이름을 올렸습니다. 또한 캘리포니아와 로스앤젤레스에서 공동 1위를 차지했습니다.

Cedars-Sinai Health System 계열사인 Torrance Memorial Medical Center 및 Huntington Health도 주 및 지역 순위에서 높은 순위를 기록했습니다. Torrance Memorial Medical Center는 캘리포니아에서 7위, 로스앤젤레스에서 4위를 차지하였으며, Huntington Health는 캘리포니아에서 10위, 로스앤젤레스에서는 5위를 차지했습니다. 

"이러한 뛰어난 성과는 치유, 연구, 교육 및 지역사회 봉사라는 네 가지 사명을 실현하기 위해 매일 헌신하는 의료 전문가 및 직원들의 노고 덕분입니다"라고 Cedars-Sinai Medical Center 및 Cedars-Sinai Health System의 사장 겸 최고경영자(Chief Executive Officer, CEO)인 Peter L. Slavin, MD가 말했습니다.

화요일에 발표된 U.S. News 순위는 환자 결과, 환자 경험, 복잡한 의료 질환을 다루는 역량 및 그 외 다양한 건강 관련 지표를 기반으로 합니다.

U.S. News는 다양한 전문 분야, 시술 및 환경에서 높은 순위를 차지하고 평가를 받은 전국의 상위 20개 병원을 명예의 전당에 선정했습니다.

또한 해당 간행물은 미국 내 임상 전문 분야별 최고 병원 순위를 발표했습니다.

Cedars-Sinai Medical Center의 10개 전문 분야가 미국 최고 수준으로 선정되었으며, 그중 3개는 상위 5위 안에 들었습니다.

• 심혈관외과(Cardiology, Heart & Vascular Surgery)(4위)
• 소화기내과(Gastroenterology) 및 소화기외과(Gastrointestinal, GI) 수술(3위)
• 정형외과(Orthopedics)(5위)

위에서 언급한 전문 분야 외에도 폐 질환 및 폐 전문 외과(Pulmonology & Lung Surgery)(9위)는 전국적으로 상위 10위 안에 선정되었습니다.

캘리포니아에서 1위를 차지한 3가지 전문 분야는 다음과 같습니다(지역 내 U.S. News 순위가 가장 높은 분야). 

• 심혈관외과
• 소화기내과 및 GI 수술
• 정형외과

이 세 분야는 산부인과와 함께 로스앤젤레스에서 1위(U.S. News의 지역 최고 순위)를 차지했습니다.

Cedars-Sinai Health System 제휴 병원의 세 가지 전문 분야도 전국 순위에 선정되었습니다.

• Torrance Memorial Medical Center 정형외과(27위)
• Torrance Memorial Medical Center 산부인과(44위)
• Huntington Health 산부인과(공동 33위)

Cedars-Sinai Marina Hospital은 척추 수술, 당뇨병, 심부전, 고관절 골절, 고관절 치환술 및 폐렴을 포함한 일반적인 성인 시술 및 질환 분야에서 "우수한 성과"를 거둔 병원으로 선정되었습니다.

Slavin은 이러한 높은 순위는 의료 산업에 급격한 변화가 일어나고 있는 시기에도 Cedars-Sinai의 환자 치료 철학을 반영하는 것이라고 말했습니다.

그는 이렇게 말했습니다. "우리는 로스앤젤레스와 전 세계 환자들의 건강을 증진시키겠다는 변함없는 사명감에 따라 움직이고 있습니다. 그것이 우리의 최우선 과제입니다.”

U.S. News 于周二发布的排行榜，综合评估医院在患者治疗结局、患者就医体验、复杂病例诊疗能力等多项与健康相关的指标。

对于国际患者而言，这一排名充分体现了 Cedars-Sinai 在临床医疗、科研创新等方面达到国际领先标准，也进一步印证了患者能够在这家享誉全球、值得信赖的医疗机构获得世界一流的医疗服务。

“连续 11 年位列美国最佳医院排行榜，彰显了我们为患者提供卓越临床诊疗服务和推动突破性医学研究的坚定承诺。” Cedars-Sinai International 首席执行官 Heitham Hassoun, MD 表示，“无论患者身处全球何地，我们都将持续把 Cedars-Sinai 的创新成果和全球领先的医疗服务带给患者。”

U.S. News 根据医院在多个专科、诊疗项目及疾病诊疗等方面的综合表现，评选出表现最优异的医院入选荣誉榜。

Cedars-Sinai 共有 10 个专科领域入选全美最佳专科排名，其中 3 个专科领域名列美国前五名：

• 心脏病学、心脏与血管外科
• 胃肠病学与胃肠外科
• 骨科

其他名列美国顶尖专科的领域包括：肿瘤科、糖尿病与内分泌科、老年医学科、神经内科与神经外科、妇产科、肺病学与肺外科以及泌尿科。

“这些优异成绩充分体现了全体医护人员和员工的不懈努力。他们每天都在践行 Cedars-Sinai '治疗、探索、教育与社区服务'四大使命。” Cedars-Sinai Medical Center 及 Cedars-Sinai Health System 总裁兼首席执行官Peter L. Slavin, MD 表示， “我们始终秉持改善洛杉矶乃至全球患者健康的坚定使命。”

The U.S. News rankings, released Tuesday, are based on patient outcomes, patient experience, ability to handle complex medical conditions and a variety of other health-related measures.

The rankings signal to international patients that Cedars-Sinai meets rigorous standards for clinical excellence, research and innovation, providing further assurance that patients will receive world-class care from a trusted, globally recognized institution.

"Being ranked among the best hospitals in the U.S. for 11 consecutive years reflects our consistent commitment to providing patients with excellent clinical care and access to transformational research," said Heitham Hassoun, MD, chief executive of Cedars-Sinai International. “We will continue bringing Cedars-Sinai's innovation and top-ranked care closer to our patients wherever they are around the globe.”

U.S. News selects the top-performing hospitals for the Honor Roll based on their high rankings and ratings in multiple specialties, procedures and conditions.

Ten Cedars-Sinai specialties made the list of top clinical programs in the U.S. Three of the specialties were ranked in the top five:

• Cardiology, Heart & Vascular Surgery
• Gastroenterology & GI Surgery
• Orthopedics

Other top-ranked specialties in the U.S. included Cancer; Diabetes & Endocrinology; Geriatrics; Neurology & Neurosurgery; Obstetrics & Gynecology; Pulmonology & Lung Surgery; and Urology.

"These strong results are a credit to the dedicated healthcare professionals and staff who work every day to advance our four-part mission of healing, discovery, education and community service," said Peter L. Slavin, MD, president and CEO of Cedars-Sinai Medical Center and Cedars-Sinai Health System. "We are driven by an enduring commitment to improve the health of patients in Los Angeles and across the globe."

Read more on the Cedars-Sinai Newsroom: Cedars-Sinai Launches Flagship Outpatient Clinic in London

The protein restores the blood stem cell niche—the specialized environment that supports blood-forming stem cells—allowing the bone marrow to resume producing the blood cells the body needs.

Their preclinical study, published in Blood, could yield future treatments that help cancer patients recover faster after chemotherapy and radiation.

“The mechanisms that govern how the blood stem cell niche recovers after injury are not well understood,” said John Chute, MD, director of the Division of Hematology and Cellular Therapy at Cedars-Sinai and senior author of the study. “We identified a mechanism that stimulates niche recovery, which opens an exciting avenue to help patients replenish their entire blood system after chemotherapy or radiation.”

Chute compared the niche to the soil in a garden in which blood stem cells—which generate all of the body’s blood cells—blossom or grow. The niche is made up of several types of cells that tend to the blood stem cells, spurring them to divide and multiply so that they can replace blood cells that are damaged or lost.

“Chemotherapy and radiation therapy cause severe DNA damage to the niche cells,” Chute said. “The blood stem cells can’t regenerate because of this damage to their ‘soil,’ and this depletes the patient’s blood count for weeks.”

For patients, this means debilitating fatigue and increased risk of infection, bleeding and prolonged hospitalization.

Investigators found that a protein called R-spondin 2, which amplifies the signaling in cells that line blood vessels in the bone marrow, speeds up the recovery of the niche. 

When investigators treated laboratory mice that had been exposed to total body irradiation with R-spondin 2, the blood stem cell niche—specifically the cells lining the blood vessels in the niche—recovered more quickly than in untreated mice.

A key and surprising finding was that R-spondin 2 acted on the vascular niche cells, rather than the blood stem cells themselves.

Chute said that these findings may open the door to future research focused on the discovery and augmentation of mechanisms for niche repair. Targeting such mechanisms could accelerate the recovery of patients receiving chemotherapy or undergoing stem cell transplantation.

“Our outcomes for patients undergoing blood and marrow transplant are exceptional,” said Robert Figlin, MD, interim director of Cedars-Sinai Cancer. “This type of translational research can yield further improvements for those patients and all patients undergoing chemotherapy or radiotherapy.”

Additional Cedars-Sinai authors include Vanessa N. Montinelli, Samantha Grohe, Xue Ying Song, Jacqueline Turnlund, Hannah Hackbart, Joshua Sasine, Morgan Brady, Masahiro Muraoka, Rucha Kadam, Flavia D. Cavicchioli, Sage Kang, Ashley Dawson, Mimoli Uehara, Courtny Dizon, Theresa Krack, Peibin Yue, and Yuwei He.

The paper’s other author is Kurt D. Hankenson, University of Michigan.

Funding: This work was funded, in part, by NIAID awards U01 AI159622 (PI: John Chute), R21 AI193964 and NHLBI award R01 HL086998 (PI: John Chute).

Cedars-Sinai Health Sciences University is advancing groundbreaking research and educating future leaders in medicine, biomedical sciences and allied health sciences. Learn more about the university.

Cedars-Sinai in the News

Lifestyle Intervention May Slow Brain Aging—But Only Before Age 70 | Medscape
Zaldy Tan, MD, MPH

New Study Shows Expanding Blood Pressure Treatment Could Save Over 200,000 Lives—How to Assess Your Risk | Forbes
Joseph Ebinger, MD

Polysubstance Intoxication: Managing the Unknown | ASAM Practice Pearls
Itai Danovitch, MD

Mission to the Jewish Community of Ethiopia | Jewish Journal
Rabbi Jason Weiner, PhD

Tylenol With Naproxen: FDA Approves Fast-Acting Non-Opioid for Pain Relief | Healthline
Vernon Williams, MD

Faculty Publications

Biomedical Sciences

Beyond ‘Toxicity:’ Rethinking Rage, Rivalry, and Regulation in Online Games. Aboujaoude, Elias. Journal of Behavioral Addictions, July.

Cardiac CT for Personalized Phenotyping in Stable Coronary Artery Disease: Toward Precision Medicine. Lenell, Joel, Kajetan Grodecki, Jacek Kwiecinski, Piotr J. Slomka, Marc R. Dweck, Michelle C. Williams, Marc Dewey, David E. Newby, and Damini Dey. BJR Open 8 (1): tzag014.

Synaptic Vesicles That Store Monoamines and Glutamate Differ in Protein Composition. Asmerian, Hrach, Alexia J. Diaz, Hongfei Xu, Juan A. Oses-Prieto, Jacob Alberts, Barathan Gnanabharathi, Anna M. Sanetra, Poulomi Das, Noah Carr, Alma L. Burlingame, Robert H. Edwards, and Kätlin Silm. Science Advances 12 (30): eadz6836.

Cardiac Surgery

Discharge After NSTEMI? Why Roll the Dice? Cohen, Robbin G. The Annals of Thoracic Surgery, July, S0003-4975(26)00739-3.

Glucagon-Like Peptide-1 Receptor Agonists in Obese Left Ventricular Assist Device Recipients: A Propensity-Matched Real-World Cohort Study. Divya, Aabha, Niti Dalal, Yilin Yoshida, Manreet Kanwar, Pedro Catarino, and David D’Alessandro. ASAIO Journal, July.

Hydropersulfide Donors: Mechanistic and Kinetic Insights With Biological and Potential Therapeutic Implications. Liu, Daniel, Jordan Lamar, Andrew Thampoe, Vinayak S. Khodade, and John P. Toscano. Journal of Physical Organic Chemistry 39 (7): e70087.

The Use of an Omental Flap in the Management of Complex Thoracic Aortic Infections. Brennan, Zachary, Tyler J. Wallen, Thomas M. Beaver, Eric I. Jeng, Tomas D. Martin, and George J. Arnaoutakis. Cureus 18 (6): e111366.

Cardiology

Acute Kidney Injury and Long-Term Survival After Type B Aortic Dissection: A Meta-Analysis. Jacquemyn, Xander, Rohit Ganduboina, Michel Pompeu Sá, Derek Serna-Gallegos, Irsa Hasan, and Ibrahim Sultan. Journal of Vascular Surgery 84 (1): 244–46.

Angiotensin II Type 1 Receptor Expression and Anti-AT1R Antibodies in Heart Transplantation: A Systematic Review of Distinct but Related Non-HLA Immune Pathways. Gopalan, Radha, Mohamed Reyad Mohamed, Jamal Mahar, Anusha Sunkara, Anantharam Kalya, Abdelrahman Hafez, Nancy Reinsmoen, and Francisco Arabia. Journal of Clinical Medicine 15 (14): 5419.

Deramiocel Heart-Derived Cellular Therapy in Advanced Duchenne Muscular Dystrophy (HOPE-3): A Phase 3, Randomised, Double-Blind, Placebo-Controlled Trial. McDonald, Craig M., Chet Villa, Jonathan H. Soslow, Kati Maharry, Nathaniel Hogan, Michael Binks, Kevin C. Berth, Kristi A. Elliott, Michael Taylor, Kan N. Hor, James Signorovich, Erik K. Henricson, Han C. Phan, Susan Apkon, Partha S. Ghosh, Cuixia Tian, Aravindhan Veerapandiyan, Leigh Ramos-Platt, Katheryn Gambetta, Saunder M. Bernes, Arun S. Varadhachary, Susan T. Iannaccone, Chamindra G. Laverty, Seth J. Perlman, Nancy E. Bass, Kathryn Mosher, Russell J. Butterfield, Katherine D. Mathews, Rebecca J. Scharf, Edward C. Smith, Jane Anne Emerson, Eugenio Mercuri, Mark S. Awadalla, Linda Marbán, Eduardo Marbán, and HOPE-3 Investigators. Lancet, July, S0140-6736(26)01385-1.

Effects of Omega-3 Fatty Acid Treatment on Risk for Atrial Fibrillation: An Updated Meta-Analysis of 35 Trials Including 114 592 Individuals. Abuknesha, Nada R., James H. O’Keefe, Frank Qian, Nathan L. Tintle, Yidie Lin, Yue Sun, Han-Zhu Qian, Paul S. Aisen, Christine M. Albert, William J. Aronson, Abdul Aziz A. Asbeutah, Heike A. Bischoff-Ferrari, Matthew J. Budoff, Nicholas R. Burns, Cecilia A. Cardenas, Cynthia M. Carlsson, Emily Y. Chew, Neal J. Cohen, Léopold K. Fezeu, Amana Liddell, Pilar Galan, Mark A. Hull, Tsuo-Hung Lan, Pan-Yen Lin, Alexia Mengelberg, Anne-Marie Minihane, Joseph F. Quinn, Thomas A. B. Sanders, Andrew Scholey, David A. Schoenfeld, Kirsty Sprange, Kuan-Pin Su, Christopher H. van Dyck, Carol A. Van Hulle, David Vauzour, Claire Weber, Francine K. Welty, Gary Wittert, and William S. Harris. Circulation. Arrhythmia and Electrophysiology, July, e014785.

Health Status Outcomes 7 Years After Transcatheter or Surgical Aortic Valve Replacement in Low-Surgical Risk Patients With Aortic Stenosis. Brener, Michael I., David J. Cohen, Susheel K. Kodali, Rebecca T. Hahn, Vinod H. Thourani, Raj R. Makkar, Philippe Pibarot, Xiao Yu, Bradley Lubich, Michael J. Mack, Martin B. Leon, and Suzanne V. Arnold. Journal of the American College of Cardiology, July, S0735-1097(26)06898-1.

Impact of Aortic Annulus Size on Outcomes After Aortic Valve Replacement: The PARTNER 3 Trial. Madhavan, Mahesh V., Michael J. Mack, Philippe Pibarot, Rebecca T. Hahn, Raj Makkar, Vinod H. Thourani, Susheel K. Kodali, Samir R. Kapadia, Philippe Genereux, Vasilis Babaliaros, Maria C. Alu, Bradley Lubich, Martin B. Leon, David J. Cohen, and PARTNER 3 Investigators. JACC. Cardiovascular Interventions 19 (14): 1944–55.

Investigating the Association Between Atrial Fibrillation and Out-of-Hospital Cardiac Arrest: A Danish Nationwide Matched Cohort Study. Rajan, Deepthi, Tobias Skjelbred, Peder E. Warming, Fredrik Folke, Rodrigue Garcia, Christian Torp-Pedersen, Bo G. Winkel, Sumeet S. Chugh, and Jacob Tfelt-Hansen. JACC. Clinical Electrophysiology, July, S2405-500X(26)00557-8.

Left Atrial Appendage Closure vs Anticoagulation for Stroke Prevention in Atrial Fibrillation: Meta-Analysis of Randomized Trials. Turagam, Mohit K., Jonathan L. Halperin, Christopher B. Granger, Deepak L. Bhatt, Poonam Velagapudi, Srinivas R. Dukkipati, M. Edip Gurol, Samantha Sartori, Devi G. Nair, Petr Neuzil, Shephal K. Doshi, Martin B. Leon, Valentin Fuster, and Vivek Y. Reddy. JACC. Clinical Electrophysiology, July, S2405-500X(26)00639-0.

Preprocedural New York Heart Association Class IV Independently Predicts Mortality After Effective Edge-To-Edge Repair for Primary Mitral Regurgitation. Koell, Benedikt, Lydia X. Plewe, Sebastian Ludwig, Jessica Weimann, Dhairya Patel, Lukas Stolz, Tetsu Tanaka, Teresa Trenkwalder, Felix Rudolph, Daryoush Samim, Philipp von Stein, Cristina Giannini, Julien Dreyfus, Andrea Scotti, Jean-Michel Paradis, Marianna Adamo, Nicole Karam, Yohann Bohbot, Anne Bernard, Bruno Melica, Yusuke Kobari, Yoan Lavie-Badie, Mirjam Kessler, Omar Chehab, Simon Redwood, Edith Lubos, Ole de Baker, Marco Metra, Azeem Latib, Chiara Primerano, Christos Iliadis, Fabien Praz, Muhammed Gerçek, Erion Xhepa, Marcel Weber, Raj Makkar, Juan Granada, Thomas Modine, Erwan Donal, Jörg Hausleiter, Augustin Coisne, Daniel Kalbacher, PRIME-MR Investigators∗, and PRIME-MR Investigators. Structural Heart: The Journal of the Heart Team 10 (8): 101053.

Prevalence, Correlates, and Prognostic Significance of In-Hospital Transthoracic Echocardiography Use in Stable Acute Myocardial Infarction. Shechter, Alon, Arthur Shiyovich, Robert J. Siegel, Olga Morelli, Harel Gilutz, and Ygal Plakht. Journal of Cardiovascular Development and Disease 13 (7): 322.

Protamine-Exacerbated Right Ventricular Failure After TAVR in Critical Aortic Stenosis. Menda, Jaideep, Jiun-Ruey Hu, Christy Slingwine, Sabah Skaf, Meshe Chonde, Wen Cheng, Suhail Dohad, Raj R. Makkar, and Tarun Chakravarty. JACC. Case Reports, July, 109339.

Timing, Translation, and Preparedness: Lessons Learned From COVID-19 Anticoagulation in Noncritically Ill Hospitalized Patients. Tritschler, Tobias, Valentin Fuster, Patrick R. Lawler, Michael E. Farkouh, Caterina E. Marx, Matthew D. Neal, Michelle Sholzberg, Alex C. Spyropoulos, Steven Y. C. Tong, Nuria Muñoz-Rivas, Marc Blondon, Jeffrey S. Berger, Behnood Bikdeli, Marco Cattaneo, Mary Cushman, Mark Goldin, Ewan C. Goligher, Judith S. Hochman, Peter Jüni, Zoe K. McQuilten, Nuccia Morici, Parham Sadeghipour, Balasubramanian Venkatesh, Stéphane Zuily, Alain Amstutz, Drahomir Aujesky, Marc Carrier, Robin V. Hofstetter, Srinivas Murthy, Marc Rodger, Leslie Skeith, Areti A. Veroniki, Brian Hutton, Ryan Zarychanski, Gregg W. Stone, Grégoire Le Gal, and Anticoagulation in COVID-19 Investigators. Journal of the American College of Cardiology 88 (4): 437–50.

Computational Biomedicine

Clarifying Risk-Factor Associations With Quantitative Breast Tumor Features: A Pooled Analysis of 24 Studies. Adams, Daniel, Amber N. Hurson, Thomas U. Ahearn, Irene L. Andrulis, Antonis C. Antoniou, Päivi Auvinen, Anita Bane, Sabine Behrens, Amy Berrington de Gonzalez, Katarzyna Białkowska, Clara Bodelon, Manjeet K. Bolla, Montserrat García-Closas, et al. Journal of the National Cancer Institute, July, djag244.

The Examination of Factors Contributing to Delays in Obtaining a Driver’s License for Youth With Attention-Deficit/Hyperactivity Disorder. Jusko, Morgan L., Michelle G. Bubnik-Harrison, Nicholas Albino, Larry W. Hawk, Stefany Coxe, Nicole K. Schatz, Karen L. Hulme, Rebecca K. Vujnovic, Kevin F. Hulme, William E. Pelham, and Gregory A. Fabiano. Journal of Attention Disorders, July, 10870547261470140.

Medicine

Atezolizumab Plus Bevacizumab Versus Durvalumab Plus Tremelimumab for Advanced Hepatocellular Carcinoma: A Propensity-Score-Matched Analysis. Ailawadi, Sarina, Sepideh Mehravar, Jennifer E. Murphy, Michael H. Storandt, and Amit Mahipal. Biomedicines 14 (7): 1638.

Development of a Primary Care Cardio-Kidney Risk Navigator for Clinical Decision Support. Gluckman, Tyler J., Kade Birkeland, Ankeet Bhatt, Matthew Jay Budoff, Samuel Colby Danna, Nihar R. Desai, Evan Norfolk, Ahlam Elbedewe, Grace Kiernan, Radha Pachpor, and Jamie Hirsch. Journal of Clinical Medicine 15 (14): 5379.

Duodenal Microbiome Profiles Exhibit Sex-Specific Differences. Rashid, Mohamad, Gabriela Leite, Gillian M. Barlow, Ava Hosseini, Daniel Brimberry, Dilara Flor, Gonzalo Parodi, Maritza Sanchez, Ignacio Rivera, Angel Trujillo, Maria Jesus Villanueva-Millan, Walter Morales, Stacy Weitsman, Mark Pimentel, and Ruchi Mathur. iScience 29 (8): 116679.

Hidden Risk in Normal Myocardial Perfusion Scans: AI-Detected Proximal Coronary Calcium on CT Attenuation Maps Improves Prognosis. Zhou, Jianhang, Robert J. H. Miller, Aakash Shanbhag, Aditya Killekar, Donghee Han, Krishna K. Patel, Konrad Pieszko, Jirong Yi, Meghana Kiran Urs, Giselle Ramirez, Mark Lemley, Paul B. Kavanagh, Joanna X. Liang, Assiata Kamagate, Valerie Builoff, Andrew J. Einstein, Attila Feher, Edward J. Miller, Albert J. Sinusas, Terrence D. Ruddy, Stacey Knight, Viet T. Le, Steve Mason, Panithaya Chareonthaitawee, Samuel Wopperer, Erick Alexanderson, Isabel Carvajal-Juarez, Thomas L. Rosamond, Leandro Slipczuk, Mark I. Travin, René R. S. Packard, Wanda Acampa, Mouaz Al-Mallah, Robert A. deKemp, Ronny R. Buechel, Daniel S. Berman, Damini Dey, Marcelo F. Di Carli, and Piotr J. Slomka. European Journal of Nuclear Medicine and Molecular Imaging, July.

Home and Neighborhood Food Environment Measures and Weight-for-Age z-Scores Among Children Aged 1-5 Years: An Exploratory Cross-Sectional Analysis. Stansberry, Alanis C., Camille R. Schneider-Worthington, Sarah-Jeanne Salvy, Demetria R. Pizano, Suzanne Judd, Keith Pearson, Megan Word, and Gareth Dutton. Nutrients 18 (14): 2352.

Hospitalized Patients With Oral Cavity Cancer and Ulcerative Mucositis: Implications for Key Cost Drivers and Disparities. Rudin, Lauryn, Roberto Pili, Joel B. Epstein, Karrar Aljanahi, Diggory Cordova, Richa Rajesh, Kapil Meleveedu, and Poolakkad S. Satheeshkumar. Reports 9 (3): 203.

Intestine-Specific Faf2 Depletion Ameliorates Obesity and Metabolic Dysfunction-Associated Steatotic Liver Disease by Impairing Lipid Absorption. Zhang, Jingjing, Norihiro Imai, Jinglei Cheng, Akiko Sugiyama, Hanna Kawecka, Dongming Liu, Michitaka Suzuki, Yuki Ohsaki, Shinya Yokoyama, Kenta Yamamoto, Takanori Ito, Keiko Maeda, Yoji Ishizu, Takashi Honda, Tetsuya Ishikawa, Michał Woźniak, Hiroaki Wake, David E. Cohen, and Hiroki Kawashima. International Journal of Biological Sciences 22 (12): 6261–80.

Local Growth Hormone Promotes Benign Prostatic Hyperplasia. Ryuzaki, Masaki, Svetlana Zonis, Neil A. Bhowmick, Sandrine Billet, Saravana Kumar Kailasam Mani, Stephen J. Freedland, Hyung L. Kim, Vera Chesnokova, and Shlomo Melmed. JCI Insight, July, e206012.

Longitudinal Associations Between Inflammatory Biomarkers and Fatigue in Patients With Colorectal Cancer: A Multicenter Study. Loroña, Nicole C., Louisa Liu, Elham Kazemian, Nicholas Acuna, Mary C. Playdon, Christopher L. Cubitt, Shaowli Kabir, Sylvia L. Crowder, Nathalie Nguyen, Maria Gomez, Victoria Damerell, Kathi Mooney, Patricia A. Erickson, Mmadili Ilozumba, Caroline Himbert, Erin Siegel, Cornelia M. Ulrich, Christopher I. Li, David Shibata, Adetunji T. Toriola, Jennifer Ose, Anita R. Peoples, Sheetal Hardikar, Doratha A. Byrd, Julienne E. Bower, Aasha I. Hoogland, Xiaoyin Li, Brent J. Small, Biljana Gigic, Heather S. L. Jim, and Jane C. Figueiredo. Cancer Medicine 15 (7): e72135.

Machine Learning Analysis Identifies Key Predictors of Baseline Lung Allograft Dysfunction and Increased Mortality in Lung Transplant Patients. Sankar, Keerthana, Laura DiChiacchio, Yuri Matusov, Pedro Catarino, Dominick Megna, Lorenzo Zaffiri, Jeremy Falk, Peter Chen, and Reinaldo Rampolla. JHLT Open 12 (May): 100553.

Mechanistic Interplay Between Multiple Myeloma and Severe SARS-CoV-2 Infection: Therapeutic Promise of Mesenchymal Stem Cell-Derived Extracellular Vesicles. Leyfman, Yan, Niharika Ikkurthy, Taha Kassim Dohadwala, Helena Sanchez Coloma, Jenna Ghazal, Muskan Joshi, Viviana Cortiana, Diksha Sanjana Pasnoor, Gayathri P. Menon, Noam Levi, Maduri Balasubramanian, and Chandler Park. Biomedicines 14 (7): 1617.

Neurological Comorbidity Burden, Outcomes, and Disparities in Head and Neck Cancer During COVID-19. Dhimal, Narayan, Roberto Pili, Joel B. Epstein, Vipanchika Satheeshkumar, Minu Ponnamma Mohan, Kapil Meleveedu, and Poolakkad S. Satheeshkumar. Reports 9 (3): 218.

P21-Activated Kinase 4 Drives Hepatic Stellate Cell Activation and Liver Fibrosis Through the Phosphorylation of YAP at T428. Kim, Gil-Hwan, Hyunsoo Rho, Chang Hun Lee, You-Jung Hong, Yongdo Park, Hwang Chan Yu, Mi-Young Song, Hye Jin Jo, Eun Joo Kang, Ri Han, Song Yi Yu, Ekihiro Seki, Yoonji Lee, Sangkyu Lee, Eun Ju Bae, Byung-Hyun Park, and Chang Yeob Han. Signal Transduction and Targeted Therapy 11 (1): 297.

Plain Language Summary: How Safe and Effective Is Long-Term Treatment With Intravenous Plasminogen Concentrate for People With Type 1 Plasminogen Deficiency? Shapiro, Amy D., Heather McDaniel, Robert W. Decker, Charles Nakar, Jeremy Lorber, Neelam Thukral, Joseph M. Parker, and Karen Thibaudeau. Therapeutic Advances in Hematology 17: 20406207261463031.

Quantifying and Visualizing Emergency Physician Workflow: Observational Time-Motion Study. Henreid, Andrew J., Kimon L. H. Ioannides, Joshua M. Pevnick, Tara N. Cohen, Sam S. Torbati, Teryl K. Nuckols, and Carl T. Berdahl. JMIR Medical Informatics 14 (July): e85983.

Senescent Cells in Wounds: Beneficial, Neutral, or Harmful? Yu, Grace T., Robert S. Kirsner, James L. Kirkland, and Saranya P. Wyles. The Journal of Investigative Dermatology, July, S0022-202X(26)02685-0.

Skin of Color Representation Among Common Search Engine Images. Adler, Robert, Kateryna Karpoff, Manan Mehta, Emily Cowen, Katerina Svigos, Justin Wu Marson, and Jessica Lori Feig. Journal of Drugs in Dermatology: JDD 25 (7): 670–71.

TRF2 Enriched Cytoplasmic Chromatin Drives cGAS-STAT1-Mediated Inflammation in Senescence. Kandhaya-Pillai, Renuka, Hee Yeon Kim, Jakub Belhadj, Julia M. Sidorova, Tamar Tchkonia, James L. Kirkland, and Junko Oshima. iScience 29 (8): 116770.

Using a Liver-on-Chip Model to Evaluate the Effects of Vancomycin and Daptomycin on Host Immunometabolism and Clearance of Intracellular Reservoirs of Staphylococcus Aureus during Bacteremia. Beadell, Brent, Sujung Yi, Makayla Roberts, Kyu Shik Mun, and Annie Wong-Beringer. Antimicrobial Agents and Chemotherapy, July, e0025426.

OBGYN

A Rare Case of Uterine Carcinosarcoma Presenting as Complete Uterine Inversion: A Case Report. Foy, Olivia B., Yingao Zhang, Julia Jahansooz, Michelle Pang, and Andrew Li. Gynecologic Oncology Reports 66 (August): 102166.

Orthopaedics and Sports Medicine

Allogeneic Transfusion-Related Adverse Events in Pediatric Idiopathic Scoliosis Surgery. Chan, Vivien, Geoffrey Shumilak, Armaan K. Malhotra, Andy M. Liu, Andrew Chan-Tai-Kong, Jalen Dansby, David E. Lebel, and David L. Skaggs. Journal of the Pediatric Orthopaedic Society of North America 16 (August): 100410.

Bridging Conservative Management With Injectable Orthobiologic Therapies: Proceedings of the International Consensus Meetings on Cartilage Repair of the Ankle. Tham, Alexander, Jared Rubin, James J. Butler, Paloma Gauthier, John G. Kennedy, Samuel B. Adams, Carol L. Andrews, Chayanin Angthong, Jorge P. Batista, Onno L. Baur, Stephen Bayer, Christoph Becher, Zijun Zhang, et al. Foot & Ankle Specialist, July, 19386400261456925.

Hormonal Contraceptive Use and Musculoskeletal Injury Risk in Female Athletes: A Prospective Cohort Study. Trentacosta, Natasha, Giselle Kaneda, Natasha Schimmoeller, Dave T. Huang, Jasmine Galloway, Marilee Fisher, Chloe Castaneda, Christian Blough, Thomas Kremen, Caroline Jefferies, Dmitriy Sheyn, and Melodie F. Metzger. Sports Health, July, 19417381261459590.

Lateral Extra-Articular Tenodesis Using Knotless All-Suture Anchor Fixation With Suture Tape: A Modified Technique for Augmenting Anterior Cruciate Ligament Reconstruction. Kemler, Bryson R., Seena Sebt, and Michael B. Banffy. Arthroscopy Techniques 15 (7): e70023.

Outcomes of Circumferential Minimally Invasive Technique Versus Open Technique in Adult Spinal Deformity Surgery Patients Aged Older Than 80 Years: A Propensity-Matched Analysis. Tretiakov, Peter, Kyriakos D. Chatzis, Mohammad Daher, Nima Alan, Dean Chou, Vivian Lee, Adam Kanter, Andrew K. Chan, Gregory Mundis, Juan Uribe, Kai-Ming Fu, Michael Wang, Neel Anand, David O. Okonkwo, Paul Park, Pierce Nunley, Praveen Mummaneni, Robert Eastlack, Richard Fessler, Ricardo Fontes, Shay Bess, Jay D. Turner, Peter G. Passias, and International Spine Study Group. Operative Neurosurgery, July.

Surgical Intervention for Moderate-To-Large Lesions (1-2.9 Cm2): Proceedings of the International Consensus Meetings on Cartilage Repair of the Ankle. Rubin, Jared, Alexander Tham, James J. Butler, Paloma Gauthier, John G. Kennedy, Samuel B. Adams, Carol L. Andrews, Chayanin Angthong, Jorge P. Batista, Stephen Bayer, Christoph Becher, Gregory C. Berlet, Zijun Zhang, et al. Foot & Ankle Specialist, July, 19386400261456897.

Suture Augmented Ulnar Collateral Ligament Reconstruction: A Detailed Technique. Gardner, Carson H., Seena Sebt, and Kenneth H. Akizuki. Arthroscopy Techniques, July, e70175.

Pathology and Laboratory Medicine

Ancillary Studies in the Diagnosis and Classification of Barrett Esophagus: What’s on the Menu? Hutchings, Danielle A., and Elizabeth A. Montgomery. Surgical Pathology Clinics 19 (3): 357–68.

Next-Generation Sequencing of Multivergent Morphologies in Colorectal Carcinomas Identifies Unique Targetable Alterations. Larson, Brent K., Elias Makhoul, Alexandra Gangi, Jun Gong, Maha Guindi, Andrew Hendifar, Danielle Hutchings, Michael Kozak, Keith Lai, Arsen Osipov, Eric Vail, and Kevin M. Waters. The American Journal of Surgical Pathology, July.

The Role of The Surgical Pathologist in the Recognition of Hereditary Gynecologic Cancer. Medeiros, Fabiola, and Jennifer A. Bennett. Advances in Anatomic Pathology 33 (4): 245–65.

Pediatrics

Oligonucleotide Synthesis Errors Are a Source of Untoward Variation in HDR-Mediated Gene Editing. Wyman, Stacia K., Zulema Romero, Seok-Jin Heo, Marian Navarrete, Netravathi Krishnappa, Donald B. Kohn, David I. K. Martin, Mark C. Walters, and Dario Boffelli. Genes 17 (7): 729.

Radiation Oncology

Ideal Candidates for Bladder Preservation in Muscle-Invasive Bladder Cancer. Oberoi, Japneet K., Leslie K. Ballas, Mark Tyson, and Parminder Singh. Urologic Oncology, July, S1078-1439(26)00584-3.

Surgery

ASO Visual Abstract: A Prospective, Multi-Center Randomized Controlled Trial (RCT) of the Da Vinci SP Surgical System Versus Open Surgery in Nipple Sparing Mastectomy (NSM) Procedures for Patients With Breast Cancer. Kopkash, Katherine, Mara Piltin, James Jakub, Sara Javid, Meghan R. Flanagan, Rebecca Aft, Akiko Chiba, Alysandra Lal, Ari D. Brooks, Farin Amersi, Nayana Dekhne, Jennifer Tseng, Clara Farley, Alan Kadison, Jeffrey Johnson, and Rosa F. Hwang. Annals of Surgical Oncology, July.

Factor V Leiden in Head and Neck Reconstruction: Institutional Experience and Protocol. Risbud, Adwight, Alexander Fish, Kevin S. Scher, Justin T. Moyers, Zachary S. Zumsteg, Evan S. Walgama, Allen S. Ho, and Jon Mallen-St Clair. The Journal of Craniofacial Surgery, July.

Malignancies After Vascularized Composite Allotransplantation. Schaschinger, Thomas, Tobias Niederegger, David Doll, Robert Munzinger, Gabriel Hundeshagen, Max Heiland, Curtis L. Cetrulo, Alexandre G. Lellouch, and Leonard Knoedler. Frontiers in Immunology 17 (July).

Radial Artery Pseudoaneurysm Following Transradial Catheterization: Recognition, Management, and Prevention. Carvajal, Michelle C., Shivani Shirodkar, Jessica B. Briscoe, Hilkiah Suga, Ifeanyi D. Chinedozi, Ralf Martz Sulague, Nikhita Athipathy, Nivedita Kumar, AlleaBelle Bradshaw, Hiba Juboori, Ahmet Kilic, and Jennifer S. Lawton. Journal of the Society for Cardiovascular Angiography & Interventions 5 (7): 105401.

What Is the Target Body Mass Index for Elective Hartmann’s Reversal? A NSQIP Analysis Using Stratum-Specific Likelihood Ratios. Wu, George L., Philip M. Parel, Matthew Zeller, Joseph Wetherell, Jonathan Luo, Yosef Nasseri, and Joshua H. Wolf. Journal of Gastrointestinal Surgery, July, 102529.

Workflow Disruption Cascades in the Operating Room: An Empirical Framework for Modeling High-Risk, High-Disruption Surgical States. Catchpole, Ken, John Del Gaizo, Falisha Kanji, Alexander V. Alekseyenko, Tara Cohen, and Jennifer Anger. Safety Science 204 (December): 107345.

Urology

Shaping the Future of Men’s Health: How AI Could Be a Transformative Tool for Better Patient Outcomes and Provider Efficiency. Bisset, Bryce, Vasanth Kainkaryam, Shawn Marhamati, Amin Moradi, Reza Amin, and Justin Houman. Journal of Medical Internet Research 28 (July): e81314.

Cedars-Sinai Health Sciences University is advancing groundbreaking research and educating future leaders in medicine, biomedical sciences and allied health sciences. Learn more about the university.

Cedars-Sinai in the News

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Jennifer Van Eyk, PhD

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Faculty Publications

Biomedical Sciences

A Bladder Cancer-Associated Gene Signature for Exploratory qPCR-Based Survival Stratification in NAC-Treated Muscle-Invasive Bladder Cancer. Chen, Xingyu, Toru Sakatani, Sunao Tanaka, Alberto Contreras-Sanz, Peter Black, Charles J. Rosser, and Hideki Furuya. Journal of Translational Medicine, July.

Biophysical Modeling of Anatomically Realistic Prenatal Cortical Folding Development. Hou, Jixin, Zhengwang Wu, Kun Jiang, Taotao Wu, Lu Zhang, Dajiang Zhu, Wei Gao, Mir Jalil Razavi, Tianming Liu, Ellen Kuhl, Gang Li, and Xianqiao Wang. Nature Communications, July.

Comparison of Photon-Counting and Energy-Integrating Computed Coronary Tomography Angiography for Coronary Artery Disease: A Systematic Review and Meta-Analysis. Kurugalage, Rakila, Arian Bhatia, Aditya Mukherjee, Gunaseelan K, Gemma A. Figtree, Christina A. Bursill, Damini Dey, Dennis T. L. Wong, Jessica A. Marathe, and Peter J. Psaltis. JACC. Cardiovascular Imaging, July, S1936-878X(26)00318-9.

Exploring Features of the Parasport Environment Associated With Quality Participation. Gee, Cameron M., M. Blair Evans, Adrienne R. Sinden, Celina H. Shirazipour, Kathleen A. Martin Ginis, and Amy E. Latimer-Cheung. Adapted Physical Activity Quarterly: APAQ, July, 1–10.

Cardiac Surgery

Into New Territory Without the Map: The 2026 TAVR Coverage Decision and the Registry We Must Not Lose. Bowdish, Michael. The Annals of Thoracic Surgery, July, S0003-4975(26)00727-7.

The Society of Thoracic Surgeons Risk Model for Surgical Aortic Valve Replacement After Transcatheter Aortic Valve Replacement. Hawkins, Robert B., Levi Bonnell, J. Hunter Mehaffey, Moritz Wyler von Ballmoos, Karen M. Kim, Tsuyoshi Kaneko, Tom C. Nguyen, Thomas MacGillivray, Vinod H. Thourani, Vinay Badhwar, Shinichi Fukuhara, Robert H. Habib, and Michael E. Bowdish. The Annals of Thoracic Surgery, July, S0003-4975(26)00726-5.

Cardiology

Author’s Reply to ‘POTS: A Neuroimmune Disorder With Cardiovascular Manifestations.’ Rao, Sthira, Xiao Liu, Noel Bairey Merz, and Peng-Sheng Chen. Heart Rhythm O2 7 (7): 1406.

Ethics of Navigating Organ Scarcity in Heart Transplantation. DeFilippis, Ersilia M., and Michelle M. Kittleson. Circulation 154 (3): 296–98.

Five Practical Questions for Interpreting a Meta-Analysis. Gransar, Heidi, and Daniel Berman. Journal of Cardiovascular Computed Tomography, July, S1934-5925(26)00421-1.

Funding Source and the Online and Academic Impact of Cardiovascular Trials. Zahedi Tajrishi, Farbod, Syed Bukhari, Sina Rashedi, Ashkan Hashemi, Isaac Dreyfus, Nicholas Varunok, John Burton, Seng Chan You, Younwoo Ki, Björn Redfors, Gregory Piazza, Joshua D. Wallach, Lesley H. Curtis, Sanjay Kaul, David J. Cohen, Roxana Mehran, Flávia Geraldes, Joseph S. Ross, Jane Leopold, Harlan M. Krumholz, Gregg W. Stone, and Behnood Bikdeli. Journal of the American College of Cardiology, July, S0735-1097(26)06899-3.

Left Ventricular End-Diastolic Pressure in Women With Ischemia and No Obstructive Coronary Artery Disease: The Women’s Ischemia Syndrome Evaluation - Coronary Microvascular Dysfunction Study (WISE-CVD). Ranasinghe, Sachini, Benita Tjoe, Joseph Chang, Galen Cook-Wiens, R. David Anderson, John Petersen, Bruce Samuels, Michael D. Nelson, Chrisandra Shufelt, Eileen M. Handberg, Carl J. Pepine, Janet Wei, and C. Noel Bairey Merz. International Journal of Cardiology 461 (July): 134672.

Loss of ATP-Dependent Citrate Lyase Drives Left Ventricular Dysfunction by Metabolic Remodeling. Liu, Shijie, Seth T. Gammon, Lin Tan, Yaqi Gao, Kyoungmin Kim, Mahmoud H. Elbatreek, Adrian Arrieta, Ian K. Williamson, Rebecca L. Salazar, Janet Pham, Angela Davidian, Radhika Khanna Neicheril, Benjamin D. Gould, Heidi Vitrac, Alia Sadiq, An Q. Dinh, Evan C. Lien, Francisca N. de Luna Vitorino, Joanna M. Gongora, Sara A. Martinez, Melanie T. Odenkirk, Anna K. Boatman, Jessie R. Chappel, Lawrence S. C. Czer, Evan P. Kransdorf, David J. Lefer, Blake M. Hanson, Benjamin A. Garcia, Erin M. Baker, Matthew G. Vander Heiden, Philip L. Lorenzi, Heinrich Taegtmeyer, David Piwnica-Worms, James F. Martin, and Anja Karlstaedt. Circulation 154 (3): 223–39.

Severe Left Ventricular Dilation With Preserved Contractile Reserve in an Adolescent Elite Athlete. Mutebi, Cedrick, Marius Chukwurah, Merije Toya Chukumerije, Oluwakorede Akele, Ranvir Raman Bhatia, and Aubrey J. Grant. JACC. Case Reports 31 (28): 108866.

TRISCEND II: Effect of Transcatheter Tricuspid Valve Replacement on Echocardiographic Measures of Right Heart Remodeling and Function. Sannino, Anna, Paul A. Grayburn, Susheel K. Kodali, Philipp Lurz, Vinod H. Thourani, Moody Makar, Christiane Haeffele, Jyothy Puthumana, James Lee, Peter Flueckiger, Scott Chadderdon, Ratnasari Padang, TRISCEND II Pivotal Trial Investigators, et al. JACC. Cardiovascular Imaging, July, S1936-878X(26)00310-4.

Computational Biomedicine

Multi-Level Latent Variable Models for Coheritability Analysis in Electronic Health Records. Zhao, Yinjun, Nicholas Tatonetti, and Yuanjia Wang. Statistics in Medicine 45 (15–17): e70675.

Medicine

An Enhanced Recovery Protocol in Endoscopic Bariatric Therapies Decreases Post-Procedural Healthcare Utilization. Gala, Khushboo, Farah Abdul Razzak, Omar Ghanem, Andrew C. Storm, Barham K. Abu Dayyeh, and Eric J. Vargas Valls. Obesity Surgery, July.

Comparison of Initial Artificial Intelligence (AI) and Final Physician Recommendations in AI-Assisted Virtual Urgent Care Visits. Zeltzer, Dan, Zehavi Kugler, Ran Ilan Ber, Caroline Goldzweig, and Joshua Pevnick. Annals of Internal Medicine 179 (7): 1069.

Consensus on Biomarker Utility for ACTH-Dependent Cushing’s Syndrome: A Pituitary Society Modified Delphi Panel. Fleseriu, Maria, Beverly Mk Biller, Irina Bancos, Hidenori Fukuoka, Martin Reincke, John Newell-Price, and Shlomo Melmed. The Journal of Clinical Endocrinology and Metabolism, July, dgag279.

Detailed Immunophenotypic and Genetic Characterization of Bone Marrow Clonal Plasma Cells and B-Cells in Early-Stage Monoclonal Gammopathies. Pérez-Escurza, Oihane, P. Martijn Kolijn, Jón Þórir Óskarsson, María González-González, María Jara-Acevedo, Julio Del Pozo, Quentin Lécrevisse, Juan Flores-Montero, Luzalba Sanoja-Flores, Silvia Martín, Elín Ruth Reed, Stephen Harding, Sigrún Thorsteinsdottir, Sæmundur Rögnvaldsson, Thorvardur Jon Love, Brian Durie, Anton W. Langerak, Sigurdur Yngvi Kristinsson, Alberto Orfao, iStopMM, and ECRIN-M3. Blood Cancer Journal, July.

Diagnostic Performance of Fecal Elastase and Risk Factors for Exocrine Pancreatic Insufficiency in Children With Pancreatitis: An INSPPIRE-2 Study. Gummadi, Vybhav Venkatesh, Tanja Gonska, Veronique D. Morinville, Asim Maqbool, Fuchenchu Wang, Gretchen A. Cress, Maisam Abu-El-Haija, Reuven Zev Cohen, Elissa M. Downs, Douglas S. Fishman, A. Jay Freeman, Matthew J. Giefer, Gila Ginzburg, Amit S. Grover, Andrew Y. J. Liman, Douglas Lindblad, Quin Y. Liu, Jacob A. Mark, Brian A. McFerron, Megha S. Mehta, Kenneth Ng, Robert Adam Noel, Chee Y. Ooi, Emily R. Perito, Michael Wilschanski, Yuhua Zheng, Suyu Liu, Mark Lowe, Aliye Uc, and Chronic Pancreatitis Clinical Research Consortium (formerly CPDPC). The Journal of Pediatrics, July, 115245.

Dithiothreitol Treatment Rescues C1q Assay Performance by Reducing High Background. Zhang, Xiaohai. Human Immunology 87 (9): 111809.

DNA Methylation Reprogramming of Gene Regulatory Elements Is Associated With Lung Metastasis in Triple-Negative Breast Cancer. Bedoya-López, Andrés F., Sandra Íñiguez-Muñoz, Javier I. J. Orozco, Miquel Ensenyat-Méndez, Betsy J. Valdez, Alexander D. Boiko, Mar Morote-Llabrés, Huiwen Bill Xie, Maggie L. DiNome, Pere Llinàs-Arias, and Diego M. Marzese. Communications Biology, July.

Geroprotective Insights Into the Natural Metabolite Spermidine in Aging and Age-Related Diseases. Jiang, Zhirui, Sen Tong, James L. Kirkland, and Yu Sun. Npj Aging, July.

Healthy Habits, Better Searches: Behavioral Predictors of Cancer Information Access. Acuna, Nicholas, Katelyn M. Atkins, Shaowli Kabir, and Jane C. Figueiredo. Preventive Medicine Reports 68 (August): 103565.

Long-Term Outcomes After Endoscopic Sleeve Gastroplasty: Impact of Clinician Follow-up and Lifestyle Engagement. Ghusn, Wissam, Ayah Matar, Karim Al Annan, Lea Sayegh, Khushboo Gala, Omar M. Ghanem, Daniel B. Maselli, Eric J. Vargas, Barham K. Abu Dayyeh, and Andrew C. Storm. Surgical Endoscopy, July.

Perioperative Mortality and Survival after Lymph Node Excision in Hepatocellular Carcinoma: A National Cancer Database Propensity Score-Matched Cohort Study. Lee, Huisong, Kyung Uk Jung, Michael Luu, Kambiz Kosari, Nicholas Nissen, and Ju Dong Yang. World Journal of Surgical Oncology, July.

Phase 1/2 Study of IMC-C103C, a T Cell Receptor Bispecific (MAGE-A4×CD3) ImmTAC Targeting MAGE-A4-Expressing Malignancies. Sweis, Randy F., Ignacio Melero, Diwakar Davar, Elena Garralda, Omid Hamid, Hui Amy Chen, Thomas R. Jeffry Evans, Kathleen N. Moore, Joseph J. Sacco, Fiona Thistlethwaite, Anja Williams, George R. Blumenschein, Margaret K. Callahan, Melissa L. Johnson, Erin L. Schenk, Jason Wustner, Sarah Stanhope, Kaixiang Tao, Shannon Marshall, and Juanita Lopez. Journal for Immunotherapy of Cancer 14 (7): e014638.

R Spondin 2 Regulates Regeneration of the Hematopoietic Stem Cell Niche. Montinelli, Vanessa N., Samantha Grohe, Xue Ying Song, Jacqueline Judith Turnlund, Hannah Hackbart, Joshua P. Sasine, Morgan Brady, Masahiro Muraoka, Rucha Kadam, Flavia Cavicchioli, Sage Victoria Kang, Ashley Dawson, Mimoli Ellise Uehara, Courtny Dizon, Kurt Hankenson, Theresa Krack, Peibin Yue, Yuwei He, and John P. Chute. Blood, July, blood.2025032421.

Regulatory T Cell Modulation With Selective CD28 Blockade and IL-6 Receptor Antagonist in Kidney Transplant Recipients: Results of CTOT-24, a Prospective Clinical Trial. Chandran, Sindhu, Qizhi Tang, Joey C. Leung, Brian D. Armstrong, John J. Friedewald, Allan D. Kirk, Zoltan G. Laszik, Julia Goldstein, Megan Morsheimer, and Flavio G. Vincenti. American Journal of Transplantation, July, S1600-6135(26)02676-6.

Stratified Discharge Timing Within Mucositis Cases and Its Association With Systemic Complications in Hematopoietic Stem Cell Transplant Recipients: Insights From a National Inpatient Study. Raheem, Sana, Kapil Meleveedu, Stephanie J. M. van Leeuwen, Lucky L. A. van Gennip, Lauryn Rudin, Joel B. Epstein, Roberto Pili, Nicole Blijlevens, and Poolakkad S. Satheeshkumar. Clinical Oral Investigations 30 (8): 353.

Systematic Review of Prognostic Scores and Individual Predictor Variables for Short-Term Mortality after Acute Pulmonary Embolism. Jimenez, David, Behnood Bikdeli, Victor Tapson, Cecilia Becattini, Lisa Moores, Geoffrey D. Barnes, Manuel Monreal, Stavros Konstantinides, Gregory Piazza, Raquel Morillo, Noelia Alvarez-Diaz, and Roger D. Yusen. Pulmonology 32 (1): 2703889.

Tumor Plasticity and Microenvironmental Crosstalk as Drivers of Metastasis and Therapy Resistance. Dagar, Gunjan, Manisha Dagar, Ashna Gupta, Anju Surendranath, Suraja Kumar Das, Mohd Umar Rehmani, Mukesh Tanwar, Sameer Mirza, Muzafar A. Macha, Ammira S. Al-Shabeeb Akil, Shahab Uddin, Mayank Singh, and Ajaz A. Bhat. MedComm 7 (8): e70836.

Neurology

Aging, Cellular Senescence, and Parkinson’s Disease: A Different Interpretation of the Same Evidence. Tagliati, Michele. Parkinsonism & Related Disorders 150 (July): 108427.

Fast Submillimeter Whole-Brain T2*-Weighted Imaging Using 3D-EPI With CAIPIRINHA and Deep-Learning Denoising at 3T. Nair, Sreekanth Madhusoodhanan, Bryan Quah, Jae W. Song, Jin Jin, Chang Gao, Fei Han, Elaina Luskin, Michael Luu, Brian Renner, Ke Cheng Liu, Sunil Patil, John A. Derbyshire, Ken Sakaie, Jonathan Lee, Mark A. Elliott, Russell T. Shinohara, Matthew K. Schindler, Michel Bilello, Marwa Kaisey, Omar Al-Louzi, Nader Binesh, Marcel Maya, Debiao Li, Andrew J. Solomon, Daniel S. Reich, Nancy L. Sicotte, Mark J. Lowe, Daniel Ontaneda, and Pascal Sati. Magnetic Resonance in Medicine, July.

Long-Term Safety and Efficacy of Efgartigimod PH20 in Chronic Inflammatory Demyelinating Polyradiculoneuropathy: ADHERE/ADHERE+ Trial Interim Analysis. Allen, Jeffrey A., Geoffrey Istas, Satoshi Kuwabara, Trevor Mole, Luis Querol, Simon Rinaldi, Mark Stettner, Benjamin Van Hoorick, and Richard A. Lewis. Journal of the Peripheral Nervous System: JPNS 31 (3): e70140.

Neurosurgery

Comparative Analysis of Stereotactic Radiosurgery and Microsurgery for Vestibular Schwannoma: A Clinical and Radiological Evaluation. Boyke, Andre E., Tariq Al-Saadi, Simon A. Menaker, Edward Robinson, Alan Nguyen, Michelot Michel, Brittany Morris, Younis Al-Mufargi, Behrooz Hakimian, Amin Mirhadi, Yu-Tung Wong, Mia E. Miller, and John S. Yu. Journal of Neuro-Oncology 179 (1): 3.

Global Sagittal Mismatch, Not Isolated L1 Pelvic Angle Achievement, Is Associated With Mechanical Failure after Adult Spinal Deformity Surgery. Kim, Timothy Y., James D. Lin, Joseph M. Lombardi, Richard Menger, Martin H. Pham, Lee A. Tan, Alexander Tuchman, Scott L. Zuckerman, Joseph A. Osorio, and Comprehensive Spine Study Group. The Spine Journal, July, S1529-9430(26)00583-8.

Impact of T4-L1-Hip Axis Normalization on Outcomes and Complications in Adult Spinal Deformity. Mohanty, Sarthak, Zeeshan M. Sardar, Justin L. Reyes, Fthimnir M. Hassan, Michael P. Kelly, Josephine R. Coury, Elisabeth Geraghty, Nathan J. Lee, Justin K. Scheer, Steven G. Roth, Chun Wai Hung, Ronald A. Lehman, Joseph M. Lombardi, and Lawrence G. Lenke. The Journal of Bone and Joint Surgery. American Volume, July.

Nursing

AI-Powered Voice Documentation: A Nurse-Led Pilot Program. Trias, Ryan, Bernice Coleman, Cynthia Bowers, Scott Mondejar, Golda Morales, and Peachy Hain. The American Journal of Nursing 126 (8): 48–51.

OBGYN

Cost Analysis and Resource Utilization of Gynecologic Cancer-Related Thoracenteses and Paracenteses. Zhang, Yingao, Olivia Foy, Grace Pipes, and Margaret I. Liang. JAMA Network Open 9 (7): e2624257.

Orthopaedics and Sports Medicine

Contemporary Concepts in Cervical Disk Arthroplasty: Implant Design, Constraint, Complications, and Technical Pearls. Nguyen, Austin Q., Andrei Demkov, Don Le, Rohan Vemu, Mark L. Prasarn, Corey T. Walker, Hyun W. Bae, Todd Albert, Andrew A. Sama, Sheeraz A. Qureshi, and Karim A. Shafi. JBJS Reviews 14 (7).

CORR Insights®: Can We Validate the Musculoskeletal Infection Society Criteria in Patients Suspected of Infection After Transfemoral Osseointegration Surgery? Allison, Daniel C. Clinical Orthopaedics and Related Research 484 (8): 1513–15.

One in Five Cases of Spondylolysis Are Missed on MRI: A Retrospective Analysis of Pediatric Patients With Back Pain. Kodali, Prudhvi, James P. Caruso, George Michael, Andy Liu, Suhas Etigunta, Vivien Chan, David L. Skaggs, and Kenneth D. Illingworth. Spine Deformity, July.

Pathology and Laboratory Medicine

Next-Generation Sequencing Reporting Practices Among the Genomics Organization for Academic Laboratories (GOAL) Institutions: Current State and Opportunities for Harmonization. Eno, Celeste C., Ramakrishna Sompallae, Daniel Jones, Dara L. Aisner, and T. Niroshi Senaratne. The Journal of Molecular Diagnostics: JMD, July, S1525-1578(26)00121-2.

Pediatrics

Clinic-Integrated IBCLC Care Is Associated With Higher Breastfeeding Goal Achievement and Faster Time to Goal Attainment Compared With Home-Visit Care. Ognjanovic-Jasovic, Mina. Journal of Human Lactation, July, 8903344261435718.radiolo

Expert Consensus on Bedside Transcatheter Closure of Patent Ductus Arteriosus in Extremely Low Birth Weight Infants. Ewert, Peter, Patrick J. McNamara, Lee Benson, Charles C. Roehr, Sophie Malekzadeh-Milani, Alain Fraisse, Bert Albers, Evan Zahn, and Sven Wellmann. Pediatric Research, July.

From Clinics to Discoveries: Harnessing National EHR Interoperability for Research. Lemieux, Josh, Emily R. Pfaff, Richard A. Moffitt, Jay Nakashima, Raymond Duncan, Erica Galvez, John P. Giannini, Julie A. McMurry, Anita Walden, and Melissa Haendel. JAMIA Open 9 (4): ooag137.

From Opinions to Outcomes: Optimizing Survey Methods and Principles Applicable to the Delphi Process in Critical Care Research. Ramadurai, Deepa, Vitaly Herasevich, Scott Bolesta, Gretchen M. Brophy, Deyin Doreen Hsing, Philippe R. Bauer, Pooja Amar Nawathe, Robert MacLaren, Ashish K. Khanna, and C. Jessica Dine. Critical Care Explorations 8 (7): e1438.

Mapping Mesenchymal Diversity in the Human Small Intestine and Organoids. Johnson, Kelli F., Xiangning Dong, Yu-Hwai Tsai, Angeline Wu, Sydney G. Clark, Abigail Vallie, Sha Huang, Charlie J. Childs, Rachel K. Zwick, Ian Glass, Katherine D. Walton, Ophir D. Klein, and Jason R. Spence. Nature Cell Biology, July.

Surgery

A Prospective, Multicenter Randomized Controlled Trial (RCT) of the Da Vinci SP® Surgical System versus Open Surgery in Nipple-Sparing Mastectomy (NSM) Procedures for Patients With Breast Cancer. Kopkash, Katherine, Mara Piltin, James Jakub, Sara Javid, Meghan R. Flanagan, Rebecca Aft, Akiko Chiba, Alysandra Lal, Ari D. Brooks, Farin Amersi, Nayana Dekhne, Jennifer Tseng, Clara Farley, Alan Kadison, Jeffrey Johnson, and Rosa F. Hwang. Annals of Surgical Oncology, July.

Expanding the Pancreas Donor Pool: Reassessing the Impact of Donor Body Mass Index on Transplant Outcomes. Jurkovich, Alexander, Tiffany Lim, Emma S. Crichton, Tia Ketsan, Evronia Baselious, Yujie Cui, Georgios Voidonikolas, Kambiz Kosari, Nicholas N. Nissen, Tsuyoshi Todo, Justin A. Steggerda, Steven A. Wisel, Irene K. Kim, and Todd V. Brennan. Clinical Transplantation 40 (7): e70611.

Impact of a Rib Fracture Treatment Protocol: A Propensity Score Matching Analysis. Djanie, Thermutis, Ashley Pfaff, Claire Miller, Ashar Ata, Allan E. Stolarski, Lauren Evans, Carl Rosati, Matthew Johnson, Ashley Bartscherer, Steven C. Stain, and Marcel Tafen. Trauma Surgery & Acute Care Open 11 (3): e001989.

Leak-Stratified Management of Early Bile Leaks After Liver Transplantation: A Narrative Review of Leak Characteristics, Patient Stability, and the Limited Evidence on Intervention Timing in the First 14 Postoperative Days. Satea, Murtaja, Alexandre G. Lellouch, Haïzam Oubari, Veronika Dadaev, Rotem Horowitz, Shai Hoffman, Yael Ben Avraham, Tobias Niederegger, Karam Azem, Rodolfo J. Oviedo, Narmin Zoabi, Eviatar Nesher, and Fahim Kanani. Gastrointestinal Disorders 8 (3): 36.

Optimized Metabolic Conditions Reveal the Adipogenic Competence of Wharton’s Jelly MSCs: Insight From Literature Review and Experimental Validation. Pinault, Cécile, Audrey Cras, Michel-Gabriel Cazenave, Anne Schnitzler, Jeanne Rancic, Jerome Larghero, Sophie Vacher, Curtis L. Cetrulo, Daniel Balvay, Ivan Bieche, Alexandre G. Lellouch, and David M. Smadja. Stem Cell Reviews and Reports, July.

Urology

PI-RADS-Stratified MRI-Based PSA Density for Predicting Adverse Pathology After Robotic-Assisted Laparoscopic Radical Prostatectomy. Fu, Hangcheng, Braden Millan, Patrick Michael, Ruben Blachman-Braun, Jaskirat Saini, Cody Ewing, Mitchell Hwang, Marina J. Merino, Michael Ahdoot, Sandeep Gurram, Baris Turkbey, and Peter A. Pinto. European Urology Focus, July, S2405-4569(26)00068-4.

Cedars-Sinai Health Sciences University is advancing groundbreaking research and educating future leaders in medicine, biomedical sciences and allied health sciences. Learn more about the university.

In this new senior leadership position, Thadhani will oversee the academic and clinical enterprises at Cedars-Sinai, further unifying the organization's care delivery, research and education missions. He will lead a broad team of leaders, including department chairs, institute directors, executive vice deans, vice deans and chief medical officers.

Thadhani succeeds Shlomo Melmed, MB, ChB, who served as dean of the Medical Faculty and executive vice president of Medicine and Health Sciences for 28 years. Melmed will transition to the role of dean emeritus of the Medical Faculty and executive adviser to Cedars-Sinai President and CEO Peter L. Slavin, MD.

“Dr. Thadhani is the ideal leader to succeed Dr. Melmed,” Slavin said. “His extensive background in organizational leadership, commitment to clinical medicine and academic excellence and robust scientific record position him to advance every dimension of our enterprise.”

Thadhani most recently served as executive vice president of Clinical Affairs and chief medical officer for Cedars-Sinai Medical Center and Cedars-Sinai Health System. In his new role, he will retain oversight of clinical quality and safety, medical affairs, and medical standards of care for the medical center and health system, while assuming additional responsibility for all academic and education programs, including Cedars-Sinai Health Sciences University and the Burns and Allen Research Institute.

Thadhani began his career at Massachusetts General Hospital and Harvard Medical School. He served as vice dean for Research and Education at Cedars-Sinai Medical Center from 2017 to 2019 before returning to Harvard as professor of medicine and serving as chief academic officer and dean for Faculty Affairs at Mass General Brigham and Harvard Medical School.

In 2022, he was named executive vice president for health affairs at Emory University as well as vice chair of the Emory Healthcare Board of Directors and executive director of Emory’s Woodruff Health Sciences Center, which includes Emory’s schools of medicine, public health and nursing.

Thadhani is the author or co-author of more than 300 scientific manuscripts published in leading academic journals, including The New England Journal of Medicine, The Lancet and the Journal of the American Medical Association.

A leading expert in nephrology and preeclampsia, one of the leading causes of maternal and perinatal morbidity and mortality, Thadhani played a central role with Cedars-Sinai collaborators in developing the first Food and Drug Administration-approved test to predict the condition.

His research contributions have earned recognition at the highest levels of science and medicine. Earlier this year, he was elected a Fellow of the American Association for the Advancement of Science (AAAS), following his election last year to the National Academy of Medicine.

“I am deeply honored to step into this role at such a pivotal moment for Cedars-Sinai,” Thadhani said. “I am grateful to Dr. Melmed for the extraordinary foundation he has built, and I look forward to working closely with our talented leaders and faculty to forge the next chapter of our academic and clinical mission.”

Read more from the Cedars-Sinai Newsroom: Physician-Scientist Ravi Thadhani, MD, MPH, Named AAAS Fellow

During the fiscal year that ended June 30, the medical center supported organizations through 169 grants to address critical needs, including access to healthcare, housing stability, food security and other essential resources.

A $300,000 grant to the Los Angeles Food Policy Council will strengthen regional food access through CalFresh outreach and enrollment efforts. The funding will also support the infrastructure of local farmers markets and coordinated strategies to protect food-purchasing power and access to healthy, culturally relevant food for low-income residents.

The medical center has invested in regional food systems by backing local growers and issuing grants to programs such as FeedLA through the YMCA of Metropolitan Los Angeles as well as YMCA Center for Community Well-Being locations.

A grant to ALMA Backyard Farms helped expand the urban agriculture infrastructure, workforce training opportunities and fresh food distribution in communities with limited access to healthy food and green space. This contribution includes aid toward the development of a new farm hub in Carson.

Shifts in public program protocols continue to reshape the social services landscape. Cedars-Sinai has pledged to expand its investments in community-based organizations.

The latest round of grants also included $250,000 to Neighborhood Legal Services of Los Angeles County to assist residents navigating programs like Medi-Cal, CalFresh, Covered California and Medicare.

To support healthy aging and quality of life programs, Cedars-Sinai awarded two grants to expand services for seniors and their caregivers. A grant to Comprehensive Community Health Centers will help increase behavioral health engagement and ensure those in need can receive effective medical treatment.

Watts Healthcare also received a grant to aid its Healthy Aging and Wellness Program that promotes physical, emotional and social wellbeing through preventive care, fitness and nutritional support, and mental health resources.

Cedars-Sinai funded two initiatives focused on homeless prevention and long-term support to those facing housing instability. According to the 2025 Greater Los Angeles Homeless Count, more than 72,000 people experience homelessness on any given night across L.A. County.

A grant to the housing advocacy organization Brilliant Corners supported the Los Angeles County Homeless Prevention Unit’s efforts to provide flexible financial assistance to at-risk young adults in danger of losing housing.

A grant to local nonprofit Housing Works will fund enhanced training, professional development and wellness support for frontline staff serving those who have faced homelessness.

A Cedars-Sinai grant to Planned Parenthood Los Angeles will support care through the organization’s network of health centers, school-based wellbeing centers and its community outreach efforts.

“Cedars-Sinai is deeply compelled to continue providing support to organizational partners in their dedication to helping communities across this region,” said Andrea Iloulian, MPP, executive director of Grantmaking at Cedars-Sinai. “These organizations are on the front lines of improving access to medical care for everyone as well as providing food and housing assistance. This will help ensure vulnerable populations have the support and supplies they need to survive and thrive.”

Read more from Cedars-Sinai Newsroom: $13M Gift Creates Cedars-Sinai Holoman Health Equity Center

Cedars-Sinai in the News

Do You Have ‘Texting Thumb’? Here’s How to Soothe It | Associated Press
Eugene Tsai, MD

Graham’s Death From Aortic Dissection Raises Questions About Preventing the Rare Disorder | STAT
Joanna Chikwe, MD

There’s an Injury Epidemic in Pro Sports. There's Also a Recovery Revolution. | The New York Times
Neal ElAttrache, MD

Experts Say This Common Menopause-linked Condition Can Make Everyday Movements Painful | Women’s Health
Natasha Trentacosta, MD

Can You Bring a Baby to a Concert? Experts Warn Parents About the Risks | Parents Magazine
Abhita Reddy, MD

Vibration Plates Are Trendy. But Do They Actually Work? | USA Today
Natasha Trentacosta, MD

Turning Routine Slides Into Molecular Maps | The Pathologist
Eytan Ruppin, MD

Faculty Publications

Biomedical Sciences

Antisense Oligonucleotides Treatment Uncovers Differences in the Modulation of Dysregulated Intracellular Pathways in Spinal Muscular Atrophy Motoneurons. Miralles, Maria P., Isabel Gimenez-Fernandez, Maria Beltran, Alba Sansa, Laura Martínez-España, Jordi Calderó, Manuel Portero-Otín, Rosa M. Soler, and Ana Garcera. Cell Death & Disease, July.

Measles Outbreaks in Nepal: Sustaining Rapid Response Through Equity-Focused Immunization and Surveillance. G C, Alisha, and Binod G C. Annals of Medicine and Surgery 88 (7): 4773–75.

Cardiology

Abbreviated DAPT Regimens Across the Entire Spectrum of Bleeding Risk According to the PRECISE-HBR Score. Cao, Davide, Angelo Oliva, Roxana Mehran, Samantha Sartori, Yihan Feng, Felice Gragnano, David van Klaveren, Dominick J. Angiolillo, Sripal Bangalore, Deepak L. Bhatt, Junbo Ge, James Hermiller, Raj R. Makkar, Franz-Josef Neumann, Shigeru Saito, Hector Picon, Ralph Toelg, Aziz Maksoud, Bassem M. Chehab, James W. Choi, Gianluca Campo, Jose M. de la Torre Hernandez, Mitchell W. Krucoff, Vijay Kunadian, Gennaro Sardella, Holger Thiele, Olivier Varenne, Pascal Vranckx, Stephan Windecker, and Marco Valgimigli. JACC. Cardiovascular Interventions 19 (13): 1766–77.

Automated Detection of Clinically Significant Mitral Regurgitation From Single-View B-Mode Echocardiography Using Deep Learning. Sandler, Roman A., Joseph Z. Sokol, Shubhadarshini Pawar, Anna Gilgur, Aashi Jhawer, Shirin Sadri, Daniel B. Sokol, Markos Muche, Aleksandar Stojmenski, Michael Guptan, Joshua Penn, Raj Makkar, and Aakriti Gupta. Journal of the American Society of Echocardiography, July, S0894-7317(26)00360-3.

Emerging Roles for Metabolism in Myocardial Inflammation During Heart Failure. Erebholo, Zipporah, and Anja Karlstaedt. Immunological Reviews 340 (1): e70128.

Expert Perspectives on De-Escalation of Antiplatelet Therapy - Beyond the Guidelines: Insights From the Cardiovascular Research Technologies 2026 Meeting. Galo, Jason, Matías Rodríguez Granillo, Pablo M. Rubio, Omar Mhaimeed, Adnan Kastrati, Sanjay Kaul, Usman Baber, C. Michael Gibson, Konstantinos Marmagkiolis, Manoj Kesarwani, Itsik Ben-Dor, and Ron Waksman. Cardiovascular Revascularization Medicine: Including Molecular Interventions, June, S1553-8389(26)00274-5.

Machine Learning With Genetic and Clinical Data to Predict Ischemic Outcomes After PCI. Grant, Caroline W., Brenden S. Ingraham, Ryan J. Lennon, Anvi Raina, Shulan Tian, Gurukripa Kowlgi, Larisa H. Cavallari, Craig R. Lee, Amber Beitelshees, Dominick J. Angiolillo, Francesco Franchi, Julio D. Duarte, Joseph S. Rossi, George A. Stouffer, Eric Klee, Rajiv Gulati, Charanjit Rihal, Michael Farkouh, Arjun P. Athreya, and Naveen L. Pereira. Clinical and Translational Science 19 (7): e70655.

Standardized Endpoint Definitions for Trials of Transcatheter Left Atrial Appendage Closure: A Consensus From the Left Atrial Appendage Academic Research Consortium†. Garot, Philippe, Roxana Mehran, Ole de Backer, James V. Freeman, Nina Wunderlich, Benjamin Hibbert, Apostolos Tzikas, Devi Nair, Sergio Berti, Jacqueline Saw, Xavier Freixa, Shephal K. Doshi, Ignacio Cruz-Gonzalez, Megan Coylewright, Adel Aminian, Matthew J. Price, Lorenz Räber, Xiaoxi Yao, Laura Sanchis, Christian T. Ruff, Ulf Landmesser, Dhanunjaya Lakkireddy, Christopher R. Ellis, Mirvat Alasnag, Masanori Yamamoto, Enrico G. Ferro, Shin Iwamoto, Takeshi Shiba, Yu Jin, Boris Schmidt, Vikrant Jagadeesan, Vivek Y. Reddy, David Hildick-Smith, Angelo Oliva, Mitchell W. Krucoff, Ernest Spitzer, Jens Erik Nielsen-Kudsk, C. Michael Gibson, Edip M. Gurol, Don E. Cutlip, Martin B. Leon, David R. Holmes, Marie-Claude Morice, and Mohamad Alkhouli. European Heart Journal, July, ehag482.

The Periprocedural Safety of Continued GLP-1 Receptor Agonist Prior to Cardiac Catheterization. Chi, Kuan-Yu, Suraj Adhikari, Yu Chang, Sridhar Mangalesh, Pei-Lun Lee, Abdulla A. Damluji, Jiun-Ruey Hu, and Michael G. Nanna. The American Journal of Cardiology, July, S0002-9149(26)00450-9.

Vutrisiran Health Care Resource Utilization, Costs, Discontinuation, and Mortality: A Real-World Claims Analysis. Bart, Nicole K., Daniel P. Judge, Margarita Udall, Liana Hennum, Melissa Allison, Avinash Dash, Shradha Sanghi, Rakesh Ramesh, and Richard Wright. Advances in Therapy, July.

Computational Biomedicine

PDA (Privacy-Preserving Distributed Algorithms) in Action: Ten Principles for High-Quality Multi-Site Clinical Evidence Generation. Chen, Yong, Jiayi Tong, Yiwen Lu, Rui Duan, Chongliang Luo, Marc A. Suchard, Patrick B. Ryan, Andrew E. Williams, John H. Holmes, Jason H. Moore, Hua Xu, Yun Lu, Raymond J. Carroll, Scott L. Zeger, George Hripcsak, and Martijn J. Schuemie. Journal of the American Medical Informatics Association: JAMIA, July, ocag119.

Medicine

Acute Exacerbation in Fibrotic Interstitial Lung Disease: An International Working Group Report. Khor, Yet H., Fabrizio Luppi, Ayodeji Adegunsoye, Bridget F. Collins, Erica Farrand, Sydney B. Montesi, Chad A. Newton, Vincent Cottin, Kerri A. Johannson, Bhavika Kaul, Martin Kolb, Michael Kreuter, Philip L. Molyneaux, Marlies S. Wijsenbeek, Katerina Antoniou, Jürgen Behr, Elisabeth Bendstrup, Harold R. Collard, Tamera J. Corte, Wonder P. Drake, Giovanni Ferrara, Lida P. Hariri, Cory M. Hogaboam, R. Gisli Jenkins, Naftali Kaminski, Ella A. Kazerooni, Michael P. Keane, Yasuhiro Kondoh, Joyce S. Lee, Fengming Luo, Toby M. Maher, Fernando J. Martinez, Yuben Moodley, Luca Richeldi, Marco Sebastiani, Patricia J. Sime, Susanne Stowasser, Sara Tomassetti, Athol Wells, Christopher J. Ryerson, and Anna J. Podolanczuk. American Journal of Respiratory and Critical Care Medicine, July, aamag363.

Clinical and Psychological Outcomes After Monoclonal Gammopathy Screening: A Population-Based Screening Study and Subsequent Randomized Trial of Follow-Up. Rögnvaldsson, Sæmundur, Sigrún Thorsteinsdóttir, Elias Eythorsson, Inga Dröfn Wessman, Gudrun Asta Sigurdardottir, Brynjar Vidarsson, Pall T. Onundarson, Bjarni Agnarsson, Margret Sigurdardottir, Isleifur Olafsson, Ingunn Thorsteinsdottir, Andri Steinthor Bjornsson, Jon Thorir Oskarsson, Andri Olafsson, Gauti Gislason, Ingigerdur Sverrisdottir, Thorir E. Long, Elfa Rún Guðmundsdóttir, Asdis Rosa Thordardottir, Asbjorn Jonsson, Runolfur Palsson, Olafur S. Indridason, Malin Hultcrantz, Brian G. M. Durie, Stephen J. Harding, Thor Aspelund, Ola Landgren, Thorvardur Jon Love, and Sigurdur Y. Kristinsson. Journal of Clinical Oncology, July, JCO2502771.

Comparison of Outcomes of Leadless Versus Transvenous Pacemakers Following Tricuspid Valve Surgery. Shimoda, Tomonari M., Yoshihisa Miyamoto, Hiroki A. Ueyama, Shinobu Itagaki, Tsuyoshi Kaneko, Hiroshi Gotanda, Kosuke Inoue, Shinichi Fukuhara, Gorav Ailawadi, Hiroo Takayama, Toshiki Kuno, and Yusuke Tsugawa. Journal of the American Heart Association, July, e049636.

Compensated Cirrhosis in a 40-Year-Old Woman With Progressive Familial Intrahepatic Cholestasis Type 3. Yeo, Yee Hui, Danielle Hutchings, Maha Guindi, and Paul Martin. ACG Case Reports Journal 13 (7): e02237.

Coronary 18F‑Sodium Fluoride PET Imaging: State-of-the-Art Technology and Translational Clinical Perspectives. Hashimoto, Hidenobu, Keiichiro Kuronuma, Daniel S. Berman, and Piotr J. Slomka. Journal of Cardiology, July, S0914-5087(26)00135-8.

Effectiveness of Daratumumab Plus Bortezomib, Lenalidomide, and Dexamethasone (DVRd) Versus VRd for Transplant-Eligible Newly Diagnosed Multiple Myeloma. Tan, Carlyn Rose, Lucio Gordan, Joshua Richter, Rachel DiLeo, Prerna Mewawalla, Sarah Larson, Faith Davies, David Oveisi, Niodita Gupta-Werner, Rohan Medhekar, Xin Yin, Annelore Cortoos, Marjohn Armoon, Philippe Thompson-Leduc, Alvi Rahman, Anabelle Tardif-Samson, Claire Vanden Eynde, John Reitan, Gary Milkovich, Joseph Bubalo, Adam Forman, Baylee Bryan, Douglas Sborov, Shuchita Kaila, and Saad Usmani. Future Oncology, July, 1–9.

Multiomic Profiling of Responses to Clinical and Novel Bisphosphonates Reveals Extraskeletal Effects on Ageing Related Signatures. Lu, Jinsen, Srinivasa Rao Rao, Helen Knowles, Haoqun Zhan, Beatriz Gamez, Mingyu Qin, Eleanor Platt, Lucy R. Frost, Tiffany-Jayne Allen, Gayle Marshall, Kilian V. M. Huber, Ludwig G. Bauer, Iolanda Vendrell, Darragh P. O’Brien, Benedikt Kessler, Anne Horne, Ian R. Reid, Chas Bountra, James L. Kirkland, Sundeep Khosla, Frank H. Ebetino, Emilio Roldan, R. Graham G. Russell, and James R. Edwards. Signal Transduction and Targeted Therapy 11 (1): 277.

Outcome Scoring Systems for Locoregional Therapy in Hepatocellular Carcinoma: A Systematic Review. Daruwalla, Cyrus, Evelyn Calderon, Christo Mathew, Lauren Mignogna, Ajit Vyas, David Sada, Rayhan Hai, Benjamin Hines, Muzammil Hanif, Ewout W. Steyerberg, Hashem B. El-Serag, and Ruben Hernaez. Gut, July, gutjnl-2025-337557.

The Cloacal Outgrowth Orchestrates Co-Development of the Bladder and Umbilical Arteries. Ye, Xing, Liguang Xia, Xianfa Yang, Ruirong Tan, Haochuan Zhang, Liming Lei, Jungang Huang, Yingsheng Zhang, Edward Morrisey, Ping Zhu, Zhongrong Li, Naihe Jing, and Xue Li. Development, July, dev.205398.

Transient Ischemic Dilation With 18F-Flurpiridaz PET: Establishing Thresholds for a Novel Radiotracer. Letourneau-Shesaf, Sevan, Yimin Chen, Mark Lemley, Giselle Ramirez, Paul Kavanagh, Aakash Shanbhag, Joanna X. Liang, Christopher Buckley, Robert J. H. Miller, Daniel S. Berman, and Piotr Slomka. Journal of Nuclear Cardiology, July, 102806.

Neurology

Challenges and Future Directions for Multiple Sclerosis After the 2024 McDonald Diagnostic Criteria. Oh, Jiwon, Frederik Barkhof, Amit Bar-Or, Olga Ciccarrelli, Timothy Coetzee, Massimo Filippi, Cristina Granziera, Yael Hacohen, Bernhard Hemmer, Orhun H. Kantarci, Ho Jin Kim, Christine Lebrun-Frenay, Xavier Montalban, Ellen Mowry, Daniel Ontaneda, Alexandre Prat, Daniel S. Reich, Àlex Rovira, Pascal Sati, Aksel Siva, Andrew J. Solomon, Maria Pia Sormani, Bruno Stankoff, Alan Thompson, Mar Tintore, Anthony Traboulsee, Anneke van der Walt, Heinz Wiendl, and Peter A. Calabresi. Nature Medicine, July.

Complex Deep Neural Networks for Denoising Ultra-Fast Submillimeter T2*-Weighted Imaging and Quantitative Susceptibility Mapping. Quah, Bryan, Sreekanth Madhusoodhanan Nair, Chang Gao, Michael Luu, Brian Renner, Jin Jin, Fei Han, Elaina Luskin, Arzu C. Has Silemek, Nader Binesh, Debiao Li, Marwa Kaisey, Daniel S. Reich, Nancy L. Sicotte, Russell T. Shinohara, Omar Al-Louzi, Xiuzhen Huang, Marcel Maya, Daniel Ontaneda, and Pascal Sati. European Journal of Radiology Artificial Intelligence 6 (June): 100100.

Neurosurgery

Agreement and Reliability Analysis of Sarcopenia Measures Based on Muscle Function, Body Composition, and Imaging in Spinal Deformity Patients. Semonche, Alexa, Ann A. Lazar, Justin K. Scheer, Anthony L. Mikula, Thomas Wozny, Jaemin Kim, Terry H. Nguyen, Vedat Deviren, Aaron J. Clark, and Christopher P. Ames. Journal of Neurosurgery. Spine, July, 1–8.

Clinical and Economic Burden of Poor Bone Health in Adult Spinal Deformity Surgery: A Multicenter Cohort Study. Passias, Peter G., Mohammad Daher, Kyriakos D. Chatzis, Virginie Lafage, Renaud Lafage, Pratibha Nayak, Andrew Schoenfeld, Marc Khalife, Sleiman Haddad, Emmanuelle Ferrero, Breton Line, Bassel Diebo, Alan H. Daniels, Jeffrey P. Mullin, D. Kojo Hamilton, Thomas Buell, David O. Okonkwo, Jeffrey Gum, Alekos Theologis, Praveen Mummaneni, Dean Chou, Gregory Mundis, Darryl Lau, Joshua Bunch, Brandon Carlson, Stephen Lewis, Justin Scheer, Robert Eastlack, Khaled Kebaish, Munish Gupta, Han Jo Kim, Alex Soroceanu, Anthony Mikula, Themistocles Protopsaltis, Mitsuru Yagi, Naobumi Hosogane, Lawrence Lenke, Richard Hostin, Justin Smith, Eric Klineberg, Christopher Ames, Frank Schwab, Shay Bess, Christopher Shaffrey, and International Spine Study Group. Spine, June.

Orthopaedics and Sports Medicine

A Porcine Model of Intervertebral Disc Injury Recapitulates Human Discogenic Pain Via Notochordal Cell Loss and Pain-Inducing Nucleus Pulposus Cell Emergence. Kaneda, Giselle, Jacob T. Wechsler, Melissa Chavez, Julia Sheyn, Karandeep Cheema, Chushu Shen, Dante Rigo De Righi, Lixia Wang, Yin-Chen Hsu, Pablo Avalos, Yibin Xie, Wafa Tawackoli, Candace Floyd, Debiao Li, and Dmitriy Sheyn. JOR Spine 9 (3): e70200.

Global Consensus on the Management of Primary Localized Chordoma. Radaelli, Stefano, Anna M. Frezza, Piero Fossati, Giacomo G. Baldi, Toru Akiyama, Jose M. Asencio, Stephanie Bolle, Judith V. M. G. Bovee, Augusto T. Caraceni, Gregory M. Cote, Nicolas Dea, Angelo P. Dei Tos, Global Chordoma Consensus Group, et al. JAMA Oncology, July.

Severe Multifocal Noninfectious Wound Dehiscence After Cavovarus Reconstruction in TRPV4-Associated Charcot-Marie-Tooth Disease Type 2C: A Case Report. Elhaddad, Moamen, Jacob Stibelman, Alexander Carrillo-Kashani, and Glenn Pfeffer. Foot & Ankle Specialist, July, 19386400261465090.

Pathology and Laboratory Medicine

Adapting Transformer-Based Encoder Models for Automated Billing Code Assignment of Current Procedural Terminology From Pathology Reports in Multi-Institutional Settings. Renner, Elijah, Om Patel, Sean McOsker, Minh-Khang Le, Yunrui Lu, Louis J. Vaickus, Anders Berg, Keluo Yao, and Joshua Levy. Journal of Pathology Informatics 22 (August): 100687.

On the Current Clinical Applicability of Artificial Intelligence in Pathology: An Evidence-Informed Clinical Readiness Review. Marchevsky, Alberto M., and Ann E. Walts. Annals of Diagnostic Pathology 85 (June): 152677.

Proteinuria Remission and Long-Term Kidney Outcome in Children With IgA Nephropathy. Coppo, Rosanna, Giuseppe Lucisano, Licia Peruzzi, Jie Ding, Xuhui Zhong, Yuko Shima, Koichi Nakanishi, Alexandra Cambier, Robert J. Wyatt, Zhi-Hong Liu, Ritsuko Katafuchi, Shoji Kagami, Yukio Yuzawa, Hong Xu, Francesco Emma, M. Coleen Hastings, Maria Luisa Russo, Daniela Isabel Abbrescia, Lee Er, Sean J. Barbour, Daniel C. Cattran, Mark Haas, Antonio Nicolucci, Francesco Paolo Schena, International IgA Nephropathy Network, VALIGA investigators, VALIGA pathology investigators, Oxford derivation and North American validation investigators, and International investigators. Nephrology, Dialysis, Transplantation, July, gfag153.

Real-World Evidence on Data Quality in Precision Oncology Platforms: Insights From the Molecular Twin Research Umbrella Protocol. Zuniga, Michael, Denis Marino, Yuan Yuan, Jin Sun Lee, Nazelee Dagliyan, Dominique Pope, Gangothri Namasivayam, Hui Hong, Grant Dagliyan, Warren G. Tourtellotte, Robert Figlin, and Karine Sargsyan. Frontiers in Digital Health 8: 1828544.

Small Biopsy Diagnosis of Anterior Mediastinal Masses: Histologic, Immunohistochemical, and Molecular Considerations. Lee, Jennifer, Jerry Wong, Karin Miller, and Alberto M. Marchevsky. Mediastinum 10: 28.

The Current Molecular Landscape of Endometrial and Ovarian Carcinomas: Insights and Practical Updates. Bhardwaj, Swati, and Natalie Banet. Seminars in Diagnostic Pathology 43 (4): 151033.

Pediatrics

Sensory Nerve-Derived Signaling Coordinates Oropharyngeal Structural Organization That Supports Suckling and Vocalization in Neonatal Mice. Cha, Sa, Jifan Feng, Tingwei Guo, Lin Meng, Peng Chen, Calista Ly, Thach-Vu Ho, Pedro A. Sanchez-Lara, Lauren E. McElvain, Jeffrey D. Moore, and Yang Chai. Nature Communications, July.

Tissue Tension Permits β-Catenin Phosphorylation to Drive Mesoderm Specification in Human Embryonic Stem Cells. Ayad, Nadia M. E., Aisha Almsoud, Johnathon N. Lakins, Ajinkya Ghagre, Allen J. Ehrlicher, Ophir D. Klein, FuiBoon Kai, and Valerie M. Weaver. Developmental Cell, July, S1534-5807(26)00238-8.

Psychiatry & Behavioral Neurosciences

Implementation and Sustainability of Hospital-Based Addiction Consultation Services. Evans, Sandra K., Allison J. Ober, Allyson Gittens, Alex Peltz, and Itai Danovitch. Addiction Science & Clinical Practice, July.

Surgery

A Novel lncRNA HUDRPC Suppresses Ferroptosis via the DDX5/DDIT3 Pathway to Promote Docetaxel Resistance in Prostate Cancer. Liang, Sudong, Yuanji Zheng, Xiaobo Wu, Furong Ji, Mierzhayiti Batuer, Qipeng Li, Zengke Qiu, Kaiwen Liu, Li Yang, Qingyi Zhu, and Jianzhong Lin. Cancer Letters 657 (July): 218727.

ASO Author Reflections: Evolving Axillary Management in Young Women With Breast Cancer. Boyle, Marissa K., and Armando E. Giuliano. Annals of Surgical Oncology, July.

Bone Grafting in Le Fort I Osteotomies: Multi-Institutional Data Analysis of Early Outcomes and Risk Factors. Bigus, Simon, Leonard Knoedler, Michael Alfertshofer, Helena Baecher, Tanas Ghassemi, Claudius Steffen, Samuel Knoedler, Benedikt Geldner, Alexandre G. Lellouch, Max Heiland, and Adriana C. Panayi. The Journal of Craniofacial Surgery, July.

Evaluation of Differences in Presentation and Postoperative Outcomes After Adrenalectomy for Pheochromocytoma According to Age. Jatana, Sukhdeep, Kevin Verhoeff, Yanbo Wang, Zhicheng Wang, Jiale Zhou, Xiaorong Wu, Yonghui Chen, Maciej Śledziński, Andrzej Hellmann, Marco Raffaelli, Francesco Pennestrì, Mark S. Sywak, Robert P. Sutcliffe, et al. Endocrine Connections, July, EC-25-0604.

Female Sex Is Associated With Improved Survival After Perioperative Immunotherapy in Resectable Non-Small Cell Lung Cancer. Krishna, Vikram, Claire Perez, Kellie Knabe, Bryan Navarro, Raffaele Rocco, Andrew R. Brownlee, Clark Fuller, Harmik J. Soukiasian, and Philicia Moonsamy. Journal of Thoracic Disease 18 (6): 616.

No Added Risk: National Outcomes of Magnetic Sphincter Explant With Hiatal Hernia Repair and Fundoplication. Wong, Sienna, Paul Wisniowski, Desmond Huynh, Yufei Chen, Kulmeet Sandhu, Scott Cunneen, and Miguel Burch. Surgical Endoscopy, July.

PDE5a Inhibition Restricts Cancer Metastasis by Disrupting NPC1-Mediated Cholesterol Trafficking Through a Non-Canonical cGMP-Dependent Pathway. Ariav, Yarden, Samah Hayek, Thomas Cantore, Neel Sanghvi, Lital N. Adler, Naama Darzi, Lipika R. Pal, David Robert Crawford, Tomer Malleron, Josh Silverbeck, Eliane Yardeni, Emma Hajaj, Efrat Ben-Zeev, Sanju Sinha, Shahar Ziman, Amir Shlomai, Sergey Malitsky, Maxim Itkin, Smadar Levin-Zaidman, Inna Goliand, Omer Goldman, Hila Tishler, Alexander Brandis, Tevie Mehlman, Yuri Kuznetsov, Noga Kozer, Karen Shamash, Ella Itzhaki, Neta Ben-Chaim Moskovits, Dean Ranmar, Salomon M. Stemmer, Shay Ben-Shachar, Eytan Ruppin, and Ayelet Erez. Cancer Research, July.

Photobiomodulation Therapy in Facial Aesthetic Surgery: A Systematic Review of Efficacy and Safety. Knoedler, Leonard, Jakob Fenske, Alessia Taggiasco, Romane Gaillard, Guilherme Franceschini Machado, Samuel Knoedler, Theodore Brown, Danni Yang, Kevin Sadati, Thomas Schaschinger, Haizam Oubari, Curtis L. Cetrulo Jr, and Alexandre G. Lellouch. Journal of Cosmetic Dermatology 25 (7): e71047.

Small Patients, High Stakes: The Challenge of Autonomy in Pediatric Surgery. Shue, Eveline H., and Eugene S. Kim. American Journal of Surgery, June, 117127.

Tryptophan Degradation by Intestinal Bacteroides Induces Anti-Tumor Immunity and Limits Melanoma Growth. Olea, Ximena Diaz, Kristin Beede, Gabriel Pereira, David Scott, Christopher Petucci, Eric Martens, Dmitri Rodionov, Aagam Shah, Miguel P. Martinez, Hyungsoo Kim, Ashok Kumar Sharma, Anthony Martin, Tongwu Zhang, Mark B. Faries, Omid Hamid, Suzanne Devkota, Andrei Osterman, Simon Knott, Emile E. Voest, Nadim J. Ajami, Jennifer Wargo, Amanda E. Ramer-Tait, and Ze’ev A. Ronai. Cell Reports. Medicine, July, 102921.

Urology

Development of a Unified Framework for Evaluating the Quality of Physician Communication in Prostate Cancer Treatment Consultations. Hernandez-Tirado, Alexander, Renning Zheng, Michael Luu, Nadine A. Friedrich, Paul Kokorowski, Judy Tan, and Timothy J. Daskivich. Medical Decision Making: An International Journal of the Society for Medical Decision Making, July, 272989X261458355.

Reply to Francesco Barletta, Chiara Mercinelli, Francesco Montorsi, et al. Re: Improved Survival With Enzalutamide in Biochemically Recurrent Prostate Cancer. Shore, Neal D., and Stephen J. Freedland. European Urology, July, S0302-2838(26)02156-1.

Cedars-Sinai Health Sciences University is advancing groundbreaking research and educating future leaders in medicine, biomedical sciences and allied health sciences. Learn more about the university.

“The majority of people who have a sudden cardiac arrest outside of a hospital will die, so the best protection is being aware of risk,” said Kyndaron Reinier, PhD, MPH, associate director of Epidemiology in the Center for Cardiac Arrest Prevention in the Smidt Heart Institute at Cedars-Sinai and an author of both studies. 

Sudden cardiac arrest happens when a problem with the heart’s electrical system causes the heart to stop beating. It is different from a heart attack, which is caused by a lack of blood flow to the heart. More than 350,000 people experience sudden cardiac arrest outside of a hospital in the U.S. each year, and only about 10% survive. 

Experts know that people with low left ventricular ejection fraction, when the heart’s main pumping chamber is weak and pumps less than it should, are at higher risk for sudden cardiac arrest. But this marker has become less effective and other indicators are needed to capture more people at risk.

“More than two-thirds of people who have cardiac arrest don’t have low left ventricular ejection fraction, so using this marker alone misses too many people,” Reinier said. 

A study published in the journal Circulation: Arrhythmia and Electrophysiology reports that warning symptoms combined with clinical history could predict imminent sudden cardiac arrest. A second study, published in the Journal of the American Heart Association (JAHA), reports that having more than one cardiac event over time could signal rising risk. 

Reading Warning Symptoms

In the Circulation: Arrhythmia and Electrophysiology study, investigators used machine learning to identify combinations of symptoms and medical history that best predicted sudden cardiac arrest in the near future. 

The study included people enrolled in two separate, longstanding studies in Oregon and Ventura County, California, that were founded by Sumeet Chugh, MD, director of the Center for Cardiac Arrest Prevention in the Smidt Heart Institute. The investigators compared 364 people who called 911 when experiencing symptoms such as chest pain and survived sudden cardiac arrest, with 313 people who called 911 for similar symptoms but did not experience sudden cardiac arrest. 

The analysis found that people with sudden cardiac arrest were more likely to have a combination of shortness of breath and diagnosed coronary artery disease or heart failure than people who did not experience sudden cardiac arrest. Seizure-like symptoms without chest pain or shortness of breath were also more common in people who experienced sudden cardiac arrest.

The investigators also found that chest pain combined with coronary artery disease predicted imminent arrest in women, while chest pain combined with heart failure predicted it in men. 

Warning symptoms most often occurred at least 15 minutes prior to the sudden cardiac arrest, a time frame that would make it possible to call 911. In earlier research, the investigators found that 81% of people delayed their 911 call, reducing their chances of successful revival by ambulance paramedics. 

These findings could be used to create risk-predicting algorithms for use by urgent care and emergency medicine providers, the investigators said. “While more research is needed, such risk prediction algorithms have the potential to avoid 911 call delays following warning symptoms of sudden cardiac arrest,” said Chugh, vice dean and chief AI health research officer at Cedars-Sinai.

Tracking Risk Over Time

The JAHA study was carried out in the Observational Study of Cardiac Arrest Risk (O.S.C.A.R.) cohort at Cedars-Sinai, established by Chugh, that has been tracking the health of approximately 400,000 residents of Los Angeles County from 2017 onward. Of these, the investigators followed more than 6,700 people hospitalized at Cedars-Sinai for heart failure and more than 2,900 people hospitalized in the health system for acute coronary syndrome, when an artery blockage reduces blood flow to the heart. 

Investigators found that patients in both groups who experienced a recurrent cardiovascular event faced a higher risk of sudden cardiac arrest. 

Patients who had a second coronary artery blockage were more than three times as likely to experience sudden cardiac arrest as those without a recurrence. Patients who were hospitalized a second time for heart failure were nearly twice as likely to experience sudden cardiac arrest. Risk climbed with each additional heart failure hospitalization. The investigators compared the findings to what was found in participants of the Framingham Heart Study, which enrolled participants about 50 years earlier. The results were similar, however the heart failure result in that study did not reach statistical significance.

Reinier said that physicians should consider sudden cardiac arrest as being more likely when a patient is hospitalized for a heart issue a second time.

“This may mean running additional tests,” Reinier said. “It may mean educating the patient about what cardiac arrest is and the importance of having a family member who knows to call 911 and start CPR immediately if their loved one collapses.”

Moving Beyond Dead Ends

Chugh, senior author of both studies, said the combined findings point toward a more flexible approach to prediction.

“Near-term and long-term predictions are parallel approaches that can help us move past roadblocks we face in preventing death from this lethal heart event,” Chugh said.

Additional research, including studies in different populations, are needed to confirm whether the factors the investigators studied could be used in prediction tools, study authors said. 

Cedars-Sinai investigators continue to study predictors of sudden cardiac arrest, and their work includes using AI to study patterns in heart tests called electrocardiograms and looking for genetic causes. 

Additional Cedars-Sinai authors in the Circulation: Arrhythmia and Electrophysiologystudy include Harpriya Chugh, BS; Vishnu Kadiyala, MD; Arayik Sargsyan, MPH; Audrey Uy-Evanado, MD; Kotoka Nakamura, PhD; Elizabeth Heckard, MS; Marco Mathias, BS.

Other authors include Tristan Grogan, MS; David Elashoff, PhD; Angelo Salvucci, MD; and Jonathan Jui, MD, MPH.

Funding: Dr. Chugh was funded by the National Heart Lung and Blood Institute, National Institutes of Health.

Additional Cedars-Sinai authors in the Journal of the American Heart Association study include Marita Knudsen Pope, MD, PhD; Harpriya Chugh, BS, MSHS; Thien Tan Tri Tai Truyen, MD; Marco Mathias, BS; and Audrey Uy-Evanado, MD.

Other authors include Honghuang Lin, PhD; Dan Atar, MD, Nichole Bosson, MD, MPH, and Emelia J. Benjamin, MD, ScM

Funding: The Framingham Heart Study is funded by the National Heart, Lung, and Blood Institute, National Institutes of Health. Dr. Benjamin is partially funded by The National Heart, Lung, and Blood Institute, National Institutes of Health.

Cedars-Sinai Health Sciences University is advancing groundbreaking research and educating future leaders in medicine, biomedical sciences and allied health sciences. Learn more about the university.

The preclinical study was published in Cell Reports Medicine. 

“Our study is the first to show how metabolites produced by select bacteria can induce changes in the body’s immune response when the body is fighting cancer,” said Ze’ev Ronai, PhD, director of the Translational Research Institute at Cedars-Sinai, professor of Surgery and senior author of the study. “Previous research established that gut bacteria affect the immune system and can help fight cancer. Our new findings are an important step forward because they give us a specific metabolite that can be used for future therapies.” 

The investigators focused on B. rodentium in the guts of mice and a related bacteria species, B. uniformis, in the guts of humans. When these bacteria break down the amino acid tryptophan, they produce different forms of metabolites called indoles. 

In laboratory mice, investigators found that treatment with B. rodentium restricted the growth of melanoma and colon, breast and pancreatic cancers, and that treatment with indole on its own restricted the growth of melanoma.

“Indole was more effective against these tumors than other metabolites produced by tryptophan breakdown, which are used in immunotherapies,” said Ximena Diaz Olea, a research scientist in the Ronai Lab and first author of the study. 

The investigators also looked at data from human patients who were responding well to immunotherapy for melanoma. In these patients, investigators found increased levels of the enzymes used to produce indole, suggesting higher levels of indoles were contributing to the patients’ good outcomes. 

“We are now evaluating whether increasing the levels of indoles in the gut would be sufficient to inhibit cancer,” Ronai said. “We hope to turn these findings into a therapy that will benefit patients.”

Investigators say this might be possible by giving patients capsules containing B. uniformis, then following up with nutrients to increase the bacteria’s reproduction and indole levels in the gut.

While this study focused on B. uniformis and B. rodentium, as many as 20 different bacteria species produce the enzyme that creates indole, opening further avenues for exploration, Ronai said. 

“These findings provide the foundation for modes of treatment that could complement or replace existing ones,” said Robert Figlin, MD, interim director of Cedars-Sinai Cancer. “This type of translational science paves the way toward new options for patients.” 

If investigators are successful at translating their findings into an anticancer therapy, Ronai said that it would likely be useful against many cancer types, as the immune cells bolstered by indole are effective against many cancers.

Additional Cedars-Sinai authors include Ximena Diaz Olea, Aagam Shah, Hyungsoo Kim, Ashok Kumar Sharma, Anthony Martin, Mark B. Faries, Omid Hamid, Suzanne Devkota, and Simon Knott.

Other authors include Kristin Beede, Gabriel Pereira, David Scott, Christopher Petucci, Eric Martens, Dmitri Rodionov, Miguel P. Martinez, Tongwu Zhang, Andrei Osterman, Emile E. Voest, Nadim J. Ajami, Jennifer Wargo, and Amanda E. Ramer-Tait.

Funding: This work was supported by the Cedars-Sinai shared resources in genomics, vivarium and microbiome studies; NCI grant R35CA197465 (to ZAR); the Hervey Family / San Diego Foundation (to ZAR); grant R21CA249822 (to ART and HK); and the Buffett Cancer Center funds (to ART) via NCI grant CA036727.

Cedars-Sinai Health Sciences University is advancing groundbreaking research and educating future leaders in medicine, biomedical sciences and allied health sciences. Learn more about the university.

Cedars-Sinai in the News

The Science of Fermented Food | The New York Times
Suzanne Devkota, PhD

Are Weight-Loss Drugs Also Longevity Drugs? | The New York Times
Nicolas Musi, MD

Fans Slam FIFA’s Cooling Breaks. Why the U.S. World Cup Team Doctor Disagrees | Los Angeles Times
Bert Mandelbaum, MD

Even High Amounts of Coffee May Lower Your Risk for Liver Disease | CNN
Hyunseok Kim, MD, MPH, PhD

Regular Users Can Tolerate Previously ‘Unsurvivable’ Amounts of Fentanyl | The New York Times
Itai Danovitch, MD

Navigating hATTR-CM: Why Self-Advocacy Matters | WebMD
Lily Stern, MD

What’s Top of Mind? 60 Healthcare Leaders Share Their No. 1 Priority for H2 2026 | Becker’s Hospital Review
Heitham Hassoun, MD

AI Found a Hidden Heart-Risk Signal in 100-Year-Old ECG Technology | Scientific American
Sumeet Chugh, MD

How Far and How Fast Should You Walk to Lower Blood Pressure, According to Experts | Health
Joseph Ebinger, MD

Higher Mortality Risk in Patients With IBS Using Antidepressants | Medscape
Ali Rezaie, MD

How Shingles Affects Your Body Now…And Later | HealthCentral
Sonja Rosen, MD

Mouneer Odeh, MA, Chief Data and Artificial Intelligence Officer at Cedars-Sinai | Becker’s Hospital Review/Becker’s Healthcare Podcast
Mouneer Odeh, MA

AI Is Transforming Cardiac Imaging—Often in Ways Clinicians Do Not Recognize | Cardiovascular Business
Damini Dey, PhD

Faculty Publications

Biomedical Sciences

Curcumin ((1E,6E)-1,7-Bis(4-Hydroxy-3-Methoxyphenyl)-1,6-Heptadiene-3,5-Dione) Induces Apoptosis-Like Death in Leishmania Amazonensis Promastigotes and Exhibits Leishmanicidal Activity in Infected Macrophages in Free and Beeswax-Based Nanoparticle Formulations. Carloto, Amanda Cristina Machado, Ana Carolina Jacob Rodrigues, Mariana Barbosa Detoni, Ellen Mayara Souza Cruz, Virgínia Márcia Concato-Lopes, Rodolfo Bento Balbinot, Fabrício Seidy Ribeiro Inoue, Yuri Barreiros, Arthur Poester Cordeiro, Pedro Henrique Hermes de Araújo, Claudia Sayer, Paulo Emílio Feuser, Celso Vataru Nakamura, Ivete Conchon-Costa, Danielle Lazarin-Bidóia, and Wander Rogério Pavanelli. Pathogens 15 (6): 650.

Human Astrocytes Keep Time With Inflammation. Burda, Joshua E. Neuron 114 (13): 2287–89.

Japanese Encephalitis in Nepal: Closing the Adult Immunity Gap. Gc, Alisha, Arzu Kunwar, Ankit Jaiswal, Binod Rayamajhee, and Binod Gc. Tropical Medicine and Health 54 (1): 123.

Machine Learning Multiorgan Analysis of Coronary CT Angiography Body Composition, Myocardial Infarction, and Mortality in the SCOT-HEART Trial. Ranieri Guimaraes, Alan, Steven E. Williams, Mark T. Macmillan, Kayleigh Wood, Chaoyang Wang, Jonathan R. Weir-McCall, Philip D. Adamson, Giles Roditi, Nicholas L. Mills, Marc R. Dweck, Marc Dewey, Jakob Wasserthal, Piotr J. Slomka, Damini Dey, David E. Newby, and Michelle C. Williams. Radiology 319 (3): e251821.

On the Misuse of Virus-Transformed Human Corneal Epithelial Cells as Surrogates for Normal Cells. Ljubimov, Alexander V., and Ruchi Shah. Investigative Ophthalmology & Visual Science 67 (6): 59.

Serial Changes in Epicardial Adipose Tissue Attenuation Identify Residual Atherosclerotic Risk Independent of LDL Lowering: A Post Hoc Analysis of the CAUGHT-CAD Trial. Khanna, Shaun, Edwin Xu, Cheng Hwee Soh, Sheran Vasanthakumar, Rhea Machado, Andrew Lin, Clare Arnott, Damini Dey, Stephen J. Nicholls, Thomas H. Marwick, and Nitesh Nerlekar. JACC. Cardiovascular Imaging, July, S1936-878X(26)00276-7.

The Arsenic-Alzheimer’s Disease Link: Emerging Evidence and Unanswered Questions. Dimas-Harms, Luz Jovita, and V. Alexandra Moser. Journal of Alzheimer’s Disease: JAD, July, 13872877261467042.

The Role of Supraoptic Hypothalamic Arginine Vasopressin Neurons in Aging-Associated Water Balance and Thermoregulatory Deficits in Male Mice. Morones, Nancy, Predrag Jovanovic, Anna M. Sanetra, Kaitlyn Jang, Nareg Keshishian, Zhihan C. Cui, Edward Novinbakht, Joshua J. Breunig, Anders H. Berg, Tamar Pirtskhalava, Selim Chaib, S. Ananth Karumanchi, Tamar Tchkonia, Katlin Silm, James L. Kirkland, and Celine E. Riera. Nature Communications, June.

Tumoricidal Efficacy of DZ-1 Dye Conjugated to Dihydroartemisinin in Patient-Derived Colorectal Liver Metastasis Tumoroids. Vafaeinik, Farzaneh, Badrinath Narayanasamy, Sarah Helmueller, Yi Zhang, Alexandra Gangi, Heuiran Lee, Cheryn Song, Robert Figlin, Karine Sargsyan, and Yong J. Lee. Molecular Therapy. Oncology 34 (3): 201257.

Cardiac Surgery

Authorship Asymmetry at the Women in Thoracic Surgery Inaugural Annual Conference: Gender Pairings and Senior Status Disparity. Lin, Nicole, Mariya Samoylova, Rebekah Boyd, Busra Cangut, Rajika Jindani, Marianna Papageorge, Tanisha Rajah, Sara Sakowitz, Madigan Stanley, Kaitlin Bevers, Laura DiChiacchio, Nimrat Grewal, Ammara A. Watkins, Stephanie Worrell, and Mara Antonoff. JTCVS Open 31 (June): 101725.

Expanding the Donor Pool - COVID-19-Positive Hearts in Pediatric Transplantation. Diaz-Castrillon, Carlos E., and Melita Viegas. The Annals of Thoracic Surgery, July, S0003-4975(26)00684-3.

Mid-Term Outcomes After Robotic Coronary Artery Bypass Grafting in the United States. Nammalwar, Shruthi, Adham Elsherbini, Aminah Sallam, Allen A. Razavi, Dominic Emerson, Michael E. Bowdish, Stephen Fremes, Fuad Moussa, Natalia Egorova, Joanna Chikwe, and Derrick Y. Tam. The Canadian Journal of Cardiology, June, S0828-282X(26)00638-0.

Transcatheter Versus Surgical Mitral Valve Repair in Patients Younger than 70 Years in the United States. Sallam, Aminah, Derrick Y. Tam, Armin Razavi, Betemariam Sharew, Rie Sakai Bizmark, Joann G. Elmore, Beth Glenn, James Macinko, Kristen R. Choi, Dominic Emerson, Michael Bowdish, Natalia Egorova, and Joanna Chikwe. The Annals of Thoracic Surgery, June, S0003-4975(26)00586-2.

Cardiology

A Clinically Interpretable AI System for Real-Time Quality Control of Transthoracic Echocardiography: Development, Validation, and Deployment. Shi, Zhongqing, Hanlin Cheng, Zhanru Qi, Chunjie Shan, Cynthia C. Taub, David Ouyang, Christopher Lee, Ruiyang Chen, Yue Du, Hexiang Weng, Yidi Chen, Sunnan Qian, Guanjun Guo, Xiaoxian Wang, Di Xu, Shouhua Luo, and Jing Yao. Journal of the American Society of Echocardiography, June, S0894-7317(26)00307-X.

AHA/ACC/ESC/WHF Expert Consensus Document: Second Universal Definition of Heart Failure (2026): AHA/ACC/ESC/WHF CONSENSUS DOCUMENT. Walsh, Mary Norine, Lars Kober, Karen Sliwa, Marianna Adamo, Anubha Agarwal, Amitava Banerjee, Biykem Bozkurt, Maja Cikes, Albertino Damasceno, Akshay S. Desai, G. Michael Felker, Gail Hogan, Koichiro Kinugawa, Michelle Kittleson, Carolyn S. P. Lam, Theresa McDonagh, Marco Metra, Wilfried Mullens, Antonio Luiz P. Ribeiro, Yolanda Vaughn, and Amanda Vest. European Heart Journal, June, ehag500.

AHA/ACC/ESC/WHF Expert Consensus Document: Second Universal Definition of Heart Failure (2026). Walsh, Mary Norine, Lars Kober, Karen Sliwa, Marianna Adamo, Anubha Agarwal, Amitava Banerjee, Biykem Bozkurt, Maja Cikes, Albertino Damasceno, Akshay S. Desai, G. Michael Felker, Gail Hogan, Koichiro Kinugawa, Michelle Kittleson, Carolyn S. P. Lam, Theresa Mcdonagh, Marco Metra, Wilfried Mullens, Antonio Luiz P. Ribeiro, Yolanda Vaughn, Amanda Vest, and Joint American Heart Association (AHA)/American College of Cardiology (ACC)/European Society of Cardiology (ESC)/World Heart Federation (WHF) Task Force for the Universal Definition of Heart Failure in collaboration With the Heart Failure Society of America (HFSA), the Heart Failure Association (HFA) of the European Society of Cardiology, and the Japanese Heart Failure Society (JHFS). Global Heart 21 (1): 51.

AI-Quantified Myosteatosis at CAC CT for Prediction of Atrial Fibrillation and Heart Failure: The Multi-Ethnic Study of Atherosclerosis. Azimi, Amir, Kyle Atlas, Anthony P. Reeves, Chenyu Zhang, Jakob Wasserthal, Seyed Reza Mirjalili, Thomas Atlas, Claudia I. Henschke, David F. Yankelevitz, Javier J. Zulueta, Jeffrey I. Mechanick, Andrea Branch, Ning Ma, Rowena Yip, Wenjun Fan, Sion K. Roy, Khurram Nasir, Sabee Molloi, Zahi A. Fayad, Michael V. McConnell, Ioannis A. Kakadiaris, George S. Abela, Rozemarijn Vliegenthart, David J. Maron, Jagat Narula, Kim A. Williams, Prediman K. Shah, Matthew J. Budoff, Daniel Levy, Emelia J. Benjamin, Nathan D. Wong, and Morteza Naghavi. Radiology. Cardiothoracic Imaging 8 (4): e250214.

Centers of Excellence Optimal Management Pathways for Atrial Fibrillation Specialty Services (COMPASS) Early Rhythm Control Treatment Care Pathway: A Quality Improvement Initiative. Sandhu, Roopinder K., Sean D. Pokorney, Sanghamitra Mohanty, Michelle Moore, Andrea Natale, Anne Marie Smith, T. Jared Bunch, and Jonathan P. Piccini. Heart Rhythm O2 7 (6): 1175–81.

Clinical Triage of Individuals With Warning Symptoms of Imminent Cardiac Arrest. Reinier, Kyndaron, Harpriya Chugh, Vishnu Kadiyala, Arayik Sargsyan, Audrey Uy-Evanado, Kotoka Nakamura, Elizabeth Heckard, Marco Mathias, Tristan Grogan, David Elashoff, Angelo Salvucci, Jonathan Jui, and Sumeet S. Chugh. Circulation. Arrhythmia and Electrophysiology, July, e014647.

Comparing Incidence of Heart Failure in Individuals With Enlarged Cardiac Chambers Versus Diabetes. Mirjalili, Seyed Reza, Kyle Atlas, Anthony P. Reeves, Chenyu Zhang, Jakob Wasserthal, Amir Azimi, Ali Hashemi, Mohammadhossein Mozafarybazargany, Amir Ghaffari Jolfayi, Thomas Atlas, Claudia I. Henschke, David F. Yankelevitz, Javier J. Zulueta, Jeffrey Mechanick, Andrea D. Branch, Ning Ma, Rowena Yip, Wenjun Fan, Sion K. Roy, Khurram Nasir, Sabee Molloi, Zahi Fayad, Michael V. McConnell, Ioannis A. Kakadiaris, George Abela, Rozemarijn Vliegenthart, David J. Maron, Jagat Narula, Kim A. Williams, Prediman K. Shah, Matthew J. Budoff, Daniel Levy, Roxana Mehran, Robert A. Kloner, Nathan D. Wong, and Morteza Naghavi. American Journal of Preventive Cardiology 29 (October): 101656.

Differences of Plaque Burden Measures on CCTA in Younger Men and Women. Asif, Anum, C. Noel Bairey Merz, Heidi Gransar, Donghee Han, Martha Gulati, Alan Rozanski, John D. Friedman, Sean W. Hayes, Louise E. J. Thomson, Damini Dey, Balaji Tamarappoo, and Daniel Berman. American Journal of Preventive Cardiology 29 (October): 101602.

Double Transseptal Guide Sheath Technique to Prevent Low Dock Positioning During Transcatheter Mitral Valve Replacement. Hu, Jiun-Ruey, Adishwar Singh, George Thornton, Jarmanjeet Singh, Apurva Bharucha, Christopher Rajkumar, Dhairya Patel, Wen Cheng, Aakriti Gupta, Moody Makar, and Raj Makkar. JACC. Cardiovascular Interventions, June, S1936-8798(26)01733-4.

How to Apply the DAZE Technique: Structured Approach to Fetal Cardiac Image Optimization. Perez, M., M. Sklansky, T. Anton, K. J. Stauffer, R. Basu, and D. Pretorius. Ultrasound in Obstetrics & Gynecology, 68 (1): 130–39.

Impact of Fenestration on Survival and Morbidity Following Fontan Surgery: A Time-to-Event Meta-Analysis of Reconstructed Kaplan-Meier Data. Ganduboina, Rohit, Jef Van den Eynde, Xander Jacquemyn, Omar Abdel Kerim, and Sandeep Sainathan. World Journal for Pediatric & Congenital Heart Surgery, June, 21501351261450496.

Inflammation, Metabolism, and Aging in Heart Failure With Preserved Ejection Fraction: Mechanisms and Treatment Perspectives. Teng, Yaqun, Weikang Bian, Qingyu Li, Jennifer E. Van Eyk, Xiaowei Yan, and Shuyang Zhang. Journal of Translational Internal Medicine 14 (3): 379–97.

Interlaboratory Comparison of a Glucagon and Oxyntomodulin Immuno-LC-MS/MS Assay: Implications for Diabetes Research. Moradian, Annie, Jessica O. Becker, Lorenz A. Nierves, Tai-Tu Lin, Salvatore Sechi, Michael J. MacCoss, Wei-Jun Qian, Jennifer E. van Eyk, and Andrew N. Hoofnagle. Clinical Chemistry, July, hvag078.

Leveraging Large Language Models to Identify In-Hospital Cardiac Arrest. Vo, Jonathan, Davy Weissenbacher, Kyndaron Reinier, Harpriya Chugh, Audrey Uy-Evanado, Karen O’Connor, Sumeet S. Chugh, and Graciela Gonzalez-Hernandez. JACC. Clinical Electrophysiology, June, S2405-500X(26)00532-3.

Long-Term Outcomes of Patients Receiving Dialysis and Undergoing Transcatheter Aortic Valve Replacement With Contemporary Balloon-Expandable Valves. Shitan, Hidemasa, Vivek Patel, Kazuki Suruga, Yuchao Guo, Daniel Ng, Brittany Cole, Aakriti Gupta, Tarun Chakravarty, Wen Cheng, Yuito Okada, Hasan Jilaihawi, Mamoo Nakamura, and Raj R. Makkar. International Journal of Cardiology. Heart & Vasculature 65 (August): 101959.

Paclitaxel-Coated Balloon Versus Uncoated Balloon for Coronary In-Stent Restenosis: Two-Year Follow-Up of the AGENT-IDE Randomized Clinical Trial. Moses, Jeffrey, Jiho Han, Richard Shlofmitz, William Bachinsky, Suhail Dohad, Steven Rudick, Robert Stoler, Brian K. Jefferson, William Nicholson, John Altman, Cinthia Bateman, Amar Krishnaswamy, J. Aaron Grantham, Frank J. Zidar, Jennifer A. Tremmel, Cindy Grines, Mustafa I. Ahmed, Azeem Latib, Behnam Tehrani, J. Dawn Abbott, Wayne Batchelor, Rafael Cavalcante, Ajay J. Kirtane, Robert W. Yeh, and AGENT IDE Investigators. Circulation 154 (1): 63–65.

Paternal Age and Adverse Pregnancy Outcomes: A Spline Analysis From the Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-Be Study. Conley, Patrick M., Rachel A. Newman, Tania Esakoff, and Natalie A. Bello. The Journal of Maternal-Fetal & Neonatal Medicine, 39 (1): 2686069.

Preconception Cardiometabolic Markers and Odds of Developing Adverse Pregnancy Outcomes: Results From the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). Pabon, Maria A., Danielle N. Tapp, Madison Pico, Catherine J. Vladutiu, Christian Schmidt, Emily DeFranco, Shathiyah Kulandavelu, Tali Elfassy, Margo B. Minissian, Natalie A. Bello, C. Noel Bairey Merz, Nour Makarem, Michelle L. Meyer, Krista M. Perreira, Yanping Teng, Martha Daviglus, Michelle A. Kominiarek, Carlos J. Rodríguez, Barry E. Hurwitz, Gregory A. Talavera, Susan Cheng, and Odayme Quesada. American Journal of Preventive Cardiology 28 (August): 101494.

Prosthesis-Patient Mismatch With Intra-Annular Self-Expanding Valves: An Analysis of the PORTICO IDE Trial. Fontana, Gregory P., Ron Waksman, Arash Salemi, Marc Cohen, William Abernethy, James Hermiller, Craig Baker, Joseph Montarello, Neal Kleiman, Lars Sondergaard, Eric Gnall, Roberto Rodriguez, Hemal Gada, William Brinkman, Neil J. Weissman, Paul Mahoney, and Raj Makkar. EuroIntervention: Journal of EuroPCR in Collaboration With the Working Group on Interventional Cardiology of the European Society of Cardiology 22 (13): e741–47.

Racial Differences in Adverse Pregnancy Outcomes and Incident Hypertension: A Mediation Analysis. Petito, Lucia C., Xiaoning Huang, C. Noel Bairey Merz, Natalie Bello, Janet Catov, Ernesto Licon, Abbi Lane, David M. Haas, Lisa D. Levine, Rebecca B. McNeil, Eliza Miller, Uma M. Reddy, Bethany Barone Gibbs, George Saade, Lauren Theilen, Laura E. Wiener, Brian M. Mercer, Hyagriv N. Simhan, Lynn M. Yee, Philip Greenland, William A. Grobman, and Sadiya S. Khan. Journal of the American Heart Association 15 (13): e035681.

Sex-Based Differences in Clinical Outcomes Among Cardiogenic Shock Patients Treated With Mechanical Circulatory Support. Olumuyide, Emmanuel, Ju Young Bae, Rongras Damrongwatanasuk, Ezaz Rahman, Barbara Malaga-Espinoza, Jiun-Ruey Hu, and S. Elissa Altin. Journal of Thrombosis and Thrombolysis, June.

Real-World Outcomes of Dedicated Leaflet Modification for Bioprosthetic Valve-In-Valve TAVR: A 150-Patient Commercial Experience. Makkar, Raj R., Aakriti Gupta, Ignacio Inglessis, Curtiss T. Stinis, Pradeep K. Yadav, Vinod H. Thourani, Stanley J. Chetcuti, Matthew Summers, Vivek Patel, Bassem M. Chehab, Apurva Patel, Gilbert H. L. Tang, Sahil Khera, Michael Rinaldi, Trevor Simard, Jeffrey Southard, Benjamin R. Stripe, Brian Whisenant, Keith Allen, Yoseph Rozenman, Danny Dvir, Carlos E. Sanchez, Jeffrey Popma, Martin B. Leon, and Philippe Généreux. JACC. Cardiovascular Interventions, June, S1936-8798(26)01732-2.

The Association of Eicosanoids With Lung Structure and Function: Findings From the Multi-Ethnic Study of Atherosclerosis Lung Study and Framingham Heart Study. Ambatipudi, Mythri, Jenna N. McNeill, Athar Roshandelpoor, Mona Alotaibi, Louisa A. Mounsey, Eric Hoffman, George O’Connor, Seung Hoan Choi, Norrina B. Allen, R. Graham Barr, Mohit Jain, Susan Cheng, and Jennifer E. Ho. PloS One 21 (6): e0351692.

The Epilepsy-Cog Study: Methods to Establish a Harmonized Study of Late Onset Epilepsy in a Metacohort of Six Population-Based Cohorts in the United States. Choi, Hyunmi, Jose Gutierrez, Tian Wang, Minghua Liu, Cheng-Shiun Leu, Sylwia Misiewicz, Jiying Han, Natalie Bello, Mary L. Biggs, Emily M. Briceño, Adam M. Brickman, James F. Burke, Ligong Chen, Lisandro D. Colantonio, Stefany P. Diaz Andino, Mitchell S. V. Elkind, Annette L. Fitzpatrick, Christopher Gonzalez Corona, Rebecca F. Gottesman, Alden L. Gross, Lei Huang, Emily L. Johnson, W. Craig Johnson, Deborah A. Levine, W. T. Longstreth, Sofia Pelagalli Maia, Richard P. Mayeux, Brian C. Petersen, Oluwadamilola Obalana, Dolly Reyes-Dumeyer, Tatjana Rundek, Danurys Sanchez, Steven J. Shea, Kevin Strobino, Carolyn W. Zhu, and Evan L. Thacker. Epilepsia, July.

Variability in Cardiac Stress Test Interpretation: Agreement Between Enrollment Sites and Core Laboratories in the Global ISCHEMIA Trial. O’Keefe, Evan, Brett W. Sperry, Philip G. Jones, James H. O’Keefe, Lawrence M. Phillips, Harmony R. Reynolds, Leslee J. Shaw, Daniel S. Berman, Michael H. Picard, Raymond Y. Kwong, Bernard R. Chaitman, Timothy M. Bateman, Sripal Bangalore, David J. Maron, Judith S. Hochman, John A. Spertus, and ISCHEMIA Research Group. Circulation. Population Health and Outcomes, July, e012920.

Computational Biomedicine

Cardiac Risk After Heart-Sparing Breast Radiotherapy. Quirk, Sarah, Katelyn M. Atkins, Natalie Logie, Robert J. H. Miller, Christian Guthier, Raymond H. Mak, Laura E. G. Warren, Cody Ramin, Abdulla Al-Rashdan, Jean L. Wright, and Michael Roumeliotis. JAMA Oncology, July, e262066.

Night Watch: A Survey of Older Adult Sleep-Tracking. Hoffmann, Thomas James, and Lisa Gualtieri. Behavioral Sciences 16 (6): 917.

Optimized Phenotype Definitions Boost GWAS Power. Zietz, Michael, Kathleen LaRow Brown, Undina Gisladottir, and Nicholas P. Tatonetti. PLoS Computational Biology 22 (7): e1014431.

Protocol for Constructing Multi-Ancestry Polygenic Models Using S4-Multi. Lai, Ping-Hung, Jonathan P. Tyrer, John Baierl, Paul D. P. Pharoah, and Pei-Chen Peng. STAR Protocols 7 (3): 104681.

Tutorial: Using Random Forest Analysis to Identify Auxiliary Variables of Missing Data. Coxe, Stefany, Amanda N. Baraldi, and Timothy Hayes. Prevention Science, July.

Emergency Medicine

Do Hospitals Turn Away Ambulances Only When Busy, or When Their Peers Do? Lin, Jiangheng, Gengbin Piao, and Kimon L. H. Ioannides. Annals of Emergency Medicine, July, S0196-0644(26)00377-X.

Opioid Use and Pain Resolution for Acute Pain Among Opioid-Naive Patients. Jeffery, Molly Moore, Fernanda Bellolio, Nancy Chang, Summer Allen, Marie-Carmelle Elie-Turenne, W. Jonathan Fillmore, Gregg H. Gilbert, Rebekah Heckmann, Patricia Koussis, Christine Lee, Heather Lipkind, Tamra E. Meyer, Teryl K. Nuckols, Jessica D. Ritchie, Michael A. Pacanowski, David B. Page, Mat Soukup, Stephen Tamang, Sam Torbati, Doug Wallace, Lauren Walter, Yueqin Zhao, Nilay D. Shah, Mitra Ahadpour, and Joseph S. Ross. JAMA Network Open 9 (7): e2621875.

Imaging

Superficial Siderosis and a Spinal Cord Cleft. Schievink, Wouter I., Marcel M. Maya, and Michael Levy. JAMA Neurology, June, 1–2.

Medicine

Adjuvant Radiation Therapy Is Not Associated With Improved Survival in Low-Risk Localized Merkel Cell Carcinoma: An Analysis of the National Cancer Database. Kasheri, Eli, Zachary S. Zumsteg, Vijay Kodumudi, Nima Gharavi, and Amanda Rosenthal. Journal of the American Academy of Dermatology, July, S0190-9622(26)03049-5.

Adult Chronic Pancreatitis Working Group: Goals, Accomplishments and the Path Ahead. A Report From the Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer. Yadav, Dhiraj, Liang Li, Dana K. Andersen, Melena D. Bellin, Zobeida Cruz-Monserrate, Willian Fisher, Evan L. Fogel, Christopher E. Forsmark, Phil A. Hart, Bomi Lee, Tonya Palermo, Stephen J. Pandol, Walter G. Park, Jami Saloman, Jose Serrano, Temel Tirkes, Mark D. Topazian, Stephen van Den Eeden, Santhi Swaroop Vege, Darwin L. Conwell, and Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (CPDPC). Pancreas, April.

An Approach to Globus Sensation: Clinical Pearls for Clinicians. Naik, Ilora, Neelaysh Vukkadala, and Amrit K. Kamboj. Mayo Clinic Proceedings 101 (7): 1202–10.

Atg5 Deficiency Alters Myofibroblast Accumulation and Alveolar Regeneration in Lung Fibrosis. Li, Xue, Guiying Xu, Qi Wang, Qingwen Ma, Xue Liu, Hongwei Li, Sisi Wang, Yimeng Liu, Yueyue Jin, Xuan Miao, Zuokuan He, Jinrui Dong, Kuan Li, Jianhai Wang, Yu Li, Qiuyang Zhang, Dianhua Jiang, Junping Wu, Wen Ning, and Huaiyong Chen. Stem Cell Reports, July, 102979.

Automated AI-Based Aortic Measurements From Attenuation Correction CT as an Adjunctive Cardiovascular Risk Biomarker: An International Multicenter Study. Marcinkiewicz, Anna M., Aakash Shanbhag, Panithaya Chareonthaitawee, Wenhao Zhang, Hasanian Al-Jilaihawi, Ryan Zaid, Sebastien Cadet, Giselle Ramirez, Mark Lemley, Jirong Yi, Waseem Hijazi, Valerie Builoff, Joanna X. Liang, Vinicius F. Calsavara, Andrew J. Einstein, Edward Miller, Attila Feher, Terrence D. Ruddy, Viet T. Le, Steve Mason, Stacey Knight, Erick Alexanderson, Isabel Carvajal-Juarez, Leandro Slipczuk, Mark I. Travin, Thomas L. Rosamond, Samuel Wopperer, Daniel S. Berman, Damini Dey, Marcelo Di Carli, Robert J. H. Miller, and Piotr J. Slomka. Circulation. Cardiovascular Imaging, July, e019726.

Beyond Medication: Integrative and Nutrition Therapies for Disorders of Gut-Brain Interaction. Thakur, Elyse R., Kate Scarlata, Brennan Spiegel, and David J. Hass. Gastroenterology & Hepatology 22 (4): 177–87.

Clinical Images: Skin Manifestations and Radiographic Findings of Anti-SAE1 Positive Dermatomyositis. Seng, Amara, George Matcuk, Wonwoo Shon, Lindsy Forbess, and Mariko L. Ishimori. ACR Open Rheumatology 8 (7): e90100.

Coffee Consumption and Improved Liver Outcomes: Clinical, Imaging, and Proteomic Evidence From the UK Biobank. Kim, Hyun-Seok, Mohammad Saeid Rezaee-Zavareh, Yufeng Wang, Abdelrahman M. Attia, Minsun Kwak, Seungwon Burm, Derin Celtik, Daniel Legaspi, Osama Khattab, Naomy Kim, Beza M. Mengistu, Kelsey N. Larios, David Sooik Kim, Walid Ayoub, Alexandar Kuo, Paul Martin, Aarshi Vipani, Yun Wang, Suthat Liangpunsakul, Debiao Li, Shelly C. Lu, Stephen Pandol, and Ju Dong Yang. Clinical Gastroenterology and Hepatology, July, S1542-3565(26)00404-0.

Considerations in Reviewing Network Meta-Analyses of Heterogeneous Clinical Trial Designs: A Methodological Review in Crohn’s Disease and Ulcerative Colitis. Ma, Christopher, Eric B. Collins, Si-Tien Wang, Yixi Teng, Warren Stevens, Remo Panaccione, Dolly Sharma, Namita Joshi, Pierre A. Morisset, Raja Atreya, and Gil Y. Melmed. Crohn’s & Colitis 360 8 (2): otag050.

Differences in Overall Survival for Invasive Epithelial Ovarian Cancer by Race and Ethnicity: Results From the Ovarian Cancer Association Consortium. Meagher, Nicola S., Kami K. White, Lynne R. Wilkens, Hoda Anton-Culver, Elisa V. Bandera, Michael E. Carney, Daniel W. Cramer, Kara L. Cushing-Haugen, Anna DeFazio, Jennifer A. Doherty, Aleksandra Gentry-Maharaj, Ellen L. Goode, Marc T. Goodman, Holly R. Harris, Beth Y. Karlan, Scott H. Kaufmann, Linda E. Kelemen, Martin Köbel, Jennifer M. Koziak, Loic Le Marchand, Jenny Lester, Valerie McGuire, Usha Menon, Francesmary Modugno, Kirsten B. Moysich, Celeste Leigh Pearce, Paul D. P. Pharoah, Malcolm C. Pike, Bo Qin, Harvey A. Risch, Joseph H. Rothstein, Danja Sarink, Weiva Sieh, Helen Steed, Kathryn L. Terry, Pamela J. Thompson, Linda J. Titus, Toon Van Gorp, Alice S. Whittemore, Stacey J. Winham, Susan J. Jordan, Anna H. Wu, Penelope M. Webb, AOCS Group, Lauren C. Peres, and Melissa A. Merritt. British Journal of Cancer, June.

Double-Balloon Enteroscopy for Luminal Evaluation of the Excluded Stomach: A Retrospective Multicenter Analysis. Albares, Peter, F. Otis Stephen, Lauren Pioppo-Phelan, Catherine Hudson, Alice Parish, Iris Vance, Jason Stibbe, Donna Niedzwiecki, and Daniel Wild. iGIE: Innovation, Investigation and Insights 5 (2): 161-166.e1.

Excessive Epithelial Mechanosensation Drives Nociceptive Innervation and Chronic Bladder Pain via the PIEZO1-SLC7A11-Glutamate Axis. Kim, Min Jung, Joo Hwan Noh, Ho Young Lee, Bohm Lee, Alexander Doh Park, Hyeonseo Oh, Geun-Woo D. Kim, Hye-Sook Lee, Yeonsoo Oh, Hyeonje Hwang, Chungoo Kim, Hyeonjong Lee, Xue Li, Mi Mi Oh, Donghoon Lim, Soman N. Abraham, Yongcheol Cho, Sung Wook Chi, and Hae Woong Choi. Cell, June, S0092-8674(26)00649-5.

Expert Clinical Consensus on Body Surface Gastric Mapping Phenotypes for Gastroduodenal Disorders: ‘Auckland Classification’ v1.0. Varghese, Chris, Nicky Dachs, Gabriel Schamberg, Thomas Abell, Mohammad Al-Haddad, Timothy Robert Angeli-Gordon, Shahin Ayazi, Homira Ayubi, Mohammad Bashashati, Robert Bulat, Stefan Calder, Christopher Brian Cederwall, Greg O’Grady, et al. Neurogastroenterology and Motility 38 (7): e70377.

How AI Will Transform the Care of Patients With DGBIs. Spiegel, Brennan. Gastroenterology & Hepatology 22 (5): 269–72.

Improved Outcomes With TKI Maintenance Following Brexucabtagene Autoleucel in Philadelphia-Chromosome ALL. Othman, Tamer, Gregory W. Roloff, Katharine Miller, Amy Zhang, Katherine C. Sutherland, Rawan G. Faramand, LaQuisa C. Hill, Ibrahim N. Muhsen, Nikeshan Jeyakumar, Abdullah Ladha, Joshua P. Sasine, Chenyu Lin, Noam E. Kopmar, Stephanie B. Tsai, Timothy E. O’Connor, Talal Hilal, Melhem M. Solh, Caitlin Guzowski, Virginia Tan, Navneet S. Majhail, Minoo Battiwalla, Shahbaz A. Malik, John Mathews, Paul J. Shaughnessy, Luke Mountjoy, Kaitlyn C. Dykes, Aaron C. Logan, Marc S. Schwartz, Matthew P. Connor, Jiasheng Wang, Sumithira Vasu, Muthu Kumaran, Rasmus T. Hoeg, Sean I. Tracy, Fevzi Firat Yalniz, George Yaghmour, Vinod A. Pullarkat, Ryan D. Cassaday, Jessica T. Leonard, Bijal D. Shah, Noelle V. Frey, Lori S. Muffly, and Ibrahim Aldoss. Blood Advances, June, bloodadvances.2026020707.

Incidence of Gastrointestinal Adverse Events and Healthcare Resource Utilization in Patients Using Glucagon-Like Peptide-1 Analogs: A Real-World Study. Nathani, Piyush, Sevag Hamamah, Jena Velji, Harsh K. Patel, Rohit Nathani, Dhruvil Radadiya, Aarnav Shandilya, Sachin Srinivasan, Madhav Desai, Alessandro Repici, Cesare Hassan, and Prateek Sharma. Digestive Diseases and Sciences, July.

Linear Gingival Erythema Presenting in Systemic Lupus Erythematous. Green, Brianna Ashley, and Jimmy Lam. Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases, April.

Rapid Peak Cilta-Cel Expansion Is Associated With Delayed Neurotoxicity in Multiple Myeloma. Hosoya, Hitomi, Arash Velayati, Danai Dima, Alexandria Jensen, Andrew J. Portuguese, Vanna Hovanky, Lekha Mikkilineni, Lauren C. Peres, Ariel F. Grajales-Cruz, Sylvester Homsy, Masooma Shifa Rana, Juancarlos Cancilla, Sunita Patil, Bita Sahaf, Theresa Latchford, Ciara L. Freeman, Brian J. Scott, Kun Wei Song, Omar Alexis Castaneda-Puglianini, Humza Khan, Saurabh Dahiya, Frederick L. Locke, Crystal L. Mackall, David B. Miklos, Rahul Banerjee, Doris K. Hansen, Melissa Alsina, and Surbhi Sidana. Blood, July, blood.2025032844.

Real-World Outcomes With BCMA- and GPRC5D-Targeting Bispecific Antibodies in Plasma Cell Leukemia. Gaballa, Mahmoud R., Kelley Julian, Aimaz Afrough, Doris K. Hansen, Utkarsh Goel, Andre De Menezes Silva Corraes, Danai Dima, Masooma Shifa Rana, Hitomi Hosoya, Lekha Mikkilineni, Lindsay Fogel, Shahzad Raza, Douglas W. Sborov, et al. Blood Advances, July, bloodadvances.2026020826.

Targeting Cellular Senescence in Dermatology: Senolytic and Senomorphic Strategies. Haykal, Diala, Frederic Flament, Lilit Garibyan, Kachiu Lee, Julie Escot, Audrey Gueniche, and James Kirkland. GeroScience, July.

The Association Between 6-Thioguanine Nucleotide Levels, Adalimumab Exposure, Immune Response, and Drug Clearance. Yarur, Andres, Jonathan C. Lo, Bincy Abraham, Stephen Hanauer, and Thierry Dervieux. Crohn’s & Colitis 360 8 (2): otag053.

Transcriptomics Profiles in Intestinal Sulfide Overproduction, Small Intestinal Bacterial Overgrowth, and Intestinal Methanogen Overgrowth. Freitas Germano, Juliana de, Gabriela Leite, Maria Jesus Villanueva-Millan, Daniel Brimberry, Mohamad Rashid, Ava Hosseini, Dilara Flor, Said Bogatyrev, Walter Morales, Stacy Weitsman, Maritza Sanchez, Ignacio Rivera, Cristina Moreno Fajardo, Victoria Murray, Gonzalo Parodi, Margie Parra, Zhe Lyu, Gillian M. Barlow, Ali Rezaie, Ruchi Mathur, and Mark Pimentel. mSystems, June, e0045826.

Transforming Preeclampsia Care: Molecular Diagnostics and Therapeutic Innovations. Thadhani, Ravi, and S. Ananth Karumanchi. Journal of the American Society of Nephrology: JASN, July.

Neurology

Disinhibitory Signaling Enables Flexible Coding of Top-Down Information in Cortical Networks. Aquino, Tomas G., Robert Kim, and Nuttida Rungratsameetaweemana. PLoS Biology 24 (7): e3003831.

Reduced Penetrance in Genetic ALS/FTD Spectrum Disorders: Implications for Genetic Counseling, Predictive Testing and Treatment. Harrington, Elizabeth A., Laynie Dratch, Tara A. Jones, Jamie C. Fong, Daniel D. Kinnamon, Jill Goldman, Wendy R. Uhlmann, and Jennifer Roggenbuck. Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration, July, 1–12.

The ‘Brain’s Traffic Map’ Reveals Neural Pathways Linked to Coronary Microvascular Dysfunction in Women. Has Silemek, Arzu C., Jeffrey C. Wertheimer, Janet Wei, Yibin Xie, Mitzi Gonzales, Debiao Li, Oana Dumitrascu, Sarah Kremen, Zaldy S. Tan, Micheal D. Nelson, C. Noel Bairey Merz, Pascal Sati, and Wei Gao. Brain and Behavior 16 (6): e71559.

Neurosurgery

Biomechanical Effects of a Unilateral Transforaminal Endoscopic Approach for Lumbar Decompression: A Cadaveric Study. Elhamdani, Shahed M., Aidan K. Copinga, Owen G. Corcoran, Praveer S. Vyas, Jahan Aslami, Cody J. Woodhouse, Dallas E. Kramer, Corey T. Walker, Ryan D. Sauber, Alexander K. Yu, and Boyle C. Cheng. Spine, June.

Early Findings From the Multicenter RAPID Consortium on Papillary Craniopharyngiomas. Catalino, Michael P., Duy Pham, Robert C. Rennert, William T. Couldwell, James J. Evans, Calen Callopy, Won Kim, Donato Pacione, Carter M. Suryadevara, Albert Kim, Julie Silverstein, Michael Chicoine, Paul A. Gardner, Garni Barkhoudarian, Juan C. Fernandez Miranda, Carolina Benjamin, Varun R. Kshettry, Gabriel Zada, Jamie J. Van Gompel, Sandhya R. Palit, Nathan Zwagerman, Stephanie Cheok, Daniel Prevedello, Kyle C. Wu, Adam Mamelak, Mark Pacult, Andrew Little, and Michael Karsy. Journal of Neurological Surgery. Part B, Skull Base 87 (4): 406–13.

Hierarchical Learning Creates Invariant Schema Within Plastic Neural Networks. Elder, James R., Jie Zheng, Lydia B. Shimelis, Ueli Rutishauser, and Milo M. Lin. Journal of Computational Neuroscience, June.

Infection Following Cervical Artificial Disc Replacement. Shahrestani, Shane, Anubhav Chandla, Adeesya Gausper, Andy M. Liu, Suhas K. Etigunta, Todd Lanman, Jason Cuellar, Terrence T. Kim, J. Patrick Johnson, Christopher Mikhail, David L. Skaggs, Justin K. Scheer, Alexander Tuchman, Corey T. Walker, Eli M. Baron, and Tiffany Grace Perry. Neurosurgical Focus 61 (1): E6.

MAD-MT Score: A Tool to Optimize Patient Selection for Mechanical Thrombectomy in Distal Vessel Occlusions. Chen, Huanwen, Dhairya A. Lakhani, Hamza Adel Salim, Marco Colasurdo, Vivek Yedavalli, Basel Musmar, Nimer Adeeb, Davide Simonato, Yan-Lin Li, Muhammed Amir Essibayi, Orabi Hajjeh, Nils Henninger, MAD-MT Investigators, et al. Stroke, July.

OBGYN

Standard vs. Lower Pressure Pneumoperitoneum in Laparoscopic Gynecologic Surgery: A Randomized Controlled Trial. Schneyer, Rebecca, Raanan Meyer, Ogechukwu Ezike, Connie Liao, Kelly Wright, Kacey Hamilton, Liron Bar-El, Katharine Ciesielski, and Matthew Siedhoff. American Journal of Obstetrics and Gynecology, July, S0002-9378(26)00351-0.

Orthopaedics and Sports Medicine

Beyond the Usual Suspects: Recognizing Calcified Chondroid Mesenchymal Neoplasm in Hand Soft Tissue Tumors. Weldon, Edward J., Benjamin H. Weldon, David A. Kulber, and Stuart H. Kuschner. Plastic and Reconstructive Surgery. Global Open 14 (7): e7922.

Healing Indices Are Poorly Standardized in Distraction Osteogenesis Literature. Huang, Anna Y., Mitchell Bernstein, James A. Blair, Steffen Rosslenbroich, John Scolaro, and Geoffrey S. Marecek. Injury 57 (10): 113362.

Preoperative Alignment and Risk of Proximal Junctional Failure: A Framework for Upper Instrumented Vertebra Selection in Adult Spinal Deformity. Hills, Jeffrey, Lawrence G. Lenke, Justin S. Smith, Christopher I. Shaffrey, Virginie Lafage, Renaud Lafage, Shay Bess, Michael P. Kelly, International Spine Study Group, International Spine Study Group member, Jay Turner, Juan Uribe, Scott Zuckerman, et al. The Bone & Joint Journal 108-B (7): 943–51.

Quadriceps Injuries in Major League Soccer: A 10-Year Analysis of Injury Rate, Return-to-Play, and Performance Metrics. Forsythe, Brian, Catherine Hand, Camden Bohn, Daanish Khazi-Syed, Joshua Chang, Francis Hand, Harmanjeet Singh, Andrew Savoia, Jonathan Spaan, Eric Giza, Margot Putukian, and Bert R. Mandelbaum. Arthroscopy, Sports Medicine, and Rehabilitation 8 (3): e70022.

Pathology and Laboratory Medicine

Accurate Focal-Plane Selection Is Crucial for Artificial Intelligence Assessment of Three-Dimensional Urine Cytology Specimens for Bladder Cancer Screening and Surveillance. Sayegh, Yoseph, Brody McNutt, Minh-Khang Le, I.-Chuang Liao, Keluo Yao, Camille Ng, Ahmad Kohsar, Daniel Shou, Michael Yu, YinXian Jin, Louis J. Vaickus, Xiaoying Liu, Christopher J. VandenBussche, Samuel E. Harvey, and Joshua J. Levy. Cancer Cytopathology 134 (7): e70117.

Dendritic Cell α-Ketoglutarate Regulates Tfh Polarization in Allergy. Tharakan, Anuj, Xufeng Qu, Carmen Camarena, Araba Abaidoo-Myles, Parth Naik, Jeremy Allegood, Ankit Kumar, Mihir Pokhriyal, Joseph C. Lownik, Matthew P. Zellner, Grayson W. Way, Jinze Liu, Lauren Ashley Cowart, Stephanie C. Eisenbarth, Joseph W. Landry, Daniel H. Conrad, and Rebecca K. Martin. Allergy, July.

IgA Nephropathy Across the Age Spectrum: Urgent Need to Accelerate Pediatric Access to Therapeutic Innovation. Cambier, Alexandra, Lison Lachize-Neanne, and Mark Haas. Clinical Journal of the American Society of Nephrology: CJASN, July.

Pediatrics

Compound Heterozygous ATM Variants Cause Adolescent-Onset Cerebellar and Extrapyramidal Disease Without Telangiectasia in a Consanguineous Pakistani Family. Aslam, Faiza, Weizhen Ji, Lauren Jeffries, Anant Wadhwa, Monica Konstantino, Muhammad Noman, Nigel S. Bamford, Emily Mis, Saquib A. Lakhani, and Sadaf Naz. Genetics Research 2026 (1): e5644954.

Dupilumab Is Safe and Efficacious for Treatment of Eosinophilic Esophagitis and Atopic Dermatitis in Pediatric Liver Transplant Recipients: A Case Series. Yuen, Christina, Laura J. Wozniak, Ronald Cotliar, and Robert S. Venick. Pediatric Transplantation 30 (7): e70382.

Increased 18F-FDG Avidity on PET/CT During Treatment for Rhabdomyosarcoma Confirmed to Be Mature Rhabdomyoblasts. Baca, Nicole, Fataneh Majlessipour, Christopher T. Watterson, Bonnie Balzer, Behrooz Hakimian, Daniel C. Allison, and Leo Mascarenhas. Journal of Pediatric Hematology/Oncology, July.

PEAK-II Trach: A Multi-Institutional Quality Improvement/Simulation Study Assessing Pediatric Emergency Readiness. Dunne, Olivia, Amanda Shen, Roxanna Mosavian, Jonathan Biel, Marc-Mina Tawfik, Elliot B. Schiff, Alanna M. Windsor, Jacqueline Weingarten-Arams, Sara Soshnick, Monirah Albathi Mbbs, Meredith Lind, Emily Ernest, Timothy Pian, Tensing Maa, Adam Van Horn, Ilana Harwayne-Gidansky, Regine Fortunov, Akira Nishisaki, Lesa Ward, James Beal, Kamal Abulebda, Todd Chang, Takunori Hozumi, Ankona Ghosh, Pooja Nawathe, Adrian D. Zurca, Kristin Van Genderen, Lindsay R. Koressel, Biva Narsing, Daniel C. Chiou, Ariel Sugarman, Tarif A. Choudhury, Melissa Fazzari, David W. Lounsbury, Ahsan S. Ahmed, and Christina J. Yang. Otolaryngology--Head and Neck Surgery, June.

Regional Organization of Nutrient Absorption Across the Small Intestine. Zwick, Rachel K., Mark Sharpley, Jérémie Rispal, Shervin Rabizadeh, Dario Boffelli, and Ophir D. Klein. Nature Reviews. Gastroenterology & Hepatology, July.

The Safety and Effectiveness of Early Anti-Tumor-Necrosis-Factor Therapy for Penetrating Crohn’s Disease Complications in Children. Constant, Brad D., Yixuan Feng, Jing Huang, Janet Okraku-Mantey, Jeremy Adler, Sabina Ali, Jessica Barry, Rusvelda Cruz, Erin C. Crawford, Jennifer L. Dotson, Mary Kate Ewalt, Jeannie S. Huang, Kelly Kachelries, Jacob A. Kurowski, Phillip Minar, Elana B. Mitchel, Taylor D. Montminy, Ryan Morrow, Brad Pasternak, Shervin Rabizadeh, Cary G. Sauer, Tal Shapira, Whitney M. Sunseri, Ibrahim Tarabishy, Becca Trombler, Sudha A. Anupindi, Robert N. Baldassano, Edwin F. de Zoeten, Frank I. Scott, and Lindsey Albenberg. The American Journal of Gastroenterology, July.

Radiation Oncology

Participant Heterogeneity in the Prostate Cancer Biobank of the NRG: An Obstacle to Broadening the Reach of Precision Oncology. Kamran, Sophia C., Monica Borges, Jeff Michalski, W. Robert Lee, Howard M. Sandler, Juanita Crook, Alan Pollack, Mark D. Hurwitz, Richard K. Valicenti, Deborah Watkins Bruner, Himanshu Lukka, Christopher U. Jones, Mack Roach, Colleen Lawton, Seth A. Rosenthal, Thomas M. Pisansky, Daniel Spratt, Neha Vapiwala, Jason Efstathiou, David Miyamoto, Kent Mouw, Melissa Vyfhuis, Quynh-Thu Le, Henning Willers, Eliezer Van Allen, Franklin Huang, Jean-Paul Bahary, Joelle Helou, Stephanie L. Pugh, Jennifer Wenzel, and Phuoc Tran. JCO Precision Oncology 10 (7): e2600158.

Surgery

ASO Visual Abstract: Trends in Breast and Axillary Operations in Young Patients With Operable Breast Cancer From the National Cancer Database (NCDB)-De-Escalation of Axillary Surgery and Increased Use of Radiation. Boyle, Marissa K., Marc A. Attiyeh, Farin Amersi, Alice Chung, Jin Sun Lee, and Armando E. Giuliano. Annals of Surgical Oncology, July.

Current Concepts in Platelet-Rich Plasma Therapy for Lateral Epicondylitis Through a Histopathological and Clinical Lens. Reshadi Nezhad, Navid R., and Meghan McCullough. Cureus 18 (6): e110311.

Detection of Microvascular Failure Using Bioimpedance and Sensor-Derived Clinical Indicators: A Preliminary Study. Van Dieren, Loïc, Haïzam Oubari, Leonard Knoedler, Raffaele Aguglia, Korkut Uygun, Mark A. Randolph, Filip Thiessen Ef, Alexandre G. Lellouch, and Curtis L. Cetrulo. Plastic and Reconstructive Surgery. Global Open 14 (7): e7916.

Donor Acute Kidney Injury Is Not Associated With Inferior Outcomes After Simultaneous Pancreas-Kidney Transplantation. Wang, Olyvia S., Gabriel E. Nissen, Yujie Cui, Georgios Voidonikolas, Kambiz Kosari, Tsuyoshi Todo, Justin A. Steggerda, Steven A. Wisel, Irene K. Kim, and Todd V. Brennan. American Journal of Transplantation, July, S1600-6135(26)02630-4.

Functional and Aesthetic Considerations for Selective Facial Neurectomy With Simultaneous Deep Plane Facelift and Structural Neck Contouring for Facial Paralysis With Synkinesis. Lu, Richard J., Victor Hsue, Jenna Thuman, and Babak Azizzadeh. Facial Plastic Surgery & Aesthetic Medicine, July, 26893614261458127.

Hydrogel-Encapsulated Primed MSCs Enhance Regeneration in Full-Thickness Porcine Burn Wounds. White, Kristopher, Victor Pozzo, Alec R. Andrews, Rabab Chalaby, Annie T. Dinh, Pierre Tawa, Golda Romano, Alexandre G. Lellouch, Curtis L. Cetrulo, and Ronke Olabisi. Tissue Engineering. Part A, June, 19373341261460268.

Liquid Surrogates of Spatial Tumor Ecosystems. Chang, Tian-Gen, Eldad D. Shulman, and Eytan Ruppin. Cell Research, June.

Making the OR Work: A Socio-Material Study of Ergonomics in the Operating Room. Mah, Alexis, Csilla Kalocsai, Fahad Alam, Allia Karim, Jeremie Larouche, M. Susan Hallbeck, Tara Cohen, Anna Ding, Jessica Armah, Julie Hallet, and SORE research group. The British Journal of Surgery, July, znag083.

Pathological Complete Response in a POLE-Mutated Non-Small Cell Lung Cancer Patient Treated With Perioperative Chemoimmunotherapy: A Case Report and Review of the Literature. Liguori, Luigi, Rosario De Feo, Lucia Santaniello, Brigida Miranda, Valentina Pagliara, Giovanna Polcaro, Alessandro Caputo, Giulia Cattaneo, Marco Ventin, Alberto Servetto, Cristina R. Ferrone, Stefano Pepe, and Francesco Sabbatino. MedScience, July.

Patient-Reported Outcomes in Masculinizing Gender-Affirming Chest Surgery: Validation of the GENDER-Q Chest Scales. Haley, Caleb, Shane D. Morrison, Manraj N. Kaur, Charlene Rae, Megan Lane, Danny A. Young-Afat, Tim C. van de Grift, Nicola R. Dean, Kathleen A. Armstrong, Devin Coon, Zac A. Cannell, Christian X. Lava, Sylvie D. Cornacchi, Alexis Laungani, Margriet G. Mullender, Jens Ahm Sørensen, Lotte Poulsen, Jack G. Graesser, Thomas Satterwhite, Allison C. Hu, Gerhard S. Mundinger, Hilliard T. Brydges, Jessica J. Hsu, Blair R. Peters, Jens U. Berli, Christodoulos Kaoutzanis, Nargis Kalia, Rachel Bluebond-Langner, Oren Ganor, Alireza Hamidian Jahromi, Bashar A. Hassan, Fan Liang, John H. Pang, Edward C. Ray, Gabriel A. Del Corral, Kenneth L. Fan, Lily R. Mundy, Andrea L. Pusic, and Anne F. Klassen. The British Journal of Surgery, July, znag089.

PDLIM2 Acts as a Central Regulator of Ubiquitination, Immune Signaling, and Mitochondrial Metabolism in Lung Cancer Suppression (Review). Chuang, Tsung-Hsien, Jeng-Hung Guo, Jing-Xing Yang, Jen-Chih Tseng, Hung-Jung Wang, and Chao-Yang Lai. International Journal of Oncology 69 (2): 96.

Redefining Textbook Outcome in Contemporary Colon Surgery. Zeller, Matthew Paul, Rachel Ma, Joseph Wetherell, Jessica Felton, Yosef Nasseri, and Joshua Wolf. Journal of Gastrointestinal Surgery, 30 (8): 102487.

Rib Grafts in Rhinoplasty: A Systematic Review and Meta-Analysis of Autologous, Fresh-Frozen, and Irradiated Cartilage. Datta, Shaishav, Elie P. Ramly, Victoria Tucci, Kaitlin Lees, Steven A. Hanna, David Mattos, and Richard G. Reish. Plastic and Reconstructive Surgery. Global Open 14 (6): e7875.

Single-Cell Transcriptomic Analysis Reveals Tumor-Immune Determinants of Lymph Node Colonization and Progression in Thyroid Cancer. Nguyen, Anthony T., Jolene Viramontes, Isaiah Vazquez, Catriona McWilliam, Vaishnavi Devarakonda, Regina Henson, Wendy L. Sacks, Jon Mallen-St Clair, Yufei Chen, Evan Walgama, Kevin S. Scher, Justin Moyers, Howard M. Sandler, Julie K. Jang, Zachary S. Zumsteg, Wonwoo Shon, Stephen L. Shiao, and Allen S. Ho. Science Advances 12 (27): eaea4727.

Socioeconomic Characteristics and Outcomes of Inpatient Cranial Nerve Decompression Procedures: An 18-Year HCUP-NIS Study. Hoch, Cosima C., Thomas Schaschinger, Tobias Niederegger, Paul F. Funk, Jadyn N. Heffern, Alexandre G. Lellouch, Joanna Kempa-Timler, Leonard Knoedler, Jakob Fenske, and Douglas Henderson. European Journal of Plastic Surgery 49 (1): 125.

Transplantation Tolerance Versus Immune Evasion: Mechanistic Divergences and Therapeutic Frontiers for Islet Cell Replacement. Deuse, Tobias, and Sonja Schrepfer. Cell Reports. Medicine, July, 102888.

Trends in Breast and Axillary Operations in Young Patients With Operable Breast Cancer From the National Cancer Database (NCDB): De-Escalation of Axillary Surgery and Increased Use of Radiation. Boyle, Marissa K., Marc A. Attiyeh, Farin Amersi, Alice Chung, Jin Sun Lee, and Armando E. Giuliano. Annals of Surgical Oncology, July.

Use of Internal Brace for the Surgical Management of the ‘Baby Stener’ Lesion of the Radial Collateral Ligament to the Small Finger. Woo, Dainn, and David A. Kulber. Journal of Hand Surgery Global Online 8 (5): 101050.

White Paper: Robotic Cholecystectomy-New Technology but Safe Principles Still Apply. Porter, Eleah, Irving Jorge, Cris Mk Malino, Ankit Sarin, Patrick J. Sweigert, Dale Butler, Dnyanesh Madhukar Belekar, Maggie Bosley, Domenech Asbun, Francesco M. Bianco, Jessica Lindemann, Edward L. Jones, Jennifer M. Moffett, Dana Telem, Matthew B. Bloom, L. Michael Brunt, Kevin El-Hayek, Shanley B. Deal, and B. Fernando Santos. Surgical Endoscopy 40 (5): 3575–86.

Urology

Clinical Validation of a Multiplex Urine Biomarker Assay for Surveillance of Recurrent Bladder Cancer. Lotan, Yair, Michael Luu, Menghan Liu, Sergei Tikhonekov, Takashi Kobayashi, Michael Ahdoot, Hyung Lae Kim, Sima Porten, Garry Peers, Yuki Kita, Timothy Daskivich, Kaoru Murakami, Toru Sakatani, Ian Pagano, Yingye Zheng, Zhen Zhang, Hideki Furuya, and Charles J. Rosser. Clinical Cancer Research, July.

Equity and Cancer Survival Among Veterans Health Administration Patients: A Systematic Review and Meta-Analysis. Bullard, Alyssa Jasmine, Haley I. Tupper, Kevin Su, Lin Gu, Luca F. Valle, Isla P. Garraway, Donna L. Washington, Chloe E. Bird, Robert A. Winn, Stephen J. Freedland, Christina D. Williams, and Drew Moghanaki. JAMA Network Open 9 (7): e2621585.

Enzalutamide in Biochemically Recurrent Prostate Cancer: Clinical Implications From EMBARK for Real-World Practice. Freedland, Stephen J., and Neal D. Shore. Future Oncology, July, 1–12.

How Enzalutamide Affects Sex Life and How Taking a Break From Treatment Affects Quality of Life: A Plain Language Summary of Results From the EMBARK Study in People With Hormone-Sensitive Prostate Cancer and High-Risk Biochemical Recurrence. Freedland, Stephen J., Ugo De Giorgi, Antti Rannikko, Fred Saad, Martin Gleave, Miguel Ramírez Backhaus, John Mulhall, Bhavik J. Pandya, Jasmina Ivanova, Pavol Kral, James Turnbull, and Neal Shore. Future Oncology, July, 1–13.

Integrating Natural Language Processing With ChatGPT to Improve Quality of Artificial Intelligence Summaries of Prostate Cancer Consultations. Friedrich, Nadine A., Sanjay K. Das, Michael Luu, James P. Daniels, John Heard, Avetik Barsegyan, Stephen J. Freedland, Brennan Spiegel, Paul K. Kokorowski, Graciela Gonzalez Hernandez, and Timothy J. Daskivich. JCO Clinical Cancer Informatics 10 (3): e2500199.

Intravesical Mesothelin-Based CAR T Cells Targeting MUC16 Effectively Control Bladder Cancer in Preclinical Models. Abrahimi, Parwiz, Jonathan F. Khan, Alyssa Duren-Lubanski, Winson Cai, Yacine Marouf, Nan Chen, Daniel Hirschhorn, Renata Mammone, Ileana C. Miranda, Jacob E. Tallman, Alejandra Vela-Moreno, Mohamad Hamieh, Bishoy M. Faltas, Thomas M. Carroll, Micaela L. Everitt, Hari K. K. Subramanian, Hikmat A. Al-Ahmadie, Olivier Elemento, Benjamin D. Hopkins, Douglas S. Scherr, Renier J. Brentjens, Jedd D. Wolchok, and Taha Merghoub. The Journal of Experimental Medicine 223 (7): e20250699.

Response to Comment on ‘Artificial Intelligence-Based Approaches to Augmenting and Automating Surgical Training.’ Lin, Jasmine, Ludovica Cella, Mitchell G. Goldenberg, and Andrew J. Hung. BJU International, June.

Cedars-Sinai Health Sciences University is advancing groundbreaking research and educating future leaders in medicine, biomedical sciences and allied health sciences. Learn more about the university.

Cedars-Sinai Study Links Hypertension to Socioeconomic Level

People living in under-resourced neighborhoods are more likely to develop high blood pressure—also known as hypertension—than those in wealthier areas, according to new research from Cedars-Sinai Health Sciences University. The study was published in the American Journal of Hypertension.

“The increased risk for people in the least healthy neighborhoods was similar to being a full decade older than their counterparts in the healthiest neighborhoods,” said Joseph Ebinger, MD, MS, associate professor of Cardiology and director of the Coronary Intensive Care Unit in the Smidt Heart Institute at Cedars-Sinai and senior author of the study. “Although such disparities in hypertension prevalence are known to occur, our study is notable because it demonstrates the persistence of these differences over time.”

Investigators tracked the blood pressure of more than 94,000 Cedars-Sinai patients between 2018 and 2023. They found that, over time, patients in neighborhoods in the lowest 25% of rankings on a scale that assesses education, job opportunities and other social conditions were 7% more likely to develop high blood pressure than patients in the top 75% of neighborhoods.

“Many people do not know they have hypertension and are not being treated for it,” Ebinger said. "Our findings suggest clinicians may consider targeting interventions in the context of socioeconomic data to help prevent at-risk patients from developing the condition, which increases their risk for heart disease, kidney disease and stroke."

Additional Cedars-Sinai authors include Jonathan N. Le, MD; Tzu Yu Huang, MPH; Patrick G. Botting, MSHS; Ellie Albertson, MPH, PhD; Natalie A. Bello, MD, MPH; Christina Harris, MD; Alan Kwan, MD; and Susan Cheng, MD, MPH. 

Other authors include Brian Claggett, PhD.

Funding: This study was supported by grant funding from the NIH/NHLBI (K23HL 153888-03) and by the Smidt Discovery Fund of the Smidt Heart Institute.

Study Links Angina Severity to Composition of Heart Plaque 

About half of women who experience angina, chest pain presumed to be from obstructed blood flow to the heart, don’t have significant coronary artery blockage. And yet, these women have elevated risk for heart attacks and strokes. New research from Cedars-Sinai Health Sciences University, published in Communications Medicine, helps explain why.

Investigators found that buildup in the coronary arteries of women with severe angina was more likely to consist of soft plaque. Soft plaque, also known as noncalcified plaque, is more prone to rupture and trigger dangerous blood clots than its more stable counterpart, known as calcified or hard plaque. 

The findings were based on artificial intelligence analysis of more than 100 CT coronary angiograms (noninvasive heart scans) performed on women with angina and coronary artery disease.

“Our findings expand our understanding of why angina occurs in women without significant artery blockages,” said Damini Dey, PhD, professor of Biomedical Sciences at Cedars-Sinai and corresponding author of the study. “The findings also suggest the need to consider treating these women with medications to prevent the buildup of plaques and reduce the risk of heart attacks and other cardiac events.”

Other Cedars-Sinai authors include Rafal Wolny, Guadalupe Flores Tomasino, Kajetan Grodecki, Joel Lenell, Caroline Park, Rebekah Park, Jacek Kwiecinski, Daniel S. Berman, Piotr J. Slomka, Janet Wei, Martha Gulati and C. Noel Bairey Merz.

Other authors include Osama Dasa, Vinicius Calsavara, Matthew J. Budoff, Eileen Handberg, Carl J. Pepine, Leslee J. Shaw and Balaji Tamarappoo.

Acknowledgements: This study was primarily supported by grants from the NHLBI R01HL151266 and 1R01HL148787. It was also supported by CDMRP-DoD W81XWH-17-2-0030 and McJunkin Family Foundation through funds distributed by the University of Florida, Department of Medicine, Clinical Research Consortium CDRN-1501-26692, the Edythe L. Broad and the Constance Austin Women’s Heart Research Fellowships, Cedars-Sinai Medical Center, Los Angeles, CA, the Barbra Streisand Women’s Cardiovascular Research and Education Program, Cedars-Sinai Medical Center, Los Angeles, the Linda Joy Pollin Women’s Heart Health Program, the Erika Glazer Women’s Heart Health Project, Cedars-Sinai Medical Center, Los Angeles, CA; and the VA Women’s Health Practice-Based Research Network VA HSR&D SDR 10-012. R.W. is supported by a Polish National Science Centre (grant number 2021/43/D/NZ5/02434) and Medical Research Agency (grant number KPOD.07.07-IW.07-0150/24).

Competing interests: Drs. Berman, Slomka, and Dey have received software royalties from Cedars-Sinai Medical Center and report equity in APQ Health.

How the Brain Influences Aging Throughout the Body

Cedars-Sinai Health Sciences University investigators are helping clarify the brain’s role in how the body ages. Their study, published in Nature Communications, identified a group of brain cells that become overactive with age and may impair the body’s ability to maintain consistent temperature, stay properly hydrated and efficiently convert food into energy. 

“These age-related problems make the body more vulnerable to illness and often rob people of their independence,” said Celine Riera, PhD, associate professor of Biomedical Sciences and Neurology, research scientist in the Board of Governors Regenerative Medicine Institute at Cedars-Sinai, and senior author of the study. “We found that a group of brain cells that produce a hormone called vasopressin become overactive with age, contributing to these problems.”

These brain cells are in the hypothalamus, at the base of the brain. In healthy amounts, the vasopressin they produce helps blood vessels constrict. It also helps the kidneys control the amount of water and salt in the body, which helps control blood pressure and urine output. 

When investigators artificially activated these brain cells in young laboratory mice, the cells produced more vasopressin and the mice developed changes similar to those seen in aging mice. Conversely, when investigators reduced the activity of these brain cells in aging mice, the mice were better able to maintain body temperature, hydration and metabolism, Riera said.

The findings provide scientists with new context for understanding how the brain contributes to systemic aging. Future studies may explore whether therapies targeting these brain cells can reduce age-related health problems and improve quality of life in aging people, Riera said.

Additional Cedars-Sinai authors include Nancy Morones, Predrag Jovanovic, Anna Sanetra, Kaitlyn Jang, Nareg Keshishian, Zhihan Clay Cui, Edward Novinbakht, Joshua J. Breunig, Anders Berg, Tamar Pirtskhalava, Selim Chaib, S Ananth Karumanchi, Tamar Tchkonia, Katlin Silm, and James L. Kirkland.

Funding: This work was supported by the Larry L Hillblom Foundation startup grant (C.E.R.), the Cedars-Sinai Pilot Award from the Center on Aging and Diabetes (C.E.R.), the CIRM Scholar fund EDUC-12751 (N.M.), the National Institute of Aging grant RF1AG091203 (C.E.R.) and R37AG013925 (J.L.K., T.T.).

Possible Biomarker Linked to Aggressive Thyroid Cancer

Cedars-Sinai Health Sciences University investigators have found a possible way to identify which patients are at greatest risk of thyroid cancer recurrence and might benefit from more aggressive treatment. Their findings were published in Science Advances.

“The incidence of thyroid cancer has tripled over the past three decades and it is now the most common cancer in adolescents and young adults,” said Anthony T. Nguyen, MD, PhD, assistant professor of Radiation Oncology and Biomedical Sciences and first author of the study. “The biomarker we identified, if further validated, could help us identify patients likely to have more aggressive disease so that we can intensify their treatment.” 

In five patients with locally advanced thyroid cancer, investigators used single-cell RNA sequencing to analyze gene expression patterns in individual cells of the tumor microenvironment, comparing primary thyroid tumors and matched lymph nodes to which cancer had spread. Their findings were confirmed in a separate group of 21 patients with thyroid cancer.

Among multiple differences between primary tumor and lymph node, investigators found that an increase in IL7 receptor protein expression on the surface of immune cells in the lymph nodes was linked to improved patient outcomes.

“Our study is one of the first to use single-cell RNA sequencing to identify a lymph node-specific biomarker for aggressive thyroid cancer,” said Allen Ho, MD, professor of Surgery and co-corresponding author of the study. “Low levels of IL7 receptor in the lymph node can potentially be used to identify patients with more aggressive disease who are candidates for treatment intensification.”

The other corresponding author is Stephen Shiao, MD, PhD, professor of Radiation Oncology and Biomedical Sciences and co-leader of the Cancer Therapeutics Program.

“This study is an example of the promise of single-cell RNA sequencing to assess the status of tumors for more targeted treatment,” said Robert Figlin, MD, interim director of Cedars-Sinai Cancer. 

Additional Cedars-Sinai authors include Jolene Viramontes, Isaiah Vazquez, Catriona McWilliam, Vaishnavi Devarakonda, Regina Henson, Wendy L. Sacks, Jon Mallen-St Clair, Yufei Chen, Evan Walgama, Kevin S. Scher, Justin Moyers, Julie K. Jang, Zachary S. Zumsteg, and Wonwoo Shon.

Howard M. Sandler is also an author of the study.

Funding: This work was supported by: National Institutes of Health grant K08CA191139 (SLS), Conquer Cancer Young Investigator Award (ATN), American Society for Radiation Oncology Junior Faculty Award (SLS), Cedars-Sinai Precision Health Grant (ASH).

New Expert Consensus Aims to Improve Diagnostics in Emergency Care

Cedars-Sinai Health Sciences University investigators convened a panel of medical experts to develop new definitions to improve diagnostic quality and safety in emergency departments. The definitions—diagnostic excellence and missed diagnostic opportunity—address a longstanding gap in the field, as they recognize the role uncertainty plays in emergency care. Their findings are published in Annals of Emergency Medicine. 

“Our new definitions can be used to guide investigations about the diagnostic process in emergency departments to identify opportunities for improvement,” said study first author Carl Berdahl, MD, MS, associate professor of Medicine and Emergency Medicine at Cedars-Sinai. “Future work should explore the integration of these definitions into diagnostic research and quality and safety programs, and evaluate the impact on patients’ health outcomes.”

A 2022 report from the Agency for Healthcare Research and Quality suggested about 1 in 18 patients visiting emergency departments each year receive a misdiagnosis that causes preventable harm or worsens their outcome. This report sparked controversy about what the emergency department’s role should be in assigning diagnoses.

The panel of 10 experts from emergency medicine and related specialties reviewed scientific evidence to arrive at the new definitions. It defined “diagnostic excellence” as using evidence-based practices to arrive at an accurate and timely explanation of a patient’s condition based on the information available at the time; communicating that diagnosis to patients and families; and providing equitable, patient-centered care. It defined a “missed diagnostic opportunity” as a measurable departure from evidence-based practice that may contribute to a delayed or inaccurate diagnosis, or a failure in communicating diagnostic information to patients and families.

Additional Cedars-Sinai authors include Sam S. Torbati, MD; Maxim P. Ptacek, BS; Nabeel Qureshi, PhD; and Teryl K. Nuckols, MD, MSHS.

Additional authors include Gordon D. Schiff, MD; Arjun K. Venkatesh, MD, MBA; Edward G. Seferian, MD, MS; and Johan Carrascoza-Bolanos, BS.

Members of the Multidisciplinary ED Diagnostic Excellence Panel include Adebisi Alli, DO, MS; Marie L. Crandall, MD, MPH; Anuj K. Dalal, MD; Kelly T. Gleason, PhD, BSN; Sachin Gupta, PhD, MBA; Aaryn K. Hammond, MD; Victoria Nash, MS; Michelle D. Lall, MD, MHS, Robert Sherwin, MD; Scott D. Steenburg, MD, MS.

Funding: This work was supported by the Emergency Medicine Foundation’s Diagnostic Excellence in Emergency Medicine Grant. Dr. Berdahl was also supported by K08HS029534 and the National Academy of Medicine Scholars in Diagnostic Excellence Program.

Preclinical Study: Novel CAR T-Cell Therapy Controls Bladder Cancer

Investigators at Cedars-Sinai Health Sciences University have discovered that delivering a specialized CAR T-cell therapy directly into the bladder could control bladder cancer and reduce the need for bladder-removal surgery. The preclinical study, published in the Journal of Experimental Medicine, identifies a strategy that, after further testing in humans, could improve management of organ-confined tumors.

“Current bladder cancer therapies are limited by drug shortages, severe side effects and high recurrence rates, often forcing patients to undergo life-changing bladder-removal surgery,” said Parwiz Abrahimi, MD, PhD, urologic oncologist in the Department of Urology at Cedars-Sinai and first author of the study. “This new strategy has the potential to dramatically reduce the necessity for bladder removal, preserving the patient’s quality of life while maintaining control of their cancer.”

In laboratory mice, investigators found this localized approach safely confined the treatment to the bladder and prevented the engineered cells from escaping into the bloodstream. The findings support the practice of delivering cellular therapies directly via a catheter to treat organ-confined bladder cancers.

Additional authors include Jonathan F. Khan, Alyssa Duren-Lubanski, Winson Cai, Yacine Marouf, Nan Chen, Daniel Hirschhorn, Renata Mammone, Ileana C. Miranda, Jacob E. Tallman, Alejandra Vela-Moreno, Mohamad Hamieh, Bishoy M. Faltas, Thomas M. Carroll, Micaela L. Everitt, Hari K.K. Subramanian, Hikmat A. Al-Ahmadie, Olivier Elemento, Benjamin D. Hopkins, Douglas S. Scherr, Renier J. Brentjens, Jedd D. Wolchok and Taha Merghoub.

Cedars-Sinai Scientists Identify New Driver of Inflammation 

Investigators at Cedars-Sinai Health Sciences University have identified a previously unrecognized driver of harmful inflammation. The findings, published in Nature Communications, center around TRIM21, a protein also linked to autoimmune disease.

“Our findings suggest TRIM21 may be one reason some autoimmune and autoinflammatory diseases share similar features,” said Jessica Carriere, PhD, an assistant professor of Pathology and Laboratory Medicine at Cedars-Sinai and co-corresponding author of the study. “By targeting TRIM21, we may eventually be able to develop new treatments for a range of inflammatory diseases.”

Researchers discovered that TRIM21 helps build the inflammasome, an alarm-like structure inside immune cells that triggers inflammation. While this alarm helps protect the body from infection, it also can become overactive and trigger excessive inflammation that damages healthy tissue and contributes to disease. 

The study, which looked at laboratory mice and human patient samples, showed that TRIM21 not only helps activate this inflammatory response but also enables inflammatory signals to spread from dying immune cells to nearby cells, potentially creating a chain reaction that drives inflammation throughout the body.

Additional Cedars-Sinai authors include Sana Ismaeel, Elisabeth Jäger, Vinicius Dantas Martins, Kaiden A. Sims, Huyen Nguyen, Justin Ruiz, Hemisha Khatri, Savita Devi, Andrea Dorfleutner and Christian Stehlik. 

Additional authors include Chawon Yun, Sonal Khare, Lan H. Chu, Lucia de Almeida, Janset Onyuru, Jae Jin Chae, Daniel L. Kastner, Lori Broderick and Hal M. Hoffman.

Funding: This work was supported by the National Institutes of Health (AI099009 to C.S., AI134030, AI140702, DK143393, CA301129 and AI165797 to C.S. and A.D.), the American Heart Association (834502 and 26CDA1588880 to J.C., 25POST1374216 to S.I., 26POST1558214 to V.D.M., 15PRE25700116 to L.H.C. and 18CDA34110296 to L.d.A.), and the American Cancer Society (PF-23-1149877-01-IBCD to E.J.).

Cedars-Sinai Health Sciences University is advancing groundbreaking research and educating future leaders in medicine, biomedical sciences and allied health sciences. Learn more about the university.

Scientists from the Cedars-Sinai Board of Governors Regenerative Medicine Institute will share groundbreaking discoveries and discuss new frontiers in research at ISSCR 2026, the annual meeting of the International Society for Stem Cell Research, July 8-11 in Montreal.

Clive Svendsen, PhD, executive director of the institute, will present new data from a clinical trial of a cell-based therapy for retinitis pigmentosa, a degenerative eye disease that is mostly untreatable. This Phase 1/2a clinical trial of a subretinal injection of a human neural progenitor cell product found that the therapy is well tolerated and results in long-term engraftment. 

Arun Sharma, PhD, director of the Center for Space Medicine Research, will participate in a session co-sponsored by Cedars-Sinai on regenerative medicine in low Earth orbit. The focus of Sharma’s talk is accelerating development of organoid-based disease modeling and stem cell therapies due to increased access to microgravity, as well as in-space biomanufacturing. 

Tynhinane Hamidouche, PhD, a postdoctoral scientist in the lab of Dmitriy Sheyn, PhD, is presenting research on a stem cell–based therapy for intervertebral disc degeneration and chronic low-back pain. Using human induced pluripotent stem cells, the team generates cells that produce the matrix material found inside the discs.

Paul Linesch, PhD, a postdoctoral scientist in the Svendsen Lab, is presenting research on an inducible DNA system, adapted using new technology developed at Cedars-Sinai, to turn specific genes on and off. The system could improve direction of stem cell differentiation and open new possibilities for cellular therapy. 

Molly Easter, PhD, a postdoctoral scientist in the lab of Tyler Pierson, MD, PhD, will present research on a rare brain development disorder linked to the GATAD2B gene, which helps control how genes turn on and off during brain growth. Using brain organoids generated from patient-specific induced pluripotent stem cells, the researchers found signs that the normal layering and patterning of the cortex may be disrupted in this disorder. 

Dhruv Sareen, PhD, associate professor of Biomedical Sciences and founding director of the Cedars-Sinai Biomanufacturing Center, is presenting research on the integration of an in situ seed plating system into the center’s manufacturing workflow to streamline production of complex induced pluripotent stem cell lines for clinical-grade and research use.

Avinash Srivastava, PhD, a biomedical scientist in the Cedars-Sinai Biomanufacturing Center, is presenting information on the center’s proprietary integrated induced pluripotent stem cell biomanufacturing platform. The platform integrates standardized manufacturing with advanced bioprocessing to facilitate the scalable production of high-quality engineered cell therapies.

Media Contact

To schedule an interview with a Cedars-Sinai expert, contact Christina Elston at christina.elston@cshs.org or 626-298-0702.

Shehata is a cardiac electrophysiologist, a doctor who specializes in diagnosing and treating problems with the heart’s electrical system. He has experience with a broad spectrum of heart rhythm disorders and also cares for people with heart failure and survivors of cardiac arrest.

“Over the past two decades, Dr. Shehata has emerged as a nationally recognized cardiac electrophysiologist and academic leader,” said Susan Cheng, MD, MMSc, MPH, chair of the Department of Cardiology in the Smidt Heart Institute. “His leadership will mean continued progress in this important field.”

As a researcher, Shehata has led groundbreaking clinical trials for new types of pacemakers and other technologies for treating heart rhythm disorders. He also studies ways that AI can be used to personalize care.

Shehata’s most recent research includes a trial of a new treatment for atrial fibrillation, which occurs when the upper chambers of the heart beat out of sync with the lower chambers of the heart. The treatment, pulsed field ablation, targets heart cells involved in an abnormal heart rhythm. The U.S. Food and Drug Administration approved several pulsed field ablation systems, including one studied by Shehata and other researchers, in 2024.

Shehata and colleagues have also studied leadless pacemakers, miniature devices that attach to the heart muscle and that, unlike traditional pacemakers, don’t require a battery and wires.

As division director, Shehata will oversee a program that provides research-backed care and trains new heart rhythm specialists. The program offers a two-year fellowship to medical school graduates seeking advanced knowledge and skills in electrophysiology.

“Through his leadership of the Interventional Electrophysiology Laboratory and the Clinical Cardiac Electrophysiology Fellowship Program, Dr. Shehata has expanded access to advanced therapies and enhanced the training of future electrophysiologists,” said Eduardo Marbán, MD, PhD, executive director of the Smidt Heart Institute and the Mark S. Siegel Family Foundation Distinguished Professor.

Shehata earned his medical degree from the University of California, San Diego, School of Medicine. He completed internal medicine residency training at UCLA and his cardiology fellowship training at Cedars-Sinai, where he was chief fellow. He also completed advanced fellowship training in cardiac electrophysiology at Cedars-Sinai. He served as faculty at UCLA before being recruited to join the cardiology faculty at Cedars-Sinai, where he is a professor of Cardiology.

U.S. News & World Report rates the Smidt Heart Institute a top 10 cardiovascular center in the U.S. and #1 in California.

Read more from Cedars-Sinai Stories and Insights: New AFib Treatment Helps Dad Regain His Heart Rhythm

An accomplished neurotologist and skull base surgeon, Miller joined Cedars-Sinai in 2021 and serves as director of Neurotology for the Cedars-Sinai Acoustic Neuroma and Lateral Skull Base Surgery Center. Her expertise includes otology, neurotology, cochlear implantation, vestibular schwannoma and acoustic neuroma care, lateral skull base surgery, Ménière’s disease, and hearing restoration.

“My vision is to continue to develop each of our subspecialties to the highest standard of rigorous academics and education paired with clinical excellence,” said Miller, also the inaugural LuEllen Margaret Edwards Chair in Otology and Neurotology. "Every patient who comes to us deserves care from a team that is both deeply trained and fully committed to outstanding outcomes, and every trainee deserves an environment where they can grow into an exceptional clinician."

As an initial priority, Miller has hired Cedars-Sinai’s first otolaryngology PhD researcher to help lead the development of a hearing regeneration lab.

"We are delighted for Dr. Miller to step into the role of division director," said Cristina R. Ferrone, MD, chair of the Department of Surgery at Cedars-Sinai. "Her expertise as a surgeon, dedication to education and clear vision make her an ideal leader for this team. We look forward to the many ways she will strengthen patient care and mentor the physicians of tomorrow."

Miller earned her bachelor’s degree from Harvard University and her medical degree from Harvard Medical School. She completed her surgical internship and residency in head and neck surgery at UCLA, followed by fellowship training in neurotology and skull base surgery at the University of California, San Diego (UCSD). Prior to joining Cedars-Sinai, Miller served as director of the Center for Balance and Falls at the University of California, San Francisco (UCSF), where she led clinical and research initiatives. She also spent seven years as an associate at the House Ear Clinic.

Miller succeeds Gene Liu, MD, in the role of division director.

“Over the course of his years at Cedars-Sinai, Dr. Liu made outstanding contributions to the Department of Surgery, and we are grateful for his leadership,” Ferrone said. “Through his recruitment of 19 surgeons across the network and the establishment of the ENT residency, he provided a strong foundation of excellence in the academic and clinical footprint of the division for Dr. Miller to build on.”

Read more from the Cedars-Sinai Newsroom—TODAY: Treating Hearing Loss Can Protect Your Brain From Cognitive Decline

“Continuity of care throughout the lifespan is important for sarcoma patients,” said Leo Mascarenhas, MD, director of the Adult and Pediatric Sarcoma Program and the Division of Pediatric Hematology/Oncology at Cedars-Sinai Cancer. “Our multidisciplinary expertise, which includes pathology, radiation oncology and surgical care, means both adults and children with sarcoma can receive all of their care in one place.”

Mascarenhas is a professor of Pediatrics and Medicine at Cedars-Sinai Health Sciences University and pediatric hematologist-oncologist who has more than 25 years of clinical and research experience. He has led multi-institutional clinical trials for Ewing sarcoma, rhabdomyosarcoma, osteosarcoma and other rare pediatric solid tumors.

Additional Cedars-Sinai Sarcoma Experts

James Hu, MD, associate director of the Sarcoma Program, has more than 30 years of clinical experience in medical oncology. His research focuses on evaluating novel biomarkers and liquid biopsy methods to improve the treatment of bone and soft tissue sarcomas and examining risk factors for young patients facing rare forms of cancer.

Earl Brien, MD, surgical director of the Sarcoma Bone Tumor Program and professor of Orthopaedics, is an orthopedic oncology specialist. His research focuses on surgical strategies for treating complex soft tissue sarcomas, improving surgical techniques for the removal of bone cancers while avoiding amputations, and use of circulating tumor DNA to noninvasively assess treatment response.

Jason Chan, MD, is a board-certified medical oncologist who specializes in the care of people with sarcoma, including desmoid tumors, gastrointestinal stromal tumors (GIST), as well as other soft tissue and bone sarcomas. He studies how cancers adapt and become resistant to treatment, with a focus on the ability of cancer cells to shift into different cell states that may allow them to grow, spread and survive therapy.

Fahima Dossa, MD, PhD, surgical oncologist in the Jim and Eleanor Randall Department of Surgery, primarily treats soft tissue sarcoma, including gastrointestinal stromal tumors (GIST), liposarcoma, leiomyosarcoma and desmoid tumors. She also specializes in treatment of retroperitoneal sarcoma, which develops deep in the fat or muscle of the abdomen, using a specific operative technique to help prevent recurrence.

Behrooz Hakimian, MD, is an assistant professor of Radiation Oncology whose research merges clinical trial exploration with advanced radiation oncology techniques, focusing on patient safety during therapy for complex sarcomas and soft tissue tumors.

Mitchell Kamrava, MD, is a professor of Radiation Oncology whose sarcoma research centers on optimizing preoperative radiation, reducing treatment timelines and predicting post-surgical complications. He has been a co-investigator on pivotal clinical trials evaluating a condensed five-day preoperative radiation regimen for high-risk primary soft tissue sarcomas.

Eugene Kim, MD, is a professor of Surgery and Pediatrics, director of the Division of Pediatric Surgery and vice chair of the Department of Surgery. He is recognized for his expertise in pediatric surgical oncology and he is a key member of the sarcoma team.

Joseph Schwab, MD, director of Spine Oncology in the Department of Orthopaedics, is a specialist in managing sarcomas of the spine—including rare, complex tumors like chondrosarcomas and chordomas—in adults. His research focus includes use of algorithms and machine learning to build tools that optimize clinical decision-making for bone and soft tissue tumors.

Media Contact

To schedule an interview with a Cedars-Sinai sarcoma expert, contact Christina Elston at christina.elston@cshs.org or 626-298-0702.

Cedars-Sinai in the News

Cedars-Sinai Guerin Children’s Launches First Neuro NICU in the Los Angeles Region | CBS News Online
Rangasamy Ramanathan, MD

These Beloved Snacks Are Linked to an Increased Dementia Risk. Here's What Doctors Want You to Know | HuffPost
Zaldy Tan, MD, MPH

Yes, Stair Climbing, Housework Count as Exercise. They Can Even Boost Your Mood | Healthline
Bert Mandelbaum, MD

Genetic Variants Linked to Spontaneous Cerebrospinal Fluid Leaks | Technology Networks/Genomics Research
Wouter Schievink, MD

Top World Cup Doc in Los Angeles Talks Radiology | Aunt Minnie
Joshua Scott, MD

8 Steps to Find the Best Shoes for Multiple Sclerosis | Everyday Health
Glenn Pfeffer, MD

Strength Training: 90 to 120 Minutes per Week Linked to Lower Mortality Risk, Study Finds | Natural News
Clarinda Hougen, MD

Faculty Publications

Biomedical Sciences

A Multimodal Single-Cell Framework for Ecosystem-Level Profiling of Circulating Tumor and Non-Tumor Cells. Felix, Gabriela, Francesca Aguirre, Lisa Zhou, Aaron Denmark, Rocio Alvarez, Daniel M. Kim, Jun Gong, and Megan P. Hitchins. Experimental Hematology & Oncology 15 (1): 54.

Dengue in the High Himalayas: New Challenges for Travel Medicine. Alisha, G. C., Gaurab Karki, Stephen Muhindi, Sandeep Thapa, Binod Rayamajhee, and G. C. Binod. Journal of Travel Medicine, June, taag054.

The Importance of Spatial Resolution in Detecting Chronic Myocardial Iron Remnants Following Hemorrhagic Myocardial Infarction With T2* MRI. Zhang, Xinheng, Hsin-Jung Yang, and Rohan Dharmakumar. Biomedical Physics & Engineering Express, June.

Cardiac Surgery

Strain Echocardiography for Assessment of Cardiac Graft Function Following Donation after Circulatory Death Heart Transplantation. Giao, Duc M., George E. Olverson, Ameen Basha, Abraham Sonny, Vipin Mehta, Ibraheem Hamzat, Rashid Walker, Dane C. Paneitz, Ruby Singh, Kamila Drezek, Alyssa Ramsay, Ioannis Mastoris, Kemar Brown, S. Alireza Rabi, Eriberto Michel, David A. D’Alessandro, and Asishana A. Osho. JHLT Open 13 (August): 100603.

Cardiology

Bioptome-Assisted Leaflet Snipping to Facilitate TTVR With Prior Tricuspid Clips and Alfieri Stitch. Hu, Jiun-Ruey, Jaideep Menda, Jarmanjeet Singh, George Thornton, Christopher Rajkumar, Apurva Bharucha, Dhairya Patel, Mamoo Nakamura, Aakriti Gupta, Kim Isabel, Tarun Chakravarty, Moody Makar, and Raj Makkar. JACC. Cardiovascular Interventions 19 (12): 1694–96.

Cardiometabolic Health in Pregnancy: Prevention, Management, and Long-Term Implications. Harrington, Colleen M., Amy Sarma, Amanda Jowell, Jessica Passarelli, Camille Powe, Natalie A. Bello, Jennifer Lewey, Melinda B. Davis, Lily Nedda Dastmalchi, Garima Sharma, Michael Honigberg, and Nandita Scott. JACC. Advances 5 (6 Pt 1): 102804.

Detection of Left Ventricular Outflow Obstruction From Standard B-Mode Echocardiogram Videos Using Deep Learning. Yuan, Victoria, Hirotaka Ieki, Christina Binder, Yuki Sahashi, Paul C. Cheng, and David Ouyang. JACC. Advances 5 (6 Pt 2): 102801.

Dynamic Risk Trajectories for Sudden Cardiac Arrest: The Role of Recurrent Cardiovascular Events. Pope, Marita Knudsen, Harpriya Chugh, Thien Tan Tri Tai Truyen, Marco Mathias, Audrey Uy-Evanado, Honghuang Lin, Dan Atar, Nichole Bosson, Kyndaron Reinier, Emelia J. Benjamin, and Sumeet S. Chugh. Journal of the American Heart Association, June, e049853.

First-in-Human Transcatheter Aortic Root Tricuspidization of Stenotic Bicuspid Valves: A Strategy to Optimize TAVR. Dvir, Danny, Hasan Jilaihawi, Ikki Komatsu, Anna Turyan, Rami Jubeh, Phillipe Taieb, Vivek Patel, Kazuki Suruga, and Creighton Don. JACC. Cardiovascular Interventions 19 (12): 1678–80.

How Soon Is Now?: A Call for Inaction on Donor Left Ventricular Hypertrophy. Kransdorf, Evan P., and Trinh Do. JACC. Heart Failure, June, 103186.

Prioritizing Discovery and Advancements in Arrhythmia Therapies: NIH/NHLBI Workshop. Hanna, Peter, Patrick M. Boyle, Jessica L. Caldwell, Mona El Refaey, William R. Goodyer, Shaan Khurshid, Olurotimi O. Mesubi, Joseph A. Palatinus, Anna Pfenniger, Olujimi A. Ajijola, Christine M. Albert, Antonis A. Armoundas, Emelia J. Benjamin, Colleen E. Clancy, Sana M. Al-Khatib, Kenneth Bilchick, Mario Delmar, J. Kevin Donahue, Glenn I. Fishman, Ilan Goldenberg, Robert G. Gourdie, David T. Huang, Björn C. Knollmann, Darae Ko, Steven A. Lubitz, Francis E. Marchlinski, Nicholas A. Marston, Ivan P. Moskowitz, Peter A. Noseworthy, Randall S. Prather, Przemysław B. Radwański, Sridharan Rajamani, Stacey Rentschler, Dan M. Roden, Andrea Russo, Jeffrey E. Saffitz, Nona Sotoodehnia, Gregory Webster, Sean M. Wu, Bishow B. Adhikari, W. Patricia Bandettini, Patrice Desvigne-Nickens, Sujata M. Shanbhag, David Schopfer, George Sopko, Olga A. Tjurmina, Ravi C. Balijepalli, Elizabeth McNally, and Kalyanam Shivkumar. JACC. Clinical Electrophysiology 12 (6): 1445–68.

Redo-TAVR (TAV-in-TAV) Best Practices Part 1: Short-in-Short and Short-in-Tall - A Heart and Valve Collaboratory Document. Pop, Andrei, Syed Zaid, Miho Fukui, Mohamed Abdel-Wahab, Mariama Akodad, Keith B. Allen, Ignacio J. Amat-Santos, Guilherme Attizzani, Ravinay Bhindi, Daniel J. Blackman, Michael Caskey, Lakshmi P. Dasi, Gilbert H. L. Tang, et al. JACC. Cardiovascular Interventions, June, S1936-8798(26)01819-4.

Redo-TAVR (TAV-in-TAV) Best Practices Part 2: Tall-in-Short and Tall-in-Tall - A Heart and Valve Collaboratory Document. Bapat, Vinayak N., Syed Zaid, Miho Fukui, Steven J. Yakubov, Pradeep Yadav, Mathew R. Williams, John G. Webb, Nicolas van Mieghem, Didier Tchetche, Giuseppe Tarantini, Ana Paula Tagliari, Curtiss T. Stinis, Gilbert H. L. Tang, et al. JACC. Cardiovascular Interventions, June, S1936-8798(26)01820-0.

Seven-Year Valve Durability With Transcatheter or Surgical Aortic Valve Replacement: An Ad Hoc Analysis of the PARTNER 3 Randomized Clinical Trial. Ternacle, Julien, Rebecca T. Hahn, Iria Silva, Alberto Alperi, Carlos Giuliani, Antonela Zanuttini, Alexis Théron, Abdellaziz Dahou, Nicole Cristell, Timothy Woods, Ezequiel Guzzetti, Pierre Yves Turgeon, Mathieu Bernier, Haïfa Mahjoub, Amélie Paquin, Sabah Skaf, Jonathan Beaudoin, Susheel K. Kodali, Mark Russo, Samir R. Kapadia, S. Chris Malaisrie, David J. Cohen, Jonathon Leipsic, Philipp Blanke, Mathew R. Williams, James M. McCabe, David L. Brown, Vasilis Babaliaros, Scott Goldman, Wilson Y. Szeto, Philippe Généreux, Ashish Pershad, Tamim M. Nazif, Yiran Zhang, Marissa Gunnarsson, John G. Webb, Raj R. Makkar, Vinod H. Thourani, Michael J. Mack, Martin B. Leon, Philippe Pibarot, and PARTNER 3 Investigators. JAMA Cardiology, June.

Small-Molecule Modulation of β-Arrestins. Kahsai, Alem W., Natalia Pakharukova, Henry Y. Kwon, Kunal S. Shah, Caroline T. Del Real, Bowie N. Shreiber, Jason G. Liang-Lin, Paul J. Shim, Mason A. Lee, Van A. Ngo, Allison M. Schwalb, Uyen Pham, Anand Chundi, Haoran Jiang, Emmanuel Flores-Espinoza, Samuel Liu, Preston C. Nibley, Dana K. Bassford, Hyunggu Hahn, Cal A. Kunzle, Brittany N. Thomas, Jihee Kim, Yang Zhou, Jialu Wang, Xingdong Zhang, Jeffrey S. Smith, Lindsay A. M. Rein, Alex R. B. Thomsen, Sudha K. Shenoy, Sudarshan Rajagopal, Lei Shi, Seungkirl Ahn, Howard A. Rockman, Ali Masoudi, and Robert J. Lefkowitz. Nature, June.

Computational Biomedicine

Development of the Authentication and Authorization Processes for the iAgree Portal, a Platform for Patient-Controlled Data Sharing Across Health Systems. Soohoo, Spencer L., Michelle Sophie Keller, Yunan Chen, Di Hu, Shao-Chi Huang, Tsung-Ting Kuo, Chloe Leder, Xi Lu, Daniela Meeker, Brad Morse, Harold Moyse, Gayathri Nagaraj, An T. Nguyen, Lisa M. Schilling, Andrey Soares, Mary A. Whooley, Kai Zheng, and Lucila Ohno-Machado. JAMIA Open 9 (3): ooag111.

Moving From Disclosure to Substance in AI Transparency. Zhan, Huixin, and Jason H. Moore. Patterns 7 (6): 101585.

Medicine

BIRC3 (Encoding Cellular Inhibitor of Apoptosis Protein 2) Variants Result in Dysregulated Receptor-Interacting Protein Kinase 1 Signaling Leading to Increased Epithelial Cell Death and Are Associated With Monogenic Crohn’s Disease. Li, Qi, Ryusuke Nambu, Hu Yaqiang, Xiang Shen, Carmen Argmann, Rei Guan, Erin Janssen, Tom Le Voyer, Neil Warner, Daniel D. Yu, Jing Guo, Kelvin Long, Jodie Ouahed, Michael Field, Lauren Collen, Jonas Bibus, David Illig, Meino Rohlfs, Ziqi Yu, Shaohong Yang, Wenjuan Li, Craig D. Platt, Phillip H. Comella, Daniel Jordan, Mayte Suárez-Fariñas, Mohammed F. Alosaimi, Lauren A. Peters, Jeremie Rosain, Claire Fieschi, Anne Puel, Elena W. Y. Hsieh, Takeo Naito, Zhiyang Zeng, Marta Velasco Rodríguez-Belvís, Laura Palomino, Peter Küster, Dalin Li, Christoph Klein, Scott B. Snapper, Jean-Laurent Casanova, Raif Geha, Edward Hoffenberg, Dermot P. B. McGovern, Eric Schadt, Daniel Kotlarz, Dali Li, and Aleixo M. Muise. Gastroenterology, June, S0016-5085(26)06946-5.

Constipation With Bloating: A Clinical Approach to Evaluation and Management. Cangemi, David J., Adam P. Laitman, Orit Faiman, and Bianca W. Chang. Annals of Medicine 58 (1): 2684172.

Harnessing MDM2-Mediated Targeted Degradation of Transcriptional and Epigenetic Machinery to Disrupt Oncogenic Addictions in Pediatric Sarcoma. Zhou, Jiawei, Xian Guan, Nan Li, Ying Zhang, Long Xie, Xingze Huang, Zhipeng Zhu, Zhuolin Ren, Xiaoyan Yu, Hanjun Guo, Yuanfang Wu, Lin Ma, Suya Zheng, Jingyao Zhang, Jiyang Liu, Victor Kuanmin Lee, Wenhao Chen, H. Phillip Koeffler, Jinhu Wang, Xin Han, Ye Chen, and Liang Xu. Advanced Science, June, e23088.

Impact of Fostamatinib on Inflammatory Biomarkers in Hospitalized Patients With COVID-19. Da Cruz, Raquel S., Heather L. Teague, Marcos J. Ramos-Benitez, Sonya J. Malavez-Cajigas, Trenton Williams, Rui Miao, Xin Tian, Gefei Lin, Laurence W. Busse, Akram Khan, Ari Moskowitz, David N. Hager, Todd W. Rice, Adit A. Ginde, Nicole M. Iovine, Peter Chen, Basmah Safdar, Kevin W. Gibbs, Ali Javaheri, Marjolein de Wit, Michelle Harkins, Kris Hudock, Lisa H. Merck, Aaron Barksdale, Jeffrey M. Sturek, Harry Schrager, Nathan I. Shapiro, Michael Lanspa, Estelle Harris, Subhashini Sellers, Andrew J. Goodwin, Mark A. Tidswell, Michael R. Filbin, Matthew S. Shotwell, Matthew W. Semler, Wesley H. Self, Sean P. Collins, Jeffrey R. Strich, and Accelerating COVID-19 Therapeutic Interventions and Vaccines (ACTIV-4) Host Tissue Investigators. Critical Care Explorations 8 (7): e1405.

Navigating Treatment Selection in Acute Severe Ulcerative Colitis: A Prospective Mixed Method Analysis of Factors Influencing Patient Decision-Making. Herran, Reid, Samuel Wilcox, Gal Hodish, Syed A. Hassan, Haley Mertens, Christopher V. Almario, Philip Gu, Maia Kayal, Shirley Cohen-Mekelburg, Randolph E. Regal, Shrinivas Bishu, Corey A. Siegel, Melissa DeJonckheere, Peter D. R. Higgins, and Jeffrey A. Berinstein. Digestive Diseases and Sciences, June.

Osteoporosis and Osteoporosis Therapies as Determinants of Implant Fixation Failure in Arthroplasty and Spinal Fusion Constructs: A Position Statement From the Fracture Working Group of the Council of Scientific Advisors of the International Osteoporosis Foundation. Chandran, Manju, Athanasios D. Anastasilakis, Robert D. Blank, Neil Binkley, Thierry Chevalley, M. Kassim Javaid, Willem F. Lems, E. Michael Lewiecki, Polyzois Makras, Julien Paccou, Stuart Silverman, Thierry Thomas, Maria Luisa Brandi, Eugene McCloskey, Etienne Cavalier, Kristina E. Åkesson, Gerold Holzer, and Fracture Working Group of the Committee of Scientific Advisors (CSA) of the IOF. Osteoporosis International: A Journal Established as Result of Cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, June.

Physician-Expert Insights on the Variable Costs of Delayed Diagnoses Across 6 Conditions. Hero, Joachim O., Enrique Vazquez, Carl T. Berdahl, Sara G. McCleskey, Gordon D. Schiff, and Sangeeta C. Ahluwalia. Journal of Patient Safety, June.

Professionals’ Perspectives on Trusted Persons in French Nursing Homes. Faye-Ropaul, Maïva, and Carine Khalil. BMC Health Services Research, June.

Racial and Sex Differences in Postoperative Mortality Between Patients With Versus Without Dementia. Yoshida, Ryu, Teryl K. Nuckols, Keith Norris, Melinda Maggard-Gibbons, Christian de Virgilio, Alexandra Klomhaus, Ruixin Li, Yu Jun Li, Yusuke Tsugawa, and Hiroshi Gotanda. Annals of Surgery Open: Perspectives of Surgical History, Education, and Clinical Approaches 7 (2): e667.

Reply: Liver Transplantation in AH-ACLF-Which Condition Drives Post-Transplant Outcomes? Kusztos, Victoria E., Tiffany Wu, Blake Kassmeyer, Ruben Hernaez, Constantine Karvellas, Saro Khemichian, Lance Stein, Kirti Shetty, Christina C. Lindenmeyer, Justin Boike, Robert Rahimi, Jalal Prasun, Manhal Izzy, Michael Kriss, Gene Y. Im, Ming V. Lin, Janice H. Jou, Brett E. Fortune, George T. Cholankeril, Alexander Kuo, and Douglas A. Simonetto. Liver Transplantation, June.

Revisiting Perfusion in the Forgotten Right Ventricle: Artificial Intelligence-Enhanced Quantification on PET/CT. Shanbhag, Aakash, Robert J. H. Miller, Paul Kavanagh, Giselle Ramirez, Mark Lemley, Jacek Kwiecinski, Assiata Kamagate, Leandro Slipczuk, Mark I. Travin, Erick Alexanderson, Isabel Carvajal-Juarez, René R. S. Packard, Mouaz Al-Mallah, Andrew J. Einstein, Wanda Acampa, Stacey Knight, Viet T. Le, Steve Mason, Samuel Wopperer, Panithaya Chareonthaitawee, Thomas L. Rosamond, Daniel S. Berman, Damini Dey, Marcelo F. Di Carli, and Piotr J. Slomka. Journal of Nuclear Medicine, June, jnumed.125.271894.

Single Versus Dual Computed Tomography for Attenuation Correction: Are We Ready to Simplify? Slomka, Piotr J. Journal of Nuclear Cardiology, 60 (June): 102742.

The Association Between the Acute Physiology Score and Sepsis in ICU Non-Surviving Patients With Inflammatory Bowel Disease: A Retrospective Cohort Study From the eICU-CRD. Li, Chenyang, Zhexuan Liu, Daniel D. Zhang, Fenghua Li, Dong Wang, Yuxin Luo, Yue Yao, Qian Liu, Xu Teng, Shuang Chen, and Xiaolan Zhang. Frontiers in Medicine 13: 1761815.

Uncovering Senescent Fibroblast Heterogeneity Connects DNA Damage Response to Idiopathic Pulmonary Fibrosis. Hughes, Jun-Wei B., Akshay Pujari, Anja Sandholm, Duncan Croll, Lea Baskin Monk, Isaac Joshua, Rachel Butterfield, Corrigan Horton, Kevin Schneider, Fiona Senchyna, Ian Brown, Zhixin A. Zhang, Ana L. Coelho, Tsung-Che Ho, Hideto Deguchi, Ryo Higuchi-Sanabria, Claude Jourdan Le Saux, Stefanie Deinhardt-Emmer, Lisa M. Ellerby, Alberto C. Vitari, David Furman, Cory M. Hogaboam, Alex Laslavic, Pierre-Yves Desprez, Marco Quarta, and Judith Campisi. Npj Aging, June.

OBGYN

Flowing Differently: Exploratory Characterization of Menstrual Effluent Compared to Peripheral Blood. Michel, Rachel, Ariadne Sinnis-Bourozikas, Valentina Vanos, Gregory W. Kirschen, Laura A. St Clair, Prasanthy Balasubramanian ScM, John Skinner, Zachary Mulcare, Anna Yin, Andrew H. Karaba, Jaiprasath Sachithanandham, Malini Ramaiyer, Malak El Sabeh, Jinxiao Liang, Fiza Ali, Andrew Pekosz, Sabra L. Klein, Andrea L. Cox, and Mostafa A. Borahay. F&S Science, June, S2666-335X(26)00038-8.

Orthopaedics and Sports Medicine

Letter to the Editor Regarding ‘Safety and Efficacy of Magnetically Controlled Growing Rods for Early-Onset Scoliosis in the Era of Disease-Modifying Therapies: Mid-Term Results in a Homogeneous Cohort of SMA-I Patients.’ Kodali, Prudhvi, and David Skaggs. Journal of the Pediatric Orthopaedic Society of North America 16 (August): 100388.

Pathology and Laboratory Medicine

Identification of a Novel Class of Early Exon ALK Rearrangements Across Two Pan-Tumor Sequencing Databases. Leong, Matthew, Mahzad Azimpouran, Xiaomo Li, Paul A. Fields, Adam J. Hockenberry, Roosheel Patel, Siddharth Rode, Eden Abraham, Manando Nakasaki, Saleh Heneidi, Benjamin Barrena, Matthew Gayhart, Celeste Eno, Nan Jiang, Bonnie Balzer, Jacob Mercer, Gaurav Khullar, and Eric Vail. Cancer Genetics 306–307 (June): 116–22.

Most Human Granulosa Cell Tumors Express C-MET: A Potential New Therapeutic Target. Wappler-Guzzetta, Edina A., Daniel M. Real, Shehla Aman, Chelsea Huang, Jeremy K. Deisch, and Laura J. Denham. Physiology International, June, 2060.2026.00825.

Pediatrics

Germ Layer-Specific Interaction of Ion Channels and Transporters Controls Membrane Potential and Left-Right Patterning in Xenopus Tropicalis. Tyan, Leonid, Valentyna Kostiuk, Nicholas Diab, David Zenisek, and Mustafa K. Khokha. Communications Biology, June.

Implementation of an Antimicrobial Stewardship Program in a Multicenter Neonatal Intensive Care Unit Collaborative: A Mixed-Methods Staff Resource Needs Evaluation. Gong, Cynthia L., Nabeel Qureshi, Peter Mendel, Kurlen S. E. Payton, Henry C. Lee, and Kenneth M. Zangwill. Journal of Perinatology, June.

Perioperative Anesthesia Practices in Pediatric Kidney Transplantation Across Lower-Middle Income Countries (LMICs) of South Asia: A Cross-Sectional Survey. Jani, Noopur, Kinnari Vala, Beena K. Parikh, Manisha P. Modi, and Dechu P. Puliyanda. Pediatric Transplantation 30 (6): e70378.

Surgery

Multicenter Analysis of Surgical Outcomes Following Isolated Orbital Floor Blowout Fracture Repair: A 15-Year Cohort Study Utilizing the ACS-NSQIP Database. Hoch, Cosima C., Thomas Schaschinger, Tobias Niederegger, Curtis L. Cetrulo, Maximilian Miragall, Leonard Knoedler, Max Richter, Steffen Koerdt, Jan Oliver Voss, and Alexandre G. Lellouch. Advances in Oral and Maxillofacial Surgery 23 (September): 100690.

Risk Factors and Complication Rates of Inpatient Genioplasty Procedures in the U.S. Healthcare System: A 22-Year Retrospective Multi-Center Analysis. Knoedler, Leonard, Robert Munzinger, Benedikt Geldner, Tobias Niederegger, Emre Karakas, Simon Bigus, Alexandre Lellouch, Jakob Fenske, and Jan O. Voss. Aesthetic Plastic Surgery, June.

The Utility and Applicability of the Modified 5-Item Frailty Index in Cosmetic Surgery. Knoedler, Samuel A., Leonard Knoedler, Thomas Schaschinger, Valentin Haug, Julius M. Wirtz, Doha Obed, Katharina Flöthmann, Alexandre G. Lellouch, Bong-Sung Kim, Devin Coon, Gabriel Hundeshagen, Dennis P. Orgill, and Adriana C. Panayi. Aesthetic Plastic Surgery, June.

Urology

Advancing Engineered Nanoparticles for Enhanced Efficacy in Cancer Immunotherapy: Optimizing Nanoparticles for Cancer Immunotherapy. Basu, Mukta, Elizabeth Mahapatra, Deepika Rai, and Abhimanyu Thakur. Molecular Biology Reports 53 (1): 1006.

Criteria Clinicians Use to Classify Patients as High Risk in Biochemically Recurrent Nonmetastatic Castration‑Sensitive Prostate Cancer. Freedland, Stephen J., Amanda Ribbands, Maëlys Touya, Jake Butcher, Maria Walley, David Russell, Christopher S. Bland, and Jasmina I. Ivanova. Advances in Therapy, June.

End to End AI System for Surgical Gesture Sequence Recognition and Clinical Outcome Prediction. Li, Xi, Nicholas Matsumoto, Ujjwal Pasupulety, Atharva Deo, Cherine Yang, Jay Moran, Miguel E. Hernandez, Peter Wager, Jasmine Lin, Jeanine Kim, Alvin C. Goh, Christian Wagner, Geoffrey A. Sonn, and Andrew J. Hung. NPJ Digital Medicine, June.