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2022
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Faculty Publications: July 7-14

A Comprehensive Digest of Research Publications From Cedars-Sinai Investigators

This week’s edition of Faculty Publications includes Cedars-Sinai studies that were published July 7-14. If you have a published paper from this period that does not appear on this list, please contact Sue Marone, who will add it to next week’s collection.

Biomedical Sciences 

BATF3 Protects Against Metabolic Syndrome and Maintains Intestinal Epithelial Homeostasis. Hamade, Hussein, Jasmine T. Stamps, Dalton T. Stamps, Shyam K. More, Lisa S. Thomas, Anna Y. Blackwood, Nawele L. Lahcene, Sofi L. Castanon, Brenda C. Salumbides, Yosuke Shimodaira, Helen S. Goodridge, Stephan R. Targan, and Kathrin S. Michelsen. Frontiers in Immunology 13: 841065.

Non-Protective Immune Imprint Underlies Failure of Staphylococcus Aureus IsdB Vaccine. Tsai, Chih-Ming, J. R. Caldera, Irshad A. Hajam, Austin W. T. Chiang, Chih-Hsiung Tsai, Haining Li, María Lázaro Díez, Cesia Gonzalez, Desmond Trieu, Gislâine A. Martins, David M. Underhill, Moshe Arditi, Nathan E. Lewis, and George Y. Liu. Cell Host & Microbe, June, S1931-3128(22)00311-0.

Cancer

Heterogeneity of HER2 Expression in Circulating Tumor Cells of Patients With Breast Cancer Brain Metastases and Impact on Brain Disease Control. Castro, Douglas Guedes de, Antônio Cássio Assis Pellizzon, Alexcia Camila Braun, Michael Jenwei Chen, Maria Letícia Gobo Silva, Ricardo Cesar Fogaroli, Guilherme Rocha Melo Gondim, Henderson Ramos, Elson Santos Neto, Carolina Humeres Abrahão, Liao Shin Yu, Emne Ali Abdallah, Vinicius Fernando Calsavara, and Ludmilla Thomé Domingos Chinen. Cancers14 (13): 3101.

Association Between Sustained Virological Response and Clinical Outcomes in Patients With Hepatitis C Infection and Hepatocellular Carcinoma. Parikh, Neehar D., Neil Mehta, Maarouf A. Hoteit, Ju Dong Yang, Binu V. John, Andrew M. Moon, Reena J. Salgia, Anjana Pillai, Ihab Kassab, Naba Saeed, Emil Thyssen, Piyush Nathani, Jeffrey McKinney, Wesley Chan, Claire Durkin, Matthew Connor, Manaf Alsudaney, Rajesh Konjeti, Brenda Durand, Nicholas N. Nissen, Hannah P. Kim, Raghavendra Paknikar, Nicole E. Rich, Matthew J. Schipper, and Amit G. Singal. Cancer, July.

Molecular Subclasses of Clear Cell Ovarian Carcinoma and Their Impact on Disease Behavior and Outcomes. Bolton, Kelly L., Denise Chen, Rosario I. Corona de la Fuente, Zhuxuan Fu, Rajmohan Murali, Martin K Bel, Yanis Tazi, Julie M. Cunningham, Irenaeus C. C. Chan, Brian J. Wiley, Lea A. Moukarzel, Stacey J. Winham, Sebastian M. Armasu, Jenny Lester, Esther Elishaev, Angela Laslavic, Catherine J. Kennedy, Anna Piskorz, Magdalena Sekowska, Alison H. Brand, Yoke-Eng Chiew, Paul Pharoah, Kevin M. Elias, Ronny Drapkin, Michael Churchman, Charlie Gourley, Anna DeFazio, Beth Karlan, James D. Brenton, Britta Weigelt, Michael S. Anglesio, David Huntsman, Simon A. Gayther, Jason Konner, Francesmary Modugno, Kate Lawrenson, Ellen L. Goode, and Elli Papaemmanuil. Clinical Cancer Research, July, ccr.21.3817.

Overall Survival Indirect Treatment Comparison Between Brigatinib and Alectinib for the Treatment of Front-Line Anaplastic Lymphoma Kinase-Positive Non-Small Cell Lung Cancer Using Data From ALEX and Final Results From ALTA-1L. Reckamp, Karen L., Huamao M. Lin, Holly Cranmer, Yanyu Wu, Pingkuan Zhang, Stephen Kay, Laura J. Walton, Junwu Shen, Sanjay Popat, and D. Ross Camidge. Current Medical Research and Opinion, July, 1–24.

Quantitative Nodal Burden and Mortality Across Solid Cancers. Nguyen, Anthony T., Michael Luu, Vina P. Nguyen, Diana J. Lu, Stephen L. Shiao, Mitchell Kamrava, Katelyn M. Atkins, Alain C. Mita, Kevin S. Scher, Daniel E. Spratt, Mark B. Faries, Timothy J. Daskivich, De-Chen Lin, Michelle M. Chen, Jon Mallen-St Clair, Howard M. Sandler, Allen S. Ho, and Zachary S. Zumsteg. Journal of the National Cancer Institute 114 (7): 1003–11.

Cardiac Surgery 

Robotic Repair for Barlow Mitral Regurgitation: Repairability, Safety, and Durability. Rowe, Georgina, George Gill, Alfredo Trento, Dominic Emerson, Amy Roach, Achille Peiris, Wen Cheng, Natalia Egorova, and Joanna Chikwe. The Journal of Thoracic and Cardiovascular Surgery, June, S0022-5223(22)00628-6.

Hemodynamic Effects of COVID-19 Vaccination in Hospitalized Patients Awaiting Heart Transplantation. Ohman, Rachel E., Michael C. DiVita, Meshe Chonde, Stephanie Fraschilla, Ali Nsair, Daniel Cruz, and Jeffrey J. Hsu. American Heart Journal Plus: Cardiology Research and Practice, July, 100168.

Cardiology

Recurrent Myocarditis Treated With Intravenous Immune Globulin and Steroids. Schwartz, Brandon H., Nathan R. Stein, Shervin Eshaghian, Alan C. Kwan, and Michelle M. Kittleson. The American Journal of Case Reports 23 (July): e935974.

Computational Biomedicine 

Automating Predictive Toxicology Using ComptoxAI. Romano, Joseph D., Yun Hao, Jason H. Moore, and Trevor M. Penning. Chemical Research in Toxicology, July.

Imaging

Cardiovascular Magnetic Resonance in Autoimmune Rheumatic Diseases: A Clinical Consensus Document by the European Association of Cardiovascular Imaging. Mavrogeni, S., A. Pepe, R. Nijveldt, N. Ntusi, L. M. Sierra-Galan, K. Bratis, J. Wei, M. Mukherjee, G. Markousis-Mavrogenis, L. Gargani, L. E. Sade, N. Ajmone-Marsan, P. Seferovic, E. Donal, M. Nurmohamed, M. Matucci Cerinic, P. Sfikakis, G. Kitas, J. Schwitter, J. a. C. Lima, Dana Dawson, Marc Dweck, Kristina H. Haugaa, Niall Keenan, James Moon, Ivan Stankovic, Erwan Donal, and Bernard Cosyns. European Heart Journal. Cardiovascular Imaging, July, jeac134.

Intracranial Vessel Wall Segmentation With Deep Learning Using a Novel Tiered Loss Function Incorporating Class Inclusion. Zhou, Hanyue, Jiayu Xiao, Debiao Li, Zhaoyang Fan, and Dan Ruan. Medical Physics, July.

Benefit of Early Revascularization Based on Inducible Ischemia and Left Ventricular Ejection Fraction. Rozanski, Alan, Robert J. H. Miller, Heidi Gransar, Donghee Han, Piotr Slomka, Damini Dey, Sean W. Hayes, John D. Friedman, Louise Thomson, and Daniel S. Berman. Journal of the American College of Cardiology 80 (3): 202–15.

Medicine

Understanding Physicians’ Perceptions of Patient-Identified Barriers to Osteoporosis Medication Initiation: A Cognitive Mapping Approach. Qu, Haiyan, Stuart L. Silverman, Richard M. Shewchuk, Jeffrey R. Curtis, Shamly Austin, Susan L. Greenspan, Jeri W. Nieves, Ryan C. Outman, Amy H. Warriner, Nelson B. Watts, and Kenneth G. Saag. Risk Management and Healthcare Policy 15: 1293–1302.

Crescents and IgA Nephropathy: A Delicate Marriage. Trimarchi, Hernán, Mark Haas, and Rosanna Coppo. Journal of Clinical Medicine 11 (13): 3569.

The Impact of Sensory Neuropathy and Inflammation on Epithelial Wound Healing in Diabetic Corneas. Yu, Fu-shin X., Patrick S. Y. Lee, Lingling Yang, Nan Gao, Yangyang Zhang, Alexander V. Ljubimov, Ellen Yang, Qingjun Zhou, and Lixin Xie. Progress in Retinal and Eye Research 89 (July): 101039.

Management of Pouch Neoplasia: Consensus Guidelines From the International Ileal Pouch Consortium. Kiran, Ravi P., Gursimran S. Kochhar, Revital Kariv, Douglas K. Rex, Akira Sugita, David T. Rubin, Udayakumar Navaneethan, Tracy L. Hull, Huaibin Mabel Ko, Xiuli Liu, Lisa A. Kachnic, Scott Strong, Marietta Iacucci, Willem Bemelman, Philip Fleshner, Rachael A. Safyan, Paulo G. Kotze, André D’Hoore, Omar Faiz, Simon Lo, Jean H. Ashburn, Antonino Spinelli, Charles N. Bernstein, Sunanda V. Kane, Raymond K. Cross, Jason Schairer, James T. McCormick, Francis A. Farraye, Shannon Chang, Ellen J. Scherl, David A. Schwartz, David H. Bruining, Jessica Philpott, Stuart Bentley-Hibbert, Dino Tarabar, Sandra El-Hachem, William J. Sandborn, Mark S. Silverberg, Darrell S. Pardi, James M. Church, and Bo Shen. The Lancet. Gastroenterology & Hepatology, July, S2468-1253(22)00039-5.

In Reply to ‘Abdominal Pressure and Fluid Status After Kidney Transplantation.’ Dupont, Vincent, Anne-Sophie Bonnet-Lebrun, Alice Boileve, Alexandre Debrumetz, Alain Wynckel, Antoine Braconnier, Charlotte Colosio, Laetitia Mokri, Betoul Schvartz, Vincent Vuiblet, Coralie Barbe, Mathieu Jozwiak, and Philippe Rieu. Kidney International Reports 7 (7): 1727–28.

Evaluating Environmental and Inhibitory Control Strategies to Improve Outcomes in a Widely Available Weight Loss Program. Cáceres, Nenette A., Qihan Yu, Jessica Capaldi, Márcio Augusto Diniz, Hollie Raynor, Gary D. Foster, Aaron R. Seitz, and Sarah-Jeanne Salvy. Contemporary Clinical Trials 119 (July): 106844.

Correlation between Middle Turbinate Insertion in Relation to Sphenopalatine Foramen and Failure Rates of Cryotherapy and Radiofrequency Treatment for Chronic Rhinitis. Fan, Timothy, Megha Chandna, Daniel Gorelik, Masayoshi Takashima, Michael T. Yim, Nicholas R. Rowan, Prachi Dubey, Jordan J. Garner, Jason F. Ohlstein, Arthur W. Wu, and Omar G. Ahmed. International Forum of Allergy & Rhinology, July.

Editorial Cycles and Continuity of Diabetes Care. Riddle, Matthew C., with and on behalf of Associate Editors Vanita Aroda, George Bakris, Lawrence Blonde, Andrew J. M. Boulton, Jessica Castle, Linda DiMeglio, Linda Gonder-Frederick, Frank Hu, Steven Kahn, Sanjay Kaul, Robert Moses, Stephen Rich, Julio Rosenstock, Elizabeth Selvin, Adrian Vella, and Judith Wylie-Rosett. Diabetes Care 45 (7): 1493–94.

Machine Learning Models Are Superior to Non-Invasive Tests in Identifying Clinically Significant Stages of NAFLD and NAFLD-Related Cirrhosis. Chang, Devon, Emily Truong, Edward A. Mena, Fabiana Pacheco, Micaela Wong, Maha Guindi, Tsuyoshi T. Todo, Nabil Noureddin, Walid Ayoub, Ju Dong Yang, Irene K. Kim, Anita Kohli, Naim Alkhouri, Stephen Harrison, and Mazen Noureddin. Hepatology (Baltimore, Md.), July.

The Current State of Care for Black and Hispanic Inflammatory Bowel Disease Patients. Liu, Julia J., Bincy P. Abraham, Paula Adamson, Edward L. Barnes, Kelly A. Brister, Oriana M. Damas, Sarah C. Glover, Kimberly Hooks, Ana Ingram, Gilaad G. Kaplan, Edward V. Loftus, Dermot P. B. McGovern, Melodie Narain-Blackwell, Florence-Damilola Odufalu, Sandra Quezada, Vonda Reeves, Bo Shen, Thaddeus S. Stappenbeck, and Latonia Ward. Inflammatory Bowel Diseases, July, izac124.

Neurology

Engineered Exosomes for Studies in Tumor Immunology. Alptekin, Ahmet, Mahrima Parvin, Hasanul I. Chowdhury, Mohammad H. Rashid, and Ali S. Arbab. Immunological Reviews, July.

Neurosurgery

Editorial: Role of Inflammation in Neurodegenerative Diseases. Koronyo-Hamaoui, Maya, Bhakta Prasad Gaire, Sally Ann Frautschy, and Jorge Ivan Alvarez. Frontiers in Immunology 13: 958487.

OBGYN

Having an Impact. How You Can Help Patients in a Time of Increasing Abortion Restrictions. Schimmoeller, Natasha, and Bryna J. Harwood. Contemporary OB/GYN 67 (7): 7–7.

Long-Term Sequelae of Adverse Pregnancy Outcomes. Torosyan, Nare, Dalia Aziz, and Odayme Quesada. Maturitas 165 (July): 1–7.

Thrombotic Microangiopathy Syndromes-Common Ground and Distinct Frontiers. Hanna, Ramy M., Kammi Henriksen, Kamyar Kalantar-Zadeh, Antoney Ferrey, Richard Burwick, and Kenar D. Jhaveri. Advances in Chronic Kidney Disease 29 (2): 149-160.e1.

Soluble Concentrations of the Terminal Complement Complex C5b-9 Correlate With End-Organ Injury in Preeclampsia. Valencia, Catalina M., Alyssa R. Hersh, Richard M. Burwick, Jesús A. Velásquez, Jorge Gutiérrez-Marín, Francisco Edna, Jaime L. Silva, Juliana Trujillo-Otálvaro, Johanna Vargas-Rodríguez, Yamile Bernal, Alvaro Quintero, Mónica Rincón, and Jorge E. Tolosa. Pregnancy Hypertension 29 (July): 92–97.

Orthopaedics

Accelerated Return to Play in Professional Basketball Players With Surgically-Treated Metacarpal Shaft Fractures. Parikh, Harin B., Mojca C. Herman, and Steven S. Shin. The Iowa Orthopaedic Journal 42 (1): 201–6.

Is Psychiatric Illness Associated With Worse Outcomes Following Pilon Fracture? Rezzadeh, Kevin, Bo Zhang, Diana Zhu, Mark Cubberly, Hayk Stepanyan, Babar Shafiq, Phillip Lim, Ranjan Gupta, Jacques Hacquebord, and Kenneth Egol. The Iowa Orthopaedic Journal 42 (1): 63–68.

Predictors of Quadriceps Strength Asymmetry Following ACL Reconstruction: A CHAID Decision Tree Analysis. Straub, Rachel K., Bert Mandelbaum, and Christopher M. Powers. Medicine and Science in Sports and Exercise, July.

Radiation Oncology 

Patient Reported Outcomes for Quality of Life (QOL) by Expanded Prostate Cancer Index (EPIC) on Average 15 Years Post Treatment. Seymour, Zachary A., Stephanie Daignault-Newton, P. W. McLaughlin, Howard Sandler, William Jackson, Skyler B. Johnson, David Miller, John Wei, Martin Sanda, and Daniel A. Hamstra. Clinical and Translational Radiation Oncology 36 (September): 56–62.

Surgery

Plastic Surgeons as Medical Directors: A Natural Transition into Medical Leadership. Jalalabadi, Faryan, Andrew M. Ferry, Andrew Chang, Edward M. Reece, Shayan A. Izaddoost, Victor J. Hassid, Youssef Tahiri, Edward P. Buchanan, and Sebastian J. Winocour. Archives of Plastic Surgery 49 (2): 221–26.

A Novel Approach for Engagement in Team Training in High-Technology Surgery: The Robotic-Assisted Surgery Olympics. Cohen, Tara N., Jennifer T. Anger, Falisha F. Kanji, Jennifer Zamudio, Elise DeForest, Connor Lusk, Ray Avenido, Christine Yoshizawa, Stephanie Bartkowicz, Lynne S. Nemeth, and Ken Catchpole. Journal of Patient Safety, July.

Excluding Hollow Viscus Injury for Abdominal Seat Belt Sign Using Computed Tomography. Delaplain, Patrick T., Erika Tay-Lasso, Walter L. Biffl, Kathryn B. Schaffer, Margaret Sundel, Samar Behdin, Mira Ghneim, Todd W. Costantini, Jarrett E. Santorelli, Emily Switzer, Morgan Schellenberg, Jessica A. Keeley, Dennis Y. Kim, Andrew Wang, Navpreet K. Dhillon, Deven Patel, Eric M. Campion, Caitlin K. Robinson, Susan Kartiko, Megan T. Quintana, Jordan M. Estroff, Katharine A. Kirby, and Jeffry Nahmias. JAMA Surgery, July.