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Faculty Publications: Sept. 22-29

A Comprehensive Digest of Research Publications From Cedars-Sinai Investigators

This week’s edition of Faculty Publications includes Cedars-Sinai studies that were published Sept. 22-29. If you have a published paper from this period that does not appear on this list, please contact Sue Marone, who will add it to next week’s collection.


Intensivists’ Perceptions of What Is Missing in Their Compassionate Care During Interactions in the Intensive Care Unit. Siddiqui, Shahla, Enas Mohamed, Balachundhar Subramaniam, Hibiki Orui, Michael Nurok, Miguel Angel Cobas, Mark E. Nunnally, Christiane Hartog, Raanan Gillon, and Beth A. Lown. BMC Health Services Research 22 (1): 1188.


A Comparative Study of Tumour-on-Chip Models With Patient-Derived Xenografts for Predicting Chemotherapy Efficacy in Colorectal Cancer Patients. Ong, Louis Jun Ye, Shumei Chia, Stephen Qi Rong Wong, Xiaoqian Zhang, Huiwen Chua, Jia Min Loo, Wei Yong Chua, Clarinda Chua, Emile Tan, Hannes Hentze, Iain Beehuat Tan, Ramanuj DasGupta, and Yi-Chin Toh. Frontiers in Bioengineering and Biotechnology 10: 952726.

Hepatocellular Carcinoma Surveillance: Current Practice and Future Directions. Ahn, Joseph C., Yi-Te Lee, Vatche G. Agopian, Yazhen Zhu, Sungyong You, Hsian-Rong Tseng, and Ju Dong Yang. Hepatoma Research 8: 10.

Characterizing Mechanism-Based Pain Phenotypes in Patients With Chronic Pancreatitis: A Cross-Sectional Analysis of the Prospective Evaluation of Chronic Pancreatitis for EpidEmiologic and Translational Studies. Saloman, Jami L., Darwin L. Conwell, Evan Fogel, Santhi Swaroop Vege, Liang Li, Shuang Li, Dana K. Andersen, William E. Fisher, Christopher E. Forsmark, Phil A. Hart, Stephen J. Pandol, Walter G. Park, Anna Evans Phillips, Mark Topazian, Stephen K. Van Den Eeden, Jose Serrano, Dhiraj Yadav, and Consortium for the Study of Chronic Pancreatitis, Diabetes and Pancreatic Cancer. Pain, June.

Exploratory Genomic Analysis of High Grade Neuroendocrine Neoplasms Across Diverse Primary Sites. Sun, Thomas Yang, Lan Zhao, Paul Van Hummelen, Brock Martin, Kathleen Hornbacker, HoJoon Lee, Li C. Xia, Sukhmani K. Padda, Hanlee P. Ji, and Pamela Kunz. Endocrine-Related Cancer, September, ERC-22-0015.

Polycomb Directed Cell Fate Decisions in Development and Cancer. German, Beatriz, and Leigh Ellis. Epigenomes 6 (3): 28.

High-Content Drug Discovery Targeting Molecular Bladder Cancer Subtypes. Rinaldetti, Sébastien, Qiong Zhou, Joshua M. Abbott, Florus C. de Jong, Hector Esquer, James C. Costello, Dan Theodorescu, and Daniel V. LaBarbera. International Journal of Molecular Sciences 23 (18): 10605.

AST-487 Inhibits RET Kinase Driven TERT Expression in Bladder Cancer. Agarwal, Neeraj, Qiong Zhou, Deepak Arya, Sébastien Rinaldetti, Jason Duex, Daniel V. LaBarbera, and Dan Theodorescu. International Journal of Molecular Sciences 23 (18): 10819.

Transcriptome Analysis Identifies TODL as a Novel LncRNA Associated With Proliferation, Differentiation, and Tumorigenesis in Liposarcoma Through FOXM1 Running Title: TODL LncRNA as a Potential Therapeutic Target for Liposarcoma. Kanojia, Deepika, Anuradha Kirtonia, Namburi Sai Valli Srujana, Sree Priyanka Jeevanandan, Pavithra Shyamsunder, Shruthi Sanjitha Sampath, Pushkar Dakle, Anand Mayakonda, Harvinder Kaur, Jiang Yanyi, H. Phillip Koeffler, and Manoj Garg. Pharmacological Research, September, 106462.

Cardiac Surgery 

Teaching Business in Resident Education. Loo, Megan, Robbin G. Cohen, and Michael E. Bowdish. The Annals of Thoracic Surgery, September, S0003-4975(22)01236-X.

Editor’s Choice: The Biggest Challenges in Cardiothoracic Surgery. Mitzman, Brian, and Joanna Chikwe. The Annals of Thoracic Surgery 114 (4): 1099–1103.


Association of Coronary Artery Calcium Score With Qualitatively and Quantitatively Assessed Adverse Plaque on Coronary CT Angiography in the SCOT-HEART Trial. Osborne-Grinter, Maia, Jacek Kwiecinski, Mhairi Doris, Priscilla McElhinney, Sebastien Cadet, Philip D. Adamson, Alastair J. Moss, Shirjel Alam, Amanda Hunter, Anoop S. V. Shah, Nicholas L. Mills, Tania Pawade, Chengjia Wang, Jonathan R. Weir-McCall, Giles Roditi, Edwin J. R. van Beek, Leslee J. Shaw, Edward D. Nicol, Daniel Berman, Piotr J. Slomka, David E. Newby, Marc R. Dweck, Damini Dey, and Michelle C. Williams. European Heart Journal. Cardiovascular Imaging 23 (9): 1210–21.

TCT-389 First Report of Percutaneous Left Atrial Appendage Occlusion With Watchman FLX With TEE Guidance and Zero Contrast. Chakravarty, Tarun, Derek Leong, Neel Bhardwaj, Christy Slingwine, Laura Zung, Sabah Skaf, Siddharth Singh, Moody Makar, and Raj Makkar. Journal of the American College of Cardiology, Transcatheter Cardiovascular Therapeutics Abstracts, 80 (12, Supplement): B157.

TCT-404 Prognostic Impact of Cardiac Damage Across the Spectrum of Aortic Stenosis Severity: Results From a Large Real-World Database. Genereux, Philippe, Rahul Sharma, Robert Cubeddu, Martin Leon, David Cohen, Samir Kapadia, Raj Makkar, Vinod Thourani, Michael Dobbles, Glenn Barnhart, and Linda Gillam. Journal of the American College of Cardiology, Transcatheter Cardiovascular Therapeutics Abstracts, 80 (12, Supplement): B163–64.

TCT-521 Hemodynamic and Mortality Outcome for Transcatheter Valve in Degenerated Internally Stented Surgical Valves Compared With Other Degenerated Surgical Valves. AlBadri, Ahmed, Jubin Joseph, Hasan Jilaihawi, Vivek Patel, and Raj Makkar. Journal of the American College of Cardiology, Transcatheter Cardiovascular Therapeutics Abstracts, 80 (12, Supplement): B213.

TCT-587 Radial vs Femoral Access for Continuous Mechanical Aspiration Thrombectomy Before Percutaneous Coronary Intervention for Acute Coronary Syndrome: A Post Hoc Analysis of the CHEETAH Study. Metzger, D. Christopher, Brian Kolski, Jeff Chambers, Suhail Dohad, Willis Wu, Sahil Parikh, and Jay Mathews. Journal of the American College of Cardiology, Transcatheter Cardiovascular Therapeutics Abstracts, 80 (12, Supplement): B241–42.

Deep Learning-Based Attenuation Correction Improves Diagnostic Accuracy of Cardiac SPECT. Shanbhag, Aakash D., Robert J. H. Miller, Konrad Pieszko, Mark Lemley, Paul Kavanagh, Attila Feher, Edward J. Miller, Albert J. Sinusas, Philipp A. Kaufmann, Donghee Han, Cathleen Huang, Joanna X. Liang, Daniel S. Berman, Damini Dey, and Piotr J. Slomka. Journal of Nuclear Medicine, Society of Nuclear Medicine, September, jnumed.122.264429.

Factors Associated With Duration of Breastfeeding in Women Giving Birth for the First Time. Haas, David M., Ziyi Yang, Corette B. Parker, Judith Chung, Samuel Parry, William A. Grobman, Brian M. Mercer, Hyagriv N. Simhan, Robert M. Silver, Ronald J. Wapner, George R. Saade, Philip Greenland, Noel Bairey Merz, Uma M. Reddy, Victoria L. Pemberton, and nuMoM2b study and the nuMoM2b Heart Health Study. BMC Pregnancy and Childbirth 22 (1): 722.

Ischemia With No Obstructive Coronary Artery Disease (INOCA): A Patient Self-Report Quality of Life Survey From INOCA International. Gulati, Martha, Najah Khan, Maria George, Colin Berry, Alaide Chieffo, Paolo G. Camici, Filippo Crea, Juan-Carlos Kaski, Mario Marzilli, and C. Noel Bairey Merz. International Journal of Cardiology, September, S0167-5273(22)01396-1.

Impact of Right Ventricle-Pulmonary Artery Coupling on Clinical Outcomes in the PARTNER 3 Trial. Cahill, Thomas J., Philippe Pibarot, Xiao Yu, Vasilis Babaliaros, Philipp Blanke, Marie-Annick Clavel, Pamela S. Douglas, Omar K. Khalique, Jonathon Leipsic, Raj Makkar, Maria C. Alu, Susheel Kodali, Michael J. Mack, Martin B. Leon, and Rebecca T. Hahn. JACC. Cardiovascular Interventions 15 (18): 1823–33.

Computational Biomedicine 

Mining High-Level Imaging Genetic Associations via Clustering AD Candidate Variants With Similar Brain Association Patterns. Wu, Ruiming, Jingxuan Bao, Mansu Kim, Andrew J. Saykin, Jason H. Moore, Li Shen, and null On Behalf Of Adni. Genes 13 (9): 1520.


Free-Breathing 3D CEST MRI of Human Liver at 3.0 T. Han, Pei, Karandeep Cheema, Tianle Cao, Hsu-Lei Lee, Fei Han, Nan Wang, Hui Han, Yibin Xie, Anthony G. Christodoulou, and Debiao Li. Magnetic Resonance in Medicine, September.


The Roles of Gut Microbiome and Plasma Metabolites in the Associations Between ABO Blood Groups and Insulin Homeostasis: The Microbiome and Insulin Longitudinal Evaluation Study (MILES). Li-Gao, Ruifang, Kirk Grubbs, Alain G. Bertoni, Kristi L. Hoffman, Joseph F. Petrosino, Gautam Ramesh, Martin Wu, Jerome I. Rotter, Yii-Der Ida Chen, Anne M. Evans, Richard J. Robinson, Laura Sommerville, Dennis Mook-Kanamori, Mark O. Goodarzi, Gregory A. Michelotti, and Patricia A. Sheridan. Metabolites 12 (9): 787.

Simple Diagnostic Algorithm Identifying At-Risk Nonalcoholic Fatty Liver Disease Patients Needing Specialty Referral Within the United States. Alkhouri, Naim, Pankaj Aggarwal, Phuc Le, Julia Payne, Celine Sakkal, Prido Polanco, Stephen Harrison, and Mazen Noureddin. World Journal of Hepatology 14 (8): 1598–1607.

New Insights into the Alveolar Epithelium as a Driver of Acute Respiratory Distress Syndrome. Sanches Santos Rizzo Zuttion, Marilia, Sarah Kathryn Littlehale Moore, Peter Chen, Andrew Kota Beppu, and Jaime Lynn Hook. Biomolecules 12 (9): 1273.

AGA Clinical Practice Update on Management of Refractory Celiac Disease: Expert Review. Green, Peter H. R., Shirley Paski, Cynthia W. Ko, and Alberto Rubio-Tapia. Gastroenterology, September, S0016-5085(22)00967-2.

Reply. Cohen, Benjamin L., Phillip Fleshner, and Bruce E. Sands. Gastroenterology, September, S0016-5085(22)01080-0.

Case Report of CCDC149-ALK Fusion: A Novel Genetic Alteration and a Clinically Relevant Target in Metastatic Papillary Thyroid Carcinoma. Lee, Hannah, Vimal Krishnan, Lori J. Wirth, Carmelo Nucera, Peter M. Sadow, Mariza Venturina, Alain Mita, and Wendy Sacks. Thyroid, September.

Pulmonary Embolism. Tapson, Victor F., and David Jiménez. The New England Journal of Medicine 387 (13): 1241–42.

Excess Diabetes Mellitus-Related Deaths During the COVID-19 Pandemic in the United States. Lv, Fan, Xu Gao, Amy Huaishiuan Huang, Jian Zu, Xinyuan He, Xiaodan Sun, Jinli Liu, Ning Gao, Yang Jiao, Margaret G. Keane, Lei Zhang, Yee Hui Yeo, Youfa Wang, and Fanpu Ji. EClinicalMedicine 54 (December): 101671.


From Pathology to MRI and Back: Clinically Relevant Biomarkers of Multiple Sclerosis Lesions. Kolb, Hadar, Omar Al-Louzi, Erin S. Beck, Pascal Sati, Martina Absinta, and Daniel S. Reich. NeuroImage. Clinical36 (September): 103194.

Intrathecal Methotrexate Toxicity Resulting in Brain Death Due to Generalized Cerebral Edema Case Report. Pang, Haoming, Julie L. Chan, Serguei I. Bannykh, Michael Gezalian, Shouri Lahiri, Shahed Toossi, and Maranatha Ayodele. The Neurohospitalist 12 (4): 697–701.


Label-Free Hyperspectral Imaging and Deep-Learning Prediction of Retinal Amyloid β-Protein and Phosphorylated Tau. Du, Xiaoxi, Yosef Koronyo, Nazanin Mirzaei, Chengshuai Yang, Dieu-Trang Fuchs, Keith L. Black, Maya Koronyo-Hamaoui, and Liang Gao. PNAS Nexus 1 (4): pgac164.

A Systematic Review and Meta-Analysis of Silicon Nitride and Biomaterial Modulus as It Relates to Subsidence Risk in Spinal Fusion Surgery. Ament, Jared D., Amir Vokshoor, Randy Yee, and J. Patrick Johnson. North American Spine Society Journal 12 (December): 100168.


Oral Care Knowledge, Attitudes, and Practices of Black/African American Caregivers of Autistic Children and Non-Autistic Children. Como, Dominique H., Lucía I. Floríndez-Cox, Leah I. Stein Duker, Jose C. Polido, Brandi P. Jones, Mary Lawlor, and Sharon A. Cermak. Children (Basel, Switzerland) 9 (9): 1417.

Leveraging a Funding Collaborative to Develop More PhD Prepared Nurse Scientists and Leaders. Ladden, Maryjoan D., Laurie Ecoff, Lorina Marshall-Blake, Jane W. Swanson, Susan Moyer, and Lindsey Ryan. Nursing Outlook, September, S0029-6554(22)00116-6.

Sugars and Sweeteners in Tobacco and Nicotine Products: FDA Regulatory Implications. Rezk-Hanna, Mary, Reinskje Talhout, and Sven-Eric Jordt. Nicotine & Tobacco Research, September, ntac222.

Influence of a Formal Mentor on Hospital-Based Nurse Research Resources and Outcomes. Saul, Trisha, Teresa Rangel, Marietta V. Sperry, Carrie Doyle, Jamie K. Roney, and Sherri Mendelson. The Journal of Nursing Administration 52 (10): 549–53.


Strategies Reducing Risk of Surgical-Site Infection Following Pediatric Spinal Deformity Surgery. Matsumoto, Hiroko, Lisa Bonsignore-Opp, Shay I. Warren, Bradley T. Hammoor, Michael J. Troy, Kody K. Barrett, Brendan M. Striano, Benjamin D. Roye, Lawrence G. Lenke, David L. Skaggs, Michael P. Glotzbecker, John M. Flynn, David P. Roye, and Michael G. Vitale. Spine Deformity, September.

A Central Collinear Start Point for Reconstruction Nailing of Femur Fractures: A Technical Trick and Case Series. Robles, Abrianna S., Donald J. DeSanto, Jeffrey S. Earhart, and Geoffrey S. Marecek. Journal of Orthopaedic Trauma, September.


PD-L1 Over-Expression Varies in Different Subtypes of Lung Cancer: Will This Affect Future Therapies? Ullah, Asad, Steven Pulliam, Nabin Raj Karki, Jaffar Khan, Sana Jogezai, Sandresh Sultan, Lal Muhammad, Marjan Khan, Nimra Jamil, Abdul Waheed, Sami Belakhlef, Intisar Ghleilib, Eric Vail, Saleh Heneidi, and Nagla Abdel Karim. Clinics and Practice 12 (5): 653–71.


Pre-Transplant Angiotensin II Receptor Type I Antibodies in Pediatric Renal Transplant Recipients: An Observational Cohort Study. Pizzo, Helen, James Mirocha, Jua Choi, Jonathan Garrison, Mark Haas, Xiaohai Zhang, Elaine S. Kamil, Irene Kim, Stanley C. Jordan, and Dechu P. Puliyanda. Pediatric Transplantation, September, e14400.

Surgical Complexity and Physician Compensation: An Analysis of Relative Under-Valuation for Pediatric Brachial Plexus Surgery. McCullough, Meghan C., Jordan Wlodarczyk, Laya Jacob, Korri Hershenhouse, and Mitchel Seruya. Hand (New York, N.Y.), September, 15589447221120844.


Penile and Scrotal Skin Measurements to Predict Final Vaginal Depth With Penile Inversion Vaginoplasty. Smith, Shannon M., Nance Yuan, Jenna Stelmar, Michael Zaliznyak, Grace Lee, Catherine Bresee, and Maurice M. Garcia. Sexual Medicine 10 (6): 100569.

A Case of Mediastinal Emphysema Following Functional Endoscopic Sinus Surgery. Nasrollahi, Tasha, Michela Borrelli, Jonathan Raskin, and Bozena B. Wrobel. Ear, Nose, & Throat Journal, September, 1455613221121492.

An Observation-First Strategy For Liver Injuries With ‘Blush’ On CT Is Safe And Effective. Samuels, Jason M., Heather Carmichael, Robert McIntyre, Shane Urban, Shana Ballow, Rachel C. Dirks, M. C. Spalding, Aimee LaRiccia, Michael S. Farrell, Deborah M. Stein, Michael S. Truitt, Heather M. Grossman Verner, Caleb J. Mentzer, T. J. Mack, Chad G. Ball, Kaushik Mukherjee, Georgi Mladenov, Daniel J. Haase, Hossam Abdou, Thomas J. Schroeppel, Jennifer Rodriquez, Jeffry Nahmias, Erika Tay, Miklosh Bala, Natasha Keric, Morgan Crigger, Navpreet K. Dhillon, Eric J. Ley, Tanya Egodage, John Williamson, Tatiana Cp Cardenas, Vadine Eugene, Kumash Patel, Kristen Costello, Stephanie Bonne, Fatima S. Elgammal, Warren Dorlac, Claire Pederson, Clay Cothren Burlew, Nicole L. Werner, James M. Haan, Kelly Lightwine, Gregory Semon, Kristen Spoor, Catherine Velopulos, and Laura A. Harmon. The Journal of Trauma and Acute Care Surgery, September.