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Faculty Publications: Aug. 4-11

A Comprehensive Digest of Research Publications From Cedars-Sinai Investigators

This week’s edition of Faculty Publications includes Cedars-Sinai studies that were published Aug. 4-11. If you have a published paper from this period that does not appear on this list, please contact Sue Marone, who will add it to next week’s collection.


Three Lives Changed Forever…. Johnson, Calvin. Anesthesiology, July.

Biomedical Sciences 

Early Innate Immune Responses in Different COVID-19 Sub-Phenotypes Through a Transcriptomics Lens. Yang, Wei. Clinical and Translational Discovery 2 (2): e79.


A Focus on Relapsed Multiple Myeloma. Noonan, Kimberly, Sandra Rome, and Beth Faiman. Journal of the Advanced Practitioner in Oncology 13 (Suppl 4): 15–21.

Efficacy and Safety of Replacing Lenalidomide With Pomalidomide for Patients With Multiple Myeloma Refractory to a Lenalidomide-Containing Combination Regimen. Afari, Jonathan, Tanya M. Spektor, Carley Turner, Alexa Cohen, Alberto Bessudo, Haresh Jhangiani, Nashat Gabrail, Samir Kubba, Jeffrey D. Neidhart, Shahrooz Eshaghian, Regina A. Swift, Benjamin M. Eades, Clara Kim, Susanna Kim, Robert Vescio, and James R. Berenson. Experimental Hematology, August, S0301-472X(22)00581-1.

Microbiota-Driven Mechanisms at Different Stages of Cancer Development. Ivleva, Elena A., and Sergei I. Grivennikov. Neoplasia (New York, N.Y.) 32 (August): 100829.

Four Immune Modulating Genes in Primary Melanoma That Predict Metastatic Potential. Erdrich, Jennifer, Kristel Lourdault, Alex Judd, David Kaufman, Ke Wei Gong, Melanie Gainsbury, Nan Deng, Wonwoo Shon, and Richard Essner. The Journal of Surgical Research 279 (August): 682–91.

Acute Health-Related Quality of Life Outcomes and Systemic Inflammatory Markers Following Contemporary Breast Cancer Surgery. Radin, Arielle S., Julienne E. Bower, Michael R. Irwin, Arash Asher, Sara A. Hurvitz, Steve W. Cole, Catherine M. Crespi, and Patricia A. Ganz. NPJ Breast Cancer 8 (1): 91.

A Phase 1 Study of Ruxolitinib, Steroids and Lenalidomide for Relapsed/Refractory Multiple Myeloma Patients. Berenson, James R., Clara Kim, Sean Bujarski, Jennifer To, Tanya M. Spektor, Daisy Martinez, Carley Turner, Matthew Ghermezi, Benjamin M. Eades, Regina A. Swift, Gary Schwartz, Shahrooz Eshaghian, Robert A. Moss, Stephen Lim, and Robert Vescio. Hematological Oncology, August.

Oral Pain in the Cancer Patient. Samim, Firoozeh, Joel B. Epstein, and Rachael Osagie. Current Opinion in Supportive and Palliative Care 16 (3): 174–79.

Cardiac Surgery 

Improving Quality in Cardiothoracic Surgery: Exploiting the Untapped Potential of Machine Learning.Orfanoudaki, Agni, Joseph A. Dearani, David M. Shahian, Vinay Badhwar, Felix Fernandez, Robert Habib, Michael E. Bowdish, and Dimitris Bertsimas. The Annals of Thoracic Surgery, August, S0003-4975(22)01003-7.

Perioperative and Long-Term Outcomes after Open Conversion of Endovascular Aneurysm Repair Versus Primary Open Aortic Repair. Elsayed, Nadin, Rami Alhakim, Omar Al Nouri, Donald Baril, Fred Weaver, and Mahmoud B. Malas. Journal of Vascular Surgery, August, S0741-5214(22)02103-6.

Contemporary Management and Outcomes of Peripheral Venous Aneurysms - a Multi-Institutional Study. Patel, Rhusheet, Karen Woo, Thomas W. Wakefield, Robert J. Beaulieu, Manar Khashram, Giovanni De Caridi, Filippo Benedetto, Sherene Shalhub, Asmaa El-Ghazali, Jeffrey E. Silpe, Mihai Rosca, Tina U. Cohnert, Gregor K. Siegl, Christopher Abularrage, Rebecca Sorber, Catherine M. Wittgen, Paul G. Bove, Graham W. Long, Kristofer M. Charlton-Ouw, Hunter M. Ray, Peter Lawrence, and Donald Baril. Journal of Vascular Surgery. Venous and Lymphatic Disorders, August, S2213-333X(22)00326-2.


Soluble Urokinase Plasminogen Activator Receptor and Venous Thromboembolism in COVID-19. Luo, Shengyuan, Alexi Vasbinder, Jeanne M. Du-Fay-de-Lavallaz, Joanne Michelle D. Gomez, Tisha Suboc, Elizabeth Anderson, Annika Tekumulla, Husam Shadid, Hanna Berlin, Michael Pan, Tariq U. Azam, Ibrahim Khaleel, Kishan Padalia, Chelsea Meloche, Patrick O’Hayer, Tonimarie Catalan, Pennelope Blakely, Christopher Launius, Kingsley-Michael Amadi, Rodica Pop-Busui, Sven H. Loosen, Athanasios Chalkias, Frank Tacke, Evangelos J. Giamarellos-Bourboulis, Izzet Altintas, Jesper Eugen-Olsen, Kim A. Williams, Annabelle Santos Volgman, Jochen Reiser, Salim S. Hayek, and ISIC (International Study of Inflammation in COVID‐19) Group. Journal of the American Heart Association, August, e025198.

Three Newly Recognized Likely Pathogenic Gene Variants Associated With Hereditary Transthyretin Amyloidosis. Patel, Jignesh K., Andrew M. Rosen, Adam Chamberlin, Benjamin Feldmann, Christian Antolik, Heather Zimmermann, Tami Johnston, and Arvind Narayana. Neurology and Therapy, August.

Outcomes of Redo Transcatheter Aortic Valve Replacement According to the Initial and Subsequent Valve Type. Landes, Uri, Ilan Richter, Haim Danenberg, Ran Kornowski, Janarthanan Sathananthan, Ole De Backer, Lars Søndergaard, Mohamed Abdel-Wahab, Sung-Han Yoon, Raj R. Makkar, Holger Thiele, Won-Keun Kim, John G. Webb, et al. JACC. Cardiovascular Interventions 15 (15): 1543–54.

Missing Pieces of the Transcatheter Aortic Valve Replacement Subclinical Leaflet Thrombosis Puzzle.Makkar, Raj, and Tarun Chakravarty. Circulation 146 (6): 494–97.

Computational Biomedicine 

Genetic Heterogeneity: Challenges, Impacts, and Methods through an Associative Lens. Woodward, Alexa A., Ryan J. Urbanowicz, Adam C. Naj, and Jason H. Moore. Genetic Epidemiology, August.


Diet and Physical Activity Behaviors of Families Receiving Maternal and Child Health Services: The Perspective of the Home Visitor. Miller, Sydney, Celina H. Shirazipour, Aimee Fata Holmes, Sarah-Jeanne Salvy, and Kayla de la Haye. Journal of Healthy Eating and Active Living 2 (1): 9–22.

The Mental Health Burden of Racial and Ethnic Minorities During the COVID-19 Pandemic. Nguyen, Long H., Adjoa Anyane-Yeboa, Kerstin Klaser, Jordi Merino, David A. Drew, Wenjie Ma, Raaj S. Mehta, Daniel Y. Kim, Erica T. Warner, Amit D. Joshi, Mark S. Graham, Carole H. Sudre, Ellen J. Thompson, Anna May, Christina Hu, Solveig Jørgensen, Somesh Selvachandran, Sarah E. Berry, Sean P. David, Maria Elena Martinez, Jane C. Figueiredo, Anne M. Murray, Alan R. Sanders, Karestan C. Koenen, Jonathan Wolf, Sebastien Ourselin, Tim D. Spector, Claire J. Steves, and Andrew T. Chan. PloS One 17 (8): e0271661.

The Prevalence of Alcoholic and Nonalcoholic Fatty Liver Disease in Adolescents and Young Adults in the United States: Analysis of the NHANES Database. Alkhouri, Naim, Ashraf Almomani, Phuc Le, Julia Y. Payne, Imad Asaad, Celine Sakkal, Miriam Vos, Mazen Noureddin, and Prabhat Kumar. BMC Gastroenterology 22 (1): 366.

All-Cause Health Care and Work Loss Burden Associated With Nonsteroidal Anti-Inflammatory Drug and Opioid Treatment in Employed Patients With Osteoarthritis. Silverman, Stuart, Sheena Thakkar, Heather Sell, Alan G. White, Nathaniel Downes, William Pajerowski, Rebecca L. Robinson, Craig G. Beck, Birol Emir, and Patricia Schepman. Journal of Occupational and Environmental Medicine 64 (8): 699–706.

Social Media for the Dissemination of Educational Videos About Inflammatory Bowel Diseases. Deen, Welmoed K. van, Mike Simpson, Taylor P. Dupuy, Carine Khalil, Nirupama N. Bonthala, and Brennan M. R. Spiegel. The American Journal of Gastroenterology 117 (8): 1320–23.

Calcium, Mitochondria and the Initiation of Acute Pancreatitis. Pandol, Stephen J., and Roberta A. Gottlieb. Pancreatology, August, S1424-3903(22)00466-5.

The Fibrosis-4 (FIB-4) Index Predicts Cardiovascular Major Adverse Events and Mortality in Patients With Non-Alcoholic Fatty Liver Disease. Chew, Nicholas Ws, Cheng Han Ng, Kai En Chan, Douglas Chee, Nicholas Syn, Tamaki Nobuharu, Mark Muthiah, and Mazen Noureddin. The Canadian Journal of Cardiology, August, S0828-282X(22)00499-8.

Cell-Free RNA Transcriptome and Prediction of Adverse Pregnancy Outcomes. Gray, Kathryn J., Martin Hemberg, and S. Ananth Karumanchi. Clinical Chemistry, August, hvac109.

Prospective Changes in Diastolic Function in Patients With Rheumatoid Arthritis. Park, Elizabeth, Kazato Ito, Rabia Iqbal, Isabelle Amigues, Sabahat Bokhari, Jennifer Van Eyk, Christopher Depender, Jon T. Giles, and Joan Bathon. Arthritis Research & Therapy 24 (1): 184.

Effectiveness of Early Time-Restricted Eating for Weight Loss, Fat Loss, and Cardiometabolic Health in Adults With Obesity: A Randomized Clinical Trial. Jamshed, Humaira, Felicia L. Steger, David R. Bryan, Joshua S. Richman, Amy H. Warriner, Cody J. Hanick, Corby K. Martin, Sarah-Jeanne Salvy, and Courtney M. Peterson. JAMA Internal Medicine, August.

Complete Alcohol Abstinence Increases the Risk of NAFLD but Not Severity. A Population Analysis With Transient Elastography. Xiao, Jieling, Cheng Han Ng, Kai En Chan, Ansel Shao Pin Tang, Readon Teh, Abel Ho Zhi Ling, Jie Ning Yong, Wen Hui Lim, Darren Jun Hao Tan, Caitlyn Tan, Khin Maung Win, Aung Hlaing Bwa, Nicholas W. S. Chew, Daniel Huang, Yock Young Dan, Mazen Noureddin, Mohammad Shadab Siddiqui, Arun Sanyal, Nobuharu Tamaki, and Mark Muthiah. Scandinavian Journal of Gastroenterology, August, 1–7.

Impaired Renal Reserve Contributes to Preeclampsia via the Kynurenine and Soluble Fms-like Tyrosine Kinase 1 Pathway. Dupont, Vincent, Anders H. Berg, Michifumi Yamashita, Chengqun Huang, Ambart E. Covarrubias, Shafat Ali, Aleksandr Stotland, Jennifer E. Van Eyk, Belinda Jim, Ravi Thadhani, and S. Ananth Karumanchi. The Journal of Clinical Investigation, August, e158346.

Remission and Low Disease Activity (LDA) Prevent Damage Accrual in Patients With Systemic Lupus Erythematosus: Results From the Systemic Lupus International Collaborating Clinics (SLICC) Inception Cohort. Ugarte-Gil, Manuel Francisco, John Hanly, Murray Urowitz, Caroline Gordon, Sang-Cheol Bae, Juanita Romero-Diaz, Jorge Sanchez-Guerrero, Sasha Bernatsky, Ann Elaine Clarke, Daniel J. Wallace, David Alan Isenberg, Anisur Rahman, Joan T. Merrill, Paul R. Fortin, Dafna D. Gladman, Ian N. Bruce, Michelle Petri, Ellen M. Ginzler, Mary Anne Dooley, Rosalind Ramsey-Goldman, Susan Manzi, Andreas Jönsen, Ronald F. van Vollenhoven, Cynthia Aranow, Meggan Mackay, Guillermo Ruiz-Irastorza, Sam Lim, Murat Inanc, Ken Kalunian, Søren Jacobsen, Christine Peschken, Diane L. Kamen, Anca Askanase, Bernardo A. Pons-Estel, and Graciela S. Alarcón. Annals of the Rheumatic Diseases, August, annrheumdis-2022-222487.


Recommendations to Address Key Recruitment Challenges of Alzheimer’s Disease Clinical Trials. Langbaum, Jessica B., Julie Zissimopoulos, Rhoda Au, Niranjan Bose, Chris J. Edgar, Evan Ehrenberg, Howard Fillit, Carl V. Hill, Lynne Hughes, Michael Irizarry, Sarah Kremen, Darius Lakdawalla, Nancy Lynn, Kristina Malzbender, Tetsuyuki Maruyama, Holly A. Massett, Deep Patel, Desi Peneva, Eric M. Reiman, Klaus Romero, Carol Routledge, Michael W. Weiner, Stacie Weninger, and Paul S. Aisen. Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association, August.


Probing the Human Brain at Single-Neuron Resolution With High-Density Cortical Recordings. Meisenhelter, Stephen, and Ueli Rutishauser. Neuron 110 (15): 2353–55.

Trends and Long-Term Health Care Utilization of Computer Assisted Neuronavigation in Spine Fusions: An Exact Matched Analysis of National Administrative Database. Sharma, Mayur, Syed Abdullah Uddin, George Hanna, Beatrice Ugiliweneza, Terrence T. Kim, J. Patrick Johnson, Maxwell Boakye, and Doniel Drazin. World Neurosurgery, August, S1878-8750(22)01066-X.

Single-Neuron Models Linking Electrophysiology, Morphology, and Transcriptomics Across Cortical Cell Types. Nandi, Anirban, Thomas Chartrand, Werner Van Geit, Anatoly Buchin, Zizhen Yao, Soo Yeun Lee, Yina Wei, Brian Kalmbach, Brian Lee, Ed Lein, Jim Berg, Uygar Sümbül, Christof Koch, Bosiljka Tasic, and Costas A. Anastassiou. Cell Reports 40 (6): 111176.


It’s Complicated! Needlesticks in the Perioperative Area: How We Standardized the Process. Gonzalez, Rowena, Alena Mascetta, Rusela DeSilva, Carleen Chhun, and Amanda Sibley. Journal of PeriAnesthesia Nursing 37 (4): e3–4.


Maternal and Fetal Outcomes of Pregnancy Occurring After a Diagnosis of Immune-Mediated Thrombotic Thrombocytopenic Purpura. Brown, Jenna, Bindu Potugari, Marshall A. Mazepa, Ruhail Kohli, Alison R. Moliterno, Robert A. Brodsky, Jason A. Vaught, Richard Burwick, and Shruti Chaturvedi. Annals of Hematology, August.


Accelerated Rehabilitation Following Thumb Ulnar Collateral Ligament Repair With Suture Tape Augmentation: A Case Series of Professional Basketball Players. Parikh, Harin Bhavin, M. C. Herman, A. R. Phillips, and S. S. Shin. Journal of Hand Therapy, August, S0894-1130(22)00081-3.

Re-Evaluating Consensus and Uncertainty Among Treatment Options for Early Onset Scoliosis: A 10-Year Update. Matsumoto, Hiroko, Adam N. Fano Bs, Theodore Quan Bs, Behrooz A. Akbarnia, Laurel C. Blakemore, John M. Flynn, David L. Skaggs, John T. Smith, Brian D. Snyder, Paul D. Sponseller, Richard E. McCarthy, Peter F. Sturm, David P. Roye, John B. Emans, and Michael G. Vitale. Spine Deformity, August.


Computational Pathology in Ovarian Cancer. Orsulic, Sandra, Joshi John, Ann E. Walts, and Arkadiusz Gertych. Frontiers in Oncology 12.

Third CMAS (CytoJournal Monograph/Atlas Series) Titled ‘Uterine Cervix Cancer and The Bethesda System.’ Shidham, Vinod B., Shikha Bose, Zubair Wahid Baloch, Meherbano Mustafa Kamal, Jasvinder Kaur Bhatia, and Lester J. Layfield. CytoJournal 19: 45.

KMT2A-CBL Fusion in Rapidly Progressive Myeloid Disorder. Chaum, Manita, Eric Vail, Rhona Schreck, Jeremy Lorber, and Celeste C. Eno. Cancer Genetics 266–267 (July): 90–92.

The Histopathology of Anorectal Neisseria Gonorrhoeae Infection. Cox, Brian K., Brent K. Larson, Danielle A. Hutchings, Margie Morgan, Bonnie L. Balzer, and Kevin M. Waters. American Journal of Clinical Pathology, August, aqac089.

Dual Therapy With an Angiotensin Receptor Blocker and a JAK1/2 Inhibitor Attenuates Dialysate-Induced Angiogenesis and Preserves Peritoneal Membrane Structure and Function in an Experimental CKD Rat Model. Zhang, Pei, Kana N. Miyata, Cynthia C. Nast, Janine A. LaPage, Madisyn Mahoney, Sonny Nguyen, Kamran Khan, Qiaoyuan Wu, Sharon G. Adler, and Tiane Dai. Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis, August, 8968608221116956.


Lymphangiocrine Signals Are Required for Proper Intestinal Repair After Cytotoxic Injury. Palikuqi, Brisa, Jérémie Rispal, Efren A. Reyes, Dedeepya Vaka, Dario Boffelli, and Ophir Klein. Cell Stem Cell 29 (8): 1262-1272.e5.

Radiation Oncology 

Local Failure Events in Prostate Cancer Treated With Radiotherapy: A Pooled Analysis of 18 Randomized Trials From the Meta-Analysis of Randomized Trials in Cancer of the Prostate Consortium (LEVIATHAN). Ma, Ting Martin, Fang-I. Chu, Howard Sandler, Felix Y. Feng, Jason A. Efstathiou, Christopher U. Jones, Mack Roach, Seth A. Rosenthal, Thomas Pisansky, Jeff M. Michalski, Michel Bolla, Theo M. de Reijke, Philippe Maingon, Anouk Neven, James Denham, Allison Steigler, David Joseph, Abdenour Nabid, Luis Souhami, Nathalie Carrier, Luca Incrocci, Wilma Heemsbergen, Floris J. Pos, Matthew R. Sydes, David P. Dearnaley, Alison C. Tree, Isabel Syndikus, Emma Hall, Clare Cruickshank, Shawn Malone, Soumyajit Roy, Yilun Sun, Nicholas G. Zaorsky, Nicholas G. Nickols, Robert E. Reiter, Matthew B. Rettig, Michael L. Steinberg, Vishruth K. Reddy, Michael Xiang, Tahmineh Romero, Daniel E. Spratt, Amar U. Kishan, and Meta-analysis of Randomized trials in Cancer of the Prostate MARCAP Consortium investigators. European Urology, August, S0302-2838(22)02523-4.


The Promise of Patient Reported Outcome Measurements in Endocrine Surgery. Chen, Yufei, and Monica Jain. American Journal of Surgery, July, S0002-9610(22)00446-9.

Patient Characteristics and Diagnostic Tests Associated With Syncopal Falls: A Southwestern Surgical Congress Multicenter Study. Lee, Janet S., Abid D. Khan, Christopher M. Quinn, Kathryn Colborn, Deven C. Patel, Galinos Barmparas, Daniel R. Margulies, Christine J. Waller, Kara J. Kallies, Alec J. Fitzsimmons, Shanu N. Kothari, Alexander R. Raines, Heidi Mahnken, Julie Dunn, Linda Zier, Robert C. McIntyre, Shane Urban, Julia R. Coleman, Eric M. Campion, Clay C. Burlew, and Thomas J. Schroeppel. American Journal of Surgery, July, S0002-9610(22)00484-6.

Indirect Comparison of the Efficacy of Radiofrequency Neurolysis and Cryotherapy in the Treatment of Chronic Rhinitis. Gorelik, Daniel, Alexander Choi, Nicole Desisto, Adriana Ordonez, Masayoshi Takashima, Nicholas R. Rowan, Dennis M. Tang, Tariq Syed, Michael T. Yim, and Omar G. Ahmed. International Forum of Allergy & Rhinology, August.

Adaptive Nasal Bone Remodeling Secondary to Chronic Virtual Reality Headset Use. Nasrollahi, Tasha S., Matthew K. Lee, and Gene C. Liu. American Journal of Otolaryngology 43 (5): 103587.

Characteristics Associated With Outstanding General Surgery Residency Graduate Performance, as Rated by Surgical Educators. Purdy, Amanda C., Brian R. Smith, Farin Amersi, Kristine E. Calhoun, Juliana Tolles, Christine Dauphine, Janell Holloway, Mayank Roy, Benjamin T. Jarman, Amy Y. Han, Angela L. Neville, Karen J. Dickinson, Edgardo S. Salcedo, Edgar Shields Frey, V. Prasad Poola, Kenric M. Murayama, Formosa Chen, Esther Wu, Ross J. Fleischman, and Christian de Virgilio. JAMA Surgery, August.

Radiofrequency Ablation (RFA) Compared to Observation for Benign Thyroid Nodules: Emerging Considerations for Judicious Use. Sinclair, Catherine F., Amanda J. Bastien, and Allen S. Ho. Current Opinion in Endocrinology, Diabetes, and Obesity, August.

Reply by Authors. Garg, Harshit, Sarah P. Psutka, Abraham Ari Hakimi, Hyung L. Kim, Ahmed M. Mansour, Deepak K. Pruthi, Michael A. Liss, Hanzhang Wang, Christine S. Gaspard, Chethan Ramamurthy, Robert S. Svatek, and Dharam Kaushik. The Journal of Urology 208 (3): 560.