Systemic Lupus Erythematosus

We have assembled 1,000 SLE subjects in a registry, and they are now being entered into a research repository. Our initial efforts are focused on preclinical disease in first-degree relatives (a genetically enriched cohort likely to evolve into Systemic Lupus Erythematosus) in order to examine which biomarkers and genes will predict the onset of clinical Systemic Lupus Erythematosus (SLE). In collaboration with the Cedars-Sinai Department of Pathology and Laboratory Medicine, we are examining candidate genes in stored clinical specimens (kidney biopsy tissue) that we can associate with the most severe clinical SLE phenotype.

It is well recognized that premature ischemic heart disease is a cause of increased SLE mortality and occurs with great frequency, along with angina chest pain, in SLE subjects. Our preliminary studies revealed that microvascular ischemic heart disease is prevalent in SLE women who have chest pain and do not have evidence of macrovascular (large vessel) coronary artery disease. This discovery could be a potential link between a vexing clinical problem (premature ischemic heart disease in SLE women) and a potential mechanism that might be amenable to treatment. Finally, we have observed a significant degree of clinical depression, accounting for a major impact on the quality of life in the underserved, largely Hispanic SLE patients in Southern California, through our collaborations with Community Health Services in the UCLA Fielding School of Public Health, Harbor - UCLA Medical Center, University of Southern California and Loma Linda University. These data have contributed to at least four multidisciplinary and multi-institutional reports that have been published in major journals that speak to clinicians, health service researchers and bio-psychologists.

Achievements in SLE

Program Interactions in SLE

Have Questions or Need Help?

If you have questions or would like to learn more about the Rheumatology Fellowship at Cedars-Sinai, please call or send us a message.

Cedars-Sinai Medical Center
8700 Beverly Blvd.
Becker Building, B131
Los Angeles, CA 90069

Mariko Ishimori, MD Director, Division of Rheumatology