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Faculty Publications: June 16-23

A Comprehensive Digest of Research Publications From Cedars-Sinai Investigators

This week’s edition of Faculty Publications includes Cedars-Sinai studies that were published June 16-23. If you have a published paper from this period that does not appear on this list, please contact Sue Marone, who will add it to next week’s collection.

Biomedical Sciences 

Regenerative and Restorative Medicine for Eye Disease. Van Gelder, Russell N., Michael F. Chiang, Michael A. Dyer, Thomas N. Greenwell, Leonard A. Levin, Rachel O. Wong, and Clive N. Svendsen. Nature Medicine 28 (6): 1149–56.


State-of-the-Science Concepts of HPV-Related Oropharyngeal Squamous Cell Carcinoma: A Comprehensive Review. Louredo, Brendo Vinicius Rodrigues, Ana Carolina Prado-Ribeiro, Thaís Bianca Brandão, Joel B. Epstein, Cesar Augusto Migliorati, Alicia Rumayor Piña, Luiz Paulo Kowalski, Pablo Agustin Vargas, Márcio Ajudarte Lopes, and Alan Roger Santos-Silva. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, April, S2212-4403(22)00893-8.

Single-Agent Anti-PD-1 or Combined With Ipilimumab in Patients With Mucosal Melanoma: An International, Retrospective, Cohort Study. Dimitriou, F., K. Namikawa, I. L. M. Reijers, E. I. Buchbinder, J. A. Soon, A. Zaremba, P. Teterycz, et al. Annals of Oncology, June, S0923-7534(22)01731-8.

Dual Stromal Targeting Sensitizes Pancreatic Adenocarcinoma for Anti-PD-1 Therapy. Blair, Alex B., Jianxin Wang, John Davelaar, Andrew Baker, Keyu Li, Nan Niu, Junke Wang, et al. Gastroenterology, June, S0016-5085(22)00645-X.

To Extract or Not Extract Teeth Prior to Head and Neck Radiotherapy? A Systematic Review and Meta-Analysis. Normando, Ana Gabriela Costa, Maria Eduarda Pérez-de-Oliveira, Eliete Neves Silva Guerra, Márcio Ajudarte Lopes, André Caroli Rocha, Thaís Bianca Brandão, Ana Carolina Prado-Ribeiro, et al. Supportive Care in Cancer, June.

MASCC/ISOO Expert Opinion on the Management of Oral Problems in Patients With Advanced Cancer. Jones, Jac A., Yanin Chavarri-Guerra, Luisa Barreto Costa Corrêa, David R. Dean, Joel B. Epstein, Eduardo R. Fregnani, Jiyeon Lee, et al. Supportive Care in Cancer, June.

A Novel CEBPE Variant Causes Severe Infections and Profound Neutropenia. Banday, Aaqib Zaffar, Anit Kaur, Tadayuki Akagi, Dharmagat Bhattarai, Masahiro Muraoka, Diksha Dev, Jhumki Das, et al. Journal of Clinical Immunology, June.

Interleukin-27 Signaling Serves as an Immunological Checkpoint for Innate Cytotoxic Cells to Promote Hepatocellular Carcinoma. Aghayev, Turan, Aleksandra M. Mazitova, Jennifer R. Fang, Iuliia O. Peshkova, Matthew Rausch, Manhsin Hung, Kerry F. White, et al. Cancer Discovery, June, candisc.1628.2020-11-7 00:59:46.747.

Single-Cell RNA-Seq of a Soft-Tissue Sarcoma Model Reveals the Critical Role of Tumor-Expressed MIF in Shaping Macrophage Heterogeneity. Tessaro, Fernando H. G., Emily Y. Ko, Marco De Simone, Roberta Piras, Marina T. Broz, Helen S. Goodridge, Bonnie Balzer, Stephen L. Shiao, and Jlenia Guarnerio. Cell Reports 39 (12): 110977.

Statins and Prostate Cancer-Hype or Hope? The Epidemiological Perspective. Craig, Emma L., Konrad H. Stopsack, Emma Evergren, Linda Z. Penn, Stephen J. Freedland, Robert J. Hamilton, and Emma H. Allott. Prostate Cancer and Prostatic Diseases, June.

Cardiac Surgery 

Kinetics of Cellular and Humoral Responses to Third BNT162B2 COVID-19 Vaccine Over Six Months in Heart Transplant Recipients - Implications for the Omicron Variant. Peled, Yael, Arnon Afek, Yitshak Kreiss, Galia Rahav, Ital Nemet, Limor Kliker, Victoria Indenbaum, et al. The Journal of Heart and Lung Transplantation, May, S1053-2498(22)01955-6.

Commentary: Finding the Wheat in the Weeds. Mallios, Demetrios N., and Michael E. Bowdish. The Journal of Thoracic and Cardiovascular Surgery, May, S0022-5223(22)00624-9.

Vaccines, Antibodies, and Donors: Varying Attitudes and Policies Surrounding COVID-19 and Heart Transplantation. DeFilippis, Ersilia M., Larry A. Allen, Ankeet S. Bhatt, Susan Joseph, Michelle Kittleson, Orly Vardeny, Mark H. Drazner, and Anuradha Lala. Journal of Cardiac Failure, May, S1071-9164(22)00537-1.

Repair of Pseudoaneurysm in Extra-Anatomic Aortic Arch Bypass Graft. El Nihum, Lamees Ibrahim, M. Mujeeb Zubair, Ponraj Chinnadurai, and Thomas E. MacGillivray. JTCVS Techniques 13 (June): 11–13.

Surgical and Endovascular Treatment of Late Post-Coarctation Repair Aortic Aneurysms: Results from an International Multicenter Study. Melissano, Germano, Ludovic Canaud, Davide Pacini, Victor Bilman, Young Erben, Aung Ye Oo, Vicente Riambau, et al. Journal of Vascular Surgery, June, S0741-5214(22)01627-5.

Continued Variation in Defining a ‘Suitable Donor’ Across the United States. Tremblay, L. Philippe, Joshua Chan, and Dominic Emerson. The Annals of Thoracic Surgery, June, S0003-4975(22)00831-1.


Variability Independent of Mean Blood Pressure as a Real-World Measure of Cardiovascular Risk. Ebinger, Joseph E., Matthew Driver, David Ouyang, Patrick Botting, Hongwei Ji, Mohamad A. Rashid, Ciantel A. Blyler, et al. EClinicalMedicine 48 (June): 101442.

Myocardial Blood Flow Reserve: The Achilles’ Heel of CAD Prognostication? Gulati, Martha, and Purvi Parwani. JACC. Cardiovascular Imaging, June, S1936-878X(22)00259-5.

Testosterone Does Not Shorten Action Potential Duration in Langendorff Perfused Rabbit Ventricles. Ueoka, Akira, Yen-Ling Sung, Xiao Liu, Carine Rosenberg, Zhenhui Chen, Thomas H. Everett, Michael Rubart, James E. Tisdale, and Peng-Sheng Chen. Heart Rhythm, June, S1547-5271(22)02073-2.

Free-Breathing, Non-ECG, Simultaneous Myocardial T1 , T2 , T2 *, and Fat-Fraction Mapping With Motion-Resolved Cardiovascular MR Multitasking. Cao, Tianle, Nan Wang, Alan C. Kwan, Hsu-Lei Lee, Xianglun Mao, Yibin Xie, Kim-Lien Nguyen, et al. Magnetic Resonance in Medicine, June.

Transcatheter Aortic Valve Implantation in Patients With Bicuspid Valve Morphology: A Roadmap Towards Standardization. Xiong, Tian-Yuan, Walid Ben Ali, Yuan Feng, Kentaro Hayashida, Hasan Jilaihawi, Azeem Latib, Michael Kang-Yin Lee, et al. Nature Reviews. Cardiology, June.

Safety of Provocative Testing With Intracoronary Acetylcholine and Implications for Standard Protocols. Takahashi, Tatsunori, Bruce A. Samuels, Weijia Li, Manish A. Parikh, Janet Wei, Jeffery W. Moses, William F. Fearon, et al. Journal of the American College of Cardiology 79 (24): 2367–78.

The Role of Informed Consent in Clinical and Research Settings. Hariri, Essa, Mazen Al Hammoud, Erin Donovan, Kevin Shah, and Michelle M. Kittleson. The Medical Clinics of North America 106 (4): 663–74.

Extracting More From Less: A New Frontier for High-Throughput Clinical Phenotyping. Ouyang, David, and Susan Cheng. Circulation: Cardiovascular Quality & Outcomes 15 (6): e009055–e009055.

Emergency Medicine 

The Impact of Positive Reinforcement on Teamwork Climate, Resiliency, and Burnout During the COVID-19 Pandemic: The TEAM-ICU (Transforming Employee Attitudes via Messaging Strengthens Interconnection, Communication, and Unity) Pilot Study. Green, Jack, Carl T. Berdahl, Xin Ye, and Jeffrey C. Wertheimer. Journal of Health Psychology, June, 13591053221103640.


Editorial: Innovations in Imaging for Early Diagnosis and Monitoring for Patients With Gastrointestinal Cancer. Pandol, Stephen J., Temel Tirkes, and Debiao Li. Frontiers in Oncology 12: 913387.

Age Related Compositional Plaque Burden by CT in Patients With Future ACS. Rosendael, Alexander R. van, Inge J. van den Hoogen, Fay Y. Lin, Umberto Gianni, Yao Lu, Daniele Andreini, Mouaz H. Al-Mallah, et al. Journal of Cardiovascular Computed Tomography, May, S1934-5925(22)00073-9.

Differences in Prognostic Value of Myocardial Perfusion Single-Photon Emission Computed Tomography Using High-Efficiency Solid-State Detector Between Men and Women in a Large International Multicenter Study. Tamarappoo, Balaji K., Yuka Otaki, Tali Sharir, Lien-Hsin Hu, Heidi Gransar, Andrew J. Einstein, Mathews B. Fish, et al. Circulation. Cardiovascular Imaging 15 (6): e012741.

Abstract No. 147 Comparison of Celect Inferior Vena Cava Filter Thrombus Incidence Based on Filter Position at Time of Filter Retrieval. Hoang, K., S. Win, and K. Gupta. Journal of Vascular & Interventional Radiology 33 (6): S68–69.


Editorial: Neutralizing Antibodies in the Prevention and Treatment of COVID-19. Razonable, Raymund R., and Peter Chen. Frontiers in Immunology 13: 938069.

Pre-Clinical Autoimmunity in Lupus Relatives: Self-Reported Questionnaires and Immune Dysregulation Distinguish Relatives Who Develop Incomplete or Classified Lupus From Clinically Unaffected Relatives and Unaffected, Unrelated Individuals. Munroe, Melissa E., Kendra A. Young, Joel M. Guthridge, Diane L. Kamen, Gary S. Gilkeson, Michael H. Weisman, Mariko L. Ishimori, et al. Frontiers in Immunology 13: 866181.

Relationship Between a Vitamin D Genetic Risk Score and Autoantibodies Among First-Degree Relatives of Probands With Rheumatoid Arthritis and Systemic Lupus Erythematosus. Vanderlinden, Lauren A., Elizabeth A. Bemis, Jennifer Seifert, Joel M. Guthridge, Kendra A. Young, Mary Kristen Demoruelle, Marie Feser, et al. Frontiers in Immunology 13: 881332.

Inflammatory and Non-Inflammatory Thyroid Eye Disease: Comparison of Disease Signs, Symptoms and Quality of Life in US Patients. Wang, Yao, Lissa Padnick-Silver, Megan Francis-Sedlak, Robert J. Holt, Colleen Foley, and Raymond S. Douglas. Endocrine Practice, June, S1530-891X(22)00536-5.

Non-Alcoholic Steatohepatitis Drug Development Pipeline: An Update. Chew, Nicholas, Cheng Han Ng, Emily Truong, Mazen Noureddin, and Kris Kowdley. Seminars in Liver Disease, June.

Medical and Surgical Implications of Mesenteric Adipose Tissue in Crohn’s Disease: A Review of the Literature. Gu, Phillip, Shishir Dube, and Dermot P. B. McGovern. Inflammatory Bowel Diseases, June, izac120.

Endocrine Autoantibodies Determine Immune Checkpoint Inhibitor-Induced Endocrinopathy: A Prospective Study. Labadzhyan, Artak, Kristopher Wentzel, Omid Hamid, Kamlynn Chow, Sungjin Kim, Lawrence Piro, and Shlomo Melmed. Journal of Clinical Endocrinology & Metabolism, June, 1976–82.

Does Gender Impact a Diagnosis of Ankylosing Spondylitis? Hwang, Mark C., Martin Rozycki, David Kauffman, Theresa Arndt, Esther Yi, and Michael H. Weisman. ACR Open Rheumatology 4 (6): 540–46.


Teaching Cases in Differential Diagnosis: Misdiagnosis of MS Perpetuated for 14 Years. Lashgari, Ghazal, Andrew J. Solomon, and Marwa Kaisey. Multiple Sclerosis and Related Disorders 64 (June): 103950.

A New Advanced MRI Biomarker for Remyelinated Lesions in Multiple Sclerosis. Rahmanzadeh, Reza, Riccardo Galbusera, Po-Jui Lu, Erik Bahn, Matthias Weigel, Muhamed Barakovic, Jonas Franz, et al. Annals of Neurology, June.


The Future of Diagnostic Laparoscopy - Cons. Simko, Sarah, and Kelly N. Wright. Reproduction & Fertility 3 (2): R91–95.

The Transition to Parenthood in Obstetrics: Enhancing Prenatal Care for Two Generation Impact. Monk, Catherine, Sona Dimidjian, Ellen Galinsky, Kimberly D. Gregory, M. Camille Hoffman, Elizabeth A. Howell, Emily S. Miller, et al. American Journal of Obstetrics & Gynecology MFM, June, 100678.


Prevalence and Modes of Posterior Hardware Failure With a Staged Protocol for Circumferential Minimally Invasive Surgical Correction of Adult Spinal Deformity: A 13-Year Experience. Anand, Neel, Andrew Chung, Christopher Kong, Alisa Alayan, Babak Khandehroo, Sheila Kahwaty, and David Gendelberg. International Journal of Spine Surgery, June, 8256.

An Increased Allograft Width for Circumferential Labral Reconstruction Better Restores Distractive Stability of the Hip: A Cadaveric Biomechanical Analysis. Maldonado, David R., Michael B. Banffy, Dave Huang, Trevor J. Nelson, Shrey Kanjiya, and Melodie F. Metzger. The American Journal of Sports Medicine, June, 3635465221101126.

Biomechanical Comparison of Ulnar Collateral Ligament Reconstruction With and Without Suture Augmentation. Narvaez, Michael V., Trevor J. Nelson, Keon Youssefzadeh, Orr Limpisvasti, and Melodie F. Metzger. The American Journal of Sports Medicine, June, 3635465221101421.

Subtalar Fusion for Correction of Forefoot Abduction in Stage II Adult-Acquired Flatfoot Deformity. Davies, James P., Xiaoyue Ma, Jonathan Garfinkel, Matthew Roberts, Mark Drakos, Jonathan Deland, and Scott Ellis. Foot & Ankle Specialist 15 (3): 221–35.


Factors Associated With Safe Prescription Opioid Disposal After Surgery in Adolescents. Odegard, Marjorie N., Shadassa Ourshalimian, Donia Hijaz, Stephanie Y. Chen, Eugene Kim, Kenneth Illingworth, and Lorraine I. Kelley-Quon. The Journal of Surgical Research 279 (June): 42–51.

Better and Faster Is Cheaper. Sanford Kobayashi, Erica F., and David P. Dimmock. Human Mutation, June.

Lack of the Normal Humoral Immune Response to Gluten in Early Infancy in HLA-DQ2.5 Homozygous Subjects at High Risk for Coeliac Disease. Korponay-Szabo, I., B. Srinivasan, Á. Diós, J. Gyimesi, K. Werkstetter, L. M Mearin, R. Valenta, and S. Koletzko. Journal of Pediatric Gastroenterology & Nutrition 74 (June): 167–167.


AUTHOR REPLY. Heard, John R., W. Austin Wyant, Stacy Loeb, Robert Marcovich, and Justin M. Dubin. Urology 164 (June): 73.

Time Is Domain: Factors Affecting Primary Fascial Closure after Trauma and Non-Trauma Damage Control Laparotomy (Data from the EAST SLEEP-TIME Multicenter Registry). Kwon, Eugenia, Cassandra Krause, Xian Luo-Owen, Kaitlin McArthur, Meghan Cochran-Yu, Lourdes Swentek, Sigrid Burruss, et al. European Journal of Trauma & Emergency Surgery 48 (3): 2107–16.

Dexmedetomidine and Paralytic Exposure after Damage Control Laparotomy: Risk Factors for Delirium? Results from the EAST SLEEP-TIME Multicenter Trial. Krause, Cassandra, Eugenia Kwon, Xian Luo-Owen, Kaitlin McArthur, Meghan Cochran-Yu, Lourdes Swentek, Sigrid Burruss, et al. European Journal of Trauma & Emergency Surgery 48 (3): 2097–2105.